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Journal Article
Journal Article
PLoS Pathogens, ISSN 1553-7366, 02/2015, Volume 11, Issue 2
  The identification of Mycobacterium tuberculosis genes necessary for persistence in vivo provides insight into bacterial biology as well as host defense... 
Proteins | Studies | Hypotheses | Antibiotics | Microscopy | Cell division | Acidification | Infections | Magnesium | Experiments | Fatty acids | Defects
Journal Article
Nature Neuroscience, ISSN 1097-6256, 02/2013, Volume 16, Issue 2, pp. 183 - 192
A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the gold-standard analgesic morphine and other opiates. We found that... 
LAMINA-I NEURONS | NEUROTROPHIC FACTOR | P2X RECEPTORS | DOWN-REGULATION | OPIOID-RECEPTOR GENE | SPINAL-CORD-INJURY | UNDERLYING NEUROPATHIC PAIN | ALTERED CHLORIDE HOMEOSTASIS | NERVE INJURY | NEUROSCIENCES | INDUCED ABNORMAL PAIN | Brain-Derived Neurotrophic Factor - genetics | Biophysical Phenomena - drug effects | Motor Activity - drug effects | Male | Ribosome Inactivating Proteins, Type 1 - pharmacology | Touch | CD11b Antigen - genetics | Microglia - physiology | Time Factors | Chlorides - metabolism | Pain Threshold - drug effects | Biophysical Phenomena - genetics | Vocalization, Animal - drug effects | Brain-Derived Neurotrophic Factor - metabolism | Homeostasis - drug effects | Protein Synthesis Inhibitors - pharmacology | Spinal Cord - cytology | Neurons - drug effects | Membrane Potentials - drug effects | Hot Temperature - adverse effects | Microglia - drug effects | Mice, Inbred C57BL | Rats | Mice, Transgenic | Signal Transduction - genetics | Down-Regulation - drug effects | Rats, Sprague-Dawley | Symporters - metabolism | Gene Expression Regulation - drug effects | Narcotics - administration & dosage | Patch-Clamp Techniques | Rotarod Performance Test | Animals | Hyperalgesia - drug therapy | Signal Transduction - drug effects | Naloxone - pharmacology | Narcotic Antagonists - pharmacology | Mice | CD11b Antigen - metabolism | Receptors, Purinergic P2X4 - metabolism | Morphine - administration & dosage | Receptors, Purinergic P2X4 - genetics | Ion Channel Gating - drug effects | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7657, pp. 254 - 258
Journal Article
Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7652, pp. 112 - 115
Protease-activated receptors ( PARs) are a family of G-proteincoupled receptors ( GPCRs) that are irreversibly activated by proteolytic cleavage of the N... 
PHENIX | ANTAGONIST | THROMBIN | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | RESOLUTION | Allosteric Regulation - drug effects | Benzyl Alcohols - chemistry | Allosteric Site - drug effects | Humans | Receptor, PAR-2 - metabolism | Imidazoles - chemistry | Models, Molecular | Crystallography, X-Ray | Antibodies, Blocking - pharmacology | Imidazoles - pharmacology | Benzimidazoles - chemistry | Receptor, PAR-2 - chemistry | Immunoglobulin Fab Fragments - pharmacology | Receptor, PAR-2 - antagonists & inhibitors | Signal Transduction - drug effects | Antibodies, Blocking - chemistry | Immunoglobulin Fab Fragments - chemistry | Benzyl Alcohols - pharmacology | Benzimidazoles - pharmacology | Ligands | Benzodioxoles - chemistry | Kinetics | Benzodioxoles - pharmacology | Physiological aspects | Cell receptors | Allosteric proteins | Cytochrome | Residues | G protein-coupled receptors | Peptides | Molecular structure | Hydrogen | Homology | Antagonists | Hydrophobicity | Hydrogen bonding | Optimization | Proteins | Lipophilic | Allosteric properties | Imidazole | Cleavage | Inhibition | Thromboembolism | Lysozyme | Hydrogen ion concentration | Deoxyribonucleic acid--DNA | Cultivation | Architecture | Fab | Crystals | Crystallization | Pharmacology | Inflammation | Glycosylation | Computer programs | Chemistry | Diffraction | Antagonist drugs | Lysine | Isoforms | Computer applications | Mutation | Internet | Receptor mechanisms | Binding sites | Glutamine | Cancer | Index Medicus
Journal Article
BRITISH JOURNAL OF NUTRITION, ISSN 0007-1145, 10/2009, Volume 102, Issue 8, pp. 1121 - 1124
The risk of Alzheimer's disease is increased for carriers of apoE4 (E4) or the PPAR-alpha L162V polymorphism (L162V), but it is decreased in fish and seafood... 
DEMENTIA | ALZHEIMERS-DISEASE | ApoE4 | HEALTHY-YOUNG | CARDIOVASCULAR-DISEASE RISK | LIPOPROTEIN METABOLISM | COGNITIVE DECLINE | NUTRITION & DIETETICS | LIPID FRACTIONS | GENE | DOCOSAHEXAENOIC ACID | PPAR-alpha | EPA | FISH | DHA
Journal Article
NEUROBIOLOGY OF AGING, ISSN 0197-4580, 07/2016, Volume 43, pp. 47 - 57
Journal Article
Journal Article