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Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 10784 - 8
Characterization of the genomic landscapes of intracranial tumours has revealed a clear role for the PI3K-AKT-mTOR pathway in tumorigenesis and tumour... 
IN-VITRO | HIGH-GRADE | PATHWAY | MDR1A P-GLYCOPROTEIN | MULTIDISCIPLINARY SCIENCES | BARRIER | PI3 KINASE INHIBITOR | NVP-BKM120 | ABC TRANSPORTERS | ANTITUMOR-ACTIVITY | CANCER RESISTANCE PROTEIN | TOR protein | Animal models | Blood-brain barrier | Brain tumors | AKT protein | Antitumor activity | Tumorigenesis | Bioavailability | 1-Phosphatidylinositol 3-kinase | Tumors
Journal Article
2008, Blood-brain barrier : understanding the regulatory gatekeeper between brain and body
Web Resource
2008, Blood-brain barrier : regulatory gatekeeper between brain and body
Web Resource
International Journal of Cancer, ISSN 0020-7136, 10/2014, Volume 135, Issue 7, pp. 1700 - 1710
Journal Article
FEBS open bio, ISSN 2211-5463, 04/2017, Volume 7, Issue 4, p. 439
Tight regulation of the eukaryotic cell cycle is paramount to ensure genomic integrity throughout life. Cell cycle checkpoints are present in each phase of the... 
Journal Article
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 1908 - 1908
Journal Article
Translational Cancer Research, ISSN 2218-676X, 12/2017, Volume 6, Issue S9, pp. S1431 - S1434
Journal Article
International Journal of Cancer, ISSN 0020-7136, 09/2013, Volume 133, Issue 5, pp. 1222 - 1233
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e82331 - e82331
Brain cancer is a devastating disease affecting many people worldwide. Effective treatment with chemotherapeutics is limited due to the presence of the... 
MALIGNANT GLIOMA | CELLS | TRANSPORT | MULTIDISCIPLINARY SCIENCES | BARRIER | METASTASES | ADRIAMYCIN | BIODISTRIBUTION | MODEL | CHEMOTHERAPY | PACLITAXEL | Doxorubicin - blood | Glutathione - pharmacokinetics | Doxorubicin - therapeutic use | Capillaries - pathology | Humans | Brain Neoplasms - pathology | Body Weight - drug effects | Polyethylene Glycols - therapeutic use | Drug Delivery Systems | Brain - blood supply | Glutathione - pharmacology | Time Factors | Doxorubicin - analogs & derivatives | Female | Polyethylene Glycols - pharmacology | Glutathione - therapeutic use | Tissue Distribution - drug effects | Glutathione - analogs & derivatives | Endothelial Cells - metabolism | Polyethylene Glycols - pharmacokinetics | Treatment Outcome | Brain Neoplasms - drug therapy | Doxorubicin - pharmacokinetics | Brain - drug effects | Animals | Mice, Nude | Glioblastoma - pathology | Survival Analysis | Brain - pathology | Cell Proliferation - drug effects | Mice | Brain Neoplasms - ultrastructure | Endothelial Cells - pathology | Glioblastoma - drug therapy | Doxorubicin - pharmacology | Glutathione - blood | Drugs | Plasma physics | Drug delivery systems | Anthracyclines | Thiols | Gliomas | Brain tumors | Drug therapy | Cancer | Vehicles | Nuclear medicine | Bioluminescence | Neurosciences | Brain cancer | Glioblastoma | Drug delivery | Metastasis | Cancer therapies | Doxorubicin | Antioxidants | Blood-brain barrier | Inhibition | Xenobiotics | Glutathione | Medical treatment | Pharmacology | Breast cancer | Disease control | Endothelial cells | Studies | Chemotherapy | Brain research | Diffusion barriers | Medical prognosis | Pharmacokinetics | Tumors | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 02/2016, Volume 530, Issue 7591, pp. 490 - 494
Journal Article
Cancer Cell, ISSN 1535-6108, 10/2007, Volume 12, Issue 4, pp. 328 - 341
The Polycomb group and oncogene is required for the proliferation of various differentiated cells and for the self-renewal of stem cells and leukemic cancer... 
STEMCELL | CELLCYCLE | CANCER-CELLS | GROWTH-FACTOR RECEPTOR | ONCOLOGY | PLEOMORPHIC XANTHOASTROCYTOMA | MYC TRANSGENIC MICE | SELF-RENEWAL | NEURAL STEM-CELL | ACUTE MYELOID-LEUKEMIA | NEUROBLASTOMA-CELLS | III BETA-TUBULIN | BRAIN-TUMORS | Neurons - pathology | Receptor, Epidermal Growth Factor - genetics | Cell Proliferation | Astrocytes - pathology | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Stem Cells - metabolism | Brain Neoplasms - metabolism | Neoplasms, Experimental - pathology | Receptor, Epidermal Growth Factor - metabolism | Glioblastoma - genetics | Time Factors | Nuclear Proteins - deficiency | Glioblastoma - metabolism | Cell Differentiation | Neurons - metabolism | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | Transduction, Genetic | Cells, Cultured | Brain Neoplasms - genetics | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Proto-Oncogene Proteins - deficiency | Cell Transformation, Neoplastic - metabolism | Mice, Knockout | Phenotype | Animals | Polycomb Repressive Complex 1 | Mice, Nude | Glioblastoma - pathology | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Stem Cells - pathology | Mice | Mice, Inbred BALB C | Mutation | Neoplasms, Experimental - metabolism | Cell Transformation, Neoplastic - pathology | Neoplasm Staging | 3T3 Cells | Astrocytes - metabolism | Index Medicus
Journal Article
Investigational New Drugs, ISSN 0167-6997, 6/2013, Volume 31, Issue 3, pp. 800 - 800
  We explored whether barasertib (AZD1152), a selective Aurora B kinase inhibitor, is a substrate for P-glycoprotein (Pgp, MDR1), breast cancer resistance... 
Medicine & Public Health | Pharmacology/Toxicology | Oncology
Journal Article
Trends in Molecular Medicine, ISSN 1471-4914, 09/2018, Volume 24, Issue 9, pp. 763 - 780
Glioblastoma is a highly aggressive brain tumor that is characterized by its unparalleled invasiveness. Invasive glioblastoma cells not only escape surgery and... 
preclinical models | glioblastoma | invasion | molecular pathways | extracellular matrix
Journal Article