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British Journal of Cancer, ISSN 0007-0920, 02/2018, Volume 118, Issue 3, pp. 366 - 377
Background: Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active... 
FEEDBACK ACTIVATION | ONCOGENIC KRAS | MTOR | EGFR | LUNG-CANCER | pancreatic cancer | DUCTAL ADENOCARCINOMAS | CELL PLASTICITY | ONCOLOGY | therapeutic resistance | PRECLINICAL MODELS | IN-VIVO | RESISTANCE | TUMORIGENESIS | Benzoxazoles - pharmacology | Pancreatic Neoplasms - metabolism | TOR Serine-Threonine Kinases - metabolism | Cell Survival | Humans | Carcinoma, Pancreatic Ductal - metabolism | Pancreatic Neoplasms - genetics | Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors | Bortezomib - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | Pyrimidines - pharmacology | Carcinoma, Pancreatic Ductal - genetics | MAP Kinase Signaling System | TOR Serine-Threonine Kinases - antagonists & inhibitors | Animals | TOR Serine-Threonine Kinases - genetics | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Mice | Mechanistic Target of Rapamycin Complex 2 - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - metabolism | Camptothecin - pharmacology | Phosphatidylinositol 3-Kinase - metabolism | TOR protein | Adenocarcinoma | Intervention | Animal models | Recombination | AKT protein | Recombinase | Gene deletion | Kinases | Subgroups | Signal transduction | Pathways | Clonal deletion | Rewiring | Genetic analysis | Deletion | Pancreas | Extracellular signal-regulated kinase | Cultures | Pharmacology | Rapamycin | Signaling | Inhibitors | Pancreatic cancer | Metabolic pathways | Three dimensional models | Cancer | Tumors | Index Medicus | Translational Therapeutics
Journal Article
Nature Communications, ISSN 2041-1723, 02/2016, Volume 7, Issue 1, pp. 10770 - 10770
Journal Article
by Rad, Roland and Rad, Roland and Rad, Lena and Rad, Lena and Wang, Wei and Wang, Wei and Strong, Alexander and Strong, Alexander and Ponstingl, Hannes and Ponstingl, Hannes and Bronner, Iraad F and Bronner, Iraad F and Mayho, Matthew and Mayho, Matthew and Steiger, Katja and Steiger, Katja and Weber, Julia and Weber, Julia and Hieber, Maren and Hieber, Maren and Veltkamp, Christian and Veltkamp, Christian and Eser, Stefan and Eser, Stefan and Geumann, Ulf and Geumann, Ulf and Öllinger, Rupert and Öllinger, Rupert and Zukowska, Magdalena and Zukowska, Magdalena and Barenboim, Maxim and Barenboim, Maxim and Maresch, Roman and Maresch, Roman and Cadiñanos, Juan and Cadiñanos, Juan and Friedrich, Mathias and Friedrich, Mathias and Varela, Ignacio and Varela, Ignacio and Constantino-Casas, Fernando and Constantino-Casas, Fernando and Sarver, Aaron and Sarver, Aaron and Ten Hoeve, Jelle and Ten Hoeve, Jelle and Prosser, Haydn and Prosser, Haydn and Seidler, Barbara and Seidler, Barbara and Bauer, Judith and Bauer, Judith and Heikenwälder, Mathias and Heikenwälder, Mathias and Metzakopian, Emmanouil and Metzakopian, Emmanouil and Krug, Anne and Krug, Anne and Ehmer, Ursula and Ehmer, Ursula and Schneider, Gönter and Schneider, Günter and Knösel, Thomas and Knösel, Thomas and Römmele, Petra and Rümmele, Petra and Aust, Daniela and Aust, Daniela and Grützmann, Robert and Grötzmann, Robert and Pilarsky, Christian and Pilarsky, Christian and Ning, Zemin and Ning, Zemin and Wessels, Lodewyk and Wessels, Lodewyk and M Schmid, Roland and Schmid, Roland M and A Quail, Michael and Quail, Michael A and Vassiliou, George and Vassiliou, George and Esposito, Irene and Esposito, Irene and Liu, Pentao and Liu, Pentao and Saur, Dieter and Saur, Dieter and Bradley, Allan and Bradley, Allan
Nature Genetics, ISSN 1061-4036, 01/2015, Volume 47, Issue 1, pp. 47 - 56
Here we describe a conditional piggyBac transposition system in mice and report the discovery of large sets of new cancer genes through a pancreatic... 
PATHWAYS | FIDGETIN | SOMATIC MUTAGENESIS | LANDSCAPE | CHROMOSOMAL TRANSPOSITION | GENETICS & HEREDITY | SLEEPING-BEAUTY | PROTEINS | EXPRESSION | DISCOVERY | TOOL | Pancreatic Neoplasms - chemistry | Humans | Molecular Sequence Data | Neoplasm Proteins - antagonists & inhibitors | Gene Expression Profiling | Gene Regulatory Networks | Repressor Proteins - analysis | Repressor Proteins - antagonists & inhibitors | Moths - genetics | Proton-Translocating ATPases - genetics | Cell Transformation, Neoplastic - genetics | Transposases - genetics | DNA Transposable Elements - genetics | Forkhead Transcription Factors - antagonists & inhibitors | Neoplasm Proteins - genetics | Transgenes | Amino Acid Sequence | Pancreatic Neoplasms - pathology | RNA, Small Interfering - pharmacology | Gene Expression Regulation | Genes, Synthetic | Repressor Proteins - genetics | Mice, Transgenic | Pancreatic Neoplasms - genetics | Forkhead Transcription Factors - genetics | Genes, p16 | Gene Knock-In Techniques | Transposases - physiology | Animals | Forkhead Transcription Factors - analysis | Mice | Mutagenesis, Insertional | Noncoding DNA | Usage | Pancreatic cancer | Genetic aspects | Diagnosis | Research | Genetic screening | Studies | Medical research | Vertebrates | Mutagenesis | Genes | Genomes | Tumorigenesis | Mutation | Binding sites | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Nature medicine, ISSN 1078-8956, 11/2014, Volume 20, Issue 11, pp. 1340 - 1347
Journal Article
Stroke, ISSN 0039-2499, 05/2016, Volume 47, Issue 5, pp. e89 - e89
Journal Article
Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7690, pp. 62 - 68
Journal Article
Lancet Neurology, The, ISSN 1474-4422, 2016, Volume 15, Issue 11, pp. 1117 - 1117
  The results of our study cannot be used to explain a dose-dependent association with thromboembolism because most of the patients in the FFP group received... 
Neurology | Expansion | Blood pressure | Index Medicus
Journal Article
Journal Article
Journal Article
Nature Reviews Neurology, ISSN 1759-4758, 09/2013, Volume 9, Issue 9, pp. 492 - 493
Intracerebral haemorrhage is the most serious complication of intravenous thrombolysis in ischaemic stroke, and whether thrombolysis can be performed in... 
Care and treatment | Prognosis | Tissue plasminogen activator | Research | Stroke patients | Thrombosis | Health aspects | Blood clot | Risk factors | Diseases
Journal Article
Journal Article