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Brain Pathology, ISSN 1015-6305, 05/2016, Volume 26, Issue 3, p. 398
It is now established that [alpha]-synuclein can be physiologically secreted to the extracellular space. In this sense, mechanisms that govern the secretion of... 
Proteins | Pathology
Journal Article
Nature Medicine, ISSN 1078-8956, 03/2013, Volume 19, Issue 3, pp. 351 - 357
Previous attempts to identify neuroprotective targets by studying the ischemic cascade and devising ways to suppress it have failed to translate to efficacious... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | BRAIN-INJURY | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOCAL CEREBRAL-ISCHEMIA | HEAT-SHOCK PROTEIN | RAT MODEL | DELAYED NEURONAL DEATH | CELL BIOLOGY | HIPPOCAMPUS | RAPAMYCIN PROTECTS | CA1 | TRANSIENT FOREBRAIN ISCHEMIA | Rats, Wistar | Multiprotein Complexes | Male | Hypoxia-Ischemia, Brain - prevention & control | Autophagy - drug effects | Neuroprotective Agents - metabolism | Mechanistic Target of Rapamycin Complex 1 | RNA Interference | Tumor Suppressor Proteins - genetics | Prosencephalon - blood supply | CA3 Region, Hippocampal - metabolism | CA1 Region, Hippocampal - metabolism | Hypoxia-Ischemia, Brain - metabolism | Tumor Suppressor Proteins - metabolism | Adenine - analogs & derivatives | CA1 Region, Hippocampal - physiology | CA3 Region, Hippocampal - physiology | Cells, Cultured | Ischemic Preconditioning | Prosencephalon - injuries | Rats | Adenine - pharmacology | Sirolimus - pharmacology | Animals | Proteins - metabolism | Hypoxia | RNA, Small Interfering | TOR Serine-Threonine Kinases | Proteins - antagonists & inhibitors | Stroke (Disease) | Complications and side effects | Autophagy (Cytology) | Care and treatment | Physiological aspects | Genetic aspects | Research | Pharmacology | Ischemia | Gene expression | Neurons | Autophagy | Index Medicus | global cerebral ischemia | endogenous neuroprotection | autophagy | CA3 | proteomics | hippocampus | hamartin | preconditioning
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2010, Volume 30, Issue 20, pp. 6838 - 6851
alpha-Synuclein is central in Parkinson's disease pathogenesis. Although initially alpha-synuclein was considered a purely intracellular protein, recent data... 
FIBRIL FORMATION | PROTEIN | MULTIVESICULAR BODIES | HUMAN PLASMA | ACTIVATES MICROGLIA | CONGO RED | ENDOPLASMIC-RETICULUM | FAMILIAL PARKINSONS-DISEASE | RELEASE | BODY FORMATION | NEUROSCIENCES | Molecular Weight | Serum - metabolism | Calcium - metabolism | Microscopy, Electron, Transmission - methods | Humans | Culture Media, Conditioned - chemistry | Cell Survival - genetics | Brefeldin A - pharmacology | Neurons - ultrastructure | Piperidines - pharmacology | Neurons - metabolism | alpha-Synuclein - genetics | Protein Synthesis Inhibitors - pharmacology | Exosomes - ultrastructure | Cell Survival - drug effects | Calcium - pharmacology | Immunoprecipitation - methods | Multivesicular Bodies - pathology | Endocytosis - drug effects | Rats | Microscopy, Confocal - methods | Analysis of Variance | Cell Line, Tumor | beta-Galactosidase - genetics | Multivesicular Bodies - drug effects | Temperature | Chromatography, High Pressure Liquid - methods | Culture Media, Conditioned - pharmacology | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Subcellular Fractions - ultrastructure | Transfection | Exosomes - physiology | beta-Galactosidase - metabolism | Presenilin-1 - pharmacology | Cell Death - drug effects | Cytotoxicity Tests, Immunologic - methods | Gene Expression Regulation, Neoplastic - drug effects | Neurons - drug effects | Neuroblastoma - pathology | Pyrazoles - pharmacology | Subcellular Fractions - drug effects | Multivesicular Bodies - ultrastructure | Cells, Cultured | Hydrogen Peroxide - pharmacology | Receptors, Transferrin - metabolism | Subcellular Fractions - metabolism | Peptides - pharmacology | Nerve Tissue Proteins - metabolism | Animals | Neuroblastoma - ultrastructure | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Mass Spectrometry - methods | alpha-Synuclein - metabolism | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 16533 - 18
Approximately 90% of alpha-synuclein (alpha-Synuclein) deposited in Lewy bodies is phosphorylated at serine 129 suggesting that the accumulation of... 
FIBRILLATION | TRANSMISSION | PROTEIN | MICROGLIA | LEWY BODY | MULTIDISCIPLINARY SCIENCES | SER-129 | MOUSE | MODEL | AGGREGATION | BRAIN | Phosphorylation | Dopamine | Immune response | Serine | Substantia nigra | Synuclein | Macrophages | Seeding | Lewy bodies | Recruitment | Fibrillogenesis | Pathology | Inoculation | Interleukin 10 | Neostriatum | Dopamine receptors | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 04/2017, Volume 152, Issue 5, pp. S968 - S968
Journal Article
Journal Article
Journal Article