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1. Full Text Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes
by Sandstrom, A and Mitchell, PS and Goers, L and Mu, EW and Lesser, CF and Vance, RE
SCIENCE, ISSN 0036-8075, 04/2019, Volume 364, Issue 6435, pp. 42 - 42
Inflammasomes are multiprotein platforms that initiate innate immunity by recruitment and activation of caspase-1. The NLRP1B inflammasome is activated upon... 
ANTHRAX LETHAL TOXIN | BACTERIA | PROTEIN | RECOGNITION | MULTIDISCIPLINARY SCIENCES | MOUSE | SUSCEPTIBILITY | RHO GTPASES | CASPASE-1 ACTIVATION | UBIQUITIN LIGASES | CELL-DEATH | Proteases | Physiological aspects | Enzymes | Pathogenic microorganisms | Binding proteins | Ubiquitin | Proteinase | Innate immunity | Activation | Genomes | Leucine | Macrophages | Lethal factor | Immunity | Recruitment | Fragmentation | Caspase-1 | Degradation | Proteins | Receptors | Cell activation | Enzymatic activity | Protease | Proteolysis | Cleavage | Ubiquitin-protein ligase | Immune system | Biodegradation | Antigens | Pathogens | Immune response | Polypeptides | Secretion | Caspase | Proteinase inhibitors | Inflammation | Anthrax lethal toxin | Screens | Proteasome inhibitors | Domains | Protease inhibitors | Cell death | Anthrax | Proteasomes | Ligands | Destabilization | Apoptosis
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2. Full Text Defusing inflammasomes
by Sandstrom, Andrew and Vance, Russell E
Journal of Experimental Medicine, ISSN 0022-1007, 03/2018, Volume 215, Issue 3, pp. 723 - 724
In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome... 
MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNOLOGY | Caspase | Cell activation | Activation | Macrophages | Caspase-1
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3. Full Text The NAIP/NLRC4 inflammasomes
by Vance, Russell E
Current Opinion in Immunology, ISSN 0952-7915, 2015, Volume 32, pp. 84 - 89
Highlights • The NAIP/NLRC4 inflammasomes initiate inflammation in response to bacterial ligands. • A crystal structure of NLRC4 provides structural insights... 
Allergy and Immunology | ACTIVATION | FLAGELLIN | CAUSES AUTOINFLAMMATION | RECOGNITION | CRYSTAL-STRUCTURE | MUTATION | BACTERIAL LIGANDS | PYROPTOSIS | IMMUNOLOGY | NLRC4 CAUSES | CELL-DEATH | Epithelial Cells - metabolism | Inflammasomes - metabolism | Humans | Neuronal Apoptosis-Inhibitory Protein - chemistry | Neuronal Apoptosis-Inhibitory Protein - genetics | Immunity, Innate | Neuronal Apoptosis-Inhibitory Protein - metabolism | CARD Signaling Adaptor Proteins - genetics | Host-Pathogen Interactions | CARD Signaling Adaptor Proteins - metabolism | Macrophages - metabolism | Animals | CARD Signaling Adaptor Proteins - chemistry | Protein Binding | Mutation | Macrophages - immunology | Cells | Structure | Proteases | Crystals
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4. Full Text NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease
by Nichols, Randilea D and Von Moltke, Jakob and Vance, Russell E
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 2209 - 12
Inflammasomes are cytosolic multiprotein complexes that initiate protective immunity in response to infection, and can also drive auto-inflammatory diseases,... 
CAUSES AUTOINFLAMMATION | CASPASE-1 | PSEUDOMONAS-AERUGINOSA | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MUTATION | BACTERIAL LIGANDS | GENE-EXPRESSION | IL-1-BETA | NLRC4 CAUSES | NEUTROPHIL RECRUITMENT | Apoptosis Regulatory Proteins - immunology | Humans | Mice, Inbred C57BL | Male | Calgranulin A - genetics | Macrophages | Systemic Inflammatory Response Syndrome - genetics | Inflammasomes - genetics | Mice, Knockout | Animals | Calcium-Binding Proteins - immunology | Myeloid Cells - immunology | Inflammasomes - immunology | Systemic Inflammatory Response Syndrome - immunology | Apoptosis Regulatory Proteins - genetics | Female | Mice | Calgranulin A - immunology | Calcium-Binding Proteins - genetics | Disease | Eicosanoids | Activation | Leukocytes (neutrophilic) | Interleukin 1 receptors | Immunity | Inflammatory diseases | Interleukin 18 | Signal transduction | Signaling | Monocytes | Cell activation | Cell death | Interleukin 1
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5. Full Text Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
by Kofoed, Eric M and Vance, Russell E
Nature, ISSN 0028-0836, 09/2011, Volume 477, Issue 7366, pp. 592 - 597
Inflammasomes are a family of cytosolic multiprotein complexes that initiate innate immune responses to pathogenic microbes by activating the caspase 1... 
LEGIONELLA-PNEUMOPHILA INFECTION | ACTIVATION | FLAGELLIN | EVOLUTION | CASPASE-1 | INTERLEUKIN-1-BETA | MACROPHAGES | BIRC1E | MULTIDISCIPLINARY SCIENCES | SECRETION | CELL-DEATH | Apoptosis Regulatory Proteins - immunology | Flagellin - immunology | Neuronal Apoptosis-Inhibitory Protein - deficiency | Salmonella typhimurium - immunology | Humans | Mice, Inbred C57BL | Antigens, Bacterial - immunology | Cells, Cultured | Substrate Specificity | Caspase 1 - metabolism | Neuronal Apoptosis-Inhibitory Protein - immunology | Neuronal Apoptosis-Inhibitory Protein - metabolism | Immunity, Innate - immunology | Bacteria - immunology | Macrophages - metabolism | Animals | Calcium-Binding Proteins - immunology | Inflammasomes - immunology | HEK293 Cells | Ligands | Mice | Macrophages - immunology | Bone marrow | Salmonella | Bacteria | Apoptosis
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6. Full Text STING and the innate immune response to nucleic acids in the cytosol
by Burdette, Dara L and Vance, Russell E
Nature Immunology, ISSN 1529-2908, 01/2013, Volume 14, Issue 1, pp. 19 - 26
Cytosolic detection of pathogen-derived nucleic acids is critical for the initiation of innate immune defense against diverse bacterial, viral and eukaryotic... 
INTERFERON | DAI DLM-1/ZBP1 | RECOGNITION | REGULATORY FACTOR | ADAPTER | SENSOR | CYCLIC DI-GMP | I IFN PRODUCTION | PROTEIN REVEALS | IMMUNOLOGY | DNA-DEPENDENT ACTIVATOR | Signal Transduction | Cytosol - immunology | Humans | Autoimmune Diseases - immunology | DNA, Bacterial - immunology | Membrane Proteins - immunology | Autoimmune Diseases - etiology | Immunity, Innate | Host-Pathogen Interactions | Bacterial Infections - complications | Protein Transport - immunology | Animals | Bacterial Infections - immunology | Nucleotides, Cyclic - immunology | Immune response | DNA synthesis | Genetic aspects | Interferon | Cellular signal transduction | Research | Properties | Cytosol
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7. Legionella pneumophila Is Directly Sensitive to 2-Deoxyglucose-Phosphate via Its UhpC Transporter but Is Indifferent to Shifts in Host Cell Glycolytic Metabolism
by Jordan V Price and Kallie Jiang and Abigail Galantowicz and Alana Freifeld and Russell E Vance
Journal of Bacteriology, ISSN 0021-9193, 08/2018, Volume 200, Issue 16
Toll-like receptor (TLR) stimulation induces a pronounced shift to increased glycolytic metabolism in mammalian macrophages. We observed that bone... 
Phosphorylation | Hexose | Phosphate transporter | Biochemistry | Macrophages | Mammals | Cells | Deoxyglucose | Mammalian cells | Proteins | Toll-like receptors | Glycolysis | Bone marrow | Bacteria | Replication | Gram-negative bacteria | Intracellular | Legionnaires' disease bacterium | Transporter
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8. Full Text NAIPs: Building an innate immune barrier against bacterial pathogens: NAIPs function as sensors that initiate innate immunity by detection of bacterial proteins in the host cell cytosol
by Kofoed, Eric M and Vance, Russell E
BioEssays, ISSN 0265-9247, 07/2012, Volume 34, Issue 7, pp. 589 - 598
The innate immune system of mammals encodes several families of immune detector proteins that monitor the cytosol for signs of pathogen invasion. One important... 
Flagellin | Innate immunity | Inflammasome | NLRC4 | NLR | NAIP | Inflammasomes - metabolism | Cytosol - immunology | Humans | Substrate Specificity | Neuronal Apoptosis-Inhibitory Protein - immunology | Bacteria - immunology | CARD Signaling Adaptor Proteins - metabolism | Bacterial Infections - immunology | Calcium-Binding Proteins - immunology | Flagellin - metabolism | Bacterial Proteins - immunology | Bacterial Infections - microbiology | Calcium-Binding Proteins - metabolism | Protein Structure, Tertiary | CARD Signaling Adaptor Proteins - immunology | Bacteria - metabolism | Flagellin - immunology | Immunity, Innate | Neuronal Apoptosis-Inhibitory Protein - metabolism | Host-Pathogen Interactions | Inflammasomes - immunology | Bacterial Proteins - metabolism | Cytosol - metabolism | Cytosol - microbiology | Bacterial Infections - metabolism
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9. Full Text Intracellular innate immune surveillance devices in plants and animals
by Jones, Jonathan D. G and Vance, Russell E and Dangl, Jeffery L
Science, ISSN 0036-8075, 12/2016, Volume 354, Issue 6316, pp. aaf6395 - aaf6395
Multicellular eukaryotes coevolve with microbial pathogens, which exert strong selective pressure on the immune systems of their hosts. Plants and animals use... 
DEFENSE RESPONSES | NB-LRR PROTEIN | DISEASE RESISTANCE PROTEIN | INFLAMMASOME ACTIVATION | MULTIDISCIPLINARY SCIENCES | NLR PROTEINS | III EFFECTOR | WRKY TRANSCRIPTION FACTORS | PATHOGEN EFFECTORS | BACTERIAL PEPTIDOGLYCAN | CELL-DEATH | Immunologic Surveillance | NLR Proteins - genetics | Plant Diseases - immunology | Plant Diseases - microbiology | Plants - microbiology | Immunity, Innate | NLR Proteins - immunology | NLR Proteins - chemistry | Host-Pathogen Interactions | Animals | Protein Domains | Plants - immunology | Evolution, Molecular | Pathogens | Defense mechanisms | Flowers & plants | Immune system | Modular construction | Construction | Microorganisms | Plants (organisms) | Devices | Recognition
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10. Full Text Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor
by Chavarría-Smith, Joseph and Vance, Russell E
PLoS Pathogens, ISSN 1553-7366, 06/2013, Volume 9, Issue 6, p. e1003452
Inflammasomes are multimeric protein complexes that respond to infection by recruitment and activation of the Caspase-1 (CASP1) protease. Activated CASP1... 
MANIPULATION | RECOGNITION | TOXIN | MACROPHAGES | KINASE | MICROBIOLOGY | PYROPTOSIS | CELL-DEATH | INACTIVATION | VIROLOGY | RESISTANCE | ARABIDOPSIS | PARASITOLOGY | Apoptosis Regulatory Proteins - immunology | Inflammasomes - metabolism | Bacterial Toxins - immunology | Humans | Rats, Inbred F344 | Antigens, Bacterial - immunology | Rats | Antigens, Bacterial - genetics | Inflammasomes - genetics | Apoptosis Regulatory Proteins - metabolism | Bacterial Toxins - metabolism | Animals | Proteolysis | Inflammasomes - immunology | Apoptosis Regulatory Proteins - genetics | Bacillus anthracis - immunology | Bacterial Toxins - genetics | Mice | Bacillus anthracis - genetics | Antigens, Bacterial - metabolism | Bacillus anthracis - metabolism | Cell Line, Transformed | Immune response | Cytokines | Anthrax | Physiological aspects | Host-parasite relationships | Research | Health aspects | Proteins | Medical research | Kinases | Immune system
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11. Full Text Self-tolerance of natural killer cells
by Raulet, David H and Vance, Russell E
Nature Reviews Immunology, ISSN 1474-1733, 07/2006, Volume 6, Issue 7, pp. 520 - 531
Natural killer (NK) cells, similar to other lymphocytes, acquire tolerance to self. This means that NK cells have the potential to attack normal self cells but... 
LY49 RECEPTOR REPERTOIRE | VIRUS-INFECTED CELLS | DEFICIENT HEMATOPOIETIC-CELLS | MHC-CLASS-I | BARE LYMPHOCYTE SYNDROME | BONE-MARROW | MARROW GRAFT-REJECTION | INHIBITORY RECEPTORS | NKG2D RECEPTOR | IMMUNOLOGY | MURINE NK CELLS | Histocompatibility Antigens - immunology | Lymphocyte Activation - immunology | Models, Immunological | Animals | Self Tolerance - immunology | Humans | Killer Cells, Natural - immunology | Receptors, Immunologic - immunology | Lymphocyte Subsets - immunology
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