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Organic Process Research & Development, ISSN 1083-6160, 01/2015, Volume 19, Issue 1, pp. 132 - 138
A concise scalable synthesis of a chiral dipeptide acid, key substructure of the HCV protease inhibitor faldaprevir, has been developed. A green process with... 
BILN-2061 | HEPATITIS-C VIRUS | AMINES | NS3 PROTEASE | N,N-DIMETHYLAMINES | ESTERIFICATION | AMIDATION | CHEMISTRY, ORGANIC | LARGE-SCALE SYNTHESIS | CHEMISTRY, APPLIED | EQUIMOLAR AMOUNTS | CARBOXYLIC-ACIDS
Journal Article
Organic Letters, ISSN 1523-7060, 01/2008, Volume 10, Issue 2, pp. 341 - 344
Asymmetric hydrogenation of unsaturated urea esters with the BIPI Ligands has been examined. Optimization of the P−N ligand structure has led to the... 
IMIDAZOLINE LIGANDS | ENANTIOSELECTIVE HYDROGENATION | COMPLEXES | CHEMISTRY, ORGANIC | AMINO ACID-DERIVATIVES | CATALYSTS | NUCLEOPHILIC AROMATIC-SUBSTITUTION | Phosphines - chemistry | Stereoisomerism | Urea - analogs & derivatives | Esters | Ligands | Molecular Structure | Catalysis | Hydrogenation | Rhodium - chemistry | Urea - chemistry
Journal Article
Organic Process Research & Development, ISSN 1083-6160, 07/2008, Volume 12, Issue 4, pp. 603 - 613
The pilot-plant synthesis of nevirapine analogue 1 is described. The compound was prepared in eight steps from substituted pyridine raw materials and... 
Journal Article
Organic Letters, ISSN 1523-7060, 09/2005, Volume 7, Issue 19, pp. 4277 - 4280
Diisobutylaluminum hydride (DIBAL-H) and triisobutylaluminum have been found to be outstanding reductants for secondary phosphine oxides (SPOs). All classes of... 
CATALYSIS | STYRENES | POSITIONS | IMIDAZOLINE LIGANDS | TRANSITION-METAL COMPLEXES | BIDENTATE LIGANDS | ENANTIOSELECTIVE HYDROGENATION | ASYMMETRIC HECK REACTION | CHEMISTRY, ORGANIC | COORDINATION | DIPHENYLPHOSPHINE | Ligands | Molecular Structure | Phosphines - chemistry | Aluminum - chemistry | Oxidation-Reduction | Oxides - chemistry
Journal Article
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