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cardiac & cardiovascular systems (48) 48
index medicus (48) 48
heart failure (42) 42
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failure (5) 5
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heart-failure (5) 5
influenza vaccines - administration & dosage (5) 5
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clinical medicine (4) 4
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heart (4) 4
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angiotensin receptor antagonists - therapeutic use (3) 3
antibodies, viral - blood (3) 3
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1. Full Text Angiotensin receptor-neprilysin inhibitors in heart failure: A shifting paradigm
by Vardeny, Orly
Evidence-Based Medicine, ISSN 1356-5524, 04/2015, Volume 20, Issue 2, pp. 61 - 61
  Context ACE inhibitors prolong survival in patients with heart failure with reduced ejection fraction (HFrEF) and have served as the backbone of heart... 
Humans | Neprilysin - antagonists & inhibitors | Female | Male | Tetrazoles - therapeutic use | Aminobutyrates - therapeutic use | Angiotensin Receptor Antagonists - therapeutic use | Enalapril - therapeutic use | Heart Failure - drug therapy | Heart failure | Heart attacks | ACE inhibitors | Quality of life | Index Medicus
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2. Full Text Influence of Baseline and Worsening Renal Function on Efficacy of Spironolactone in Patients With Severe Heart Failure
by Vardeny, Orly, PharmD, MS and Wu, Dong Hong, PhD and Desai, Akshay, MD, MPH and Rossignol, Patrick, MD and Zannad, Faiez, MD and Pitt, Bertram, MD and Solomon, Scott D., MD and RALES Investigators
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2012, Volume 60, Issue 20, pp. 2082 - 2089
Objectives This study investigated the influence of baseline and worsening renal function (WRF) on the efficacy of spironolactone in patients with severe heart... 
Cardiovascular | Internal Medicine | heart failure | spironolactone | renal dysfunction | SURVIVAL | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | PROTEINURIA | PRIMARY ALDOSTERONISM | THERAPY | DYSFUNCTION | CHRONIC KIDNEY-DISEASE | EPLERENONE | BLOCKADE | CARDIOVASCULAR RISK | Heart failure | Enzymes | Care and treatment | Enzyme inhibitors | Spironolactone | Cardiac patients | Angiotensin | Antiandrogens | Heart attack | Pharmacy | Drugstores | Hypertension | Heart attacks | Mortality | Medical prognosis | Hospitalization | Diabetes | Drug therapy | Potassium
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3. Full Text The Role of Neprilysin Inhibitors in Cardiovascular Disease
by Mills, Jared and Vardeny, Orly
Current Heart Failure Reports, ISSN 1546-9530, 12/2015, Volume 12, Issue 6, pp. 389 - 394
Heart failure affects over five million Americans each year and contributes to morbidity, mortality, and high health care costs. Despite the benefits of RAAS... 
Heart failure | Cardiac Surgery | Cardiovascular mortality | Neprilysin inhibitor | Internal Medicine | Vascular Surgery | HFpEF | HFrEF | Medicine & Public Health | Natriuretic peptide levels | Cardiology | Imaging / Radiology | Angiotension II | Tetrazoles - pharmacology | Humans | Angiotensin Receptor Antagonists - pharmacology | Neprilysin - antagonists & inhibitors | Tetrazoles - therapeutic use | Aminobutyrates - pharmacology | Aminobutyrates - therapeutic use | Angiotensin Receptor Antagonists - therapeutic use | Heart Failure - drug therapy | Randomized Controlled Trials as Topic | Complications and side effects | Care and treatment | Analysis | Cardiac patients | Research | Health aspects | Medical care, Cost of | Index Medicus
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4. Full Text Influenza and Heart Failure
by Vardeny, Orly and Solomon, Scott D
JACC: Heart Failure, ISSN 2213-1779, 02/2019, Volume 7, Issue 2, pp. 118 - 120
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5. Full Text Influence of baseline and worsening renal function on efficacy of spironolactone in patients with severe heart failure: Insights from rales (randomized aldactone evaluation study)
by Vardeny, Orly and Wu, Dong Hong and Desai, Akshay and Rossignol, Patrick and Zannad, Faiez and Pitt, Bertram and Solomon, Scott D and RALES Investigators
Journal of the American College of Cardiology, ISSN 0735-1097, 11/2012, Volume 60, Issue 20, pp. 2082 - 2089
Objectives: This study investigated the influence of baseline and worsening renal function (WRF) on the efficacy of spironolactone in patients with severe... 
heart failure | spironolactone | renal dysfunction | Length of Stay | Prognosis | Double-Blind Method | Diuretics - pharmacology | Humans | Risk Factors | Heart Failure - physiopathology | Male | Treatment Outcome | Hospitalization | Heart Failure - drug therapy | Glomerular Filtration Rate - drug effects | Spironolactone - pharmacology | Diuretics - therapeutic use | Female | Spironolactone - therapeutic use | Heart Failure - mortality | Index Medicus | Abridged Index Medicus
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6. Full Text Erratum: ß2 adrenergic receptor polymorphisms and nocturnal blood pressure dipping status in theWisconsin Sleep Cohort Study (Journal of the American Society of Hypertension (2011) 5, 2, (114-122) DOI: 10.1016/j.jash.2011.01.005)
by Vardeny, Orly
Journal of the American Society of Hypertension, ISSN 1933-1711, 2011, Volume 5, Issue 3, p. 193
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7. Full Text Abstract 16349: Influenza Activity is Associated With Hospitalizations for Heart Failure- Results From the Atherosclerosis Risk in Communities Study
by Kytomaa, Sonja and Hegde, Sheila and Vardeny, Orly and Claggett, Brian and Udell, Jacob and Solomon, Scott
Circulation, ISSN 0009-7322, 11/2018, Volume 138, Issue Suppl_1 Suppl 1, pp. A16349 - A16349
IntroductionInfluenza is associated with an increased risk of cardiovascular events, yet few studies have explored the temporal association between influenza... 
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8. Full Text Influenza vaccination: A one-shot deal to reduce cardiovascular events
by Vardeny, Orly and Solomon, Scott D
European Heart Journal, ISSN 0195-668X, 2017, Volume 38, Issue 5, pp. 334 - 337
MORTALITY | CARDIAC & CARDIOVASCULAR SYSTEMS | HEART-FAILURE | DISEASE | RISK | PNEUMONIA | ASSOCIATION | SECONDARY PREVENTION | HOSPITALIZATION | Influenza Vaccines | Humans | Vaccination | Influenza, Human | Index Medicus
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9. Full Text Transitioning to the National Institutes of Health single institutional review board model: Piloting the use of the Streamlined, Multi-site, Accelerated Resources for Trials IRB Reliance
by Vardeny, Orly and Hernandez, Adrian F and Cohen, Lauren W and Franklin, Amy and Baqai, Mina and Palmer, Sarah and Bierer, Barbara E and Cobb, Nichelle
Clinical Trials, ISSN 1740-7745, 6/2019, Volume 16, Issue 3, pp. 290 - 296
Background/Aims Obtaining ethical approval from multiple institutional review boards is a long-standing challenge to multi-site clinical trials and often leads... 
Formulations | Heart | Medical research | Learning curves | Evaluation | Costs | Review boards | Clinical trials | Activation | Thorax | Vaccines | Institutions | Surveys | Medical centres | Influenza | Qualitative analysis | Cost analysis | Heart diseases | Culture
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10. Full Text High-dose influenza vaccine to reduce clinical outcomes in high-risk cardiovascular patients: Rationale and design of the INVESTED trial
by Vardeny, Orly and Udell, Jacob A and Joseph, Jacob and Farkouh, Michael E and Hernandez, Adrian F and McGeer, Alison J and Talbot, H. Keipp and Bhatt, Deepak L and Cannon, Christopher P and Goodman, Shaun G and Anand, Inder and DeMets, David L and Temte, Jon and Wittes, Janet and Nichol, Kristin and Yancy, Clyde W and Gaziano, J. Michael and Cooper, Lawton S and Kim, KyungMann and Solomon, Scott D
American Heart Journal, ISSN 0002-8703, 08/2018, Volume 202, pp. 97 - 103
Influenza leads to significant cardiopulmonary morbidity and mortality—particularly in patients with cardiovascular disease—that may be prevented with a... 
UNITED-STATES | CARDIAC & CARDIOVASCULAR SYSTEMS | REGRESSION-ANALYSIS | MYOCARDIAL-INFARCTION | HEART-FAILURE | DISEASE | PREVENTION | ACUTE CORONARY SYNDROMES | FAILURE TIME DATA | RECURRENT EVENTS | ACUTE INFECTION | Influenza Vaccines - administration & dosage | Double-Blind Method | Humans | Risk Factors | Male | Hospitalization | Influenza, Human - complications | Myocardial Infarction | Pneumonia - mortality | Cardiovascular Diseases - mortality | Heart Failure | Influenza, Human - mortality | Adult | Female | Influenza, Human - prevention & control | Research Design | Influenza vaccines | Influenza | Patient outcomes | Cardiac patients | Risk factors | Myocardial infarction | Guillain-Barre syndrome | Vaccination | Clinical trials | Objectives | Risk | Cardiovascular disease | Infections | Vaccines | Medical laboratories | Seasons | Heart diseases | Active control | Antigens | Immune response | Life expectancy | Risk groups | Mortality | Health risks | Risk reduction | Thorax | Patients | Morbidity | Immune systems | Antibiotics | Strategy | Infarction | Research design | Cardiovascular diseases | Index Medicus | Abridged Index Medicus | influenza | clinical trial | heart failure | vaccine | myocardial infarction
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11. Full Text INFLUENCE OF BASELINE AND WORSENING RENAL FUNCTION ON EFFICACY OF SPIRONOLACTONE IN PATIENTS WITH SEVERE HEART FAILURE ENROLLED IN THE RANDOMIZED ALDACTONE EVALUATION
by Vardeny, Orly and Zannad, Faiez and Pitt, Bertram and Solomon, Scott
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2012, Volume 59, Issue 13, pp. E863 - E863
  Methods We utilized data from the Randomized Aldactone Evaluation Study (RALES) in 1663 pts NYHA class III or IV HF and an ejection fraction < 35%. 
Cardiovascular | Internal Medicine | Heart failure | Care and treatment | Cardiac patients | Medical research | Mortality
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12. Full Text Natriuretic peptide and high-sensitivity troponin for cardiovascular risk prediction in diabetes: The Atherosclerosis Risk in Communities (ARIC) study
by Gori, Mauro and Gupta, Deepak K and Claggett, Brian and Selvin, Elizabeth and Folsom, Aaron R and Matsushita, Kunihiro and Bello, Natalie A and Cheng, Susan and Shah, Amil and Skali, Hicham and Vardeny, Orly and Ni, Hanyu and Ballantyne, Christie M and Astor, Brad C and Klein, Barbara E and Aguilar, David and Solomon, Scott D
Diabetes Care, ISSN 0149-5992, 05/2016, Volume 39, Issue 5, pp. 677 - 685
OBJECTIVE Cardiovascular disease (CVD) is the major cause of morbidity and mortality in diabetes; yet, heterogeneity in CVD risk has been suggested in... 
MORTALITY | POPULATION | EVENTS | MYOCARDIAL-INFARCTION | ENDOCRINOLOGY & METABOLISM | ADULTS | MELLITUS | CORONARY-HEART-DISEASE | FAILURE | ASSOCIATION | NT-PROBNP | Diabetes Mellitus - blood | Prevalence | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Risk Factors | Proportional Hazards Models | Atherosclerosis - complications | Atherosclerosis - mortality | Male | Biomarkers - blood | Diabetes Complications - blood | Diabetes Complications - complications | Diabetes Complications - mortality | Incidence | Atherosclerosis - blood | Hypertension - blood | Troponin T - blood | Electrocardiography | Female | Diabetes Mellitus - mortality | Natriuretic Peptide, Brain - blood | Care and treatment | Usage | Mortality | Analysis | Electrocardiogram | Influence | Diabetes | Cardiovascular diseases | Hypertension | Atherosclerosis | Biomarkers | African Americans | Neuropeptides | Hormones | Index Medicus | Cardiovascular Disease and Diabetes
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13. Full Text MORTALITY FOLLOWING INITIATION OR DISCONTINUATION OF GUIDELINE DIRECTED MEDICAL THERAPIES IN HOSPITALIZED HEART FAILURE PATIENTS IN THE ATHEROSCLEROSIS RISK IN COMMUNITIES STUDY
by Tran, Richard and Aldemerdash, Ahmed and Chang, Patricia and Sueta, Carla and Kaufman, Brystana and Asafu-Adjei, Josephine and Vardeny, Orly and Daubert, Eliza and Kucharska-Newton, Anna and Stearns, Sally and Rodgers, Jo
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2016, Volume 67, Issue 13, pp. 1549 - 1549
  Initiate versusNever Discontinue versusMaintain Initiate versusNever Discontinue versusMaintain ACEI/ARB 0.60 (0.44-0.81) 1.20 (0.84-1.73) 0.56 (0.37-0.85)... 
Cardiovascular | Internal Medicine | Heart failure | Medical research | Patient outcomes | Cardiac patients | Mortality | Atherosclerosis | Therapeutics | Medicine, Experimental | Practice guidelines (Medicine) | Risk factors | Homeopathy | Materia medica and therapeutics | Confidence intervals | Hospitalization
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14. Full Text Guideline‐Directed Medical Therapy and Survival Following Hospitalization in Patients with Heart Failure
by Tran, Richard H and Aldemerdash, Ahmed and Chang, Patricia and Sueta, Carla A and Kaufman, Brystana and Asafu‐adjei, Josephine and Vardeny, Orly and Daubert, Eliza and Alburikan, Khalid A and Kucharska‐Newton, Anna M and Stearns, Sally C and Rodgers, Jo E
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, ISSN 0277-0008, 04/2018, Volume 38, Issue 4, pp. 406 - 416
BackgroundModification of guideline-directed medical therapy (GDMT) in hospitalized patients with heart failure (HF) has not been extensively evaluated.... 
predictors | mortality | guideline‐directed medical therapy | heart failure | modification | guideline-directed medical therapy | BETA-BLOCKER CONTINUATION | 30-DAY READMISSION | ATHEROSCLEROSIS RISK | SPIRONOLACTONE | PHARMACOLOGY & PHARMACY | ALL-CAUSE READMISSION | WITHDRAWAL | BURDEN | BENEFICIARIES | Cardiovascular Agents - administration & dosage | Comorbidity | United States | Humans | Middle Aged | Proportional Hazards Models | Hospitalization - statistics & numerical data | Male | Disease Progression | Heart Failure - drug therapy | Stroke Volume | Cardiovascular Agents - therapeutic use | Aged, 80 and over | Female | Aged | Retrospective Studies | Heart Failure - mortality | Practice Guidelines as Topic | Heart failure | Medical research | Enzymes | Care and treatment | Patient outcomes | Mortality | Practice guidelines (Medicine) | Nitrates | Analysis | Cardiac patients | Atherosclerosis | Angiotensin | Medicine, Experimental | Heart | Therapy | Statistical analysis | Digoxin | Regression analysis | Aldosterone | Survival | Patients | Confidence intervals | Enzyme inhibitors | Statistical models | Arteriosclerosis | Hazard assessment | Health risk assessment | Heart diseases | Failure | Ejection | Index Medicus | GDMT
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15. Full Text Abstract 17374: Reduced Risk of Hyperkalemia in Heart Failure Patients Treated With an MRA and Sacubitril/Valsartan Compared With Enalapril: The PARADIGM-HF Trial
by Solomon, Scott and Packer, Milton and Claggett, Brian and Vardeny, Orly and Zile, Michael and Swedberg, Karl and Rouleau, Jean and Shi, Victor and Lefkowitz, Martin and McMurray, John
Circulation, ISSN 0009-7322, 11/2016, Volume 134, Issue Suppl_1 Suppl 1, pp. A17374 - A17374
IntroductionCurrent guidelines recommend treating heart failure and reduced ejection fraction witha) ACE inhibitors, ARBs or sacubitril/valsartan, b)... 
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16. Full Text Abstract 19930: Genetically elevated NT-proBNP, Cardiovascular Outcomes and Life Expectancy in Elderly Blacks and Whites
by Seidelmann, Sara and Vardeny, Orly and Claggett, Brian and Yu, Bing and Bravo, Paco and Gupta, Ankur and MacRae, Calum and Boerwinkle, Eric and Solomon, Scott
Circulation, ISSN 0009-7322, 11/2016, Volume 134, Issue Suppl_1 Suppl 1, pp. A19930 - A19930
IntroductionThe functional variant rs198389 in the promoter region of the B-type Natriuretic Peptide (NPPB) gene has been associated with increased gene... 
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17. Full Text Influenza and Heart Failure: A Catchy Comorbid Combination
by Vardeny, Orly and Solomon, Scott D
JACC: Heart Failure, ISSN 2213-1779, 02/2019, Volume 7, Issue 2, pp. 118 - 120
influenza | acute heart failure | vaccination | RISK | CARDIAC & CARDIOVASCULAR SYSTEMS | OUTCOMES
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18. Full Text Efficacy of sacubitril/valsartan vs. enalapril at lower than target doses in heart failure with reduced ejection fraction: the PARADIGM‐HF trial
by Vardeny, Orly and Claggett, Brian and Packer, Milton and Zile, Michael R and Rouleau, Jean and Swedberg, Karl and Teerlink, John R and Desai, Akshay S and Lefkowitz, Martin and Shi, Victor and McMurray, John J.V and Solomon, Scott D and Prospective Comparison ARNI ACEI D and Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) Investigators and Sahlgrenska akademin and Institute of Medicine, Department of Molecular and Clinical Medicine and Institutionen för medicin, avdelningen för molekylär och klinisk medicin and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy
European Journal of Heart Failure, ISSN 1388-9842, 10/2016, Volume 18, Issue 10, pp. 1228 - 1234
AimsIn this analysis, we utilized data from PARADIGM-HF to test the hypothesis that participants who exhibited any dose reduction during the trial would have... 
Clinical trial | Chronic heart failure | Valsartan | Sacubitril | Neprilysin inhibitor | BETA-BLOCKER THERAPY | NEPRILYSIN | CARDIAC & CARDIOVASCULAR SYSTEMS | INHIBITION | OUTCOMES | Double-Blind Method | Humans | Middle Aged | Heart Failure - physiopathology | Stroke Volume - drug effects | Male | Heart Failure - drug therapy | Dose-Response Relationship, Drug | Tetrazoles - administration & dosage | Female | Aged | Aminobutyrates - administration & dosage | Enalapril - administration & dosage | Angiotensin Receptor Antagonists - administration & dosage | Index Medicus | Medical Treatment | Klinisk medicin | Clinical Medicine
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19. Full Text Incidence, predictors, and outcomes related to hypo- and hyperkalemia in patients with severe heart failure treated with a mineralocorticoid receptor antagonist
by Vardeny, Orly and Vardeny, Orly and Claggett, Brian and Claggett, Brian and Anand, Inder and Anand, Inder and Rossignol, Patrick and Rossignol, Patrick and Desai, Akshay S and Desai, Akshay S and Zannad, Faiez and Zannad, Faiez and Pitt, Bertram and Pitt, Bertram and Solomon, Scott D and Solomon, Scott D and Randomized Aldactone Evaluation Study (RALES) Investigators, Aldactone Evaluation Study (RALES) Investigators and Randomized Aldactone Evaluation and Randomized Aldactone Evaluation Study (RALES) Investigators
Circulation: Heart Failure, ISSN 1941-3289, 2014, Volume 7, Issue 4, pp. 573 - 579
Background-Mineralocorticoid receptor antagonists reduce morbidity and mortality in patients with heart failure but can cause hyperkalemia, which contributes... 
Heart failure | Pharmacology | Spironolactone | Potassium | SURVIVAL | MORTALITY | heart failure | MILD PATIENTS HOSPITALIZATION | CARDIAC & CARDIOVASCULAR SYSTEMS | potassium | MYOCARDIAL-INFARCTION | EFFICACY | spironolactone | LOW SERUM POTASSIUM | pharmacology | EMPHASIS-HF | EPLERENONE | WORSENING RENAL-FUNCTION | Hyperkalemia - blood | Follow-Up Studies | Hypokalemia - blood | Spironolactone - administration & dosage | Heart Ventricles - diagnostic imaging | Incidence | Dose-Response Relationship, Drug | Hypokalemia - chemically induced | Hyperkalemia - epidemiology | Retrospective Studies | Heart Failure - diagnostic imaging | Spironolactone - adverse effects | Heart Failure - mortality | Severity of Illness Index | Mineralocorticoid Receptor Antagonists - administration & dosage | Echocardiography | Survival Rate - trends | Double-Blind Method | Global Health | Risk Factors | Ventricular Function, Left - drug effects | Mineralocorticoid Receptor Antagonists - adverse effects | Treatment Outcome | Heart Failure - drug therapy | Stroke Volume | Heart Ventricles - physiopathology | Hyperkalemia - chemically induced | Hypokalemia - epidemiology | Cause of Death - trends | Potassium - blood | Index Medicus
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20. Full Text Angiotensin receptor-neprilysin inhibitors in heart failure: a shifting paradigm
by Wattie, Nora I and Vardeny, Orly and Lavoie, Patrick and Kishi, Taro
Evidence Based Nursing, ISSN 1356-5524, 04/2015, Volume 20, Issue 2, p. 61
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