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Critical Reviews in Oncology / Hematology, ISSN 1040-8428, 12/2019, Volume 144, p. 102814
Leukemia stem cells (LSCs) have low levels of ROS and rely on mitochondrial integrity for their survival. In AML cells, ROS levels and stemness potential are... 
BCL-2 | Mitochondria | ROS | HSC | LSC | Autophagy | Venetoclax
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Journal of Clinical Oncology, ISSN 0732-183X, 08/2012, Volume 30, Issue 24, pp. 2946 - 2955
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The New England Journal of Medicine, ISSN 0028-4793, 09/2009, Volume 361, Issue 13, pp. 1235 - 1248
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The New England Journal of Medicine, ISSN 0028-4793, 03/2011, Volume 364, Issue 11, pp. 1027 - 1036
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Medicinal Research Reviews, ISSN 0198-6325, 03/2019, Volume 39, Issue 2, pp. 517 - 560
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PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, p. e111568
Both normal as well leukemic hematopoietic stem cells critically depend on their microenvironment in the bone marrow for processes such as self-renewal,... 
STEM-CELLS | MULTIDISCIPLINARY SCIENCES | BCR-ABL | IN-VIVO | GUANOSINE TRIPHOSPHATASES REPRESENT | GENE-EXPRESSION PROFILES | STEM/PROGENITOR CELLS | SELF-RENEWAL | RAC ACTIVATION | ACUTE MYELOID-LEUKEMIA | GROUP-B | Antigens, CD34 | Tumor Stem Cell Assay | Up-Regulation | Cell Proliferation | Prognosis | Cell Survival | Leukemia, Myeloid, Acute - pathology | Down-Regulation | Humans | Leukemia, Myeloid, Acute - metabolism | Fetal Blood - metabolism | Cell Transformation, Neoplastic - metabolism | Chemotaxis | Neoplastic Stem Cells - metabolism | Karyotyping | Cell Line, Tumor | Neoplastic Stem Cells - pathology | Adaptor Proteins, Signal Transducing - metabolism | Cell Transformation, Neoplastic - pathology | Fusion Proteins, bcr-abl - metabolism | Infant, Newborn | G proteins | RNA | Chromosomes | Analysis | Hematopoietic stem cells | BCR protein | Cell proliferation | Laboratories | Downstream effects | Leukemia | Genes | Ovarian cancer | Proteins | Granulocytes | Penicillin | Bone marrow | Inhibition | Fusion protein | CD34 antigen | Medical research | Immunoglobulins | Cell survival | Hematology | Myeloid leukemia | Cultures | Abl protein | Pharmacology | Gene expression | SDF-1 protein | Survival | Progenitor cells | Progeny | Signaling | Depletion | Stem cells | Cells (biology) | Cytoskeleton | Differentiation | Acute myeloid leukemia | Cell migration
Journal Article