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Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2013, Volume 56, Issue 17, pp. 6985 - 6990
We have observed previously that modification of ring size and substitution pattern may be used as a strategy to mitigate the metabolic instability of... 
MEDICINAL CHEMISTRY | CHEMISTRY, MEDICINAL | DRUG DISCOVERY | BINDING | ORAL-DRUGS | SOLUBILITY | FAMILY | TOOL | Cytochrome P-450 Enzyme System - metabolism | Ethers - chemistry
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 06/2010, Volume 1, Issue 6, pp. 435 - 449
The interplay among commonly used physicochemical properties in drug design was examined and utilized to create a prospective design tool focused on the... 
CNS drugs | Multiparameter optimization (MPO) | CNS MPO | High-throughput screening | Most basic pK | Polarity | Topological polar surface area | Hydrogen bond donor | Central nervous system (CNS) | Lipophilicity | Molecular weight | CNS candidates | desirability score | hydrogen bond donor | Madin-Darby canine kidney | central nervous system (CNS) | DISCOVERY | drug-drug interactions | dofetilide binding | most basic pK(a) | multivariant optimization | Harrington optimization | polarity | BIOCHEMISTRY & MOLECULAR BIOLOGY | high-throughput screening | molecular weight | PROLONGATION | NEUROSCIENCES | PREDICTION | P-glycoprotein | passive permeability | lipophilicity | cellular toxicity | human liver microsome stability | topological polar surface area | Unbound intrinsic clearance | transformed human liver epithelial cells | BINDING | Cell Line | Cell Survival - drug effects | Molecular Weight | Humans | Microsomes, Liver - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Central Nervous System - pathology | Cytochrome P-450 Enzyme System - metabolism | Structure-Activity Relationship | Drug Discovery | Central Nervous System Agents - pharmacokinetics | Algorithms | Animals | Hydrogen Bonding | Central Nervous System Agents - pharmacology | Dogs | Drug Design | Endpoint Determination | Central Nervous System - drug effects | Neurons - drug effects | Central Nervous System Agents - toxicity
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 2017, Volume 60, Issue 18, pp. 7764 - 7780
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2015, Volume 58, Issue 1, pp. 419 - 432
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 06/2010, Volume 1, Issue 6, pp. 420 - 434
Journal Article
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Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2014, Volume 57, Issue 3, pp. 861 - 877
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Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2012, Volume 55, Issue 21, pp. 9055 - 9068
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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 05/2012, Volume 341, Issue 2, pp. 396 - 409
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