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1. Cerebral SPECT imaging
by Van Heertum, Ronald L and Tikofsky, Ronald S
1995, 2nd ed., ISBN 9780781701884, xi, 219
Tomography | Brain | Tomography, Emission
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2. Advances in cerebral SPECT imaging
: an atlas and guideline for practitioners
by Tikofsky, Ronald S and Van Heertum, Ronald L
1989, ISBN 0812112601, 129
Radiography | Brain | methods | Tomography, Emission-Computed, Single-Photon | atlases | Tomography | Brain Diseases | Data processing | diagnosis
Book
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3. Full Text F-18 FDG PET imaging of chronic traumatic brain injury in boxers: a statistical parametric analysis
by Provenzano, Frank Anthony and Jordan, Barry and Tikofsky, Ronald S and Saxena, Chitra and Van Heertum, Ronald L and Ichise, Masanori
Nuclear Medicine Communications, ISSN 0143-3636, 11/2010, Volume 31, Issue 11, pp. 952 - 957
PURPOSEThe participation in concussive susceptible sports such as boxing may cause chronic traumatic brain injury. The objective of this study was to determine... 
boxers | chronic traumatic brain injury | positron emission tomography | statistical parametric mapping | CEREBRAL GLUCOSE-METABOLISM | MRI | PROFESSIONAL BOXERS | RISK | DIFFUSION | SIGN | DEFICITS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
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4. Full Text Companion diagnostics and molecular imagingenhanced approaches for oncology clinical trials
by Van Heertum, Ronald L and Scarimbolo, Robert and Ford, Robert and Berdougo, Eli and O’Neal, Michael
Drug Design, Development and Therapy, ISSN 1177-8881, 09/2015, Volume 9, pp. 5215 - 5223
Molecular imaging | Diagnostic assays | Personalized medicine | Oncology trials | Companion diagnostics
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5. Full Text Brain serotonin1A receptor binding in major depression is related to psychic and somatic anxiety
by Sullivan, Gregory M and Oquendo, Maria A and Simpson, Norman and Van Heertum, Ronald L and Mann, J. John and Parsey, Ramin V
Biological Psychiatry, ISSN 0006-3223, 12/2005, Volume 58, Issue 12, pp. 947 - 954
Background: The anxious phenotype of the 5-HT receptor knockout mouse and the anxiolytic properties of 5-HT agonists suggest that the 5-HT receptor modulates... 
Hypochondriacal | Panic | Psychic | Somatic | Serotonin | Depression | 5-HT | Pyridines | Piperazines | Depressive Disorder, Major - metabolism | Humans | Middle Aged | Anxiety - psychology | Male | Panic Disorder - diagnostic imaging | Positron-Emission Tomography | Depressive Disorder, Major - diagnostic imaging | Panic Disorder - metabolism | Brain Chemistry - physiology | Hippocampus - metabolism | Psychiatric Status Rating Scales | Image Processing, Computer-Assisted | Anxiety - diagnostic imaging | Prefrontal Cortex - metabolism | Serotonin Antagonists | Adult | Female | Aged | Anxiety - metabolism | Principal Component Analysis | Receptor, Serotonin, 5-HT1A - metabolism
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6. Procedure guideline for brain perfusion SPECT using99mTc radiopharmaceuticals 3.0
by Juni, Jack E and Waxman, Alan D and Devous Sr, Michael D and Tikofsky, Ronald S and Ichise, Masanori and Van Heertum, Ronald L and Carretta, Robert F and Chen, Charles C
Journal of Nuclear Medicine Technology, ISSN 0091-4916, 09/2009, Volume 37, Issue 3, pp. 191 - 195
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7. Full Text Functional cerebral SPECT and PET imaging: Fourth edition
by Van Heertum, Ronald L and Tikofsky, Ronald S and Ichise, Masanori
04/2013, ISBN 9781451153392
Book
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8. Full Text Increased baseline occupancy of D2 receptors by dopamine in schizophrenia
by Anissa Abi-Dargham and Janine Rodenhiser and David Printz and Yolanda Zea-Ponce and Roberto Gil and Lawrence S. Kegeles and Richard Weiss and Thomas B. Cooper and J. John Mann and Ronald L. Van Heertum and Jack M. Gorman and Marc Laruelle
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2000, Volume 97, Issue 14, pp. 8104 - 8109
The classical dopamine hypothesis of schizophrenia postulates a hyperactivity of dopaminergic transmission at the D 2 receptor. We measured in vivo occupancy... 
Predictive Value of Tests | Recurrence | Schizophrenia - metabolism | Humans | Tyrosine 3-Monooxygenase - antagonists & inhibitors | Male | Receptors, Dopamine D2 - metabolism | Corpus Striatum - metabolism | Antipsychotic Agents - therapeutic use | Adult | Female | Schizophrenia - drug therapy | alpha-Methyltyrosine - pharmacology | Chronic Disease | Dopamine - metabolism | Biological Sciences
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9. Full Text Altered Serotonin 1A Binding in Major Depression: A [carbonyl-C-11]WAY100635 Positron Emission Tomography Study
by Parsey, Ramin V and Oquendo, Maria A and Ogden, R. Todd and Olvet, Doreen M and Simpson, Norman and Huang, Yung-yu and Van Heertum, Ronald L and Arango, Victoria and Mann, J. John
Biological Psychiatry, ISSN 0006-3223, 2006, Volume 59, Issue 2, pp. 106 - 113
Serotonin 1A receptors (5-HT ) are implicated in the pathophysiology of major depressive disorder (MDD) and in the action of selective serotonin reuptake... 
Unipolar | polymorphism | medication | antidepressants | genotype | Medication | Genotype | Antidepressants | Polymorphism | ANTIDEPRESSANT-TREATMENT | HEALTHY-SUBJECTS | PSYCHIATRY | unipolar | CEREBROSPINAL-FLUID | SUICIDE VICTIMS | POSTSYNAPTIC 5-HT1A | NEUROSCIENCES | 1(A) RECEPTOR | 5-HT1A RECEPTOR-BINDING | BIPOLAR DEPRESSION | MONOAMINE METABOLITES | RAT-BRAIN | Depressive Disorder, Major - metabolism | Humans | Receptor, Serotonin, 5-HT1A - genetics | Male | Piperazines - metabolism | Reference Values | Positron-Emission Tomography | Depressive Disorder, Major - diagnostic imaging | Promoter Regions, Genetic - genetics | Polymorphism, Genetic | Antidepressive Agents - therapeutic use | Receptor, Serotonin, 5-HT1A - drug effects | Pyridines - metabolism | Depressive Disorder, Major - genetics | Adolescent | Adult | Female | Serotonin Antagonists - metabolism | Carbon Radioisotopes - metabolism | Receptor, Serotonin, 5-HT1A - metabolism | Depressive Disorder, Major - drug therapy | Phenols | Serotonin uptake inhibitors | PET imaging | Serotonin | Medical societies | Major depressive disorder
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10. Full Text Interventional Nuclear Brain Imaging
by Leung, David K., MD, PhD and Van Heertum, Ronald L., MD
Seminars in Nuclear Medicine, ISSN 0001-2998, 2009, Volume 39, Issue 3, pp. 195 - 203
Interventional nuclear brain imaging incorporates a variety of radiopharmaceutical techniques to enhance the functional assessment of the central nervous... 
Radiology | OBSTRUCTIVE SLEEP-APNEA | STRIATAL DOPAMINE RELEASE | ADVANCED PARKINSONS-DISEASE | GLUCOSE-METABOLISM | TEMPORARY BALLOON OCCLUSION | REUPTAKE INHIBITOR CITALOPRAM | CEREBRAL-BLOOD-FLOW | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | EMISSION COMPUTED-TOMOGRAPHY | INTERNAL CAROTID-ARTERY | SEROTONIN TRANSPORTERS | Brain - diagnostic imaging | Parkinson Disease - diagnostic imaging | Cerebrovascular Circulation - physiology | Receptors, Opioid, mu - metabolism | Humans | Middle Aged | Brain Mapping - methods | Positron-Emission Tomography - methods | Seizures - diagnostic imaging | Balloon Occlusion - methods | Brain - blood supply | Serotonin - metabolism | Adult | Female | Sleep Apnea, Obstructive - diagnostic imaging | Aged | Alzheimer Disease - diagnostic imaging | Radiopharmaceuticals | Dopamine - metabolism
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11. Full Text Companion diagnostics and molecular imaging-enhanced approaches for oncology clinical trials
by Van Heertum, RL and Scarimbolo, R and Ford, R and Berdougo, E and O'Neal, M
DRUG DESIGN DEVELOPMENT AND THERAPY, ISSN 1177-8881, 2015, Volume 9, Issue default, pp. 5215 - 5223
In the era of personalized medicine, diagnostic approaches are helping pharmaceutical and biotechnology sponsors streamline the clinical trial process.... 
oncology trials | ESTROGEN-RECEPTORS | CHEMISTRY, MEDICINAL | RESPONSE CRITERIA | SOLID TUMORS | GUIDELINES | molecular imaging | personalized medicine | INTERNATIONAL WORKING GROUP | BREAST-CANCER | diagnostic assays | RECOMMENDATIONS | PHARMACOLOGY & PHARMACY | companion diagnostics | CARCINOMA | PET | Radiopharmaceuticals - administration & dosage | Medical Oncology - methods | Molecular Diagnostic Techniques | Humans | Neoplasms - diagnosis | Clinical Trials as Topic - methods | Precision Medicine - methods | Clinical trials | Usage | Diagnostic imaging | Biological assay | Innovations | Drugs | Biotechnology | Regulatory agencies | Nuclear magnetic resonance--NMR | Target recognition | Lung cancer | Medical services | Oncology | Drug development | Cancer therapies | Epidermal growth factor | Precision medicine | Vitamin B | Food | Medical research | Modernization | Medical imaging | Biological products | Medical treatment | Breast cancer | FDA approval | Patients | Diagnostic software | Biomarkers | Critical path | Diagnostic systems | Commercialization | Cancer
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12. Full Text Effect of a Triallelic Functional Polymorphism of the Serotonin-Transporter-Linked Promoter Region on Expression of Serotonin Transporter in the Human Brain
by Parsey, Ramin V and Hastings, Ramin S and Oquendo, Maria A and Hu, Xianzhang and Goldman, David and Huang, Yung-yu and Simpson, Norman and Arcement, Julie and Huang, Yiyun and Ogden, R. Todd and Van Heertum, Ronald L and Arango, Victoria and Mann, J. John
American Journal of Psychiatry, ISSN 0002-953X, 01/2006, Volume 163, Issue 1, pp. 48 - 51
OBJECTIVE: The authors examined effects of a triallelic functional polymorphism of the human serotonin-transporter-linked promoter region (5-HTTLPR) on in vivo... 
SYSTEM | GENE | 5-HTTLPR | GENOTYPE | AVAILABILITY | PSYCHIATRY | ALLELIC VARIANTS | SUICIDAL-BEHAVIOR | MAJOR DEPRESSION | BINDING | SPECT | Brain - diagnostic imaging | Gene Expression | Age Factors | Isoquinolines | Depressive Disorder, Major - metabolism | Gene Frequency | Humans | Genotype | Male | Positron-Emission Tomography | Depressive Disorder, Major - diagnostic imaging | Promoter Regions, Genetic - genetics | Polymorphism, Genetic | Brain - metabolism | Serotonin Plasma Membrane Transport Proteins - metabolism | Phenotype | Serotonin Plasma Membrane Transport Proteins - genetics | Depressive Disorder, Major - genetics | Alleles | Adult | Female | Carbon Radioisotopes | Research | Serotonin | Neurological research | Depression, Mental | Psychiatric research
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13. Full Text Lower Serotonin Transporter Binding Potential in the Human Brain During Major Depressive Episodes
by Parsey, Ramin V and Hastings, Ramin S and Oquendo, Maria A and Huang, Yung-yu and Simpson, Norman and Arcement, Julie and Huang, Yiyun and Ogden, R. Todd and Van Heertum, Ronald L and Arango, Victoria and Mann, J. John
American Journal of Psychiatry, ISSN 0002-953X, 01/2006, Volume 163, Issue 1, pp. 52 - 58
OBJECTIVE: CSF analysis, neuroendocrine challenges, serotonin depletion studies, and treatment studies implicate the serotonergic system in the pathophysiology... 
DENSITY | GRAPHICAL ANALYSIS | MOOD DISORDERS | ABNORMALITIES | PSYCHIATRY | ELIMINATION | SUICIDE VICTIMS | EXPRESSION | PREFRONTAL CORTEX | PET | AMYGDALA | Brain - diagnostic imaging | Isoquinolines | Mesencephalon - metabolism | Depressive Disorder, Major - metabolism | Humans | Suicide, Attempted - statistics & numerical data | Male | Brain - metabolism | Psychiatric Status Rating Scales | Adult | Female | Severity of Illness Index | Amygdala - diagnostic imaging | Amygdala - metabolism | Hospitalization | Depressive Disorder, Major - diagnostic imaging | Ambulatory Care | Antidepressive Agents - therapeutic use | Serotonin Plasma Membrane Transport Proteins - metabolism | Suicide, Attempted - psychology | Mesencephalon - diagnostic imaging | Positron-Emission Tomography - statistics & numerical data | Antidepressive Agents - adverse effects | Depressive Disorder, Major - diagnosis | Carbon Radioisotopes | Research | Serotonin | Neurological research | Depression, Mental | Psychiatric research
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14. Full Text Lugano 2014 criteria for assessing FDG-PET/CT in lymphoma: An operational approach for clinical trials
by Van Heertum, Ronald L and Scarimbolo, Robert and Wolodzko, John G and Klencke, Barbara and Messmann, Richard and Tunc, Feza and Sokol, Levi and Agarwal, Rajan and Strafaci, James A and O’Neal, Michael
Drug Design, Development and Therapy, ISSN 1177-8881, 06/2017, Volume 11, pp. 1719 - 1728
An operationalized workflow paradigm is presented and validated with pilot subject data. This approach is reproducible with a high concordance rate between... 
Molecular imaging | Lymphoma | Oncology trials | Lugano criteria | oncology trials | B-CELL LYMPHOMA | CHEMISTRY, MEDICINAL | INTERNATIONAL WORKSHOP | THERAPY | RESPONSE CRITERIA | lymphoma | CLASSIFICATION | PHARMACOLOGY & PHARMACY | SCAN | molecular imaging | Reproducibility of Results | Lymphoma - diagnostic imaging | Humans | Middle Aged | Image Interpretation, Computer-Assisted | Male | Molecular Imaging | Workflow | Aged, 80 and over | Adult | Female | Fluorodeoxyglucose F18 | Aged | Clinical Trials as Topic - standards | Neoplasm Staging | Research Design | Observer Variation | Cohort Studies | Positron Emission Tomography Computed Tomography - standards | CT imaging | Usage | Care and treatment | Lymphomas | Diagnosis | PET imaging | Confidence intervals | Medical research | Clinical trials | Lesions | Medical imaging | Transplants & implants | Disease | Working groups | Oncology | Bone marrow | Blood diseases | Cancer
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15. Full Text Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia
by Kegeles, Lawrence S and Abi-Dargham, Anissa and Zea-Ponce, Yolanda and Rodenhiser-Hill, Janine and Mann, J.John and Van Heertum, Ronald L and Cooper, Thomas B and Carlsson, Arvid and Laruelle, Marc
Biological Psychiatry, ISSN 0006-3223, 2000, Volume 48, Issue 7, pp. 627 - 640
Background: Recent brain imaging studies have indicated that schizophrenia is associated with increased amphetamine-induced dopamine release in the striatum.... 
[ 123I]IBZM | ketamine | Schizophrenia | amphetamine | dopamine | SPECT | glutamate | I]IBZM | Amphetamine | Dopamine | Ketamine | Glutamate | IN-VIVO MICRODIALYSIS | NONCOMPETITIVE NMDA ANTAGONIST | PSYCHIATRY | schizophrenia | [I-123]IBZM | EMISSION-TOMOGRAPHY PET | NEUROSCIENCES | DUAL-PROBE MICRODIALYSIS | VENTRAL TEGMENTAL AREA | RAT SUBSTANTIA-NIGRA | CEREBRAL BLOOD-FLOW | ACID RECEPTOR SUBTYPES | MEDIAL PREFRONTAL CORTEX | METHYL-D-ASPARTATE | Receptors, N-Methyl-D-Aspartate - drug effects | Synaptic Transmission - physiology | Corpus Striatum - physiopathology | Humans | Prefrontal Cortex - physiopathology | Amphetamine - pharmacology | Tomography, Emission-Computed, Single-Photon | Male | Excitatory Amino Acid Antagonists - pharmacology | Receptors, N-Methyl-D-Aspartate - physiology | Prefrontal Cortex - drug effects | Dopamine Agents - pharmacology | Schizophrenia - physiopathology | Corpus Striatum - drug effects | Pyrrolidines | Adult | Female | Synaptic Transmission - drug effects | Benzamides | Ketamine - pharmacology | Dopamine Antagonists | Dopamine - metabolism
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16. Full Text Regional Heterogeneity of 5-HT1A Receptors in Human Cerebellum as Assessed by Positron Emission Tomography
by Parsey, Ramin V and Arango, Victoria and Olvet, Doreen M and Oquendo, Maria A and Van Heertum, Ronald L and Mann, J John
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 7/2005, Volume 25, Issue 7, pp. 785 - 793
Two measures used in brain imaging are binding potential (BP) and the specific to nonspecific equilibrium partition coefficient (V3“). V3” determined using the... 
Brain | Reference tissue | Serotonin | C]WAY-100635 | Modeling | PET | [C-11]WAY-100635 | DEPRESSION | modeling | ANTAGONIST | RADIOLIGAND | reference tissue | H-3 WAY-100635 | MODEL | brain | SUICIDE VICTIMS | NEUROSCIENCES | serotonin | ENDOCRINOLOGY & METABOLISM | SEGMENTATION | BINDING-SITES | HEMATOLOGY | Cerebellum - metabolism | Humans | Male | Piperazines - metabolism | Positron-Emission Tomography | Sex Characteristics | Autoradiography | Magnetic Resonance Imaging | Cerebellum - diagnostic imaging | Pyridines - metabolism | Cerebellum - cytology | Adult | Female | Kinetics | Receptor, Serotonin, 5-HT1A - metabolism
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17. Full Text Cognitive reserve modulates functional brain responses during memory tasks: a PET study in healthy young and elderly subjects
by Scarmeas, Nikolaos and Zarahn, Eric and Anderson, Karen E and Hilton, John and Flynn, Joseph and Van Heertum, Ronald L and Sackeim, Harold A and Stern, Yaakov
Neuroimage, ISSN 1053-8119, 2003, Volume 19, Issue 3, pp. 1215 - 1227
Cognitive reserve (CR) is the ability of an individual to cope with advancing brain pathology so that he remains free of symptomatology. Epidemiological... 
FDG-PET | MINI-MENTAL-STATE | ALZHEIMERS-DISEASE | EDUCATION | NEUROSCIENCES | NEUROIMAGING | METABOLIC-RATES | RETRIEVAL | POSITRON-EMISSION-TOMOGRAPHY | AGE-RELATED-CHANGES | CEREBRAL-BLOOD-FLOW | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | WORKING-MEMORY | Studies | Variables | Pathology | Neuropathology | Older people | Memory | Aging | Standard deviation | Age | Dementia
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18. Functional cerebral SPECT and PET imaging
by Van Heertum, Ronald L and Tikofsky, Ronald S and Ichise, Masanori
2010, 4th ed., ISBN 0781788978
Brain | Tomography, Emission | methods | Tomography | Brain Diseases | diagnosis | Tomography, Emission-Computed
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19. Functional cerebral SPECT and PET imaging
by Van Heertum, Ronald L and Tikofsky, Ronald S and Ichise, Masanori
2010, 4th ed., ISBN 0781788978
Brain | Tomography, Emission | methods | Tomography | Brain Diseases | diagnosis | Tomography, Emission-Computed
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