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Medicinal Research Reviews, ISSN 0198-6325, 03/2014, Volume 34, Issue 2, pp. 301 - 339
Journal Article
Archiv der Pharmazie, ISSN 0365-6233, 11/2019, Volume 352, Issue 11, pp. 1900028 - n/a
Hemagglutinin is the surface protein of the influenza virus that mediates both binding and penetration of the virus into host cells. We here report on the... 
synthesis | influenza virus | cycloaddition | antiviral activity | structure elucidation
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2019, p. 115130
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2018, Volume 61, Issue 14, pp. 6193 - 6210
We here disclose chemical synthesis of ribonucleoside 5′-monophosphate (RMP), -diphosphate (RDP), and -triphosphate (RTP) and cycloSal-, DiPPro-, and TriPPPro... 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2018, Volume 61, Issue 14, pp. 6193 - 6210
We here disclose chemical synthesis of ribonucleoside 5'-monophosphate (RMP), -diphosphate (RDP), and -triphosphate (RTP) and cycloSal DiPPro-, and TriPPPro... 
DELIVERY-SYSTEM | DIPHOSPHATE PRODRUGS | MARBURG VIRUS | CHEMISTRY, MEDICINAL | VIRAL-RNA POLYMERASE | BIOLOGICAL EVALUATION | IN-VIVO ACTIVITIES | INTRACELLULAR METABOLISM | ANTIVIRAL EVALUATION | FAVIPIRAVIR T-705 | EBOLA-VIRUS
Journal Article
Journal Article
Antiviral Research, ISSN 0166-3542, 07/2019, Volume 167, pp. 1 - 5
The antiviral drug T-705 (favipiravir) and its non-fluorinated analogue T-1105 inhibit the polymerases of RNA viruses after being converted to their... 
Antiviral | Activation | Cell line dependency | Nicotinamide mononucleotide analogue | Favipiravir | MECHANISM | RIBAVIRIN | TIAZOFURIN | IN-VITRO | VIROLOGY | METABOLISM | VIRUS-REPLICATION | PHARMACOLOGY & PHARMACY | INHIBITOR
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2016, Volume 60, Issue 11, pp. 6679 - 6691
T-705 (favipiravir) is a new antiviral agent in advanced clinical development for influenza therapy. It is supposed to act as an alternative substrate for the... 
NUCLEOTIDE POOL | IN-VITRO | NEURAMINIDASE INHIBITORS | MECHANISM | TRANSCRIPTION | BIOLOGICAL EVALUATION | POLYMERASE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | INFECTION | ANTIVIRAL AGENT | LETHAL MUTAGENESIS | DNA-Directed RNA Polymerases - antagonists & inhibitors | Influenza A Virus, H3N2 Subtype - drug effects | Humans | Influenza A Virus, H3N2 Subtype - metabolism | Reassortant Viruses - genetics | Reassortant Viruses - drug effects | Structure-Activity Relationship | Influenza A Virus, H3N2 Subtype - genetics | IMP Dehydrogenase - genetics | Influenza A Virus, H1N1 Subtype - growth & development | Viral Proteins - metabolism | Influenza A Virus, H3N2 Subtype - growth & development | RNA, Viral - antagonists & inhibitors | Antiviral Agents - chemistry | Madin Darby Canine Kidney Cells | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H1N1 Subtype - metabolism | Amides - pharmacology | A549 Cells | Virus Replication - drug effects | Antiviral Agents - pharmacology | Reassortant Viruses - metabolism | RNA, Viral - biosynthesis | Viral Proteins - genetics | Viral Proteins - antagonists & inhibitors | DNA-Directed RNA Polymerases - genetics | Ribavirin - chemistry | Influenza A Virus, H1N1 Subtype - drug effects | Chick Embryo | Reassortant Viruses - growth & development | IMP Dehydrogenase - metabolism | Pyrazines - chemistry | Animals | Mutation - drug effects | Sequence Analysis, RNA | IMP Dehydrogenase - antagonists & inhibitors | Gene Expression Regulation, Viral | Dogs | Amides - chemistry | DNA-Directed RNA Polymerases - metabolism | Pyrazines - pharmacology | Ribavirin - pharmacology
Journal Article
Journal Article
Phosphorus, Sulfur, and Silicon and the Related Elements, ISSN 1042-6507, 07/2015, Volume 190, Issue 7, pp. 1075 - 1087
We report on synthesis and the structure-activity relationship of carboxamide-derived inhibitors of the influenza virus fusion function of the viral... 
synthesis | antiinfluenza activity | Hydrazides | spirothiazolidinone | hemagglutinin | CHEMISTRY, ORGANIC | MICROWAVE-ASSISTED SYNTHESIS | DERIVATIVES | CHEMISTRY, INORGANIC & NUCLEAR
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2018, Volume 61, Issue 1, pp. 98 - 118
Two series of easily accessible anilines were identified as inhibitors of influenza A virus subtype H1N1, and extensive chemical synthesis and analysis of the... 
A VIRUS | MEMBRANE-FUSION | WILD-TYPE | MOLECULAR-DYNAMICS | RESISTANT MUTANTS | CHEMISTRY, MEDICINAL | V27A MUTANT | VIRAL HEMAGGLUTININ | FORCE-FIELD | M2 ION-CHANNEL | DUAL INHIBITORS
Journal Article