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Journal Article
Science, ISSN 0036-8075, 12/2011, Volume 334, Issue 6060, pp. 1241 - 1245
Aβ (beta-amyloid peptide) is an important contributor to Alzheimer's disease (AD). We modeled Aβ toxicity in yeast by directing the peptide to the secretory... 
Oligomers | Yeasts | Endocytosis | Receptors | Neurons | Secretion | RESEARCH ARTICLES | Predisposing factors | Cell membranes | Alzheimers disease | Genetic screening | COMMON VARIANTS | CELLS | IDENTIFIES VARIANTS | MEMBRANE | MULTIDISCIPLINARY SCIENCES | ENDOPLASMIC-RETICULUM | ALPHA-SYNUCLEIN | SACCHAROMYCES-CEREVISIAE | PEPTIDE | OLIGOMERS | GENOME-WIDE ASSOCIATION | Genetic Testing | Saccharomyces cerevisiae - genetics | Humans | Protein Multimerization | Secretory Pathway | Glutamates - metabolism | Saccharomyces cerevisiae - metabolism | Monomeric Clathrin Assembly Proteins - genetics | Amyloid beta-Peptides - genetics | Monomeric Clathrin Assembly Proteins - metabolism | Amyloid beta-Peptides - metabolism | Neurons - physiology | Cell Membrane - metabolism | Peptide Fragments - genetics | Peptide Fragments - metabolism | Caenorhabditis elegans - metabolism | Disease Susceptibility | Genetic Association Studies | Animals, Genetically Modified | Caenorhabditis elegans - genetics | Risk Factors | Cells, Cultured | Rats | Saccharomyces cerevisiae Proteins - genetics | Clathrin - metabolism | Protein Transport | Saccharomyces cerevisiae - cytology | Peptide Fragments - chemistry | Animals | Caenorhabditis elegans - cytology | Alzheimer Disease - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Cytoskeleton - metabolism | Amyloid beta-Peptides - chemistry | Alzheimer Disease - genetics | Saccharomyces cerevisiae - growth & development | Basic Medicine | Other Basic Medicine | peptide | membrane | Medical and Health Sciences | Medicin och hälsovetenskap | oligomers | alpha-synuclein | saccharomyces cerevisiae | cells | identifies variants | Medicinska och farmaceutiska grundvetenskaper | Annan medicinsk grundvetenskap | genome-wide association | endoplasmic reticulum | common variants
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2014, Volume 111, Issue 34, pp. 12281 - 12281
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2017, Volume 114, Issue 52, pp. E11313 - E11322
Calcineurin is an essential Ca -dependent phosphatase. Increased calcineurin activity is associated with α-synuclein (α-syn) toxicity, a protein implicated in... 
Parkinson's Disease | Tacrolimus | Calcineurin | α-synuclein | FKBP12 | NERVOUS-SYSTEM | MULTIDISCIPLINARY SCIENCES | MODEL | calcineurin | alpha-synuclein | SACCHAROMYCES-CEREVISIAE | MIDBRAIN DOPAMINERGIC-NEURONS | FK506 BINDING-PROTEINS | DEGENERATION | CYCLOSPORINE-A | NEUROTROPHIC ACTIONS | BRAIN | PARKINSONS-DISEASE | Biological Sciences | PNAS Plus | Parkinson’s Disease
Journal Article
Science, ISSN 0036-8075, 11/2013, Volume 342, Issue 6161, pp. 983 - 987
The induced pluripotent stern (iPS) cell field holds promise for in vitro disease modeling. However, identifying innate cellular pathologies, particularly for... 
Physiological aspects | Parkinson's disease | Research | Health aspects | Stem cells | Neurophysiology | Toxicity | Neurons | Patients | Parkinsons disease
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 12/2017, Volume 114, Issue 52, p. E11313
Calcineurin is an essential [Ca.sup.2+]-dependent phosphatase. Increased calcineurin activity is associated with [alpha]-synuclein ([alpha]-syn) toxicity, a... 
Physiological aspects | Parkinson's disease | Health aspects | Calcineurin
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2017, Volume 114, Issue 52, p. E11313
Calcineurin is an essential Ca2+-dependent phosphatase. Increased calcineurin activity is associated with a-synuclein (a-syn) toxicity, a protein implicated in... 
Regulatory agencies | Peptidylprolyl isomerase | Parkinson's disease | Calcium | Neurodegenerative diseases | Toxicity | Medical treatment | Calcineurin | Parkinsons disease | Proline | Pharmacology | Dephosphorylation | Synuclein | Recruitment | Proteins | Neurological diseases | Neurotoxicity | Tacrolimus-binding protein | Tacrolimus | Rodents | Inhibition | Movement disorders
Journal Article
Science, ISSN 0036-8075, 12/2011, Volume 334, Issue 6060, pp. 1241 - 1245
A[beta] (beta-amyloid peptide) is an important contributor to Alzheimer's disease (AD). We modeled A[beta] toxicity in yeast by directing the peptide to the... 
Physiological aspects | Yeast fungi | Alzheimer's disease | Health aspects | Risk factors | Amyloid beta-protein | Signal transduction | Endocytosis | Yeast | Peptides | Neurobiology | Alzheimers disease
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2014, Volume 111, Issue 34, p. E3544
  Calcineurin (CN) is a highly conserved Ca^sup 2+^ -calmodulin (CaM)-dependent phosphatase that senses Ca^sup 2+^ concentrations and transduces that... 
Toxicity | Homeostasis | Phosphatase
Journal Article
Science (Washington), ISSN 0036-8075, 12/2011, Volume 334, Issue 6060, pp. 1241 - 1245
A beta (beta-amyloid peptide) is an important contributor to Alzheimer's disease (AD). We modeled A beta toxicity in yeast by directing the peptide to the... 
Journal Article
Science (New York, N.Y.), ISSN 0036-8075, 12/2011, Volume 334, Issue 6060, pp. 1241 - 1245
Aβ (amyloid beta peptide) is an important contributor to Alzheimer’s disease (AD). We modeled Aβ toxicity in yeast by directing the peptide to the secretory... 
Journal Article
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