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The New England Journal of Medicine, ISSN 0028-4793, 03/2016, Volume 374, Issue 12, pp. 1123 - 1133
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2017, Volume 377, Issue 3, pp. 211 - 221
Loss-of-function variants in ANGPTL3 were associated with lower plasma levels of lipids and lower rates of coronary disease. A monoclonal antibody against... 
MEDICINE, GENERAL & INTERNAL | HEART-DISEASE | REMNANT CHOLESTEROL | PLASMA-LIPIDS | IMMUNOGLOBULIN GENES | ATHEROSCLEROSIS | RISK | CORONARY-ARTERY-DISEASE | FAMILIAL COMBINED HYPOLIPIDEMIA | LIPOPROTEIN-LIPASE GENE | TRANSGENIC MICE | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Male | Angiopoietins - antagonists & inhibitors | Dose-Response Relationship, Drug | Dyslipidemias - blood | Angiopoietin-like Proteins | Lipids - blood | Female | Disease Models, Animal | Dyslipidemias - drug therapy | Atherosclerosis - drug therapy | Double-Blind Method | Antibodies, Monoclonal - pharmacology | Coronary Artery Disease - metabolism | Mice, Inbred Strains | Atherosclerosis - metabolism | Animals | Antibodies, Monoclonal - administration & dosage | Coronary Artery Disease - genetics | Lipid Metabolism - drug effects | Aged | Mice | Mutation | Angiopoietins - genetics | Cholesterol, LDL | Research | Antibiosis | Atherosclerosis | Lipoproteins (low density) | Medical research | Angiopoietin | Genomics | Genes | Coronary artery | Triglycerides | Biochemistry | Gene expression | Cholesterol | Serum levels | Proteins | Antagonism | Arteriosclerosis | Plasma levels | Cardiovascular diseases | Lipoproteins (high density) | Heart diseases | Drug dosages | Pharmaceuticals | Index Medicus | Abridged Index Medicus
Journal Article
Science, ISSN 0036-8075, 12/2016, Volume 354, Issue 6319, pp. aaf6814 - aaf6814
Journal Article
by Gusarova, Viktoria and O'Dushlaine, Colm and Teslovich, Tanya M and Benotti, Peter N and Mirshahi, Tooraj and Gottesman, Omri and Van Hout, Cristopher V and Murray, Michael F and Mahajan, Anubha and Nielsen, Jonas B and Fritsche, Lars and Wulff, Anders Berg and Gudbjartsson, Daniel F and Sjögren, Marketa and Emdin, Connor A and Scott, Robert A and Lee, Wen-Jane and Small, Aeron and Kwee, Lydia C and Dwivedi, Om Prakash and Prasad, Rashmi B and Bruse, Shannon and Lopez, Alexander E and Penn, John and Marcketta, Anthony and Leader, Joseph B and Still, Christopher D and Kirchner, H. Lester and Mirshahi, Uyenlinh L and Wardeh, Amr H and Hartle, Cassandra M and Habegger, Lukas and Fetterolf, Samantha N and Tusie-Luna, Teresa and Morris, Andrew P and Holm, Hilma and Steinthorsdottir, Valgerdur and Sulem, Patrick and Thorsteinsdottir, Unnur and Rotter, Jerome I and Chuang, Lee-Ming and Damrauer, Scott and Birtwell, David and Brummett, Chad M and Khera, Amit V and Natarajan, Pradeep and Orho-Melander, Marju and Flannick, Jason and Lotta, Luca A and Willer, Cristen J and Holmen, Oddgeir L and Ritchie, Marylyn D and Ledbetter, David H and Murphy, Andrew J and Borecki, Ingrid B and Reid, Jeffrey G and Overton, John D and Hansson, Ola and Groop, Leif and Shah, Svati H and Kraus, William E and Rader, Daniel J and Chen, Yii-Der I and Hveem, Kristian and Wareham, Nicholas J and Kathiresan, Sekar and Melander, Olle and Stefansson, Kari and Nordestgaard, Børge G and Tybjærg-Hansen, Anne and Abecasis, Goncalo R and Altshuler, David and Florez, Jose C and Boehnke, Michael and McCarthy, Mark I and Yancopoulos, George D and Carey, David J and Shuldiner, Alan R and Baras, Aris and Dewey, Frederick E and Gromada, Jesper and Diabetes - Cardiovascular Disease and Kardiovaskulär forskning - hypertoni and Cardiovascular Research - Hypertension and Diabetes - kardiovaskulär sjukdom and Lund University and Genomics, Diabetes and Endocrinology and EpiHealth: Epidemiology for Health and Genomik, diabetes och endokrinologi and Institutionen för kliniska vetenskaper, Malmö and Lunds universitet and Department of Clinical Sciences, Malmö
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2252 - 11
Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient... 
HEART-DISEASE | REMNANT CHOLESTEROL | PLASMA-LIPIDS | MULTIDISCIPLINARY SCIENCES | MICE | ANGIOPOIETIN-LIKE PROTEIN-4 | LIPOPROTEIN-LIPASE | HAN CHINESE | CHINESE POPULATION | GENOME-WIDE ASSOCIATION | ADIPOSE-TISSUE | Diabetes Mellitus, Type 2 - genetics | Humans | Homeostasis | Male | Diabetes Mellitus, Type 2 - metabolism | Case-Control Studies | Genetic Variation | Diabetes Mellitus, Type 2 - etiology | Female | Lipoprotein Lipase - metabolism | Genetic Association Studies | Mice, Inbred C57BL | Risk Factors | Gene Silencing | Angiopoietin-like 4 Protein - deficiency | Mice, Knockout | Whole Exome Sequencing | Animals | Insulin Resistance - genetics | Angiopoietin-like 4 Protein - metabolism | Heterozygote | Mice | Blood Glucose - metabolism | Amino Acid Substitution | Angiopoietin-like 4 Protein - genetics | Deactivation | Angiopoietin | Diabetes mellitus | Health risks | Risk reduction | Risk | Lipoprotein lipase | Glucose | Lipase | Inactivation | Insulin | Proteins | Confidence intervals | Sensitivity | Nutrient loss | Rodents | Arteriosclerosis | Atherosclerosis | Genetics | Diabetes | Diabetes mellitus (non-insulin dependent) | Index Medicus | Medicinsk genetik | Basic Medicine | Medical Genetics | Clinical Medicine | Medical and Health Sciences | Endokrinologi och diabetes | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Klinisk medicin | Endocrinology and Diabetes
Journal Article
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 2116
Identification of high-impact loss-of-function variants for common disease is challenging because these variants are typically rare and thus statistical power... 
Obesity | Splicing | Gene frequency | Transcription | Alleles | Association analysis | Population studies | Hypothalamus | Guanine nucleotide-binding protein | Guanine | DNA sequencing
Journal Article
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 271
American Indians suffer from a high prevalence of obesity. Although their obesity is typically polygenic in nature, we are systematically analyzing known... 
Obesity | Phosphorylation | Transcription | Genes | Stat3 protein | Melanocortin MC4 receptors | Bardet-Biedl syndrome | Body mass index | Food intake | Leptin | Alleles | Mutation | BBS gene
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 05/2018, Volume 102, Issue 5, pp. 874 - 889
Journal Article
Circulation, ISSN 0009-7322, 11/2016, Volume 134, Issue Suppl_1 Suppl 1, pp. A16563 - A16563
IntroductionLoss of function (LoF) variants in ANGPTL3 have been associated with low plasma low density lipoprotein cholesterol (LDL-C), high density... 
Journal Article
by Gusarova, Viktoria and O'Dushlaine, Colm and Teslovich, Tanya M and Benotti, Peter N and Mirshahi, Tooraj and Gottesman, Omri and Van Hout, Cristopher V and Murray, Michael F and Mahajan, Anubha and Nielsen, Jonas B and Fritsche, Lars and Wulff, Anders Berg and Gudbjartsson, Daniel F and Sjögren, Marketa and Emdin, Connor A and Scott, Robert A and Lee, Wen-Jane and Small, Aeron and Kwee, Lydia C and Dwivedi, Om Prakash and Prasad, Rashmi B and Bruse, Shannon and Lopez, Alexander E and Penn, John and Marcketta, Anthony and Leader, Joseph B and Still, Christopher D and Kirchner, H Lester and Mirshahi, Uyenlinh L and Wardeh, Amr H and Hartle, Cassandra M and Habegger, Lukas and Fetterolf, Samantha N and Tusie-Luna, Teresa and Morris, Andrew P and Holm, Hilma and Steinthorsdottir, Valgerdur and Sulem, Patrick and Thorsteinsdottir, Unnur and Rotter, Jerome I and Chuang, Lee-Ming and Damrauer, Scott and Birtwell, David and Brummett, Chad M and Khera, Amit V and Natarajan, Pradeep and Orho-Melander, Marju and Flannick, Jason and Lotta, Luca Andrea and Willer, Cristen J and Holmen, Oddgeir L and Ritchie, Marylyn D and Ledbetter, David H and Murphy, Andrew J and Borecki, Ingrid B and Reid, Jeffrey G and Overton, John D and Hansson, Ola and Groop, Leif and Shah, Svati H and Kraus, William E and Rader, Daniel J and Chen, Yii-Der I and Hveem, Kristian and Wareham, Nicholas John and Kathiresan, Sekar and Melander, Olle and Stefansson, Kari and Nordestgaard, Børge G and Tybjærg-Hansen, Anne and Abecasis, Goncalo R and Altshuler, David and Florez, Jose C and Boehnke, Michael and McCarthy, Mark I and Yancopoulos, George D and Carey, David J and Shuldiner, Alan R and Baras, Aris and Dewey, Frederick E and Gromada, Jesper
ISSN 2041-1723, 2018
Journal Article