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by Jacquemont, S and Reymond, A and Zufferey, F and Harewood, L and Walters, R.G and Kutalik, Z and Martinet, D and Shen, Y and Valsesia, A and Beckmann, N.D and Thorleifsson, G and Belfiore, M and Bouquillon, S and Campion, D and Leeuw, N. de and Vries, L.B.A. de and Esko, T and Fernandez, B.A and Fernandez-Aranda, F and Fernandez-Real, J.M and Gratacos, M and Guilmatre, A and Hoyer, J and Jarvelin, M.R and Kooy, R.F and Kurg, A and Caignec, C. Le and Mannik, K and Platt, O.S and Sanlaville, D and Haelst, M.M. van and Villatoro Gomez, S and Walha, F and Wu, B.L and Yu, Y and Aboura, A and Addor, M.C and Alembik, Y and Antonarakis, S.E and Arveiler, B and Barth, M and Bednarek, N and Bena, F and Bergmann, S and Beri, M and Bernardini, L and Blaumeiser, B and Bonneau, D and Bottani, A and Boute, O and Brunner, H.G and Cailley, D and Callier, P and Chiesa, J and Chrast, J and Coin, L and Coutton, C and Cuisset, J.M and Cuvellier, J.C and David, A and Freminville, B. de and Delobel, B and Delrue, M.A and Demeer, B and Descamps, D and Didelot, G and Dieterich, K and Disciglio, V and Doco-Fenzy, M and nat, S and Duban-Bedu, B and Dubourg, C and El-Sayed Moustafa, J.S and Elliott, P and Faas, B.H.W and Faivre, L and Faudet, A and Fellmann, F and Ferrarini, A and Fisher, R and Flori, E and Forer, L and Gaillard, D and Gerard, M and Gieger, C and Gimelli, S and Gimelli, G and Grabe, H.J and Guichet, A and Guillin, O and Hartikainen, A.L and Heron, D and Hippolyte, L and Holder, M and Homuth, G and Isidor, B and Jaillard, S and Jaros, Z and Jimenez-Murcia, S and Helas, G.J and ...
Nature, ISSN 0028-0836, 2011, Volume 478, Issue 7367, pp. 97 - 102
Both obesity and being underweight have been associated with increased mortality. Underweight, defined as a body mass index (BMI) DEPENDENT PROBE AMPLIFICATION | FAILURE-TO-THRIVE | METABOLIC SYNDROME | RELATIVE QUANTIFICATION | SNP GENOTYPING DATA | HIDDEN-MARKOV MODEL | MULTIDISCIPLINARY SCIENCES | BODY-MASS INDEX | TIME QUANTITATIVE PCR | COPY NUMBER VARIATION | CIRCULAR BINARY SEGMENTATION | Humans | Middle Aged | Child, Preschool | RNA, Messenger - analysis | Head - anatomy & histology | Infant | Male | Developmental Disabilities - genetics | Gene Expression Profiling | North America | Obesity - genetics | Case-Control Studies | Young Adult | Mental Disorders - genetics | Aging | Gene Duplication - genetics | Adult | Female | Transcription, Genetic | Energy Metabolism - genetics | Child | Infant, Newborn | Chromosomes, Human, Pair 16 - genetics | Body Mass Index | Gene Dosage - genetics | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Europe | RNA, Messenger - genetics | Mutation - genetics | Body Height - genetics | Thinness - genetics | Phenotype | Comparative Genomic Hybridization | Adolescent | Heterozygote | Aged | Cohort Studies | Sequence Deletion - genetics | Obesity | Chromosome mapping | Usage | Genetic variation | Genetic aspects | Cognition disorders | Research | Risk factors | Schizophrenia | Gender | Behavior | Gene expression | Bias | Life Sciences | Human health and pathology | Genetics | Endocrinology and metabolism | Gene Duplication | Developmental Disabilities | Sequence Deletion | Thinness | genetics | Genetic Predisposition to Disease | Head | Gene Dosage | analysis | Energy Metabolism | Mental Disorders | Chromosomes, Human, Pair 16 | Body Height | Mutation | anatomy & histology | RNA, Messenger
Journal Article
Nature, ISSN 0028-0836, 04/2010, Volume 464, Issue 7289, pp. 704 - 712
Journal Article
Nature Genetics, ISSN 1061-4036, 2012, Volume 44, Issue 2, pp. 133 - 139
We performed exome sequencing to detect somatic mutations in protein-coding regions in seven melanoma cell lines and donor-matched germline cells. All melanoma... 
HUMAN BREAST | METASTASIS | BYPASS | GENE | GENETICS & HEREDITY | GERMLINE MUTATIONS | BRAF | MECHANISMS | MALIGNANT-MELANOMA | MAPK PATHWAY | GENOME | Gene mutations | Melanoma | Exome sequencing | Reports | Genetic aspects | Research | Mitogen-activated protein kinases | Proteins | Medical research | Mutation | Kinases
Journal Article
Nature Methods, ISSN 1548-7091, 12/2013, Volume 10, Issue 12, pp. 1177 - 1184
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1793, pp. 231 - 258
Differences between genomes can be due to single nucleotide variants (SNPs), translocations, inversions and copy number variants (CNVs, gain or loss of DNA).... 
Genome-wide association studies | Human disease | Copy number variation | Duplication | DNA | Structural variation | Deletion | Human genetics | Computational Biology - methods | Genetic Predisposition to Disease | Humans | Workflow | Genome-Wide Association Study - methods | Genomics - methods | DNA Copy Number Variations
Journal Article
Cardiovascular research, ISSN 0008-6363, 01/2019, Volume 115, Issue 11, pp. 1629 - 1645
To identify genetic variants that have a regulatory impact on circulating miRNAs and to connect genetic risk to blood traits/biomarkers through the circulating... 
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 09/2019, Volume 10, Issue 1, pp. 1 - 11
Supplementation with the NAD(+) precursor nicotinamide riboside (NR) ameliorates and prevents a broad array of metabolic and aging disorders in mice. However,... 
HEPATIC GLUCONEOGENESIS | LIFE-SPAN | HOMEOSTASIS | ACTIVATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | DISEASE | NAD(+) | MONONUCLEOTIDE | NUTRIENT | DEFICIENCY | NADPH | Therapeutic applications | Liver | DNA damage | Dietary supplements | Disorders | Metabolism | Kinases | Insulin | NAD | Glucose tolerance | Intolerance | Poly(ADP-ribose) Polymerase 1 | Mitochondria | Diet | Aging | Mice | Nicotinamide | Supplementation | Metabolic disorders | Deoxyribonucleic acid--DNA
Journal Article
The American Journal of Clinical Nutrition, ISSN 0002-9165, 07/2018, Volume 108, Issue 1, p. 13
Background Weight loss in obese individuals aims to reduce the risk of type 2 diabetes by improving glycemic control. Yet, significant intersubject variability... 
Intervention | Plasma | Metabolomics | Model testing | Lecithin | Variability | Body weight | Homeostasis | Proline | Lipids | Body weight loss | Body mass index | Metabolites | Mathematical models | Lipid metabolism | Diabetes mellitus (non-insulin dependent) | Obesity | Nutrient deficiency | Diabetes mellitus | Health risks | Risk reduction | Insulin | Sensitivity | Diet | Body mass | Hypocaloric diet | Body size | Weight reduction
Journal Article