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1. Full Text PURIFICATION AND CHARACTERIZATION OF AKR1B10 FROM HUMAN LIVER: ROLE IN CARBONYL REDUCTION OF XENOBIOTICS
by Hans-Jörg Martin and Ursula Breyer-Pfaff and Vladimir Wsol and Simone Venz and Simone Block and Edmund Maser
Drug metabolism and disposition, ISSN 0090-9556, 03/2006, Volume 34, Issue 3, pp. 464 - 470
Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Inactivation, Metabolic | Aldehyde Reductase - genetics | Liver - enzymology | Oxidation-Reduction | Electrophoresis, Polyacrylamide Gel | Humans | Molecular Sequence Data | Immunoblotting | Recombinant Proteins - genetics | Xenobiotics - pharmacokinetics | Xenobiotics - chemistry | Aldehyde Reductase - physiology | Recombinant Proteins - isolation & purification | Aldehyde Reductase - isolation & purification | Spectrometry, Mass, Electrospray Ionization | Escherichia coli - genetics | Base Sequence | Index Medicus
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2. Full Text Nicotinamide N-Methyltransferase and Its Precursor Substrate Methionine Directly and Indirectly Control Malignant Metabolism During Progression of Renal Cell Carcinoma
by Holstein, Sina and Venz, Simone and Junker, Heike and Walther, Reinhard and Stope, Matthias B and Zimmermann, Uwe
Anticancer research, ISSN 0250-7005, 10/2019, Volume 39, Issue 10, pp. 5427 - 5436
Life Sciences & Biomedicine | Oncology | Science & Technology | Cell culture | Biotechnology | Incubation | Therapeutic applications | Interleukin | Methyltransferase | Methionine | Cell viability | Metabolism | Substrates | Western blotting | Interleukin 6 | Cell growth | Precursors | N-Methyltransferase | Kidney cancer | Reagents | Biomarkers | Nicotinamide | Clear cell-type renal cell carcinoma | Nicotinamide N-methyltransferase
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3. Full Text The marine triterpene glycoside frondoside A exhibits activity in vitro and in vivo in prostate cancer
by Dyshlovoy, Sergey A and Menchinskaya, Ekaterina S and Venz, Simone and Rast, Stefanie and Amann, Kerstin and Hauschild, Jessica and Otte, Katharina and Kalinin, Vladimir I and Silchenko, Alexandra S and Avilov, Sergey A and Alsdorf, Winfried and Madanchi, Ramin and Bokemeyer, Carsten and Schumacher, Udo and Walther, Reinhard and Aminin, Dmitry L and Fedorov, Sergey N and Shubina, Larisa K and Stonik, Valentin A and Balabanov, Stefan and Honecker, Friedemann and von Amsberg, Gunhild
International journal of cancer, ISSN 0020-7136, 05/2016, Volume 138, Issue 10, pp. 2450 - 2465
castration‐resistant prostate cancer | anti‐metastatic activity | apoptosis | frondoside A | autophagy | anti-metastatic activity | castration-resistant prostate cancer | Life Sciences & Biomedicine | Oncology | Science & Technology | Triterpenes - pharmacology | Apoptosis - drug effects | Humans | Drug Resistance, Neoplasm | Male | Autophagy - drug effects | Prostatic Neoplasms, Castration-Resistant - genetics | Prostatic Neoplasms, Castration-Resistant - pathology | Apoptosis Regulatory Proteins - genetics | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Disease Models, Animal | Cell Survival - drug effects | Tumor Stem Cell Assay | Reproducibility of Results | Prostatic Neoplasms, Castration-Resistant - drug therapy | Glycosides - pharmacology | Prostatic Neoplasms, Castration-Resistant - metabolism | Apoptosis Regulatory Proteins - metabolism | Xenograft Model Antitumor Assays | Animals | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Proteins | Keratin | Drug resistance | Prostate cancer | Analysis | Rodents | Medical prognosis | Cell cycle | Metastasis | Autophagy | Apoptosis | Cell proliferation | Drugs | Alternative splicing | Bax protein | Bcl-2 protein | Toxicity | Drug development | Caspase-3 | Immunosuppressive agents | Metastases | Castration | Down-regulation | Interleukin 1 | Cathepsin B | Cleavage | Inhibition | Cell survival | Immunomodulation | Tumor cells | Caspase | Poly(ADP-ribose) polymerase | Androgens | Lungs | Bcl protein | Proteomes | Phagocytosis | Index Medicus
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4. Full Text Inhibition of calpain-1 stabilizes TCF11/Nrf1 but does not affect its activation in response to proteasome inhibition
by Nowak, Karolin and Taubert, Ramona M and Haberecht, Stefanie and Venz, Simone and Krüger, Elke
Bioscience reports, ISSN 0144-8463, 09/2018, Volume 38, Issue 5, pp. 1 - 11
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Translocation | Transcription factors | Calcium | Homeostasis | Calpain | Activation | siRNA | Kinases | Nuclear transport | Proteins | Degradation | Organic chemistry | Proteasomes | Cleavage | Inhibition | Endoplasmic reticulum | Index Medicus
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5. Full Text Isoform 1 of TPD52 (PC-1) promotes neuroendocrine transdifferentiation in prostate cancer cells
by Moritz, Tom and Venz, Simone and Junker, Heike and Kreuz, Sarah and Walther, Reinhard and Zimmermann, Uwe
Tumor biology, ISSN 1010-4283, 8/2016, Volume 37, Issue 8, pp. 10435 - 10446
TPD52 | PC-1 | Biomedicine | LNCaP | PrLZ | Cancer Research | Neuroendocrine transdifferentiation | Prostate cancer | Life Sciences & Biomedicine | Oncology | Science & Technology | Neuroendocrine Cells - chemistry | Adenocarcinoma - pathology | Humans | Neoplasm Proteins - physiology | Male | Recombinant Fusion Proteins - metabolism | Cell Transdifferentiation - physiology | Transfection | Receptors, Androgen - biosynthesis | Antineoplastic Agents, Hormonal - therapeutic use | Cell Transdifferentiation - drug effects | Protein Domains | Neoplasm Proteins - genetics | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Interleukin-6 - therapeutic use | Neuroendocrine Cells - pathology | Protein Isoforms - physiology | Androgens | Interleukin-6 - pharmacology | Neoplasms, Hormone-Dependent - pathology | Androgen Antagonists - therapeutic use | Biomarkers | Cell Line, Tumor | Neoplasm Proteins - analysis | Neoplasms, Hormone-Dependent - drug therapy | Protein Isoforms - genetics | Development and progression | Interleukins | Tumor proteins | Proteins | Cellular biology | Index Medicus
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6. Full Text Proteomic‐based investigations on the mode of action of the marine anticancer compound rhizochalinin
by Dyshlovoy, Sergey A and Otte, Katharina and Venz, Simone and Hauschild, Jessica and Junker, Heike and Makarieva, Tatyana N and Balabanov, Stefan and Alsdorf, Winfried H and Madanchi, Ramin and Honecker, Friedemann and Bokemeyer, Carsten and Stonik, Valentin A and Amsberg, Gunhild
Proteomics (Weinheim), ISSN 1615-9853, 06/2017, Volume 17, Issue 11, pp. 1700048 - n/a
Rhizochalinin | ERK1/2 | Ingenuity pathway analysis (IPA) | Prostate cancer | Antimigratory activity | Prostatic Neoplasms - metabolism | Keratins, Type II - metabolism | Humans | Male | LIM Domain Proteins - metabolism | Fatty Alcohols - pharmacology | Rhizoctonia - chemistry | Interleukin-1beta - metabolism | Cytoskeletal Proteins - metabolism | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Proteomics - methods | Prostatic Neoplasms - drug therapy | Fibroblasts - metabolism | Prostatic Neoplasms - pathology | Cells, Cultured | Proteome - analysis | HSP70 Heat-Shock Proteins - metabolism | Cell Movement - drug effects | MAP Kinase Signaling System - drug effects | Fibroblasts - drug effects | Cell Proliferation - drug effects | Adaptor Proteins, Signal Transducing - metabolism | Keratins, Hair-Specific - metabolism | Stathmin - metabolism | Drug Screening Assays, Antitumor | Proteins | Keratin | Care and treatment | Analysis | Investigations | Cancer | Surgical implants | Leukocyte migration | Biochemistry | Western blotting | Cell adhesion & migration | Anticancer properties | Synergistic effects | Biomedical materials | Functional anatomy | Antitumor agents | Castration | Interleukin 1 | Biocompatibility | Activation analysis | Extracellular signal-regulated kinase | Data processing | Biological activity | Mode of action | Stathmin | Screening | Molecular modelling | Inhibitors | Proteomics | Isoforms | In vivo methods and tests | ATP | Prostate | In vitro methods and tests | Cell migration | Adenosine triphosphatase | Index Medicus
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7. Full Text Altered expression of tumor protein D52 regulates apoptosis and migration of prostate cancer cells
by Ummanni, Ramesh and Teller, Steffen and Junker, Heike and Zimmermann, Uwe and Venz, Simone and Scharf, Christian and Giebel, Jürgen and Walther, Reinhard
The FEBS journal, ISSN 1742-464X, 11/2008, Volume 275, Issue 22, pp. 5703 - 5713
TPD52 | cell migration | apoptosis | cell proliferation | prostate carcinoma | Cell proliferation | Prostate carcinoma | Cell migration | Apoptosis | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Prostatic Neoplasms - pathology | Cell Proliferation | Signal Transduction | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation - physiology | Apoptosis - genetics | Male | Integrin alphaVbeta3 | Cell Movement - genetics | Proto-Oncogene Proteins c-akt | Prostatic Neoplasms - genetics | Cell Line, Tumor | Mitochondria - physiology | Neoplasm Proteins - genetics | RNA | Membrane potentials | Fluorescence | Analysis | Cancer cells | Physiological aspects | Genetic research | Health aspects | Prostate cancer | Protein kinases | Integrins | Tumors | Biochemistry | Cellular biology | Proteomics | Index Medicus
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8. Full Text Inspired by Sea Urchins: Warburg Effect Mediated Selectivity of Novel Synthetic Non-Glycoside 1,4-Naphthoquinone-6S-Glucose Conjugates in Prostate Cancer
by Dyshlovoy, Sergey A and Pelageev, Dmitry N and Hauschild, Jessica and Sabutskii, Yurii E and Khmelevskaya, Ekaterina A and Krisp, Christoph and Kaune, Moritz and Venz, Simone and Borisova, Ksenia L and Busenbender, Tobias and Denisenko, Vladimir A and Schlueter, Hartmut and Bokemeyer, Carsten and Graefen, Markus and Polonik, Sergey G and Anufriev, Victor Ph and von Amsberg, Gunhild
Marine drugs, ISSN 1660-3397, 05/2020, Volume 18, Issue 5, p. 251
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Index Medicus | natural products | prostate cancer | sea urchins | glucose uptake | thioglucoside conjugates
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9. Full Text Anti‐migratory activity of marine alkaloid monanchocidin A – proteomics‐based discovery and confirmation
by Dyshlovoy, Sergey A and Venz, Simone and Hauschild, Jessica and Tabakmakher, Ksenya M and Otte, Katharina and Madanchi, Ramin and Walther, Reinhard and Guzii, Alla G and Makarieva, Tatyana N and Shubina, Larisa K and Fedorov, Sergey N and Stonik, Valentin A and Bokemeyer, Carsten and Balabanov, Stefan and Honecker, Friedemann and v. Amsberg, Gunhild
Proteomics (Weinheim), ISSN 1615-9853, 05/2016, Volume 16, Issue 10, pp. 1590 - 1603
Monanchocidin A | Anti‐migratory activity | Biomedicine | Apolipoprotein E | Germ cell tumor cells | eIF5A | EIF5A | Anti-migratory activity | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Cell Survival - drug effects | Proteome - genetics | Gene Expression - drug effects | Guanidine - pharmacology | Humans | Guanidine - analogs & derivatives | Cell Movement - drug effects | Proteomics | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Proteome - metabolism | Drug Screening Assays, Antitumor | Alkaloids | Analysis | Metastasis | Apolipoproteins | Intermediate filament proteins | Genetic translation | Vimentin | Transcription | Translation initiation | Cytotoxicity | Cisplatin | Biological activity | Molecular chains | Cell adhesion & migration | Mode of action | Proteins | Molecular modelling | Isoforms | Cell migration | Cancer | Tumors | Index Medicus
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10. Full Text Exosomal particles secreted by prostate cancer cells are potent mRNA and protein vehicles for the interference of tumor and tumor environment
by Rauschenberger, Lisa and Staar, Doreen and Thom, Kathleen and Scharf, Christian and Venz, Simone and Homuth, Georg and Schlüter, Rabea and Brandenburg, Lars‐Ove and Ziegler, Patrick and Zimmermann, Uwe and Weitschies, Werner and Völker, Uwe and Lendeckel, Uwe and Walther, Reinhard and Burchardt, Martin and Stope, Matthias B
The Prostate, ISSN 0270-4137, 03/2016, Volume 76, Issue 4, pp. 409 - 424
microenvironment | prostate cancer | protein uptake | exosomes | Endocrinology & Metabolism | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Microscopy, Electron, Transmission | RNA Transport - physiology | Humans | RNA, Messenger - analysis | Tumor Microenvironment | Cell Communication - physiology | Male | Protein Transport - physiology | Proteins - analysis | RNA, Messenger - metabolism | Particle Size | Animals | Proteins - metabolism | Prostatic Neoplasms - ultrastructure | Exosomes - physiology | Dogs | HEK293 Cells | Madin Darby Canine Kidney Cells | Cell Line, Tumor | Dynamic Light Scattering | Exosomes - ultrastructure | Proteins | DNA microarrays | Messenger RNA | Analysis | Cancer cells | Physiological aspects | Development and progression | Prostate cancer | Mass spectrometry | Tumors | Index Medicus
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11. Full Text Cabazitaxel overcomes cisplatin resistance in germ cell tumour cells
by Gerwing, Mirjam and Jacobsen, Christine and Dyshlovoy, Sergey and Hauschild, Jessica and Rohlfing, Tina and Oing, Christoph and Venz, Simone and Oldenburg, Jan and Oechsle, Karin and Bokemeyer, Carsten and von Amsberg, Gunhild and Honecker, Friedemann
Journal of cancer research and clinical oncology, ISSN 0171-5216, 9/2016, Volume 142, Issue 9, pp. 1979 - 1994
Medicine & Public Health | Hematology | Oncology | Cancer Research | Internal Medicine | Germ cell tumour | Cisplatin resistance | Cabazitaxel | Apoptosis | Life Sciences & Biomedicine | Science & Technology | Paclitaxel - pharmacology | Taxoids - pharmacology | Apoptosis - drug effects | Humans | Male | Antineoplastic Agents - therapeutic use | Testicular Neoplasms - pathology | Cisplatin - therapeutic use | Testicular Neoplasms - drug therapy | Cell Line, Tumor | Neoplasms, Germ Cell and Embryonal - drug therapy | Antineoplastic Agents - pharmacology | Cell Cycle - drug effects | Neoplasms, Germ Cell and Embryonal - pathology | Drug Resistance, Neoplasm - drug effects | Antimitotic agents | Chemotherapy | Antineoplastic agents | Analysis | Tumors | Cancer | Index Medicus
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