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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2018, Volume 115, Issue 17, pp. 4465 - 4470
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2016, Volume 113, Issue 16, pp. 4476 - 4481
Inhibition of the vascular endothelial growth factor (VEGF) pathway has failed to improve overall survival of patients with glioblastoma (GBM). We previously... 
Anti-angiogenic therapy | Macrophage polarization | Tumor microenvironment | Microglia reprogramming | Anti-tumor immunity | anti-angiogenic therapy | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | macrophage polarization | RANDOMIZED-TRIAL | ANGIOPOIETIN-2 | CANCER | THERAPY | microglia reprogramming | TIE2-EXPRESSING MONOCYTES | BLOOD-VESSELS | TUMOR-ASSOCIATED MACROPHAGES | tumor microenvironment | NORMALIZATION | anti-tumor immunity | ENDOTHELIAL GROWTH-FACTOR | Macrophages - pathology | Antibodies, Bispecific - pharmacology | Vesicular Transport Proteins - metabolism | Humans | Neoplasm Proteins - antagonists & inhibitors | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Neoplasm Proteins - metabolism | Neoplasms, Experimental - pathology | Xenograft Model Antitumor Assays | Macrophages - metabolism | Vesicular Transport Proteins - antagonists & inhibitors | Animals | Antibodies, Neoplasm - pharmacology | Ribonuclease, Pancreatic - metabolism | Glioblastoma - pathology | Cell Line, Tumor | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Mice | Neoplasms, Experimental - metabolism | Glioblastoma - drug therapy | Ribonuclease, Pancreatic - antagonists & inhibitors | Neoplasms, Experimental - drug therapy | Viral antibodies | Care and treatment | Antibodies | Physiological aspects | Models | Macrophages | Vascular endothelial growth factor | Health aspects | Glioblastoma multiforme | Genotype & phenotype | Survival analysis | Protein expression | Cells | Tumors | Cancer | Index Medicus | Biological Sciences
Journal Article
细胞研究:英文版, ISSN 1001-0602, 2016, Volume 26, Issue 9, pp. 973 - 974
Astrocytes are emerging as essential regulators of brain metastasis progression. In a current issue of Nature, Chen et al. identify a novel mechanism of... 
BREAST-CANCER | SURVIVAL | CELLS | GENES | CELL BIOLOGY | Gap Junctions | Brain | Nucleotides, Cyclic | Astrocytes | Humans | Brain Neoplasms | Index Medicus | Research Highlight
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2018, Volume 115, Issue 37, pp. E8717 - E8726
Blood-brain/blood-tumor barriers (BBB and BTB) and interstitial transport may constitute major obstacles to the transport of therapeutics in brain tumors. In... 
Blood–brain/blood–tumor barrier | Brain tumor | Drug transport | Focused ultrasound | Pharmacokinetics | blood-brain/blood-tumor barrier | EFFICACY | MULTIDISCIPLINARY SCIENCES | SIZE | drug transport | brain tumor | EMERGING STRATEGIES | TRASTUZUMAB EMTANSINE | BREAST-CANCER | PRESSURE | TRANSPORT | FLUORESCENCE MICROSCOPY | THERAPY | FLUID | pharmacokinetics | focused ultrasound | Brain - diagnostic imaging | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Trastuzumab - pharmacokinetics | Humans | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Brain Neoplasms - metabolism | Breast Neoplasms - metabolism | Brain - metabolism | Brain Neoplasms - secondary | Microbubbles | Doxorubicin - administration & dosage | Ultrasonography - methods | Maytansine - analogs & derivatives | Trastuzumab - administration & dosage | Brain Neoplasms - drug therapy | Blood-Brain Barrier - drug effects | Breast Neoplasms - drug therapy | Doxorubicin - pharmacokinetics | Blood-Brain Barrier - metabolism | Xenograft Model Antitumor Assays | Maytansine - administration & dosage | Animals | Breast Neoplasms - pathology | Maytansine - pharmacokinetics | Brain - pathology | Cell Line, Tumor | Mice | Drug Delivery Systems - methods | Drugs | Drug delivery systems | Care and treatment | Blood-brain barrier | Brain cancer | Physiological aspects | Metastasis | Drug therapy | Methods | Vehicles | Brain | Brain tumors | Xenotransplantation | Drug delivery | Doxorubicin | Blood | Optimization | Metastases | Anticancer properties | FUS protein | Antitumor agents | Extravasation | Xenografts | Modelling | Ultrasound | Experimental data | Data processing | Breast cancer | Pharmacology | ErbB-2 protein | Endothelial cells | Chemotherapy | Microscopy | Barriers | Disruption | Transport | Trastuzumab | Tumors | Cancer | Index Medicus | Biological Sciences | Physical Sciences | PNAS Plus | blood–tumor barrier | blood–brain
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 04/2015, Volume 107, Issue 4, p. 1
Background: Matrix metalloproteinase (MMP) 14 may mediate tumor progression through vascular and immune-modulatory effects. Methods: Orthotopic murine breast... 
VASCULAR NORMALIZATION | INVASION | CANCER CELLS | ANGIOGENESIS | ONCOLOGY | MATRIX-METALLOPROTEINASE INHIBITORS | DRUG-DELIVERY | NITRIC-OXIDE SYNTHASE | TUMOR-GROWTH | EXPRESSION | BETA | Up-Regulation | Immunoglobulin G - blood | Breast Neoplasms - immunology | Humans | Gene Expression Regulation, Neoplastic | Neovascularization, Pathologic | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Smad3 Protein - metabolism | Breast Neoplasms - metabolism | Nitric Oxide Synthase Type II - antagonists & inhibitors | Dose Fractionation | Female | Antineoplastic Agents - pharmacology | Matrix Metalloproteinase 14 - drug effects | Antibodies, Monoclonal - pharmacology | Enzyme Inhibitors - pharmacology | Smad2 Protein - metabolism | Nitric Oxide Synthase Type II - drug effects | Breast Neoplasms - blood supply | Matrix Metalloproteinase 14 - metabolism | Breast Neoplasms - drug therapy | Enzyme Inhibitors - therapeutic use | Macrophages - enzymology | Gene Expression Regulation, Enzymologic | Breast Neoplasms - radiotherapy | Phenotype | Animals | Signal Transduction - drug effects | Mammary Neoplasms, Experimental | Cell Line, Tumor | Macrophages - drug effects | Amidines - pharmacology | Mice | Benzylamines - pharmacology | Transforming Growth Factor beta - metabolism | Nitric Oxide Synthase Type II - metabolism | Enzymes | Genotype & phenotype | Immunoglobulins | Immunology | Radiation therapy | Gene expression | Tumors | Index Medicus
Journal Article
Annals of Surgical Oncology, ISSN 1068-9265, 12/2013, Volume 20, Issue 13, pp. 4169 - 4182
Journal Article
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Journal Article
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