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1. Full Text Doomed from the TERT? A Two-Stage Model of Tumorigenesis in IDH-Wild-Type Glioblastoma
by Stead, Lucy F and Verhaak, Roel G.W
Cancer Cell, ISSN 1535-6108, 04/2019, Volume 35, Issue 4, pp. 542 - 544
Using longitudinal molecular profiling, Körber et al. propose in this issue of that IDH-wild-type glioblastomas initiate years pre-diagnosis with... 
ONCOLOGY | TUMOR EVOLUTION | CELL BIOLOGY | Tumors
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2. Full Text Hiding in the dark: Uncovering cancer drivers through image-guided genomics
by Yoshihara, Kosuke and Verhaak, Roel
Genome Biology, ISSN 1474-7596, 12/2014, Volume 15, Issue 12, pp. 563 - 563
Genome analysis which takes into account tumor purity leads to discovery of PTEN as a tumor suppressor gene in high-grade serous ovarian cancer. 
SEROUS OVARIAN-CANCER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EXPRESSION | GENETICS & HEREDITY | Ovarian Neoplasms - genetics | PTEN Phosphohydrolase - genetics | Prognosis | Humans | Image Interpretation, Computer-Assisted - methods | Ovarian Neoplasms - pathology | Female | Biomarkers, Tumor - genetics | Cystadenocarcinoma, Serous - genetics | Cystadenocarcinoma, Serous - pathology | Genomics - methods | Index Medicus | Research Highlight
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3. Full Text CSIG-16. DEPLETION OF CLK2 SENSITIZES GLIOMA CELLS TO PI3K/mTOR AND FGFR INHIBITION
by Park, Soon Young and Dong, Jianwen and Martinez-Ledesma, Emmanuel and Piao, Yuji and Verhaak, Roel G.W and de Groot, John F
Neuro-Oncology, ISSN 1522-8517, 11/2016, Volume 18, Issue suppl_6, pp. vi44 - vi44
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4. Full Text Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma
by Liu, Chong and Sage, Jonathan C and Miller, Michael R and Verhaak, Roel G.W and Hippenmeyer, Simon and Vogel, Hannes and Foreman, Oded and Bronson, Roderick T and Nishiyama, Akiko and Luo, Liqun and Zong, Hui
Cell, ISSN 0092-8674, 07/2011, Volume 146, Issue 2, pp. 209 - 221
Cancer cell of origin is difficult to identify by analyzing cells within terminal stage tumors, whose identity could be concealed by the acquired plasticity.... 
PROGENITOR CELLS | NEURAL STEM-CELLS | GLIOBLASTOMA | HUMAN BRAIN | SUPPRESSOR GENE | WHITE-MATTER | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTEGRATED GENOMIC ANALYSIS | GROWTH | NG2 CELLS | SUBVENTRICULAR ZONE | CELL BIOLOGY | Neurons - pathology | Astrocytes - pathology | Brain Neoplasms - pathology | Brain Neoplasms - genetics | Molecular Sequence Data | Glioma - embryology | Neural Stem Cells - pathology | Glioma - genetics | Oligodendroglia - pathology | Genes, p53 | Animals | Brain Neoplasms - embryology | Glioma - pathology | Biomarkers | Neoplastic Stem Cells - pathology | Mosaicism | Mice | Mutation | Neurofibromin 1 - genetics | Physiological aspects | Tumor proteins | Gliomas | Analysis | Stem cells | Cancer | Animal models | Mosaics | Glioma | Tumor cells | Brain tumors | Neural stem cells | Malignancy | Gene expression | Glial stem cells | p53 protein | Tumors
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5. Full Text Ets Factors Regulate Neural Stem Cell Depletion and Gliogenesis in Ras Pathway Glioma
by Breunig, Joshua J and Levy, Rachelle and Antonuk, C. Danielle and Molina, Jessica and Dutra-Clarke, Marina and Park, Hannah and Akhtar, Aslam Abbasi and Kim, Gi Bum and Hu, Xin and Bannykh, Serguei I and Verhaak, Roel G.W and Danielpour, Moise
Cell Reports, ISSN 2211-1247, 07/2015, Volume 12, Issue 3, pp. 535 - 535
CELL BIOLOGY
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6. Full Text Regulation of mRNA expression in breast cancer - a cis-tematic trans-action
by Verhaak, Roel G.W and Mills, Gordon B
Breast Cancer Research, ISSN 1465-5411, 10/2012, Volume 14, Issue 5, pp. 322 - 322
Large research consortia such as the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), The Cancer Genome Atlas and International Cancer... 
ONCOLOGY | SUBTYPES | TUMORS | GENES | Female | Breast Neoplasms - genetics | Humans | RNA, Messenger - genetics | Gene Expression Regulation, Neoplastic | Viewpoint
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7. Full Text Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer
by Du, Zhou and Fei, Teng and Verhaak, Roel G W and Su, Zhen and Zhang, Yong and Brown, Myles and Chen, Yiwen and Liu, X Shirley
Nature Structural and Molecular Biology, ISSN 1545-9993, 07/2013, Volume 20, Issue 7, pp. 908 - 913
Despite growing appreciation of the importance of long noncoding RNAs (lncRNAs) in normal physiology and disease, our knowledge of cancer-related lncRNAs... 
CHROMATIN | TRANSCRIPTOME | BIOCHEMISTRY & MOLECULAR BIOLOGY | RISK | IDENTIFICATION | CELL BIOLOGY | EXON ARRAYS | BIOPHYSICS | GENE | MODELS | COPY-NUMBER ALTERATION | EXPRESSION | SEQ | DNA, Intergenic | Adenocarcinoma - pathology | Prognosis | Oligonucleotide Array Sequence Analysis | Exons | Humans | Molecular Sequence Data | Male | Genes, Overlapping | Molecular Targeted Therapy | Biomarkers, Tumor | RNA, Long Noncoding - analysis | RNA, Neoplasm - analysis | Prostatic Neoplasms - genetics | Neoplasms - genetics | Conserved Sequence | Adenocarcinoma - genetics | Gene Expression Regulation, Neoplastic - genetics | Amino Acid Sequence | DNA Probes | Prostatic Neoplasms - pathology | Introns | Kaplan-Meier Estimate | Models, Molecular | Neoplasms - mortality | Gene Expression Profiling - methods | Neoplasms - classification | Gene Dosage | RNA, Long Noncoding - genetics | RNA, Long Noncoding - classification | Sequence Homology, Amino Acid | Sequence Alignment | Cell Line, Tumor - chemistry | RNA, Neoplasm - genetics | Protein Conformation | Physiological aspects | Genetic aspects | Research | RNA | Cancer | Biomedical research | RNA-protein interactions | Ribonucleic acid--RNA | Molecular biology | DNA probes
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8. Full Text GlioVis data portal for visualization and analysis of brain tumor expression datasets
by Bowman, Robert L and Wang, Qianghu and Carro, Angel and Verhaak, Roel G.W and Squatrito, Massimo
Neuro-Oncology, ISSN 1522-8517, 2017, Volume 19, Issue 1, pp. 139 - 141
ONCOLOGY | CANCER GENOMICS DATA | CLINICAL NEUROLOGY | Humans | Brain Neoplasms - pathology | Brain Neoplasms - genetics | Databases, Genetic | Biomedical Research - methods | Statistics as Topic | Internet | Brain Neoplasms - metabolism | Letter to the Editor
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9. Full Text Toward understanding and exploiting tumor heterogeneity
by Alizadeh, Ash A and Aranda, Victoria and Bardelli, Alberto and Blanpain, Cedric and Bock, Christoph and Borowski, Christine and Caldas, Carlos and Califano, Andrea and Doherty, Michael and Elsner, Markus and Esteller, Manel and Fitzgerald, Rebecca and Korbel, Jan O and Lichter, Peter and Mason, Christopher E and Navin, Nicholas and Pe'Er, Dana and Polyak, Kornelia and Roberts, Charles W M and Siu, Lillian and Snyder, Alexandra and Stower, Hannah and Swanton, Charles and Verhaak, Roel G W and Zenklusen, Jean C and Zuber, Johannes and Zucman-Rossi, Jessica
Nature Medicine, ISSN 1078-8956, 08/2015, Volume 21, Issue 8, pp. 846 - 853
The extent of tumor heterogeneity is an emerging theme that researchers are only beginning to understand. How genetic and epigenetic heterogeneity affects... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | EVOLUTION | RNA | PREDICT | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRATUMOR HETEROGENEITY | RESISTANCE | PATIENT | GENOME | CELL BIOLOGY | Epigenomics | Neoplasms - genetics | Humans | Tumor Microenvironment | Benchmarking | High-Throughput Nucleotide Sequencing | Neoplasms - pathology | Neoplasms - drug therapy | Epigenetic inheritance | Genetic aspects | Research | Spontaneous generation | Risk factors | Tumors | Conferences | Epigenetics | Cancer | Epigenètica
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10. Full Text Inferring tumour purity and stromal and immune cell admixture from expression data
by Yoshihara, Kosuke and Shahmoradgoli, Maria and Martínez, Emmanuel and Vegesna, Rahulsimham and Kim, Hoon and Torres-Garcia, Wandaliz and Treviño, Victor and Shen, Hui and Laird, Peter W and Levine, Douglas A and Carter, Scott L and Getz, Gad and Stemke-Hale, Katherine and Mills, Gordon B and Verhaak, Roel G.W
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, p. 2612
Infiltrating stromal and immune cells form the major fraction of normal cells in tumour tissue and not only perturb the tumour signal in molecular studies but... 
MOLECULAR SUBTYPES | BREAST-CANCER | SURVIVAL | MICROENVIRONMENT | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | DIFFERENTIATION | SIGNATURE | T-CELLS | PREDICTION | Gene Library | Oligonucleotide Array Sequence Analysis | Cell Separation | Humans | Stromal Cells - metabolism | Transcriptome | Gene Expression Profiling | DNA Copy Number Variations | Algorithms | Neoplasms - genetics | Neoplasms - immunology | Sensitivity and Specificity | Female | High-Throughput Nucleotide Sequencing | Software | Genome, Human | Neoplasms - pathology | Leukocytes - metabolism | Research Design | Stromal Cells - cytology | Leukocytes - cytology
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11. Full Text Moving the needle: Optimizing classification for glioma
by Verhaak, Roel G.W
Science Translational Medicine, ISSN 1946-6234, 08/2016, Volume 8, Issue 350, pp. 350fs14 - 350fs14
Genomic markers provide unbiased information that is increasingly being used to enhance traditional histopathology approaches for classification of cancer... 
MEDICINE, RESEARCH & EXPERIMENTAL | GENOMIC ANALYSIS | CENTRAL-NERVOUS-SYSTEM | TUMORS | CELL BIOLOGY | Glioblastoma - diagnosis | Glioma - classification | Glioma - diagnosis | Brain Neoplasms - classification | Brain Neoplasms - diagnosis | Humans | Oligodendroglioma - diagnosis | Biomarkers, Tumor - metabolism | Glioblastoma - classification | Astrocytoma - classification | Oligodendroglioma - classification | Astrocytoma - diagnosis
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12. Full Text Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
by Campbell, Joshua D and Alexandrov, Anton and Kim, Jaegil and Wala, Jeremiah and Berger, Alice H and Pedamallu, Chandra Sekhar and Shukla, Sachet A and Guo, Guangwu and Brooks, Angela N and Murray, Bradley A and Imielinski, Marcin and Hu, Xin and Ling, Shiyun and Akbani, Rehan and Rosenberg, Mara and Cibulskis, Carrie and Ramachandran, Aruna and Collisson, Eric A and Kwiatkowski, David J and Lawrence, Michael S and Weinstein, John N and Verhaak, Roel G.W and Wu, Catherine J and Hammerman, Peter S and Cherniack, Andrew D and Getz, Gad and Artyomov, Maxim N and Schreiber, Robert and Govindan, Ramaswamy and Meyerson, Matthew and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Nature Genetics, ISSN 1061-4036, 06/2016, Volume 48, Issue 6, pp. 607 - 616
To compare lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SqCC) and to identify new drivers of lung carcinogenesis, we examined the exome... 
HETEROGENEITY | MUTATIONAL PROCESSES | LANDSCAPE | QUANTIFICATION | KINASE | GENETICS & HEREDITY | IDENTIFICATION | CANCER | EXPRESSION | DRIVER MUTATIONS | PREDICTION | Lung Neoplasms - genetics | Recurrence | Antigens, Neoplasm | Carcinoma, Squamous Cell - genetics | Humans | Adenocarcinoma - genetics | Genome, Human | DNA Copy Number Variations | Adenocarcinoma | Usage | Squamous cell carcinoma | Nucleotide sequencing | Risk factors | DNA sequencing | Genomics | Lung cancer | Colleges & universities | Quality control | Defense contracts | Genomes | Mutation | Grants | Signatures | Tumors | Smoking | Index Medicus
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13. Full Text Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
by Koivunen, Peppi and Lee, Sungwoo and Duncan, Christopher G and Lopez, Giselle and Lu, Gang and Ramkissoon, Shakti and Losman, Julie A and Joensuu, Päivi and Bergmann, Ulrich and Gross, Stefan and Travins, Jeremy and Weiss, Samuel and Looper, Ryan and Ligon, Keith L and Verhaak, Roel G. W and Yan, Hai and Kaelin Jr, William G
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7390, pp. 484 - 488
The identification of succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH) mutations in human cancers has rekindled the... 
HYPOXIA-INDUCIBLE FACTOR | CELLS | ACTIVE-SITE | OXYGEN SENSING PATHWAY | MULTIDISCIPLINARY SCIENCES | L-2-HYDROXYGLUTARIC ACIDURIA | PROLYL 4-HYDROXYLASES | MUTATIONS | ONCOMETABOLITE 2-HYDROXYGLUTARATE | TUMORS | HYDROXYLASES | Dioxygenases - metabolism | Humans | Hypoxia-Inducible Factor 1 - metabolism | Glioma - metabolism | Procollagen-Proline Dioxygenase - metabolism | Glioma - genetics | Cell Transformation, Neoplastic - genetics | Glioma - pathology | Glutarates - chemistry | Nuclear Proteins - genetics | Oncogenes | Astrocytes - cytology | Astrocytes - drug effects | Cell Line | Glioma - enzymology | Isocitrate Dehydrogenase - genetics | Nuclear Proteins - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases | Enzyme Activation - drug effects | Cell Transformation, Neoplastic - metabolism | Dioxygenases - genetics | Procollagen-Proline Dioxygenase - genetics | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Cell Proliferation - drug effects | Glutarates - metabolism | Cell Transformation, Neoplastic - drug effects | Glutarates - pharmacology | Astrocytes - metabolism | Genetic aspects | Gene mutations | Enantiomers | Properties | Identification and classification | Cancer cells | Hypoxia | Polypeptides | Mutation | Microbiology | Gene expression | Brain cancer
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14. Full Text Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
by Verhaak, Roel G.W and Hoadley, Katherine A and Purdom, Elizabeth and Wang, Victoria and Qi, Yuan and Wilkerson, Matthew D and Miller, C. Ryan and Ding, Li and Golub, Todd and Mesirov, Jill P and Alexe, Gabriele and Lawrence, Michael and O'Kelly, Michael and Tamayo, Pablo and Weir, Barbara A and Gabriel, Stacey and Winckler, Wendy and Gupta, Supriya and Jakkula, Lakshmi and Feiler, Heidi S and Hodgson, J. Graeme and James, C. David and Sarkaria, Jann N and Brennan, Cameron and Kahn, Ari and Spellman, Paul T and Wilson, Richard K and Speed, Terence P and Gray, Joe W and Meyerson, Matthew and Getz, Gad and Perou, Charles M and Hayes, D. Neil and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 1, pp. 98 - 110
The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based... 
CELLCYCLE | MALIGNANT GLIOMA | MOLECULAR SUBTYPES | NEURAL STEM-CELLS | ONCOLOGY | RECURSIVE PARTITIONING ANALYSIS | COPY NUMBER | RECEPTOR | MUTATIONS | MULTIFORME TUMORS | EXPRESSION | REVEALS | CELL BIOLOGY | Receptor, Epidermal Growth Factor - genetics | Gene Expression | Prognosis | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Brain Neoplasms - pathology | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Factor Analysis, Statistical | Gene Dosage | Gene Expression Profiling | Glioblastoma - genetics | Brain Neoplasms - classification | DNA Mutational Analysis | Receptor, Platelet-Derived Growth Factor alpha - genetics | Glioblastoma - pathology | Adult | Glioblastoma - classification | Aged | Mutation | Neurofibromatosis 1 - genetics
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