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Journal of Clinical Investigation, ISSN 0021-9738, 12/2008, Volume 118, Issue 12, pp. 3930 - 3942
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2013, Volume 19, Issue 1, pp. 57 - 64
Chemotherapeutic agents are widely used for cancer treatment. In addition to their direct cytotoxic effects, these agents harness the host's immune system,... 
MEDICINE, RESEARCH & EXPERIMENTAL | CANCER-CHEMOTHERAPY | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GEMCITABINE | BETA | CELL BIOLOGY | 5-FLUOROURACIL | INHIBITION | MICROENVIRONMENT | ANTITUMOR IMMUNITY | BEARING MICE | T-CELLS | Neoplasms - metabolism | Cell Proliferation | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Cathepsin B - genetics | Humans | Caspase 1 - metabolism | Deoxycytidine - pharmacology | Signal Transduction - immunology | Neoplasms - genetics | RNA Interference | Female | Antineoplastic Agents - pharmacology | Interleukin-1beta - biosynthesis | Dendritic Cells - metabolism | bcl-2-Associated X Protein - genetics | Interleukin-17 - secretion | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Cathepsin B - metabolism | Mice, Knockout | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | Cell Line, Tumor | Fluorouracil - pharmacology | Mice | Mice, Inbred BALB C | RNA, Small Interfering | Receptors, Interleukin-1 - antagonists & inhibitors | Deoxycytidine - analogs & derivatives | Chemotherapy | Gemcitabine | Cathepsins | Physiological aspects | Dosage and administration | Research | Health aspects | Fluorouracil | Cancer | Cells | Inflammatory diseases | Tumors | Engineering Sciences | Automatic
Journal Article
Current Molecular Medicine, ISSN 1566-5240, 07/2011, Volume 11, Issue 5, pp. 365 - 372
Accumulating evidence suggests that the success of some anticancer therapies not only relies on their direct cytotoxicity on tumor cells but also on their... 
T-cells | Adaptive immunity | Immunomodulation | Myeloid-derived suppressor cells | Anticancer immunity | MEDICINE, RESEARCH & EXPERIMENTAL | immunomodulation | CARCINOMA PATIENTS | TUMOR PROGRESSION | PRODUCTION IN-VITRO | adaptive immunity | CANCER-PATIENTS | MICROENVIRONMENT | INFLAMMATION | anticancer immunity | REGULATORY T-CELLS | SUNITINIB | MICE | ACCUMULATION
Journal Article
Journal Article
NATURE IMMUNOLOGY, ISSN 1529-2908, 08/2015, Volume 16, Issue 8, pp. 859 - 859
The receptor NLRP3 is involved in the formation of the NLRP3 inflammasome that activates caspase-1 and mediates the release of interleukin 1 beta (IL-1 beta)... 
CANCER-CELLS | FACTOR IRF4 | INTERLEUKIN-4 | ACTIVATION | RNA-SEQ | FACTOR-4 | HELPER-CELL-DIFFERENTIATION | GENE-EXPRESSION | IMMUNOLOGY | TUMOR-GROWTH | NALP3 INFLAMMASOME
Journal Article
NATURE IMMUNOLOGY, ISSN 1529-2908, 08/2014, Volume 15, Issue 8, pp. 758 - 758
The T(H)9 subset of helper T cells was initially shown to contribute to the induction of autoimmune and allergic diseases, but subsequent evidence has... 
METASTATIC MELANOMA | TGF-BETA | FACTOR PU.1 | RNA-SEQ | IFN-GAMMA | IMMUNE-RESPONSES | IN-VIVO | MOUSE MODEL | IMMUNOLOGY | CD8(+) T-CELLS | TH17 CELLS
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, p. e33418
Switching to a glycolytic metabolism is a rapid adaptation of tumor cells to hypoxia. Although this metabolic conversion may primarily represent a rescue... 
OXYGEN | AUTOCRINE LOOP | METABOLISM | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | AEROBIC GLYCOLYSIS | GENE-EXPRESSION | GROWTH-FACTOR | HIF-1-ALPHA | CANCER | HYPOXIA-INDUCIBLE FACTOR-1 | Immunohistochemistry | RNA, Small Interfering - genetics | Enzyme-Linked Immunosorbent Assay | Endothelial Cells - metabolism | Humans | Lactic Acid - metabolism | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Neoplasms - blood supply | Hypoxia-Inducible Factor 1 - metabolism | Blotting, Western | Cell Movement - physiology | Symporters - metabolism | Fibroblast Growth Factors - metabolism | Monocarboxylic Acid Transporters - metabolism | Animals | Analysis of Variance | RNA Interference | Luciferases | Polymerase Chain Reaction | Nuclear Magnetic Resonance, Biomolecular | Mice | Neovascularization, Pathologic - metabolism | Lactic Acid - pharmacology | Endothelial Cells - physiology | Physiological aspects | Fibroblast growth factors | Vascular endothelial growth factor | Tumors | Endothelium | Fibroblast growth factor | Hypoxia-inducible factor 1 | Nuclear magnetic resonance--NMR | Leukocyte migration | Activation | Angiogenesis | Rodents | Oxidation | Inhibition | Vascular endothelial growth factor receptor 2 | Hypoxia-inducible factors | Fibroblast growth factor 2 | Tumor cells | Metabolism | Endothelial cells | Microscopy | Nitric oxide | Glycolysis | Hypoxia | Lactic acid | Transporter | Cell migration | Cancer | Nuclear magnetic resonance | NMR
Journal Article
Cancer Research, ISSN 0008-5472, 02/2015, Volume 75, Issue 3, pp. 475 - 479
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 02/2013, Volume 133, Issue 2, pp. 499 - 508
Dacarbazine (DTIC) is a cytotoxic drug widely used for melanoma treatment. However, the putative contribution of anticancer immune responses in the efficacy of... 
METASTATIC MELANOMA | IMMUNOGENICITY | IMMUNOTHERAPY | RECEPTOR | ANTITUMOR IMMUNITY | SUPPRESSOR-CELLS | EXPRESSION | CYTOTOXICITY | RADIATION | CHEMOTHERAPY | DERMATOLOGY | Skin Neoplasms - drug therapy | Humans | Melanoma, Experimental - drug therapy | NK Cell Lectin-Like Receptor Subfamily K - immunology | Antineoplastic Agents, Alkylating - pharmacology | Interferon-gamma - metabolism | Melanoma, Experimental - immunology | NK Cell Lectin-Like Receptor Subfamily K - metabolism | Dacarbazine - pharmacology | CD8-Positive T-Lymphocytes - metabolism | Killer Cells, Natural - immunology | Disease Models, Animal | Skin Neoplasms - pathology | Skin Neoplasms - immunology | Mice, Inbred C57BL | Melanoma, Experimental - pathology | Up-Regulation - drug effects | Animals | Up-Regulation - immunology | Mice, Nude | CD8-Positive T-Lymphocytes - drug effects | Interferon-gamma - immunology | Cell Line, Tumor | Ligands | Killer Cells, Natural - drug effects | Mice | Killer Cells, Natural - metabolism | CD8-Positive T-Lymphocytes - immunology | Animal models | CD8 antigen | Tumor cells | Melanoma | Cytotoxicity | Lymphocytes T | Immunosuppressive agents | Dacarbazine | NKG2 antigen | Cell activation | Immunosuppression | Major histocompatibility complex | Immunogenicity | Natural killer cells | Cancer | Up-Regulation | Interferon-gamma | NK Cell Lectin-Like Receptor Subfamily K | Killer Cells, Natural | CD8-Positive T-Lymphocytes | Life Sciences | Immunology | Melanoma, Experimental | Skin Neoplasms | Antineoplastic Agents, Alkylating
Journal Article
Immunity, ISSN 1074-7613, 03/2012, Volume 36, Issue 3, pp. 362 - 373
Although Th17 cells are known to promote tissue inflammation and autoimmunity, their role during cancer progression remains elusive. Here, we showed that... 
GROWTH-FACTOR-BETA | EFFECTOR T-CELLS | TGF-BETA | T(H)17 CELLS | ROR-GAMMA-T | SIGNALING PATHWAY | IL-17 | ADENOSINE | GENERATION | IMMUNOLOGY | CANCER | 5'-Nucleotidase - genetics | RNA, Small Interfering - genetics | Antigens, CD - genetics | DNA-Binding Proteins - metabolism | Th17 Cells - drug effects | T-Lymphocytes - metabolism | Th17 Cells - metabolism | Lymphocytes, Tumor-Infiltrating - metabolism | Transcription Factors - immunology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Promoter Regions, Genetic | DNA-Binding Proteins - immunology | Mice, Inbred C57BL | Gene Expression Regulation | Mice, Transgenic | Binding Sites - genetics | Mice, Knockout | Transcription Factors - metabolism | Transforming Growth Factor beta - pharmacology | Animals | Interleukin-6 - pharmacology | Apyrase - genetics | Th17 Cells - immunology | T-Lymphocytes - immunology | Mice | STAT3 Transcription Factor - immunology | STAT3 Transcription Factor - antagonists & inhibitors | Lymphocytes, Tumor-Infiltrating - immunology | Autoimmunity | DNA binding proteins | T cells | Transforming growth factors | Proteins | Transcription factors | Statistical analysis | Plasmids | Rodents | Cytotoxicity | Deoxyribonucleic acid--DNA | Immune system | Cancer | 5'-Nucleotidase | T-Lymphocytes | Interleukin-6 | Life Sciences | Lymphocytes, Tumor-Infiltrating | Immunology | Apyrase | RNA, Small Interfering | STAT3 Transcription Factor | Th17 Cells | Transcription Factors | Binding Sites | Transforming Growth Factor beta | Antigens, CD | DNA-Binding Proteins
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, p. e65181
Bleomycin (BLM) is an anticancer drug currently used for the treatment of testis cancer and Hodgkin lymphoma. This drug triggers cancer cell death via its... 
CALRETICULIN EXPOSURE | LUNG | RESPONSES | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | VINBLASTINE | MECHANISMS | SUPPRESSOR-CELLS | EXPRESSION | PULMONARY-FIBROSIS | CUTTING EDGE | Immunity, Innate - drug effects | Humans | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Immunity - drug effects | T-Lymphocytes, Regulatory - drug effects | Animals | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | Bleomycin - pharmacology | Female | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Mice | Cell Death - drug effects | CD8-Positive T-Lymphocytes - immunology | Transforming Growth Factor beta - metabolism | Care and treatment | Bleomycin | Immune response | Cell death | Biochemistry | Interferon | B cells | Non-Hodgkin's lymphomas | Transforming growth factors | T cells | Cancer | Cell proliferation | Disease | CD8 antigen | Transforming growth factor-b | Cytotoxicity | Lymphocytes T | Chaperones | Cancer therapies | Immunity | Anticancer properties | Calreticulin | Lymphocytes | Rodents | Foxp3 protein | Growth factors | Antigens | Dendritic cells | Immunoregulation | Secretion | Tumor cells | Mortality | Radiation therapy | Lymphoma | Chemotherapy | Pulmonary fibrosis | Immunogenicity | Antitumor activity | Hodgkin's disease | Phagocytosis | Apoptosis | Life Sciences | Immunology
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 2, pp. 1957 - 1971
Until recently, the molecular diagnosis of hereditary breast and ovarian cancer (HBOC) was mostly based on BRCA1/2 testing. Next generation sequencing and the... 
Management | Genomic capture | Next generation sequencing | Breast and ovarian cancer susceptibility genes | Candidate genes | anagement | next generation sequencing | genomic capture | LYNCH SYNDROME | BRCA2 | IDENTIFICATION | GENOMIC MEDICINE | CELL BIOLOGY | HETEROGENEITY | candidate genes | PREDISPOSITION | HIGH-RISK | GENES | MUTATIONS | breast and ovarian cancer susceptibility genes | ATAXIA-TELANGIECTASIA | Practice Patterns, Physicians' - standards | Evidence-Based Practice | Hereditary Breast and Ovarian Cancer Syndrome - diagnosis | Practice Guidelines as Topic - standards | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Transcriptome | Male | Translational Medical Research - statistics & numerical data | Genetic Testing - methods | Practice Patterns, Physicians' - statistics & numerical data | Aged, 80 and over | Adult | Female | Hereditary Breast and Ovarian Cancer Syndrome - genetics | France - epidemiology | Genetic Predisposition to Disease | Genetic Testing - standards | Genetic Testing - statistics & numerical data | Gene Frequency | Physician-Patient Relations | Professional-Family Relations | Pedigree | Translational Medical Research - standards | Aged | Biomarkers, Tumor - genetics | High-Throughput Nucleotide Sequencing | Cohort Studies | Life Sciences | Cellular Biology | Cancer
Journal Article
International Review of Cell and Molecular Biology, ISSN 1937-6448, 01/2018, Volume 341, pp. 1 - 61
Understanding the basis of cellular differentiation is a fundamental issue in developmental biology but also for the comprehension of pathological processes....