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1. Full Text Genome-wide association study on the FEV1 /FVC ratio in never-smokers identifies HHIP and FAM13A
by van der Plaat, Diana A., MSc and de Jong, Kim, PhD and Lahousse, Lies, PhD and Faiz, Alen, PhD and Vonk, Judith M., PhD and van Diemen, Cleo C., PhD and Nedeljkovic, Ivana, MD and Amin, Najaf, PhD and Brusselle, Guy G., PhD and Hofman, Albert, MD and Brandsma, Corry-Anke, PhD and Bossé, Yohan, PhD and Sin, Don D., PhD and Nickle, David C., PhD and van Duijn, Cornelia M., PhD and Postma, Dirkje S., MD and Boezen, H. Marike, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 533 - 540
Background Although a striking proportion (25% to 45%) of patients with chronic obstructive pulmonary disease are never-smokers, most genetic susceptibility... 
Allergy and Immunology | pulmonary function | genetics | Genome-wide association study | never-smokers | chronic obstructive pulmonary disease | STANDARDIZATION | METAANALYSIS | LUNG-FUNCTION | LEVEL | IMMUNOLOGY | OBSTRUCTIVE PULMONARY-DISEASE | GENERAL-POPULATION | POLYMORPHISMS | ALLERGY | ROTTERDAM | COPD | Principal components analysis | Identification | Genomes | Regression analysis | Gene expression | Estimates | Data bases | Studies | Airway management | Chronic obstructive pulmonary disease | Health risk assessment | Age | Smoking | Index Medicus | Abridged Index Medicus
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2. Full Text Serum apolipoprotein E is associated with long-term risk of Alzheimer's disease: The Rotterdam Study
by Wolters, Frank J and Koudstaal, Peter J and Hofman, Albert and Duijn, Cornelia M.van and Ikram, M.Arfan
Neuroscience Letters, ISSN 0304-3940, 03/2016, Volume 617, pp. 139 - 142
Background: Serum levels of apolipoprotein E (apoE) have been suggested as potential biomarker for dementia, but the long-term association between apoE and... 
APOE | Alzheimer | Serum apolipoprotein | Dementia | POPULATION | PLASMA | EPSILON-4 | CEREBROSPINAL-FLUID | NEUROSCIENCES | Apolipoproteins E - blood | Risk Assessment | Apolipoproteins E - genetics | Humans | Middle Aged | Female | Genotype | Male | Aged | Alzheimer Disease - blood | Medicine, Experimental | Medical research | Apolipoproteins | Alzheimer's disease | Epidemiology | Risk factors | Index Medicus
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3. Full Text Impact of cumulative SBP and serious adverse events on efficacy of intensive blood pressure treatment: a randomized clinical trial
by Rueda-Ochoa, Oscar L and Rojas, Lyda Z and Ahmad, Shahzad and van Duijn, Cornelia M and Ikram, Mohammad A and Deckers, Jaap W and Franco, Oscar H and Rizopoulos, Dimitris and Kavousi, Maryam
Journal of Hypertension, ISSN 0263-6352, 05/2019, Volume 37, Issue 5, pp. 1058 - 1069
BACKGROUND:Intensive blood pressure lowering is increasingly gaining attention. In addition to higher baseline blood pressure, cumulative SBP, visit-to-visit... 
SBP | KIDNEY-DISEASE | MORTALITY | cumulative joint model | CARDIOVASCULAR OUTCOMES | RISK | TIME | randomized controlled trial | VARIABILITY | intensive treatment | INTERVENTION TRIAL | adverse effects | PERIPHERAL VASCULAR DISEASE | CORONARY-HEART-DISEASE | HYPERTENSION | VISIT-TO-VISIT | treatment efficacy
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4. Full Text Abstract 15083: Impact of Cumulative Systolic Blood Pressure and Serious Adverse Events on Efficacy of Intensive Blood Pressure Treatment: A Randomized Clinical Trial
by Rueda-Ochoa, Oscar L and Rojas Sanchez, Lyda Z and Ahmad, Shahzad and van Duijn, Cornelia M and Ikram, M Arfan and Deckers, Jaap W and Franco, Oscar H and Rizopoulos, Dimitris and Kavousi, Maryam
Circulation, ISSN 0009-7322, 11/2018, Volume 138, Issue Suppl_1 Suppl 1, pp. A15083 - A15083
BackgroundIntensive blood pressure lowering is increasingly gaining attention. Besides higher baseline blood pressure, cumulative systolic blood pressure... 
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5. Full Text Revisiting the Role of Insulin-Like Growth Factor-I Receptor Stimulating Activity and the Apolipoprotein E in Alzheimer’s Disease
by Galle, Sara A and van der Spek, Ashley and Drent, Madeleine L and Brugts, Michael P and Scherder, Erik J. A and Janssen, Joseph A. M. J. L and Ikram, M. Arfan and van Duijn, Cornelia M
Frontiers in Aging Neuroscience, ISSN 1663-4365, 02/2019, Volume 11
Background: Alterations in insulin-like growth factor I (IGF-I) signaling have been associated with dementia and Alzheimer’s disease (AD). Studies on the... 
apolipoprotein E | dementia | KIRA assay | Alzheimer’s disease | insulin-like growth factor I | genetic epidemiology
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6. Full Text GENETIC VARIATION UNDERLYING COGNITION AND ITS RELATION WITH NEUROLOGICAL OUTCOMES
by Knol, Maria J and Cremers, Lotte G.M and Heshmatollah, Alis and Ikram, M. Arfan and Ikram, M. Kamran and Uitterlinden, André G and van Duijn, Cornelia M and Niessen, Wiro J and Vernooij, Meike W and Adams, Hieab H.H
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 07/2018, Volume 14, Issue 7, pp. P1652 - P1653
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7. Full Text ProbABEL package for genome-wide association analysis of imputed data
by Aulchenko, Yurii and Struchalin, Maksim and Tikka-Kleemola, Päivi
B M C Bioinformatics, ISSN 1471-2105, 03/2010, Volume 11, Issue 1, pp. 134 - 134
textabstractBackground: Over the last few years, genome-wide association (GWA) studies became a tool of choice for the identification of loci associated with... 
MIXED-MODEL | POPULATION | IMPUTATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | POWER | LOCI | Humans | Genotype | Models, Genetic | Polymorphism, Single Nucleotide | Software | Genome-Wide Association Study - methods | Quantitative Trait Loci | Quantitative trait loci | Usage | Research | Single nucleotide polymorphisms | Applications software | Computational biology | Index Medicus
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8. Full Text The Rotterdam Study: 2016 objectives and design update
by Albert Hofman and Guy G. O. Brusselle and Sarwa Darwish Murad and Cornelia M. van Duijn and Oscar H. Franco and André Goedegebure and M. Arfan Ikram and Caroline C. W. Klaver and Tamar E. C. Nijsten and Robin P. Peeters and Bruno H. Ch. Stricker and Henning W. Tiemeier and André G. Uitterlinden and Meike W. Vernooij
European Journal of Epidemiology, ISSN 0393-2990, 1/2015, Volume 30, Issue 8, pp. 661 - 708
The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine,... 
STUDY UPDATE | Dermatological diseases | Public Health | Liver diseases | Endocrine diseases | Oncology | Psychiatric diseases | Epidemiology | Epidemiologic methods | Ophthalmic diseases | Neurological diseases | Pharmacoepidemiology | Renal diseases | Otolaryngological diseases | Medicine & Public Health | Genetic epidemiology | Cohort study | Respiratory diseases | Biomarkers | Infectious Diseases | Cardiology | Cardiovascular diseases | ALL-CAUSE MORTALITY | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | SUDDEN CARDIAC DEATH | GENOME-WIDE ASSOCIATION | C-REACTIVE PROTEIN | SMALL VESSEL DISEASE | CAUSE-SPECIFIC MORTALITY | NONALCOHOLIC FATTY LIVER | OBSTRUCTIVE PULMONARY-DISEASE | POPULATION-BASED COHORT | CORONARY-HEART-DISEASE | Epidemiologic Research Design | Prospective Studies | Humans | Middle Aged | Netherlands - epidemiology | Risk Factors | Chronic Disease - epidemiology | Male | Life Expectancy - trends | Aged, 80 and over | Female | Aged | Population Dynamics | Respiratory tract diseases | Nervous system diseases | Ophthalmology | Liver | Resveratrol | Medical research | Disease | Public health | Index Medicus | Study Update
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9. Full Text Renin-angiotensin system inhibitors, angiotensin I-converting enzyme gene insertion/deletion polymorphism, and cancer: The Rotterdam study
by Knaap, Ronald and Siemes, Claire and Coebergh, Jan Willem and Tikka-Kleemola, Päivi and Hofman, Albert and Stricker, Bruno
Cancer, ISSN 0008-543X, 02/2008, Volume 112, Issue 4, pp. 748 - 757
textabstractBACKGROUND. Angiotensin I-converting enzyme (ACE) inhibitors, angiotensin II antagonists, and the ACE insertion/deletion (I/D) gene polymorphism... 
Angiotensin I-converting enzyme inhibitor | Angiotensin II | Prospective cohort study | Cancer | Polymorphism | Lung Neoplasms - drug therapy | Sequence Deletion | Follow-Up Studies | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Colorectal Neoplasms - genetics | Humans | Middle Aged | Netherlands - epidemiology | Male | Angiotensin II Type 1 Receptor Blockers - pharmacology | Incidence | Risk Assessment - statistics & numerical data | Peptidyl-Dipeptidase A - genetics | Prostatic Neoplasms - genetics | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Neoplasms - genetics | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Female | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Prostatic Neoplasms - drug therapy | Breast Neoplasms - epidemiology | Colorectal Neoplasms - epidemiology | Lung Neoplasms - genetics | Proportional Hazards Models | Genotype | Breast Neoplasms - drug therapy | Neoplasms - drug therapy | Polymorphism, Genetic | Prostatic Neoplasms - epidemiology | Breast Neoplasms - genetics | Lung Neoplasms - epidemiology | Renin-Angiotensin System - drug effects | Aged | Mutagenesis, Insertional | Neoplasms - epidemiology | Cohort Studies | Genetic aspects | Research | Renin-angiotensin system | ACE inhibitors | Genetic polymorphisms | Risk factors | Index Medicus | Abridged Index Medicus
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10. Full Text Variant of TREM2 Associated with the Risk of Alzheimer's Disease
by Jonsson, Thorlakur and Jonsson, Palmi V and Stefansson, Hreinn and Stefansson, Kari and Steinberg, Stacy and Jonsdottir, Ingileif and Snaedal, Jon and Bjornsson, Sigurbjorn and Huttenlocher, Johanna and Levey, Allan I and Lah, James J and Rujescu, Dan and Hampel, Harald and Giegling, Ina and Andreassen, Ole A and Engedal, Knut and Ulstein, Ingun and Djurovic, Srdjan and Ibrahim-Verbaas, Carla and Hofman, Albert and Ikram, M. Arfan and van Duijn, Cornelia M and Thorsteinsdottir, Unnur and Kong, Augustine
The New England Journal of Medicine, ISSN 0028-4793, 01/2013, Volume 368, Issue 2, pp. 107 - 116
This study shows that a variant of TREM2 , which encodes a protein that suppresses inflammation, causes susceptibility to Alzheimer's disease. Although the... 
RESPONSES | MEDICINE, GENERAL & INTERNAL | IMMUNE-SYSTEM | DEMENTIA | DENDRITIC CELLS | RECEPTOR | MUTATIONS | GENOME-WIDE ASSOCIATION | APOLIPOPROTEIN-E | SENILE PLAQUES | CUTTING EDGE | Apolipoprotein E4 - genetics | Humans | Risk Factors | Cognition | Mutation, Missense | Genotyping Techniques | Sequence Analysis, DNA | Case-Control Studies | Iceland | Membrane Glycoproteins - genetics | Genetic Variation | Aged, 80 and over | Heterozygote | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Receptors, Immunologic - genetics | Genetic variation | Causes of | Genetic aspects | Research | Apolipoproteins | Alzheimer's disease | Health aspects | Genomes | Alzheimers disease | Older people | Age | Cognitive ability | Index Medicus | Abridged Index Medicus
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