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Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2018, Volume 61, Issue 16, pp. 7387 - 7393
Beyond the targeting of E3 ubiquitin ligases to inhibit protein homeostasis, E3 ligase binders can be repurposed as targeted protein degraders (PROTACs or... 
DRUGGABLE HOT-SPOTS | MOLECULAR-DYNAMICS | CHEMISTRY, MEDICINAL | STRUCTURE-GUIDED DESIGN | RECOGNITION | STRUCTURAL BASIS | PROTEIN-PROTEIN INTERACTION | BINDING-SITES | HIF-ALPHA | INDUCED DEGRADATION | DISCOVERY | Brief
Journal Article
ISSN 1359-7345, 8/2016, Volume 52, Issue 67, pp. 1293 - 1296
Peroxiredoxins catalyze the reduction of peroxides, a process of vital importance to survive oxidative stress. A nucleophilic cysteine, also known as the... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2014, Volume 111, Issue 31, pp. 11545 - 11550
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 10, pp. 3839 - 3848
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2015, Volume 290, Issue 18, pp. 11365 - 11375
Journal Article
SCIENCE, ISSN 0036-8075, 01/2019, Volume 363, Issue 6423, pp. 143 - 143
Amyloid-beta precursor protein (APP) is central to the pathogenesis of Alzheimer's disease, yet its physiological function remains unresolved. Accumulating... 
NEURONAL-ACTIVITY | PRESYNAPTIC INHIBITION | MOLECULAR-STRUCTURE | MULTIDISCIPLINARY SCIENCES | LONG-TERM POTENTIATION | PHYSIOLOGICAL FUNCTIONS | RELEASE | RECEPTOR ANTAGONIST | MICE LACKING | APPS-ALPHA | REVEALS
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 11/2017, Volume 292, Issue 46, pp. 18831 - 18831
Journal Article
Chemical Communications: Chem Comm, ISSN 1359-7345, 08/2016, Volume 52, Issue 67, pp. 10293 - 10296
Peroxiredoxins catalyze the reduction of peroxides, a process of vital importance to survive oxidative stress. A nucleophilic cysteine, also known as the... 
Reductases | Residues | Cysteine | Tuberculosis | Computation | Chemical reactions | Peroxides | Catalysis
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2016, Volume 291, Issue 29, pp. 15020 - 15028
Journal Article