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1. Full Text Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models
by Wang, Zebin and Sun, Kaiming and Xiao, Yonghong and Feng, Bin and Mikule, Keith and Ma, XiaoYan and Feng, Ningping and Vellano, Christopher P and Federico, Lorenzo and Marszalek, Joseph R and Mills, Gordon B and Hanke, Jeffrey and Ramaswamy, Sridhar and Wang, Jing
Scientific reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1853 - 1853
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Animal models | Immunological memory | BRCA1 protein | PD-1 protein | Immunomodulation | CD8 antigen | Poly(ADP-ribose) polymerase | Breast cancer | Ovarian cancer | Metastases | CD4 antigen | Poly(ADP-ribose) Polymerase 1 | Immune checkpoint | Platinum | Interferon | Tumors | Index Medicus
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2. Full Text Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
by Ip, Carman K. M and Ng, Patrick K. S and Jeong, Kang Jin and Shao, S.H and Ju, Zhenlin and Leonard, P.G and Hua, Xu and Vellano, Christopher P and Woessner, Richard and Sahni, Nidhi and Scott, Kenneth L and Mills, Gordon B
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4583 - 14
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cell Line | Cell Proliferation | Receptor, Platelet-Derived Growth Factor alpha - chemistry | Signal Transduction | Humans | Endoplasmic Reticulum - metabolism | Glycosylation | Molecular Targeted Therapy | Mutation - genetics | Drug Resistance, Neoplasm - genetics | Phenotype | Animals | Receptor, Platelet-Derived Growth Factor alpha - genetics | Extracellular Space - chemistry | Protein Domains | Golgi Apparatus - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | TOR protein | Phosphorylation | Cell survival | Platelet-derived growth factor | MEK inhibitors | Stat3 protein | Extracellular signal-regulated kinase | AKT protein | Activation | Mannose | Kinases | 1-Phosphatidylinositol 3-kinase | Trapping | Inhibitors | Precision medicine | Mutation | Receptor mechanisms | Endoplasmic reticulum | Growth factors | Tumors | Index Medicus
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3. Full Text Pharmacologic profiling of patient-derived xenograft models of primary treatment-naive triple-negative breast cancer
by Powell, Reid T and Redwood, Abena and Liu, Xuan and Guo, Lei and Cai, Shirong and Zhou, Xinhui and Tu, Yizheng and Zhang, Xiaomei and Qi, Yuan and Jiang, Yan and Echeverria, Gloria and Feng, Ningping and Ma, XiaoYan and Giuliani, Virginia and Marszalek, Joseph R and Heffernan, Timothy P and Vellano, Christopher P and White, Jason B and Stephan, Clifford and Davies, Peter J and Moulder, Stacy and Symmans, W. Fraser and Chang, Jeffrey T and Piwnica-Worms, Helen
Scientific reports, ISSN 2045-2322, 10/2020, Volume 10, Issue 1, pp. 17899 - 17899
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Mesenchyme | Tumor cells | p53 Protein | Xenografts | Breast cancer | Patients | Kinesin | Glutathione | Index Medicus
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4. Full Text Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression
by Federico, Lorenzo and Jeong, Kang Jin and Vellano, Christopher P and Mills, Gordon B
Journal of lipid research, ISSN 0022-2275, 01/2016, Volume 57, Issue 1, pp. 25 - 35
Metabolism | Inflammation | The Cancer Genome Atlas | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Neoplasms - metabolism | Phosphoric Diester Hydrolases - metabolism | Humans | Pyrophosphatases - genetics | Neoplasms - enzymology | Phosphoric Diester Hydrolases - genetics | Carcinogenesis | Cell Transformation, Neoplastic - metabolism | Disease Progression | Pyrophosphatases - metabolism | Animals | Neoplasms - genetics | Neoplasms - pathology | Index Medicus | Thematic Review Series | metabolism | inflammation
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5. Full Text Implementation of a Multiplex and Quantitative Proteomics Platform for Assessing Protein Lysates Using DNA-Barcoded Antibodies
by Lee, Jinho and Geiss, Gary K and Demirkan, Gokhan and Vellano, Christopher P and Filanoski, Brian and Lu, Yiling and Ju, Zhenlin and Yu, Shuangxing and Guo, Huifang and Bogatzki, Lisa Y and Carter, Warren and Meredith, Rhonda K and Krishnamurthy, Savitri and Ding, Zhiyong and Beechem, Joseph M and Mills, Gordon B
Molecular & cellular proteomics, ISSN 1535-9476, 06/2018, Volume 17, Issue 6, pp. 1245 - 1258
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Neoplasms - metabolism | DNA - chemistry | Proteins - metabolism | Antibodies - chemistry | Humans | Proteomics | Cell Line, Tumor | Female | Immunohistochemistry | Multiplexing | Cellulose esters | Pharmacodynamics | Limiting factors | Antibodies | Breast cancer | Pharmacology | Tumor cell lines | Gene expression | Molecular chains | Proteins | Medicine | Lysates | Protein arrays | Cellulose nitrate | Protein expression | Deoxyribonucleic acid--DNA | Cancer | Tumors | Index Medicus | Protein lysate protocol | Protein array | Systems biology | Omics | Multiplexed | DNA-barcoded antibody | Technological Innovation and Resources | Cancer Biology | Proteomics Platform | nCounter
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6. Full Text BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency
by Sun, Chaoyang and Yin, Jun and Fang, Yong and Chen, Jian and Jeong, Kang Jin and Chen, Xiaohua and Vellano, Christopher P and Ju, Zhenlin and Zhao, Wei and Zhang, Dong and Lu, Yiling and Meric-Bernstam, Funda and Yap, Timothy A and Hattersley, Maureen and O'Connor, Mark J and Chen, Huawei and Fawell, Stephen and Lin, Shiaw-Yih and Peng, Guang and Mills, Gordon B
Cancer cell, ISSN 1535-6108, 03/2018, Volume 33, Issue 3, pp. 401 - 416.e8
CtBP-interacting protein | CtIP | homologous recombination | BRD4 inhibitor | PARP inhibitor | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | DNA Damage - drug effects | DNA Repair - drug effects | Homologous Recombination - drug effects | Humans | Mice, Transgenic | Transcription Factors - antagonists & inhibitors | DNA Repair - genetics | Transcription Factors - genetics | Mutation - genetics | Ovarian Neoplasms - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Poly(ADP-ribose) Polymerases - drug effects | Animals | Mutation - drug effects | Poly(ADP-ribose) Polymerases - genetics | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Homologous Recombination - genetics | Female | Nuclear Proteins - genetics | Ovarian Neoplasms - drug therapy | Prevention | Biotechnology | Medical colleges | Tumor proteins | Sugars | Cancer | Monosaccharides | Protein binding | Index Medicus
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7. Full Text Characterization of Human Cancer Cell Lines by Reverse-phase Protein Arrays
by Li, Jun and Zhao, Wei and Akbani, Rehan and Liu, Wenbin and Ju, Zhenlin and Ling, Shiyun and Vellano, Christopher P and Roebuck, Paul and Yu, Qinghua and Eterovic, A. Karina and Byers, Lauren A and Davies, Michael A and Deng, Wanleng and Gopal, Y.N. Vashisht and Chen, Guo and von Euw, Erika M and Slamon, Dennis and Conklin, Dylan and Heymach, John V and Gazdar, Adi F and Minna, John D and Myers, Jeffrey N and Lu, Yiling and Mills, Gordon B and Liang, Han
Cancer cell, ISSN 1535-6108, 02/2017, Volume 31, Issue 2, pp. 225 - 239
drug sensitivity | signaling pathways | proteomics | reverse-phase protein array | data portal | cancer cell lines | biomarker | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Nuclear Proteins - analysis | Humans | Computational Biology | Epithelial-Mesenchymal Transition | Proteomics | Cell Line, Tumor | RNA, Messenger - analysis | Neoplasm Proteins - analysis | Transcription Factors - analysis | Mutation | Receptor, Epidermal Growth Factor - physiology | Protein Array Analysis - methods | Medical colleges | RNA | Phosphoproteins | Analysis | Cancer | Web portals | Medicine, Experimental | Medical research | Index Medicus
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8. Full Text Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy
by Fang, Yong and McGrail, Daniel J and Sun, Chaoyang and Labrie, Marilyne and Chen, Xiaohua and Zhang, Dong and Ju, Zhenlin and Vellano, Christopher P and Lu, Yiling and Li, Yongsheng and Jeong, Kang Jin and Ding, Zhiyong and Liang, Jiyong and Wang, Steven W and Dai, Hui and Lee, Sanghoon and Sahni, Nidhi and Mercado-Uribe, Imelda and Kim, Tae-beom and Chen, Ken and Lin, Shiaw-Yih and Peng, Guang and Westin, Shannon N and Liu, Jinsong and O'Connor, Mark J and Yap, Timothy A and Mills, Gordon B
Cancer cell, ISSN 1535-6108, 06/2019, Volume 35, Issue 6, pp. 851 - 867.e7
sequential therapy | WEE1 inhibitor | replication stress | PARP inhibitor | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein-Tyrosine Kinases - metabolism | Humans | Poly(ADP-ribose) Polymerase Inhibitors - toxicity | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - genetics | G2 Phase Cell Cycle Checkpoints - drug effects | Heterografts | Neoplasms - genetics | Time Factors | Cell Cycle Proteins - genetics | Female | Drug Administration Schedule | Signal Transduction | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Neoplasms - enzymology | Mice, SCID | Antineoplastic Combined Chemotherapy Protocols - toxicity | Neoplasms - drug therapy | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Protein Kinase Inhibitors - administration & dosage | Animals | Mitosis - drug effects | Tumor Burden - drug effects | Mice, Nude | Cell Line, Tumor | Protein Kinase Inhibitors - toxicity | Cell Proliferation - drug effects | DNA Damage | Neoplasms - pathology | Protein-Tyrosine Kinases - antagonists & inhibitors | Sugars | Monosaccharides | Ovarian cancer | Index Medicus
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9. Full Text Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers
by Sun, Chaoyang and Fang, Yong and Yin, Jun and Chen, Jian and Ju, Zhenlin and Zhang, Dong and Chen, Xiaohua and Vellano, Christopher P and Jeong, Kang Jin and Ng, Patrick Kwok-Shing and Eterovic, Agda Karina B and Bhola, Neil H and Lu, Yiling and Westin, Shannon N and Grandis, Jennifer R and Lin, Shiaw-Yih and Scott, Kenneth L and Peng, Guang and Brugge, Joan and Mills, Gordon B
Science translational medicine, ISSN 1946-6234, 05/2017, Volume 9, Issue 392, p. eaal5148
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Homologous Recombination - drug effects | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Ovarian Neoplasms - genetics | Mitogen-Activated Protein Kinase Kinases - metabolism | Neoplasms - genetics | Female | Ovarian Neoplasms - drug therapy | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Mutation - genetics | Forkhead Box Protein O3 - metabolism | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | Neoplasms - drug therapy | Drug Synergism | Xenograft Model Antitumor Assays | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | Animals | MAP Kinase Signaling System - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Protein Kinase Inhibitors - therapeutic use | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | DNA Damage | Genes, ras | Drug Resistance, Neoplasm - drug effects | Index Medicus
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