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Angewandte Chemie International Edition, ISSN 1433-7851, 01/2019, Volume 58, Issue 2, pp. 515 - 519
Histone lysine demethylases (KDMs) are involved in the dynamic regulation of gene expression and they play a critical role in several biological processes.... 
lysine demethylase | covalent inhibitors | KDM5 | epigenetics | POTENT | TIME | CHEMISTRY, MULTIDISCIPLINARY | HISTONE | Proteins | Time dependence | Covalence | Inhibitors | Transcription | Lysine | Selectivity | Inhibition | Gene expression | Biological activity | Communications | Communication
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2018, Volume 61, Issue 23, pp. 10403 - 10411
Collagen is the dominant protein of the extracellular matrix. Its distinguishing feature is a three-stranded helix of great tensile strength.... 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2018, Volume 61, Issue 23, pp. 10403 - 10411
Collagen is the dominant protein of the extracellular matrix. Its distinguishing feature is a three stranded helix of great tensile strength.... 
SELECTIVE-INHIBITION | SYNTHETIC POLYPEPTIDES | CHEMISTRY, MEDICINAL | KEY ENZYMES | ACID | MECHANISM | ALPHA-DIPYRIDYL | 2-OXOGLUTARATE | IRON | SYNCATALYTIC INACTIVATION | BINDING
Journal Article
Angewandte Chemie, ISSN 0044-8249, 01/2019, Volume 131, Issue 2, pp. 525 - 529
Histone lysine demethylases (KDMs) are involved in the dynamic regulation of gene expression and they play a critical role in several biological processes.... 
Kovalente Inhibitoren | Lysin-Demethylase | KDM5 | Epigenetik | Proteins | Time dependence | Covalence | Inhibitors | Transcription | Lysine | Selectivity | Inhibition | Gene expression | Biological activity
Journal Article
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2019, Volume 1888, pp. 45 - 71
Intracellular target affinity and residence time are fundamental aspects of pharmacological mechanism (Lu and Tonge, Curr Opin Chem Biol 14:467-474, 2010).... 
BRET | Target engagement | Intracellular affinity | NanoBRET(TM) | Residence time
Journal Article
Journal of Liquid Chromatography & Related Technologies, ISSN 1082-6076, 06/2011, Volume 34, Issue 10-11, pp. 936 - 945
High performance thin-layer chromatography-densitometry (HPTLC-Dens) was used to determine the free-pool amino acid content of whole bodies of sexually... 
Biomphalaria glabrata | densitometry | temperature effects | amino acids | high performance thin layer chromatography | valine | HPTLC | CHEMISTRY, ANALYTICAL | SCHISTOSOMA-MANSONI | BIOCHEMICAL RESEARCH METHODS | NEUTRAL LIPID-CONTENT | ECHINOSTOMA-CAPRONI | REPRODUCTION | WATER
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 11/2018, Volume 140, Issue 46, pp. 15774 - 15782
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 09/2018, Volume 13, Issue 9, pp. 2758 - 2770
A new generation of heterobifunctional small molecules, termed proteolysis targeting chimeras (PROTACs), targets proteins for degradation through recruitment... 
SMALL-MOLECULE PROTACS | UBIQUITINATION | RECRUITMENT | INHIBITION | STRATEGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CEREBLON | TARGETED PROTEIN-DEGRADATION | KNOCKDOWN | DISCOVERY | MODULATION
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 06/2013, Volume 21, Issue 12, pp. 3597 - 3601
Journal Article
Journal of Parasitology, ISSN 0022-3395, 2011, Volume 97, Issue 4, pp. 746 - 747
A simplified method for the culture of neonatal Biomphalaria glabrata snails on a diet of the cyanobacteria Nostoc sp. has been developed. Previous studies... 
Flasks | Parasitology | Snails | Diet | Breeding | Cyanobacteria | RESEARCH NOTES | Bacteria | Survival rates | Eggs | Food | PARASITOLOGY | Biomphalaria - physiology | Nostoc - growth & development | Animals | Culture Media | Biomphalaria - growth & development | Nitrates | Hydrogen-Ion Concentration
Journal Article
01/2015, ISBN 0355569035
Collagens are essential structural proteins in all animals. The distinguishing feature of collagens is their triple helix, a motif in which three polypeptide... 
Chemistry | Biochemistry
Dissertation
Parasitology Research, ISSN 0932-0113, 3/2008, Volume 102, Issue 4, pp. 625 - 629
Silica gel high performance thin layer chromatography–densitometry was used to determine the neutral lipid profile in the urine of BALB/c mice experimentally... 
Medical Microbiology | Biomedicine | Immunology | Microbiology | PARASITOLOGY | Lipids - isolation & purification | Echinostoma - pathogenicity | Animals | Oleic Acids - analysis | Echinostomiasis - parasitology | Echinostomiasis - urine | Urine - chemistry | Female | Mice | Mice, Inbred BALB C | Chromatography, High Pressure Liquid | Lipids - analysis
Journal Article
Journal of Liquid Chromatography & Related Technologies, ISSN 1082-6076, 05/2010, Volume 33, Issue 7-8, pp. 1028 - 1037
Journal Article
Cell Chemical Biology, ISSN 2451-9456, 02/2018, Volume 25, Issue 2, pp. 206 - 214.e11
Journal Article
Journal of Liquid Chromatography & Related Technologies, ISSN 1082-6076, 04/2009, Volume 32, Issue 9, pp. 1210 - 1222
High-performance thin-layer chromatography was used to examine the amino acid profile of the urine of Echinostoma caproni infected mice versus that of... 
Urine | Taurine | Alanine | Echinostoma caproni | High-performance thin-layer chromatography | Amino acids | Mice | HPTLC | INTESTINAL-MUCOSA | CHEMISTRY, ANALYTICAL | NEUTRAL LIPIDS | BIOCHEMICAL RESEARCH METHODS
Journal Article
Journal of Planar Chromatography - Modern TLC, ISSN 0933-4173, 02/2008, Volume 21, Issue 1, pp. 39 - 42
HPTLC analysis has been used to compare neutral lipid profiles in the urine of humans and mice. Neutral lipids and ubiquinone were extracted from urine with... 
Urine | High-performance thin-layer chromatography | Neutral lipids | Mice | Humans | CHEMISTRY, ANALYTICAL | urine | humans | mice | neutral lipids | high-performance thin-layer chromatography
Journal Article
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