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1. Full Text Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes
by Valent, Peter, MD and Klion, Amy D., MD and Horny, Hans-Peter, MD and Roufosse, Florence, MD, PhD and Gotlib, Jason, MD and Weller, Peter F., MD and Hellmann, Andrzej, MD and Metzgeroth, Georgia, MD and Leiferman, Kristin M., MD and Arock, Michel, PharmD, PhD and Butterfield, Joseph H., MD and Sperr, Wolfgang R., MD and Sotlar, Karl, MD and Vandenberghe, Peter, MD, PhD and Haferlach, Torsten, MD and Simon, Hans-Uwe, MD, PhD and Reiter, Andreas, MD and Gleich, Gerald J., MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 130, Issue 3, pp. 607 - 612.e9
Eosinophilia is an important indicator of various neoplastic and nonneoplastic conditions. Depending on the underlying disease and mechanisms, eosinophil... 
Allergy and Immunology | eosinophilic leukemia | hypereosinophilia of undetermined significance | classification | criteria | Hypereosinophilic syndrome | CHURG-STRAUSS-SYNDROME | TYROSINE KINASE | GASTROINTESTINAL-TRACT | IMMUNOLOGY | CHRONIC MYELOPROLIFERATIVE DISEASES | SYSTEMIC MASTOCYTOSIS | GROWTH-FACTOR RECEPTOR | FAMILIAL EOSINOPHILIA | EPISODIC ANGIOEDEMA | ALLERGY | IDIOPATHIC HYPEREOSINOPHILIC SYNDROME | FIP1L1-PDGFRA FUSION | Terminology as Topic | Eosinophils - physiology | Hypereosinophilic Syndrome - classification | Eosinophilia - classification | Humans | Eosinophilia - diagnosis | Allergy | Medical colleges | Platelet-derived growth factor | Parasitic diseases | Analysis | Leukemia | Fibroblast growth factors | Allergic reaction | Public health | Lymphatic system | Disease | Cytokines | Genes | Stem cells | Classification | Thrombosis | Chromosomes | Tumors | Defects | Clinical trials | Conferences | Eosinophilia | Hypersensitivity | Leukocytes (eosinophilic) | Life Sciences | Immunology
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2. Full Text Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology
by Hartmann, Karin, MD and Escribano, Luis, MD, PhD and Grattan, Clive, MA, MD and Brockow, Knut, MD and Carter, Melody C., MD and Alvarez-Twose, Ivan, MD and Matito, Almudena, MD, PhD and Broesby-Olsen, Sigurd, MD and Siebenhaar, Frank, MD and Lange, Magdalena, MD, PhD and Niedoszytko, Marek, MD, PhD and Castells, Mariana, MD, PhD and Oude Elberink, Joanna N.G., MD, PhD and Bonadonna, Patrizia, MD and Zanotti, Roberta, MD and Hornick, Jason L., MD, PhD and Torrelo, Antonio, MD and Grabbe, Jürgen, MD and Rabenhorst, Anja, PhD and Nedoszytko, Boguslaw, PhD and Butterfield, Joseph H., MD and Gotlib, Jason, MD and Reiter, Andreas, MD and Radia, Deepti, MD and Hermine, Olivier, MD, PhD and Sotlar, Karl, MD and George, Tracy I., MD and Kristensen, Thomas K., PhD and Kluin-Nelemans, Hanneke C., MD, PhD and Yavuz, Selim, MD and Hägglund, Hans, MD, PhD and Sperr, Wolfgang R., MD and Schwartz, Lawrence B., MD, PhD and Triggiani, Massimo, MD, PhD and Maurer, Marcus, MD and Nilsson, Gunnar, PhD and Horny, Hans-Peter, MD and Arock, Michel, PharmD, PhD and Orfao, Alberto, MD, PhD and Metcalfe, Dean D., MD and Akin, Cem, MD, PhD and Valent, Peter, MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 137, Issue 1, pp. 35 - 45
Cutaneous lesions in patients with mastocytosis are highly heterogeneous and encompass localized and disseminated forms. Although a classification and criteria... 
Allergy and Immunology | diagnostic criteria | cutaneous mastocytosis | mastocytosis | urticaria pigmentosa | Classification | mast cell | standardization | ADULT PATIENTS | GERMLINE MUTATION | TRYPTASE LEVELS | C-KIT MUTATIONS | SYSTEMIC MASTOCYTOSIS | ONSET MASTOCYTOSIS | PEDIATRIC MASTOCYTOSIS | DIAGNOSTIC-CRITERIA | MAST-CELL DISORDERS | RISK-FACTORS | MAST-CELLS | IMMUNOLOGY | ALLERGY | Mastocytosis, Cutaneous - classification | Societies, Medical | Mastocytosis, Cutaneous - immunology | Humans | Mastocytosis, Cutaneous - diagnosis | Consensus | Mast cell disease | Care and treatment | Asthma | Studies | Pediatrics | Task forces | Immunology | Meetings | Biopsy | Medical prognosis | Bone marrow | Adults | Mutation | Age
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3. Full Text The Mastocytosis Society Survey on Mast Cell Disorders: Part 2-Clinical Experiences, Co-Morbidities and Additional Concerns
by Russell, Nancy C., DrPH and Jennings, Susan V., PhD and Jennings, Blair, BS and Slee, Valerie, RN, BSN and Sterling, Lisa, BS and Castells, Mariana, MD, PhD, FAAAAI and Valent, Peter, MD and Akin, Cem, MD, PhD, FAAAAI
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 135, Issue 2, pp. AB136 - AB136
  In order to determine the characteristics and experiences of people known or suspected to have a mast cell disorder, The Mastocytosis Society, a U.S. based... 
Allergy and Immunology | Medical colleges | Mast cell disease | Patients | Society
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4. Full Text Mast cell activation syndrome: Proposed diagnostic criteria
by Akin, Cem, MD, PhD and Valent, Peter, MD and Metcalfe, Dean D., MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2010, Volume 126, Issue 6, pp. 1099 - 1104.e4
The term mast cell activation syndrome (MCAS) is finding increasing use as a diagnosis for subjects who present with signs and symptoms involving the dermis,... 
Allergy and Immunology | histamine | mastocytosis | urticaria | allergy | Mast cells | anaphylaxis | tryptase | TRYPTASE LEVELS | KIT | IMMUNOLOGY | Abnormalities, Multiple - pathology | Mast Cells - immunology | Diagnosis, Differential | Cytokines - metabolism | Humans | Cell Degranulation - immunology | Abnormalities, Multiple - immunology | Abnormalities, Multiple - physiopathology | Syndrome | Prostaglandin D2 - metabolism | Abnormalities, Multiple - diagnosis | Mast Cells - pathology | Mast Cells - metabolism | Prostaglandin D2 - genetics | Leukotriene C4 - metabolism | Cytokines - genetics | Leukotriene C4 - genetics | Practice Guidelines as Topic | Allergy | Medical colleges | Allergic reaction | Public health | Stem cells | Cytokines | Disease | T cell receptors | Kinases | Patients | Allergies | Proteins | Cell growth | Pain | Rodents | Blood pressure | Mutation | Chemokines | Immune system
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5. Full Text Reply
by Akin, Cem, MD, PhD and Valent, Peter, MD and Metcalfe, Dean D., MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2011, Volume 127, Issue 5, pp. 1311 - 1312
Allergy and Immunology
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6. Diagnostic criteria and classification of mastocytosis in 2014
by Akin, Cem and Valent, Peter
Immunology and Allergy Clinics of North America, ISSN 0889-8561, 2014, Volume 34, Issue 2, pp. 207 - 218
Mastocytosis is characterized by accumulation of pathologic mast cells in tissues. Most patients with mastocytosis experience mast cell activation symptoms in... 
Mastocytosis | C-kit | World Health Organization | Diagnosis | Classification | Tryptase | WILD-TYPE | URTICARIA PIGMENTOSA | TRYPTASE LEVELS | c-kit | C-KIT MUTATION | IMMUNOLOGY | SYSTEMIC MASTOCYTOSIS | SMOLDERING MASTOCYTOSIS | ACTIVATING MUTATION | ALLERGY | HIGH PREVALENCE | MAST-CELL DISORDERS | SERUM TRYPTASE | Bone Marrow - immunology | Mastocytosis - diagnosis | Age Factors | Tryptases - blood | Humans | Mastocytosis - immunology | Proto-Oncogene Proteins c-kit - immunology | Gastrointestinal Tract - pathology | Gastrointestinal Tract - immunology | Interleukin-2 Receptor alpha Subunit - genetics | Adult | Proto-Oncogene Proteins c-kit - genetics | Child | Skin - pathology | Interleukin-2 Receptor alpha Subunit - immunology | Skin - immunology | Tryptases - genetics | Biomarkers - metabolism | Mast Cells - immunology | Gene Expression | Mastocytosis - pathology | Bone Marrow - pathology | Mast Cells - pathology | Mastocytosis - classification | Mutation | Practice Guidelines as Topic
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7. Full Text Large maculopapular cutaneous lesions are associated with favorable outcome in childhood-onset mastocytosis
by Wiechers, Tim, MD and Rabenhorst, Anja, PhD and Schick, Tina, MD and Preussner, Liane M., MD and Förster, Anja, PhD and Valent, Peter, MD and Horny, Hans-Peter, MD and Sotlar, Karl, MD and Hartmann, Karin, MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 136, Issue 6, pp. 1581 - 1590.e3
Background Mastocytosis, characterized by pathologic accumulation of mast cells, can manifest itself in adulthood or childhood. Pediatric patients usually have... 
Allergy and Immunology | KIT mutation | cutaneous mastocytosis | Childhood-onset mastocytosis | mastocytosis | urticaria pigmentosa | pediatric mastocytosis | mast cell | skin | prognosis | tryptase | BASE-LINE | TRYPTASE LEVELS | GERMLINE MUTATION | C-KIT | IMMUNOLOGY | CHILDREN | ALLERGY | URTICARIA-PIGMENTOSA | KIT D816V MUTATION | DIAGNOSTIC-CRITERIA | ALLELE BURDEN | Prognosis | Tryptases - blood | Humans | Middle Aged | Child, Preschool | Infant | Male | Urticaria Pigmentosa - pathology | Urticaria Pigmentosa - genetics | Young Adult | Adolescent | Urticaria Pigmentosa - blood | Adult | Female | Proto-Oncogene Proteins c-kit - genetics | Child | Infant, Newborn | Urticaria Pigmentosa - diagnosis | Medical colleges | Mast cell disease | Ophthalmology | Medical research | Analysis | Medicine, Experimental | Skin | Children | Health aspects | Studies | Statistical analysis | Biopsy | Cloning | Morphology | Bone marrow | Adults | Mutation | Deoxyribonucleic acid--DNA
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8. Full Text Development and characterization of a recombinant, hypoallergenic, peptide-based vaccine for grass pollen allergy
by Focke-Tejkl, Margarete, PhD and Weber, Milena, MSc and Niespodziana, Katarzyna, PhD and Neubauer, Angela, PhD and Huber, Hans, PhD and Henning, Rainer, PhD and Stegfellner, Gottfried, MSc and Maderegger, Bernhard, PhD and Hauer, Martina, MSc and Stolz, Frank, PhD and Niederberger, Verena, MD and Marth, Katharina, MD and Eckl-Dorna, Julia, MD, PhD and Weiss, Richard, PhD and Thalhamer, Josef, PhD and Blatt, Katharina, MSc and Valent, Peter, MD and Valenta, Rudolf, MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 135, Issue 5, pp. 1207 - 1217.e11
Background Grass pollen is one of the most important sources of respiratory allergies worldwide. Objective This study describes the development of a grass... 
Allergy and Immunology | allergen | Grass pollen allergy | recombinant allergen | recombinant hypoallergenic allergen derivative | peptide-carrier technology | allergen-specific immunotherapy | P 2 | RECOGNITION | IGE | BLOCKING ANTIBODIES | IMMUNOLOGY | IMMUNOGENICITY | ALLERGY | IMMUNOTHERAPY | EXTRACTS | PHLEUM-PRATENSE POLLEN | IMMUNOGLOBULIN-E | EPITOPES | Hepatitis B Surface Antigens - genetics | Recombinant Fusion Proteins - immunology | Recombinant Fusion Proteins - isolation & purification | Humans | Poaceae | Vaccines, Synthetic - immunology | Pollen - immunology | Immunoglobulin E - blood | Lymphocyte Activation - immunology | Immunoglobulin E - immunology | Lymphocytes - immunology | Allergens - immunology | Immunoglobulin G - immunology | Basophils - immunology | Inflammation Mediators - metabolism | Protein Engineering | Female | Disease Models, Animal | Hepatitis B Surface Antigens - chemistry | Lymphocytes - metabolism | Peptides - immunology | Vaccines, Subunit - immunology | Recombinant Fusion Proteins - chemistry | Rhinitis, Allergic, Seasonal - prevention & control | Animals | Protein Binding | Recombinant Fusion Proteins - genetics | Mice | Basophils - metabolism | Cytokines - biosynthesis | Allergy | Vaccines | Peptides | Allergic reaction | Proteins | Immunization | Cytokines | E coli | Pollen | Grasses | Patients | Allergies | Binding sites | Quality of life | SIT, Allergen-specific immunotherapy | CFA, Complete Freund adjuvant | Rhinitis, Sinusitis, and Upper Airway Disease | KLH, Keyhole limpet hemocyanin
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9. Full Text Familial hypertryptasemia with associated mast cell activation syndrome
by Sabato, Vito, MD and Van De Vijver, Els, MD, PhD and Hagendorens, Margo, MD, PhD and Vrelust, Inge, MD and Reyniers, Edwin, MD, PhD and Fransen, Erik, MD, PhD and Bridts, Chris, MLT and De Clerck, Luc, MD, PhD and Mortier, Geert, MD, PhD and Valent, Peter, MD, PhD and Ebo, Didier, MD, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 6, pp. 1448 - 1450.e3
  According to the current classification of MCAS, most of our family members would fit within the classification of idiopathic MCAS. [...]the major other... 
Allergy and Immunology | ALLERGY | INDUCED SPUTUM | INFLAMMATION | DISEASE | ASTHMA | CLASSIFICATION | IMMUNOLOGY | Metabolic Diseases - classification | Mastocytosis - blood | Tryptases - blood | Humans | Middle Aged | Child, Preschool | Genotype | Infant | Male | Metabolic Diseases - blood | Mastocytosis - genetics | Young Adult | Pedigree | Adolescent | Metabolic Diseases - genetics | Adult | Female | Mastocytosis - classification | Genetic Linkage | Tryptases - genetics | Medical colleges | Medical genetics | Histamine | Bone density | Mutation | Genomics | Allergies
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10. Full Text Frequent occurrence of T cell–mediated late reactions revealed by atopy patch testing with hypoallergenic rBet v 1 fragments
by Campana, Raffaela, PhD and Moritz, Katharina, MD and Marth, Katharina, MD and Neubauer, Angela, PhD and Huber, Hans, PhD and Henning, Rainer, PhD and Blatt, Katharina, PhD and Hoermann, Gregor, MD, PhD and Brodie, Tess M., PhD and Kaider, Alexandra, MSc and Valent, Peter, MD and Sallusto, Federica, PhD and Wöhrl, Stefan, MD, MSc and Valenta, Rudolf, MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 137, Issue 2, pp. 601 - 609.e8
Background Late allergic reactions are common in the course of allergen-specific immunotherapy and even occur with allergy vaccines with reduced IgE... 
Allergy and Immunology | Allergy | allergen | rBet v 1 fragments | cutaneous lymphocyte antigen | atopy patch testing | recombinant hypoallergens | late-phase reaction | birch pollen allergy | rBet v 1 | specific immunotherapy | CCR4 | T-cell proliferation | OMALIZUMAB | DERMATITIS | IGE | ALLERGEN-SPECIFIC IMMUNOTHERAPY | IMMUNOLOGY | BIRCH POLLEN ALLERGEN | RHINITIS | EPITOPE | SKIN | EXPRESSION | LYMPHOCYTES | Humans | Male | Hypersensitivity, Delayed - metabolism | Pollen - immunology | Hypersensitivity, Delayed - immunology | Rhinitis, Allergic, Seasonal - diagnosis | Rhinitis, Allergic, Seasonal - immunology | Dermatitis, Atopic - diagnosis | Young Adult | Lymphocyte Activation - immunology | Allergens - immunology | T-Lymphocytes - metabolism | Betula - adverse effects | T-Cell Antigen Receptor Specificity - immunology | Dermatitis, Atopic - immunology | Histamine Release | Hypersensitivity, Immediate - immunology | Adult | Female | Hypersensitivity, Delayed - diagnosis | Patch Tests | Hypersensitivity, Immediate - diagnosis | Antigens, Plant - immunology | Hypersensitivity, Immediate - metabolism | T-Lymphocytes - immunology | Dermatitis, Atopic - metabolism | Cytokines - biosynthesis | Medical colleges | Allergens | Immunotherapy | Immunoglobulin E | T cells | Allergic reaction | Medical research | Atopic dermatitis | Medicine, Experimental | Skin | Testing | Antigenic determinants | Studies | Cytokines | Lymphocytes | Clinical trials | Inflammation | Allergies | Quality of life | Asthma
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11. Full Text A hypoallergenic cat vaccine based on Fel d 1–derived peptides fused to hepatitis B PreS
by Niespodziana, Katarzyna, MSc and Focke-Tejkl, Margarete, PhD and Linhart, Birgit, PhD and Civaj, Vera and Blatt, Katharina and Valent, Peter, MD and van Hage, Marianne, MD and Grönlund, Hans, PhD and Valenta, Rudolf, MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2011, Volume 127, Issue 6, pp. 1562 - 1570.e6
Background Allergen-specific immunotherapy is clinically effective for the treatment of cat allergy but shows a high rate of side effects. Objective We sought... 
Allergy and Immunology | cat allergy | Recombinant allergen | peptide | hypoallergenic vaccine | Fel d 1 | immunotherapy | CONTROLLED TRIAL | ALLERGEN-SPECIFIC IMMUNOTHERAPY | IMMUNOLOGY | MAJOR ALLERGEN | BIRCH POLLEN ALLERGEN | ALLERGY | CLINICAL-EFFICACY | LATE ASTHMATIC REACTIONS | T-CELL PEPTIDES | DOMESTIC CAT | IMMUNOGLOBULIN-E | FEL-D-1 | Hepatitis B Surface Antigens - genetics | Recombinant Fusion Proteins - immunology | Humans | Hypersensitivity - immunology | Molecular Sequence Data | Vaccines, Synthetic - immunology | Case-Control Studies | Allergens - immunology | Immunoglobulin G - biosynthesis | Allergens - chemistry | Basophils - immunology | Protein Engineering | Glycoproteins - chemistry | Hepatitis B Surface Antigens - chemistry | Vaccines, Synthetic - chemistry | Glycoproteins - genetics | Amino Acid Sequence | Pets - immunology | Rabbits | Cats | Phosphoric Diester Hydrolases - metabolism | Hypersensitivity - therapy | Immunoglobulin E - metabolism | Vaccines, Synthetic - genetics | Hepatitis B Surface Antigens - immunology | Rats | Allergens - genetics | Recombinant Fusion Proteins - chemistry | Pyrophosphatases - metabolism | Glycoproteins - immunology | Animals | Recombinant Fusion Proteins - genetics | Protein Conformation | T-Lymphocytes - immunology | Mice | Desensitization, Immunologic - methods | Medical colleges | Allergy | Peptides | Immunotherapy | Leukemia | Peroxidase | Vaccines | Allergic reaction | Hepatitis B | Proteins | E coli | Lymphocytes | Allergies | Deoxyribonucleic acid--DNA
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12. Full Text Hypoallergenic Der p 1/Der p 2 combination vaccines for immunotherapy of house dust mite allergy
by Chen, Kuan-Wei, PhD and Blatt, Katharina, MSc and Thomas, Wayne R., PhD and Swoboda, Ines, PhD and Valent, Peter, MD and Valenta, Rudolf, MD and Vrtala, Susanne, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 130, Issue 2, pp. 435 - 443.e4
Background More than 50% of allergic patients have house dust mite (HDM) allergy. Group 1 and 2 allergens are the major HDM allergens. Objective We sought to... 
Allergy and Immunology | Allergy | allergen | house dust mite allergy | specific immunotherapy | recombinant hypoallergen | DER-P-1 | IGE-BINDING | FUTURE | IMMUNOLOGY | REDUCTION | MUTATION | RECOMBINANT ALLERGENS | EXPRESSION | ANTIGEN | Recombinant Fusion Proteins - immunology | Hypersensitivity - prevention & control | Escherichia coli | Humans | Vaccination | Hypersensitivity - immunology | Male | Vaccines - therapeutic use | Antigens, Dermatophagoides - immunology | Immunoglobulin E - immunology | Immunoglobulin G - immunology | Cloning, Molecular | Female | Epitopes, T-Lymphocyte - immunology | Rabbits | Immunoglobulin E - metabolism | Vaccines - immunology | Vaccines, Combined | Antigens, Dermatophagoides - genetics | Arthropod Proteins - genetics | Arthropod Proteins - immunology | Pyroglyphidae - genetics | Vaccines - genetics | Animals | Cysteine Endopeptidases - genetics | Protein Binding | Recombinant Fusion Proteins - genetics | Vaccines, Synthetic | Mice | Cysteine Endopeptidases - immunology | Immunoglobulin G - metabolism | Pyroglyphidae - immunology | Allergens | Medical colleges | Immunotherapy | Children | Universities and colleges | Vaccines | Drug therapy | Allergic reaction | Health aspects | Proteins | Immunization | Peptides | Amino acids | Patients | Allergies | Molecular weight | Cysteine | Disulfide bonds | Hybrids | Hypersensitivity | Immunoglobulin G | Immunoglobulin E | Inflammation | Lymphocytes T | Epitopes | Immunological tolerance | Affinity chromatography | Der p 1 antigen | C.D | Leukocytes (basophilic)
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13. Full Text Dissection of the IgE and T-cell recognition of the major group 5 grass pollen allergen Phl p 5
by Focke-Tejkl, Margarete, PhD and Campana, Raffaela, PhD and Reininger, Renate, PhD and Lupinek, Christian, MD and Blatt, Katharina, MSc and Valent, Peter, MD and Pavkov-Keller, Tea, PhD and Keller, Walter, PhD and Valenta, Rudolf, MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2013, Volume 133, Issue 3, pp. 836 - 845.e11
Background The major timothy grass pollen allergen Phl p 5 belongs to the most potent allergens involved in hay fever and asthma. Objective This study... 
Allergy and Immunology | Allergy | epitopes | grass pollen allergen | peptides | PRATENSE POLLEN | PROTEIN | VACCINATION | STRUCTURAL-CHARACTERIZATION | IMMUNOLOGY | PEPTIDE | BET V 1 | EPITOPE | IMMUNOTHERAPY | ASTHMA | VACCINES | Amino Acid Sequence | Epitope Mapping | Rabbits | Protein Structure, Secondary | Lymphocyte Activation | Humans | Middle Aged | Models, Molecular | Molecular Sequence Data | Male | Plant Proteins - immunology | Cross Reactions | Animals | Immunoglobulin E - immunology | Plant Proteins - chemistry | Adolescent | Basophils - physiology | Adult | Female | T-Lymphocytes - immunology | Child | Cytokines - biosynthesis | Immunoglobulin E | Allergens | T cells | Allergic reaction | Surgery | Peptides | Cytokines | Immunotherapy | Pollen | Experiments | Patients | Allergies | Binding sites | Quality of life
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