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1. Full Text MTOR inhibitor-based combination therapies for pancreatic cancer
by Hassan, Zonera and Schneeweis, Christian and Wirth, Matthias and Veltkamp, Christian and Dantes, Zahra and Feuerecker, Benedikt and Ceyhan, Güralp O and Knauer, Shirley K and Weichert, Wilko and Schmid, Roland M and Stauber, Roland and Arlt, Alexander and Krämer, Oliver H and Rad, Roland and Reichert, Maximilian and Saur, Dieter and Schneider, Günter
British journal of cancer, ISSN 0007-0920, 02/2018, Volume 118, Issue 3, pp. 366 - 377
Life Sciences & Biomedicine | Oncology | Science & Technology | Index Medicus | Translational Therapeutics | pancreatic cancer | therapeutic resistance | MTOR
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2. Full Text Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes
by Mueller, Sebastian and Engleitner, Thomas and Maresch, Roman and Zukowska, Magdalena and Lange, Sebastian and Kaltenbacher, Thorsten and Konukiewitz, Björn and Öllinger, Rupert and Zwiebel, Maximilian and Strong, Alex and Yen, Hsi-Yu and Banerjee, Ruby and Louzada, Sandra and Fu, Beiyuan and Seidler, Barbara and Götzfried, Juliana and Schuck, Kathleen and Hassan, Zonera and Arbeiter, Andreas and Schönhuber, Nina and Klein, Sabine and Veltkamp, Christian and Friedrich, Mathias and Rad, Lena and Barenboim, Maxim and Ziegenhain, Christoph and Hess, Julia and Dovey, Oliver M and Eser, Stefan and Parekh, Swati and Constantino-Casas, Fernando and De La Rosa, Jorge and Sierra, Marta I and Fraga, Mario and Mayerle, Julia and Klöppel, Günter and Cadiñanos, Juan and Liu, Pentao and Vassiliou, George and Weichert, Wilko and Steiger, Katja and Enard, Wolfgang and Schmid, Roland M and Yang, Fengtang and Unger, Kristian and Schneider, Günter and Varela, Ignacio and Bradley, Allan and Saur, DIeter and Rad, Roland
Nature (London), ISSN 0028-0836, 02/2018, Volume 554, Issue 7690, pp. 62 - 68
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Male | Genes, myc | Carcinoma, Pancreatic Ductal - genetics | Genes, p53 | NF-kappa B p52 Subunit - genetics | Female | Nuclear Proteins - genetics | Pancreatic Neoplasms - pathology | Carcinogenesis - genetics | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Pancreatic Neoplasms - genetics | Gene Dosage | Transcriptome - genetics | Transforming Growth Factor beta1 - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | Carcinoma, Pancreatic Ductal - pathology | Disease Progression | Neoplasm Metastasis - genetics | Phenotype | Animals | Adaptor Proteins, Signal Transducing - genetics | Alleles | Mice | Mutation | Cell Cycle Proteins | Evolution, Molecular | Biological research | Cell culture | Pancreatic cancer | Physiological aspects | Genetic aspects | Research | Biology, Experimental | Adenocarcinoma | Gene dosage | Pathogenesis | Genomics | Genes | Cytology | Genomes | Metastasis | Myc protein | Cell morphology | Metastases | Studies | Yes-associated protein | Genotype & phenotype | Histopathology | Evolution | Tumorigenesis | Chromosomes | Tumors | Index Medicus
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3. Full Text Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice
by Maresch, Roman and Mueller, Sebastian and Veltkamp, Christian and Öllinger, Rupert and Friedrich, Mathias and Heid, Irina and Steiger, Katja and Weber, Julia and Engleitner, Thomas and Barenboim, Maxim and Klein, Sabine and Louzada, Sandra and Banerjee, Ruby and Strong, Alexander and Stauber, Teresa and Gross, Nina and Geumann, Ulf and Lange, Sebastian and Ringelhan, Marc and Varela, Ignacio and Unger, Kristian and Yang, Fengtang and Schmid, Roland M and Vassiliou, George S and Braren, Rickmer and Schneider, Günter and Heikenwalder, Mathias and Bradley, Allan and Saur, Dieter and Rad, Roland
Nature communications, ISSN 2041-1723, 02/2016, Volume 7, Issue 1, pp. 10770 - 10770
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Chromosome Deletion | Genetic Engineering - methods | Immunohistochemistry | Proto-Oncogene Proteins p21(ras) - genetics | Carcinogenesis - genetics | Electroporation | Pancreatic Neoplasms - genetics | Pancreas - metabolism | Phylogeny | Sequence Analysis, DNA | Magnetic Resonance Imaging | Animals | Transfection - methods | CRISPR-Cas Systems | Neoplasms, Experimental - genetics | Polymerase Chain Reaction | High-Throughput Nucleotide Sequencing | Mice | Mutation | Genome | BRCA2 Protein - genetics | Translocation, Genetic - genetics | Index Medicus
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4. Full Text A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer
by Schönhuber, Nina and Seidler, Barbara and Schuck, Kathleen and Veltkamp, Christian and Schachtler, Christina and Zukowska, Magdalena and Eser, Stefan and Feyerabend, Thorsten B and Paul, Mariel C and Eser, Philipp and Klein, Sabine and Lowy, Andrew M and Banerjee, Ruby and Yang, Fangtang and Lee, Chang-Lung and Moding, Everett J and Kirsch, David G and Scheideler, Angelika and Alessi, Dario R and Varela, Ignacio and Bradley, Allan and Kind, Alexander and Schnieke, Angelika E and Rodewald, Hans-Reimer and Rad, Roland and Schmid, Roland M and Schneider, Günter and Saur, Dieter
Nature medicine, ISSN 1078-8956, 11/2014, Volume 20, Issue 11, pp. 1340 - 1347
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Adenocarcinoma - pathology | Species Specificity | Stromal Cells - pathology | Carcinoma, Pancreatic Ductal - metabolism | Male | Precancerous Conditions - metabolism | Molecular Targeted Therapy | Neoplasm Metastasis | Adenocarcinoma - metabolism | Time Factors | Mast Cells - metabolism | Female | Precancerous Conditions - pathology | Oncogenes | Proto-Oncogene Proteins p21(ras) - metabolism | Genetic Engineering - methods | Green Fluorescent Proteins - metabolism | Recombinases - metabolism | Reproducibility of Results | Stromal Cells - metabolism | Pancreas - pathology | Tamoxifen | Carcinoma, Pancreatic Ductal - pathology | Cell Lineage | Animals | Models, Biological | Mast Cells - pathology | Mice | Precision Medicine - methods | Genetic aspects | Research | Pancreatic cancer | Analysis | Genetic engineering | Gene expression | Genetic recombination | Tumors | Index Medicus
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5. Full Text Clinical Trials of Immunomodulation in Ischemic Stroke
by Veltkamp, Roland and Gill, Dipender
Neurotherapeutics, ISSN 1933-7213, 10/2016, Volume 13, Issue 4, pp. 791 - 800
Neurology | Neurosciences | Biomedicine | Immunomodulation | Neurobiology | immune system | Neurosurgery | stroke | ischemic stroke | Pharmacology & Pharmacy | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Brain Ischemia - complications | Stroke - etiology | Animals | Humans | Clinical Trials as Topic | Immunomodulation - physiology | Stroke - immunology | Stroke - therapy | Immunologic Factors - therapeutic use | Index Medicus | Review
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6. Full Text A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer
by Rad, Roland and Rad, Roland and Rad, Lena and Rad, Lena and Wang, Wei and Wang, Wei and Strong, Alexander and Strong, Alexander and Ponstingl, Hannes and Ponstingl, Hannes and Bronner, Iraad F and Bronner, Iraad F and Mayho, Matthew and Mayho, Matthew and Steiger, Katja and Steiger, Katja and Weber, Julia and Weber, Julia and Hieber, Maren and Hieber, Maren and Veltkamp, Christian and Veltkamp, Christian and Eser, Stefan and Eser, Stefan and Geumann, Ulf and Geumann, Ulf and Öllinger, Rupert and Öllinger, Rupert and Zukowska, Magdalena and Zukowska, Magdalena and Barenboim, Maxim and Barenboim, Maxim and Maresch, Roman and Maresch, Roman and Cadiñanos, Juan and Cadiñanos, Juan and Friedrich, Mathias and Friedrich, Mathias and Varela, Ignacio and Varela, Ignacio and Constantino-Casas, Fernando and Constantino-Casas, Fernando and Sarver, Aaron and Sarver, Aaron and Ten Hoeve, Jelle and Ten Hoeve, Jelle and Prosser, Haydn and Prosser, Haydn and Seidler, Barbara and Seidler, Barbara and Bauer, Judith and Bauer, Judith and Heikenwälder, Mathias and Heikenwälder, Mathias and Metzakopian, Emmanouil and Metzakopian, Emmanouil and Krug, Anne and Krug, Anne and Ehmer, Ursula and Ehmer, Ursula and Schneider, Gönter and Schneider, Günter and Knösel, Thomas and Knösel, Thomas and Römmele, Petra and Rümmele, Petra and Aust, Daniela and Aust, Daniela and Grützmann, Robert and Grötzmann, Robert and Pilarsky, Christian and Pilarsky, Christian and Ning, Zemin and Ning, Zemin and Wessels, Lodewyk and Wessels, Lodewyk and M Schmid, Roland and Schmid, Roland M and A Quail, Michael and Quail, Michael A and Vassiliou, George and Vassiliou, George and Esposito, Irene and Esposito, Irene and Liu, Pentao and Liu, Pentao and Saur, Dieter and Saur, Dieter and Bradley, Allan and Bradley, Allan
Nature genetics, ISSN 1061-4036, 01/2015, Volume 47, Issue 1, pp. 47 - 56
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Pancreatic Neoplasms - chemistry | Humans | Molecular Sequence Data | Neoplasm Proteins - antagonists & inhibitors | Gene Expression Profiling | Gene Regulatory Networks | Repressor Proteins - analysis | Repressor Proteins - antagonists & inhibitors | Moths - genetics | Proton-Translocating ATPases - genetics | Cell Transformation, Neoplastic - genetics | Transposases - genetics | DNA Transposable Elements - genetics | Forkhead Transcription Factors - antagonists & inhibitors | Neoplasm Proteins - genetics | Transgenes | Amino Acid Sequence | Pancreatic Neoplasms - pathology | RNA, Small Interfering - pharmacology | Gene Expression Regulation | Genes, Synthetic | Repressor Proteins - genetics | Mice, Transgenic | Pancreatic Neoplasms - genetics | Forkhead Transcription Factors - genetics | Genes, p16 | Gene Knock-In Techniques | Transposases - physiology | Animals | Forkhead Transcription Factors - analysis | Mice | Mutagenesis, Insertional | Noncoding DNA | Usage | Pancreatic cancer | Genetic aspects | Diagnosis | Research | Genetic screening | Studies | Medical research | Vertebrates | Mutagenesis | Genes | Genomes | Tumorigenesis | Mutation | Binding sites | Deoxyribonucleic acid--DNA | Index Medicus
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7. Full Text Fresh frozen plasma versus prothrombin complex concentrate in patients with intracranial haemorrhage related to vitamin K antagonists (INCH): a randomised trial
by Steiner, Thorsten, Prof and Poli, Sven, MD and Griebe, Martin, MD and Hüsing, Johannes and Hajda, Jacek, MD and Freiberger, Anja and Bendszus, Martin, Prof and Bösel, Julian, Prof and Christensen, Hanne, Prof and Dohmen, Christian, Prof and Hennerici, Michael, Prof and Kollmer, Jennifer, MD and Stetefeld, Henning, MD and Wartenberg, Katja E, MD and Weimar, Christian, Prof and Hacke, Werner, Prof and Veltkamp, Roland, Prof
Lancet neurology, ISSN 1474-4422, 2016, Volume 15, Issue 6, pp. 566 - 573
Neurology | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Blood Component Transfusion - methods | Single-Blind Method | Plasma | Outcome Assessment (Health Care) | Humans | Blood Component Transfusion - adverse effects | Male | Blood Coagulation Factors - administration & dosage | Anticoagulants - adverse effects | International Normalized Ratio | Vitamin K - antagonists & inhibitors | Intracranial Hemorrhages - chemically induced | Aged, 80 and over | Blood Coagulation Factors - pharmacology | Female | Aged | Stroke (Disease) | Prothrombin | Clinical trials | Thrombin | Care and treatment | Mortality | Stroke | Medical imaging | Hemophilia | Thrombosis | Clinical outcomes | Index Medicus
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8. Full Text HMGB1 as a Key Mediator of Immune Mechanisms in Ischemic Stroke
by Singh, Vikramjeet and Roth, Stefan and Veltkamp, Roland and Liesz, Arthur
Antioxidants & redox signaling, ISSN 1523-0864, 04/2016, Volume 24, Issue 12, pp. 635 - 651
Forum Review Articles | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Inflammation - metabolism | Stroke - metabolism | HMGB1 Protein - metabolism | Humans | Brain Ischemia - metabolism | HMGB1 Protein - immunology | Brain Ischemia - immunology | Stroke - immunology | Stroke (Disease) | Ubiquitin | Care and treatment | Inflammation | Research | Biological markers | Risk factors | Brain | Stroke | Traumatic brain injury | Inflammatory response | HMGB1 protein | Morbidity | Regeneration | Brain research | Head injuries | Ischemia | Cascades | Biomarkers | Brain injury | Immune system | Index Medicus
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