PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, p. e103883
Introduction: Assessment of EGFR mutation in non-small cell lung cancer (NSCLC) patients is mandatory for optimization of pharmacologic treatment. In this...
BREAST-CANCER | MOLECULAR CHARACTERIZATION | SURVIVAL | THERAPY | DNA | MULTIDISCIPLINARY SCIENCES | PROGRESSION-FREE | FACTOR-RECEPTOR MUTATIONS | DISCORDANCE | EXPRESSION | Erlotinib Hydrochloride | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Neoplastic Cells, Circulating - pathology | Exons | Humans | Molecular Sequence Data | Neoplastic Cells, Circulating - metabolism | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Carcinoma, Non-Small-Cell Lung - diagnosis | Case-Control Studies | Base Sequence | Sensitivity and Specificity | Carcinoma, Non-Small-Cell Lung - pathology | Gene Expression | Biomarkers, Tumor - blood | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Carcinoma, Non-Small-Cell Lung - blood | Biomarkers, Tumor - genetics | High-Throughput Nucleotide Sequencing | Lung Neoplasms - blood | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Lung Neoplasms - diagnosis | Care and treatment | Genetic aspects | Lung cancer, Non-small cell | Analysis | Tumors | Lung cancer | Medical services | Oncology | Metastasis | Kinases | Cancer therapies | Nuclei | Blood | Optimization | Aging | Deoxyribonucleic acid--DNA | Sequences | Epidermal growth factor receptors | Tumor cells | Non-small cell lung carcinoma | Breast cancer | Pharmacology | Real time | Patients | Medicine | Chemotherapy | Hospitals | Biopsy | Experimental design | Diagnostic software | Diagnostic systems | Prostate cancer | Cancer | Deoxyribonucleic acid
BREAST-CANCER | MOLECULAR CHARACTERIZATION | SURVIVAL | THERAPY | DNA | MULTIDISCIPLINARY SCIENCES | PROGRESSION-FREE | FACTOR-RECEPTOR MUTATIONS | DISCORDANCE | EXPRESSION | Erlotinib Hydrochloride | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Neoplastic Cells, Circulating - pathology | Exons | Humans | Molecular Sequence Data | Neoplastic Cells, Circulating - metabolism | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Carcinoma, Non-Small-Cell Lung - diagnosis | Case-Control Studies | Base Sequence | Sensitivity and Specificity | Carcinoma, Non-Small-Cell Lung - pathology | Gene Expression | Biomarkers, Tumor - blood | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Carcinoma, Non-Small-Cell Lung - blood | Biomarkers, Tumor - genetics | High-Throughput Nucleotide Sequencing | Lung Neoplasms - blood | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Lung Neoplasms - diagnosis | Care and treatment | Genetic aspects | Lung cancer, Non-small cell | Analysis | Tumors | Lung cancer | Medical services | Oncology | Metastasis | Kinases | Cancer therapies | Nuclei | Blood | Optimization | Aging | Deoxyribonucleic acid--DNA | Sequences | Epidermal growth factor receptors | Tumor cells | Non-small cell lung carcinoma | Breast cancer | Pharmacology | Real time | Patients | Medicine | Chemotherapy | Hospitals | Biopsy | Experimental design | Diagnostic software | Diagnostic systems | Prostate cancer | Cancer | Deoxyribonucleic acid
Journal Article
Frontiers in Cellular Neuroscience, ISSN 1662-5102, 09/2015, Volume 9, Issue september, p. 338
The dynamics of vestibular afferent responses are thought to be strongly influenced by presynaptic properties. In this paper, by performing whole-cell...
Hair cell | Transduction | Neuron | Utricle | Vestibular | POTASSIUM CURRENTS | utricle | TURTLE POSTERIOR CRISTA | AMPULLARIS | transduction | hair cell | COMPARATIVE TRANSDUCTION MECHANISMS | neuron | FREQUENCY-SELECTIVITY | vestibular | NEUROSCIENCES | CA2 | SEMICIRCULAR CANALS | BULLFROG UTRICULUS | CALCIUM CURRENTS | RIBBON SYNAPSE | Ion channels | Gene expression | Observations | Health aspects | Hair | Cell culture | Hair cells | Hearing protection | Glucose | Experiments | Voltage | Sensory neurons | Stochasticity | Vestibular system | Dissection
Hair cell | Transduction | Neuron | Utricle | Vestibular | POTASSIUM CURRENTS | utricle | TURTLE POSTERIOR CRISTA | AMPULLARIS | transduction | hair cell | COMPARATIVE TRANSDUCTION MECHANISMS | neuron | FREQUENCY-SELECTIVITY | vestibular | NEUROSCIENCES | CA2 | SEMICIRCULAR CANALS | BULLFROG UTRICULUS | CALCIUM CURRENTS | RIBBON SYNAPSE | Ion channels | Gene expression | Observations | Health aspects | Hair | Cell culture | Hair cells | Hearing protection | Glucose | Experiments | Voltage | Sensory neurons | Stochasticity | Vestibular system | Dissection
Journal Article
Annals of Oncology, ISSN 0923-7534, 06/2016, Volume 27, Issue suppl 2, pp. ii48.1 - ii48
Journal Article
BMC Neuroscience, ISSN 1471-2202, 2013, Volume 14, Issue Suppl 1, p. P313
Journal Article
Cogent Mathematics, ISSN 2331-1835, 12/2016, Volume 3, Issue 1
A nonlinear ecoepidemic model of new type is introduced here, in that it contains genetically distinguishable subpopulations. Further, in the system a predator...
transmissible diseases | epidemics | predator-prey | Secondary: 92D10 | Primary: 92D25 | 92D40 | genetic variability | Epidemics | Demographics | Predators | predator–prey
transmissible diseases | epidemics | predator-prey | Secondary: 92D10 | Primary: 92D25 | 92D40 | genetic variability | Epidemics | Demographics | Predators | predator–prey
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2002, Volume 277, Issue 11, pp. 9405 - 9414
Integrin-mediated cell adhesion cooperates with growth factor receptors in the control of cell proliferation, cell survival, and cell migration. One mechanism...
SIGNAL-TRANSDUCTION | AUTOPHOSPHORYLATION SITES | EPITHELIAL-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGICAL-ACTIVITY | FAMILY KINASES | EXTRACELLULAR-MATRIX | FOCAL ADHESION KINASE | ADAPTER PROTEIN | HUMAN ENDOTHELIAL-CELLS | ALPHA(V)BETA INTEGRIN | Crk-Associated Substrate Protein | Integrins - physiology | Cell Line | Phosphorylation | src-Family Kinases | Humans | Integrins - chemistry | Focal Adhesion Protein-Tyrosine Kinases | Receptor, Epidermal Growth Factor - analysis | Cell Adhesion | Focal Adhesion Kinase 1 | Receptor, Epidermal Growth Factor - chemistry | Protein-Tyrosine Kinases - physiology | Proteins | Receptor, Epidermal Growth Factor - metabolism | Tyrosine - metabolism | Retinoblastoma-Like Protein p130 | Phosphoproteins - physiology
SIGNAL-TRANSDUCTION | AUTOPHOSPHORYLATION SITES | EPITHELIAL-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGICAL-ACTIVITY | FAMILY KINASES | EXTRACELLULAR-MATRIX | FOCAL ADHESION KINASE | ADAPTER PROTEIN | HUMAN ENDOTHELIAL-CELLS | ALPHA(V)BETA INTEGRIN | Crk-Associated Substrate Protein | Integrins - physiology | Cell Line | Phosphorylation | src-Family Kinases | Humans | Integrins - chemistry | Focal Adhesion Protein-Tyrosine Kinases | Receptor, Epidermal Growth Factor - analysis | Cell Adhesion | Focal Adhesion Kinase 1 | Receptor, Epidermal Growth Factor - chemistry | Protein-Tyrosine Kinases - physiology | Proteins | Receptor, Epidermal Growth Factor - metabolism | Tyrosine - metabolism | Retinoblastoma-Like Protein p130 | Phosphoproteins - physiology
Journal Article
Italian Journal of Medicine, ISSN 1877-9344, 12/2018, Volume 12, Issue 4, pp. 276 - 279
Castleman disease (CD) is a rare lymphoproliferative disorder also known as angiofollicular lymph node hyperplasia or giant lymph node hyperplasia. CD can be...
Castleman disease | Lymphoproliferative disorder | Multicentric castleman disease | multicentric Castleman disease | lymphoproliferative disorder
Castleman disease | Lymphoproliferative disorder | Multicentric castleman disease | multicentric Castleman disease | lymphoproliferative disorder
Journal Article
European Journal of Cardio-Thoracic Surgery, ISSN 1010-7940, 12/2015, Volume 48, Issue 6, pp. e117 - e123
OBJECTIVES The therapeutic value of pulmonary middle lobectomy (PML) has been questioned. PML is currently regarded as a standard form of lobectomy, even so it...
Prognosis | Middle lobe | Lobectomy | Lung cancer | Surgery | SURVIVAL | CARDIAC & CARDIOVASCULAR SYSTEMS | LOBE | RESECTION | RESPIRATORY SYSTEM | CARCINOMA | EDITION | Carcinoma, Non-Small-Cell Lung - surgery | Lung Neoplasms - mortality | Humans | Middle Aged | Kaplan-Meier Estimate | Proportional Hazards Models | Logistic Models | Male | Treatment Outcome | Carcinoma, Non-Small-Cell Lung - diagnosis | Lymph Node Excision - mortality | Carcinoma, Non-Small-Cell Lung - mortality | Young Adult | Pneumonectomy - methods | Survival Analysis | Aged, 80 and over | Adult | Female | Lung Neoplasms - surgery | Aged | Retrospective Studies | Lung Neoplasms - diagnosis
Prognosis | Middle lobe | Lobectomy | Lung cancer | Surgery | SURVIVAL | CARDIAC & CARDIOVASCULAR SYSTEMS | LOBE | RESECTION | RESPIRATORY SYSTEM | CARCINOMA | EDITION | Carcinoma, Non-Small-Cell Lung - surgery | Lung Neoplasms - mortality | Humans | Middle Aged | Kaplan-Meier Estimate | Proportional Hazards Models | Logistic Models | Male | Treatment Outcome | Carcinoma, Non-Small-Cell Lung - diagnosis | Lymph Node Excision - mortality | Carcinoma, Non-Small-Cell Lung - mortality | Young Adult | Pneumonectomy - methods | Survival Analysis | Aged, 80 and over | Adult | Female | Lung Neoplasms - surgery | Aged | Retrospective Studies | Lung Neoplasms - diagnosis
Journal Article
The EMBO Journal, ISSN 0261-4189, 11/1998, Volume 17, Issue 22, pp. 6622 - 6632
Adhesion of human primary skin fibroblasts and ECV304 endothelial cells to immobilized matrix proteins, β1 or αv integrin antibodies stimulates tyrosine...
adhesion‐dependent cell survival | EGF receptor | MAP kinase | cell–matrix interaction | integrin signaling | Adhesion-dependent cell survival | Integrin signaling | Cell-matrix interaction | PP125(FAK) | cell-matrix interaction | TYROSINE PHOSPHORYLATION | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLOMERULAR EPITHELIAL-CELLS | PDGF-BETA-RECEPTORS | HUMAN ENDOTHELIAL-CELLS | CELL BIOLOGY | SIGNAL-TRANSDUCTION | GROWTH-FACTOR RECEPTOR | adhesion-dependent cell survival | EXTRACELLULAR-MATRIX | CYCLE PROGRESSION | Fibroblasts - enzymology | Phosphorylation | Skin - cytology | Skin - metabolism | Humans | Actins - metabolism | Integrins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Base Sequence | Cell Division | Calcium-Calmodulin-Dependent Protein Kinases - biosynthesis | Fibroblasts - metabolism | Signal Transduction | Cell Survival | Enzyme Induction | DNA Primers | Skin - enzymology | Cell Adhesion | Tyrosine - metabolism | Animals | Cytoskeleton - metabolism | Fibroblasts - cytology | Mice | Enzyme Activation | 3T3 Cells | Apoptosis
adhesion‐dependent cell survival | EGF receptor | MAP kinase | cell–matrix interaction | integrin signaling | Adhesion-dependent cell survival | Integrin signaling | Cell-matrix interaction | PP125(FAK) | cell-matrix interaction | TYROSINE PHOSPHORYLATION | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLOMERULAR EPITHELIAL-CELLS | PDGF-BETA-RECEPTORS | HUMAN ENDOTHELIAL-CELLS | CELL BIOLOGY | SIGNAL-TRANSDUCTION | GROWTH-FACTOR RECEPTOR | adhesion-dependent cell survival | EXTRACELLULAR-MATRIX | CYCLE PROGRESSION | Fibroblasts - enzymology | Phosphorylation | Skin - cytology | Skin - metabolism | Humans | Actins - metabolism | Integrins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Base Sequence | Cell Division | Calcium-Calmodulin-Dependent Protein Kinases - biosynthesis | Fibroblasts - metabolism | Signal Transduction | Cell Survival | Enzyme Induction | DNA Primers | Skin - enzymology | Cell Adhesion | Tyrosine - metabolism | Animals | Cytoskeleton - metabolism | Fibroblasts - cytology | Mice | Enzyme Activation | 3T3 Cells | Apoptosis
Journal Article
Italian Journal of Medicine, ISSN 1877-9344, 2014, Volume 8, Issue 1, pp. 44 - 50
Urticarial vasculitis is a small-vessel vasculitis characterized clinically by urticaria and microscopically by leukocytoclastic vasculitis. Hypocomplementemic...
Leukocytoclastic vasculitis | Hypocomplementemic urticarial vasculitis | Diffuse alveolar hemorrhage | hypocomplementemic urticarial vasculitis, leukocytoclastic vasculitis, diffuse alveolar hemorrhage
Leukocytoclastic vasculitis | Hypocomplementemic urticarial vasculitis | Diffuse alveolar hemorrhage | hypocomplementemic urticarial vasculitis, leukocytoclastic vasculitis, diffuse alveolar hemorrhage
Journal Article
British Journal of Anaesthesia, ISSN 0007-0912, 03/2019, Volume 122, Issue 3, pp. 361 - 369
The aim of this analysis of a large cohort study was to evaluate the association between night-time surgery and the occurrence of intraoperative adverse events...
intraoperative complications | postoperative complications | pulmonary | patient safety | general anaesthesia | MORTALITY | PERFORMANCE | SLEEP-DEPRIVATION | MECHANICAL VENTILATION | TIME | STRATEGIES | ANESTHESIA | INCREASED RISK | ANESTHESIOLOGY | OUTCOMES
intraoperative complications | postoperative complications | pulmonary | patient safety | general anaesthesia | MORTALITY | PERFORMANCE | SLEEP-DEPRIVATION | MECHANICAL VENTILATION | TIME | STRATEGIES | ANESTHESIA | INCREASED RISK | ANESTHESIOLOGY | OUTCOMES
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 6/2009, Volume 64, Issue 1, pp. 67 - 72
This study evaluated the maximum tolerated dose (MTD) and the dose limiting toxicity (DLT) of erlotinib when combined to irinotecan and capecitabine in...
Irinotecan | Biomedicine | Erlotinib | Capecitabine | Colorectal cancer | Cancer Research | Oncology | Pharmacology/Toxicology | XENOGRAFT MODELS | LEUCOVORIN | PLUS IRINOTECAN | SOLID TUMORS | OSI-774 | OXALIPLATIN | ANTITUMOR-ACTIVITY | PHASE-II TRIAL | ONCOLOGY | TYROSINE KINASE INHIBITOR | PHARMACOLOGY & PHARMACY | INFUSIONAL 5-FLUOROURACIL | Erlotinib Hydrochloride | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Fever - chemically induced | Dose-Response Relationship, Drug | Neoplasm Metastasis | Fluorouracil - administration & dosage | Colorectal Neoplasms - drug therapy | Adult | Camptothecin - administration & dosage | Female | Quinazolines - administration & dosage | Neutropenia - chemically induced | Camptothecin - analogs & derivatives | Drug Eruptions - etiology | Fluorouracil - analogs & derivatives | Deoxycytidine - administration & dosage | Mucositis - chemically induced | Maximum Tolerated Dose | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Deoxycytidine - analogs & derivatives | Cohort Studies | Care and treatment | Oncology, Experimental | Metastasis | Research | Antineoplastic agents | Fever | Antimitotic agents | Cancer patients | Pharmacy | Dosage and administration | Hyperthermia | Cancer | Index Medicus
Irinotecan | Biomedicine | Erlotinib | Capecitabine | Colorectal cancer | Cancer Research | Oncology | Pharmacology/Toxicology | XENOGRAFT MODELS | LEUCOVORIN | PLUS IRINOTECAN | SOLID TUMORS | OSI-774 | OXALIPLATIN | ANTITUMOR-ACTIVITY | PHASE-II TRIAL | ONCOLOGY | TYROSINE KINASE INHIBITOR | PHARMACOLOGY & PHARMACY | INFUSIONAL 5-FLUOROURACIL | Erlotinib Hydrochloride | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Fever - chemically induced | Dose-Response Relationship, Drug | Neoplasm Metastasis | Fluorouracil - administration & dosage | Colorectal Neoplasms - drug therapy | Adult | Camptothecin - administration & dosage | Female | Quinazolines - administration & dosage | Neutropenia - chemically induced | Camptothecin - analogs & derivatives | Drug Eruptions - etiology | Fluorouracil - analogs & derivatives | Deoxycytidine - administration & dosage | Mucositis - chemically induced | Maximum Tolerated Dose | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Deoxycytidine - analogs & derivatives | Cohort Studies | Care and treatment | Oncology, Experimental | Metastasis | Research | Antineoplastic agents | Fever | Antimitotic agents | Cancer patients | Pharmacy | Dosage and administration | Hyperthermia | Cancer | Index Medicus
Journal Article
Microscopy Research and Technique, ISSN 1059-910X, 10/1999, Volume 47, Issue 1, pp. 67 - 78
Cell matrix adhesion regulates actin cytoskeleton organization through distinct steps, from formation of filopodia and lamellipodia in the early phases of cell...
actin cytoskeleton | Rac | Src | Rho | PKC | p130Cas | integrin | p125Fak | Cdc42 | Integrin | Actin cytoskeleton | RHO-ASSOCIATED KINASE | PROTEIN-KINASE-C | TYROSINE PHOSPHORYLATION | ANATOMY & MORPHOLOGY | WISKOTT-ALDRICH-SYNDROME | SMALL GTPASE-RHO | CELL-ADHESION | MICROSCOPY | SIGNAL-TRANSDUCTION | FOCAL ADHESION | BIOLOGY | BINDING-SITE | EXTRACELLULAR-MATRIX | Immunohistochemistry | Integrins - physiology | Phalloidine | Protein Kinase C - physiology | GTP Phosphohydrolases - physiology | Protein-Serine-Threonine Kinases - physiology | cdc42 GTP-Binding Protein - physiology | Cell Adhesion - drug effects | Proto-Oncogene Proteins c-akt | Animals | Extracellular Matrix - physiology | Actins - chemistry | Fibronectins - physiology | Mice | Enzyme Activation | Pseudopodia - physiology | Actins - physiology | 3T3 Cells | Cytoskeleton - chemistry | Microscopy, Fluorescence
actin cytoskeleton | Rac | Src | Rho | PKC | p130Cas | integrin | p125Fak | Cdc42 | Integrin | Actin cytoskeleton | RHO-ASSOCIATED KINASE | PROTEIN-KINASE-C | TYROSINE PHOSPHORYLATION | ANATOMY & MORPHOLOGY | WISKOTT-ALDRICH-SYNDROME | SMALL GTPASE-RHO | CELL-ADHESION | MICROSCOPY | SIGNAL-TRANSDUCTION | FOCAL ADHESION | BIOLOGY | BINDING-SITE | EXTRACELLULAR-MATRIX | Immunohistochemistry | Integrins - physiology | Phalloidine | Protein Kinase C - physiology | GTP Phosphohydrolases - physiology | Protein-Serine-Threonine Kinases - physiology | cdc42 GTP-Binding Protein - physiology | Cell Adhesion - drug effects | Proto-Oncogene Proteins c-akt | Animals | Extracellular Matrix - physiology | Actins - chemistry | Fibronectins - physiology | Mice | Enzyme Activation | Pseudopodia - physiology | Actins - physiology | 3T3 Cells | Cytoskeleton - chemistry | Microscopy, Fluorescence
Journal Article