X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (23) 23
chemistry, medicinal (19) 19
humans (19) 19
structure-activity relationship (18) 18
mice (15) 15
chemistry, organic (14) 14
models, molecular (11) 11
antineoplastic agents - pharmacology (10) 10
cancer (10) 10
cell line, tumor (10) 10
crystallography, x-ray (10) 10
research (10) 10
proto-oncogene proteins c-akt - antagonists & inhibitors (9) 9
rats (9) 9
dogs (8) 8
enzyme inhibitors - pharmacology (8) 8
index medicus (8) 8
poly polymerase inhibitors (8) 8
potent (8) 8
administration, oral (7) 7
akt (7) 7
biochemistry & molecular biology (7) 7
biological availability (7) 7
molecular structure (7) 7
oncology, experimental (7) 7
pathway (7) 7
protein kinase inhibitors - chemistry (7) 7
protein kinase inhibitors - pharmacology (7) 7
protein kinases (7) 7
pyridines - chemistry (7) 7
antineoplastic agents - chemical synthesis (6) 6
antineoplastic agents - chemistry (6) 6
benzimidazoles - pharmacology (6) 6
enzyme inhibitors - chemistry (6) 6
neoplasms - drug therapy (6) 6
protein kinase b (6) 6
pyridines - pharmacology (6) 6
renin - antagonists & inhibitors (6) 6
selective inhibitors (6) 6
anticancer (5) 5
dacarbazine - analogs & derivatives (5) 5
discovery (5) 5
drug design (5) 5
in-vivo (5) 5
pkb (5) 5
protein-serine-threonine kinases - antagonists & inhibitors (5) 5
urokinase-type plasminogen activator - antagonists & inhibitors (5) 5
amides - pharmacology (4) 4
antineoplastic agents - therapeutic use (4) 4
binding sites (4) 4
blood pressure - drug effects (4) 4
blood-pressure (4) 4
care and treatment (4) 4
cells (4) 4
dose-response relationship, drug (4) 4
drug screening assays, antitumor (4) 4
enalkiren (4) 4
enzyme inhibitors - chemical synthesis (4) 4
gsk3 (4) 4
male (4) 4
molecular-cloning (4) 4
morpholines - pharmacology (4) 4
naphthalenes - chemistry (4) 4
oncology (4) 4
progress (4) 4
pyridines - chemical synthesis (4) 4
stereoisomerism (4) 4
xenograft model antitumor assays (4) 4
akt inhibitor (3) 3
amides - metabolism (3) 3
amino acid oxidoreductases - metabolism (3) 3
analysis (3) 3
antineoplastic agents - administration & dosage (3) 3
apoptosis (3) 3
b pkb/akt (3) 3
benzimidazoles - administration & dosage (3) 3
benzimidazoles - pharmacokinetics (3) 3
biochemistry (3) 3
cancer-cells (3) 3
cell proliferation - drug effects (3) 3
dacarbazine - administration & dosage (3) 3
derivatives (3) 3
drug synergism (3) 3
drug therapy (3) 3
enzyme inhibitors - pharmacokinetics (3) 3
enzymes (3) 3
female (3) 3
ferrets (3) 3
haplorhini (3) 3
human cancer (3) 3
indazoles - pharmacology (3) 3
inhibitors (3) 3
kinetics (3) 3
melanoma, experimental - drug therapy (3) 3
mice, scid (3) 3
monkeys (3) 3
nitric oxide synthase (3) 3
parp (3) 3
parp inhibitor (3) 3
physiological aspects (3) 3
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Clinical Cancer Research, ISSN 1078-0432, 05/2007, Volume 13, Issue 9, pp. 2728 - 2737
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 06/2005, Volume 4, Issue 6, pp. 977 - 986
The Akt kinases are central nodes in signal transduction pathways that are important for cellular transformation and tumor progression. We report the... 
FKHRL | Signal transduction | FOXO | p70s6k | PKB | PTEN | mTOR | TSC2 | TSC1 | Akt | SUPPRESSOR GENE | ONCOLOGY | INDUCED APOPTOSIS | PROTEIN-KINASE | PROSTATE-CANCER CELLS | GERMLINE MUTATIONS | MOLECULAR-CLONING | ONCOGENIC TRANSFORMATION | ANTITUMOR-ACTIVITY | PHOSPHATIDYLINOSITOL 3'-KINASE | SIGNAL-TRANSDUCTION PATHWAY | Pyridines - chemistry | Humans | Substrate Specificity | Antineoplastic Agents - therapeutic use | Proto-Oncogene Proteins - chemistry | Protein Kinase Inhibitors - chemistry | Sensitivity and Specificity | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Indazoles - chemistry | Models, Molecular | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Mice, SCID | Disease Progression | Neoplasms - drug therapy | Indazoles - pharmacology | Proto-Oncogene Proteins c-akt | Animals | Protein Kinase Inhibitors - therapeutic use | Cell Line, Tumor | Indoles - therapeutic use | Mice | Protein Kinase Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - chemistry | Pyridines - pharmacology | Neoplasms - pathology | Indoles - chemistry | Indazoles - therapeutic use
Journal Article
Journal Article
Anticancer Research, ISSN 0250-7005, 09/2008, Volume 28, Issue 5A, pp. 2625 - 2635
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2007, Volume 15, Issue 6, pp. 2441 - 2452
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2007, Volume 50, Issue 13, pp. 2990 - 3003
Journal Article
Journal Article
Journal Article
Journal Article
Biochemistry, ISSN 0006-2960, 02/2004, Volume 43, Issue 5, pp. 1254 - 1263
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2006, Volume 16, Issue 13, pp. 3424 - 3429
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2006, Volume 16, Issue 12, pp. 3150 - 3155
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2006, Volume 16, Issue 7, pp. 2000 - 2007
Journal Article