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1. Editorial: Gene Therapy for Fanconi Anemia Enters a New Clinical Era
by Verhoeyen, E
Current gene therapy, 2017, Volume 16, Issue 5, p. 296
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2. Full Text The Future: In Vivo CAR T Cell Gene Therapy
by Mhaidly, Rana and Verhoeyen, Els
Molecular Therapy, ISSN 1525-0016, 04/2019, Volume 27, Issue 4, pp. 707 - 709
Ex vivo gene delivery employing these broad spectrum LVs might, however, lead to off-target transduction of contaminating cancer or antigen-presenting cells... 
MEDICINE, RESEARCH & EXPERIMENTAL | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | Antigens | CD19 antigen | Gene transfer | CAR gene | CD8 antigen | Glycoproteins | Lymphocytes T | Patients | CD4 antigen | Antigen-presenting cells | Lymphocytes | Manufacturing | Gene therapy | Cancer
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3. Full Text Advances in Foamy Virus Vector Technology and Disease Correction Could Speed the Path to Clinical Application
by Verhoeyen, Els
Molecular Therapy, ISSN 1525-0016, 06/2012, Volume 20, Issue 6, pp. 1105 - 1107
Foamy viruses (FVs) belong to the Retroviridae family, which includes the gamma -retrovirus murine leukemia virus (MLV) and lentiviruses (LVs) such as HIV.... 
MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | ACTIVATION | INTEGRATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CHRONIC GRANULOMATOUS-DISEASE | GENETICS & HEREDITY | TRANSDUCTION | GENE-THERAPY | BETA-THALASSEMIA | Cell Membrane - chemistry | Wiskott-Aldrich Syndrome - therapy | Animals | Genetic Vectors - administration & dosage | Receptors, Virus - metabolism | Humans | Female | Male | Spumavirus - metabolism | Heparitin Sulfate - metabolism | Wiskott-Aldrich Syndrome - genetics | Spumavirus - genetics | Index Medicus
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4. Full Text High SYK expression drives constitutive activation of CD21low B cells
by Keller, Baerbel and Stumpf, Ina and Strohmeier, Valentina and Usadel, Susanne and Verhoeyen, Els and Eibel, Hermann and Warnatz, Klaus
Journal of Immunology, ISSN 0022-1767, 06/2017, Volume 198, Issue 11, pp. 4285 - 4292
Human CD21low B cells present with an activated phenotype and accumulate in distinct disorders connected with chronic immune stimulation. Signaling studies had... 
Phosphorylation | Calcium | Disorders | Chronic infection | Stimulation | Activation | CD40L protein | Cell activation | Interleukin 21 | Protein-tyrosine kinase | CpG islands | Spleen | Tyrosine | NF-κB protein | Therapeutic applications | Immunodeficiency | Inflammation | T cell receptors | Patients | Phospholipase C | Phospholipase | Signaling | Lymphocytes B | Syk protein | Autoimmune diseases | Index Medicus | Abridged Index Medicus
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5. Full Text X-linked primary immunodeficiency associated with hemizygous mutations in the moesin ( MSN ) gene
by Lagresle-Peyrou, Chantal, PhD and Luce, Sonia, MSc and Ouchani, Farid, PhD and Soheili, Tayebeh Shabi, PhD and Sadek, Hanem, MSc and Chouteau, Myriam, MSc and Durand, Amandine, MSc and Pic, Isabelle, MSc and Majewski, Jacek, PhD and Brouzes, Chantal, MD and Lambert, Nathalie, MSc and Bohineust, Armelle, PhD and Verhoeyen, Els, PhD and Cosset, François-Loïc, PhD and Magerus-Chatinet, Aude, PhD and Rieux-Laucat, Frédéric, PhD and Gandemer, Virginie, MD, PhD and Monnier, Delphine, PhD and Heijmans, Catherine, MD and van Gijn, Marielle, PhD and Dalm, Virgil A., MD and Mahlaoui, Nizar, MD, MSc and Stephan, Jean-Louis, MD and Picard, Capucine, MD, PhD and Durandy, Anne, MD, PhD and Kracker, Sven, PhD and Hivroz, Claire, PhD and Jabado, Nada, MD, PhD and de Saint Basile, Geneviève, MD, PhD and Fischer, Alain, MD, PhD and Cavazzana, Marina, MD, PhD and André-Schmutz, Isabelle, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 6, pp. 1681 - 1689.e8
Background We investigated 7 male patients (from 5 different families) presenting with profound lymphopenia, hypogammaglobulinemia, fluctuating monocytopenia... 
Allergy and Immunology | primary immunodeficiency | ezrin-radixin-moesin protein | migration | moesin | adhesion | Leukopenia | ezrinradixin-moesin protein | ERM PROTEINS | CYTOSKELETON | PHOSPHORYLATION | MICROVILLI | CLASSIFICATION | IMMUNOLOGY | CELL CORTEX | EZRIN | ALLERGY | MICE | LYMPHOCYTES | CD43 | Chromosomes, Human, X - genetics | Genetic Association Studies | Humans | Child, Preschool | Male | Mutation - genetics | Cell Adhesion | Infection - genetics | Pedigree | Adolescent | Immunologic Deficiency Syndromes - genetics | Lymphocyte Count | Adult | Aged | CD8-Positive T-Lymphocytes - immunology | Child | Microfilament Proteins - genetics | Cell Movement | Virus diseases | Autoimmunity | Antigens | Immunogenetics | Immunodeficiency | Genetic research | Genetic aspects | Health aspects | Risk factors | Immunoglobulins | Mutation | Kinases | Lymphocytes | Index Medicus | Abridged Index Medicus | Life Sciences | Genetics
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6. Full Text Consensus Statement of European Societies of Gene and Cell Therapy on the Reported Birth of Genome-Edited Babies in China
by Büning, Hildegard and Griesenbach, Uta and Fehse, Boris and Ylä-Herttuala, Seppo and Anagnou, Nicholas P and van Beusechem, Victor and Raya, Angel and Verhoeyen, Els
Human Gene Therapy, ISSN 1043-0342, 12/2018, Volume 29, Issue 12, pp. 1337 - 1338
Consensus Statement | MEDICINE, RESEARCH & EXPERIMENTAL | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | Babies | Genomes
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7. Full Text Multiplex CRISPR/Cas9 system impairs HCMV replication by excising an essential viral gene
by Gergen, Janina and Coulon, Flora and Creneguy, Alison and Elain-Duret, Nathan and Gutierrez, Alejandra and Pinkenburg, Olaf and Verhoeyen, Els and Anegon, Ignacio and Nguyen, Tuan Huy and Halary, Franck Albert and Haspot, Fabienne
PLoS ONE, ISSN 1932-6203, 02/2018, Volume 13, Issue 2, pp. e0192602 - e0192602
Anti-HCMV treatments used in immunosuppressed patients reduce viral replication, but resistant viral strains can emerge. Moreover, these drugs do not target... 
CAS9 NUCLEASES | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | HUMAN CYTOMEGALOVIRUS REPLICATION | INFECTION | INHIBIT HIV-1 REPLICATION | TRANSPLANT RECIPIENTS | MOUSE CYTOMEGALOVIRUS | ANTIVIRAL DRUGS | GENOME | HEMATOPOIETIC STEM | Cytomegalovirus infections | Development and progression | Genetic aspects | Research | Multiplexing | Drugs | CRISPR | Antiviral agents | Cytomegalovirus | Transplants & implants | Latent infection | Oncology | Activation | Genomes | Gene expression | gRNA | Latency | Proteins | Design | Immediate-early proteins | Reduction | Fibroblasts | Replication | Strategy | Mutation | Deoxyribonucleic acid--DNA | Viral infections | Index Medicus | Life Sciences | Immunology | Deoxyribonucleic acid | DNA
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8. Full Text A Novel BaEVRless-Pseudotyped γ-Globin Lentiviral Vector Drives High and Stable Fetal Hemoglobin Expression and Improves Thalassemic Erythropoiesis In Vitro
by Drakopoulou, Ekati and Georgomanoli, Maria and Lederer, Carsten W and Kleanthous, Marina and Costa, Caroline and Bernadin, Ornellie and Cosset, François-Loïc and Voskaridou, Ersi and Verhoeyen, Els and Papanikolaou, Eleni and Anagnou, Nicholas P
Human Gene Therapy, ISSN 1043-0342, 05/2019, Volume 30, Issue 5, pp. 61 - 617
It has previously been demonstrated that the self-inactivating γ-globin lentiviral vector GGHI can significantly increase fetal hemoglobin (HbF) in erythroid... 
Research Articles | BaEVRless | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | PROGENITORS | VIVO | PERFORMANCE | BONE-MARROW | gene therapy | DELTA-BETA-THALASSEMIA | beta-thalassemia | HbF | CD34(+) CELLS | THERAPY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | gamma-globin lentiviral vector | envelope glycoproteins | GENETICS & HEREDITY | GENE-TRANSFER | CHAINS | Erythropoiesis | Tropism | CD34 antigen | Phenotypes | Multiplicity of infection | Copy number | Fetuses | Glycoprotein | Viruses | Thalassemia | Glycoproteins | Gene expression | Erythroid cells | Autophagy | Efficiency | Hemoglobin | Gene therapy | Phagocytosis | Apoptosis
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9. Full Text Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists
by Prost, Stéphane and Relouzat, Francis and Spentchian, Marc and Ouzegdouh, Yasmine and Saliba, Joseph and Massonnet, Gérald and Beressi, Jean-Paul and Verhoeyen, Els and Raggueneau, Victoria and Maneglier, Benjamin and Castaigne, Sylvie and Chomienne, Christine and Chrétien, Stany and Rousselot, Philippe and Leboulch, Philippe
Nature, ISSN 0028-0836, 09/2015, Volume 525, Issue 7569, pp. 380 - 383
Whether cancer is maintained by a small number of stem cells or is composed of proliferating cells with approximate phenotypic equivalency is a central... 
CANCER-CELLS | MAINTENANCE | ACTIVATION | HEMATOPOIESIS | PATHWAY | CITED2 | MULTIDISCIPLINARY SCIENCES | IMATINIB | STAT5 | DIFFERENTIATION | HIF-1-ALPHA | Piperazines - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Cell Proliferation | Neoplastic Stem Cells - drug effects | Humans | Gene Expression Regulation, Neoplastic | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | PPAR gamma - metabolism | Thiazolidinediones - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - pharmacology | STAT5 Transcription Factor - metabolism | Benzamides - administration & dosage | Thiazolidinediones - therapeutic use | Benzamides - therapeutic use | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Neoplastic Stem Cells - pathology | Benzamides - pharmacology | Thiazolidinediones - pharmacology | Repressor Proteins - metabolism | Pyrimidines - administration & dosage | Piperazines - therapeutic use | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Pyrimidines - therapeutic use | PPAR gamma - agonists | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Trans-Activators - metabolism | Index Medicus | Life Sciences | Microbiology and Parasitology | Immunology | Bacteriology | Virology
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10. Full Text Genome editing in primary cells and in vivo using viral-derived Nanoblades loaded with Cas9-sgRNA ribonucleoproteins
by Mangeot, Philippe E and Mangeot, Philippe E and Risson, Valérie and Risson, Valérie and Fusil, Floriane and Fusil, Floriane and Marnef, Aline and Laurent, Emilie and Laurent, Emilie and Blin, Juliana and Blin, Juliana and Mournetas, Virginie and Mournetas, Virginie and Massouridès, Emmanuelle and Massouridès, Emmanuelle and Sohier, Thibault J M and Sohier, Thibault J. M and Corbin, Antoine and Corbin, Antoine and Aubé, Fabien and Aubé, Fabien and Teixeira, Marie and Teixeira, Marie and Pinset, Christian and Pinset, Christian and Schaeffer, Laurent and Schaeffer, Laurent and Legube, Gaëlle and Cosset, François-Loïc and Cosset, François-Loïc and Verhoeyen, Els and Verhoeyen, Els and Ohlmann, Théophile and Ohlmann, Théophile and Ricci, Emiliano P and Ricci, Emiliano P
Nature Communications, ISSN 2041-1723, 01/2019, Volume 10, Issue 1, pp. 45 - 45
Programmable nucleases have enabled rapid and accessible genome engineering in eukaryotic cells and living organisms. However, their delivery into target cells... 
VSV-G-LVS | PROTEIN | ENDONUCLEASE | DNA | MULTIDISCIPLINARY SCIENCES | TRANSDUCTION | GENE-TRANSFER | GLYCOPROTEIN | EXPRESSION | T-CELLS | DELIVERY | Transcription | Leukemia | Liver | Gene regulation | Ribonucleoproteins | Stem cell transplantation | Editing | Viruses | Homology | Genomes | Gene expression | Embryos | DNA repair | Virus-like particles | Hematopoietic stem cells | Hemopoiesis | Cell lines | Stem cells | Bone marrow | Pluripotency | Deoxyribonucleic acid--DNA | Index Medicus
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11. Full Text IL-34 and CSF-1 display an equivalent macrophage differentiation ability but a different polarization potential
by Boulakirba, Sonia and Pfeifer, Anja and Mhaidly, Rana and Obba, Sandrine and Goulard, Michael and Schmitt, Thomas and Chaintreuil, Paul and Calleja, Anne and Furstoss, Nathan and Orange, François and Lacas-Gervais, Sandra and Boyer, Laurent and Marchetti, Sandrine and Verhoeyen, Els and Luciano, Frederic and Robert, Guillaume and Auberger, Patrick and Jacquel, Arnaud
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 256 - 256
CSF-1 and IL-34 share the CSF-1 receptor and no differences have been reported in the signaling pathways triggered by both ligands in human monocytes. IL-34... 
RHEUMATOID-ARTHRITIS | ACTIVATION | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | INTERLEUKIN 34 | DISEASE | GENE-EXPRESSION | RECEPTOR | CYTOKINE | HUMAN MONOCYTE DIFFERENTIATION | LANGERHANS CELLS | Macrophage Activation - genetics | Macrophage Activation - immunology | Humans | Monocytes - metabolism | Macrophage Colony-Stimulating Factor - metabolism | Monocytes - immunology | Macrophages - cytology | Interleukins - metabolism | Monocytes - drug effects | Macrophages - metabolism | Signal Transduction - drug effects | Cell Differentiation - drug effects | Macrophage Colony-Stimulating Factor - pharmacology | Interleukins - pharmacology | Macrophage Activation - drug effects | Macrophages - immunology | Polarization | Phenotypes | Cell survival | Secretion | Macrophage colony-stimulating factor | Caspase | AKT protein | Lymphocytes T | Secretome | Macrophages | Autophagy | Osteoclastogenesis | Monocytes | Cell activation | Interleukin 10 | Ligands | Osteoclasts | CCL17 protein | Phagocytosis | Index Medicus | Life Sciences | Cellular Biology | Biochemistry, Molecular Biology
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12. Full Text Cyclic dinucleotides modulate human T-cell response through monocyte cell death
: Cellular immune response
by Tosolini, Marie and Pont, Frédéric and Verhoeyen, Els and Fournié, Jean-Jacques
European Journal of Immunology, ISSN 0014-2980, 12/2015, Volume 45, Issue 12, pp. 3313 - 3323
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13. Full Text Cyclic dinucleotides modulate human T‐cell response through monocyte cell death
by Tosolini, Marie and Pont, Frédéric and Verhoeyen, Els and Fournié, Jean‐Jacques
European Journal of Immunology, ISSN 0014-2980, 12/2015, Volume 45, Issue 12, pp. 3313 - 3323
Cyclic dinucleotides, a class of microbial messengers, have been recently identified in bacteria, but their activity in humans remains largely unknown. Here,... 
T lymphocytes | Activation | A2a adenosine receptor | Cyclic dinucleotides | Quiescence | Nucleotides, Cyclic - pharmacology | Apoptosis - drug effects | Lymphocyte Activation | Humans | Mice, Inbred C57BL | Caspase 1 - metabolism | Monocytes - drug effects | Adenosine A2 Receptor Antagonists - pharmacology | Monocytes - enzymology | Animals | T-Lymphocytes - drug effects | T-Lymphocytes - immunology | Mice | Dinucleoside Phosphates - pharmacology | T cells | Cell death | Biochemistry | Lymphocytes | T cell receptors | Apoptosis | Index Medicus | Life Sciences | Microbiology and Parasitology | Immunology | Bacteriology | Virology
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14. Full Text Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells
by Villa, Elodie and Proïcs, Emma and Rubio-Patiño, Camila and Obba, Sandrine and Zunino, Barbara and Bossowski, Jozef P and Rozier, Romain M and Chiche, Johanna and Mondragón, Laura and Riley, Joel S and Marchetti, Sandrine and Verhoeyen, Els and Tait, Stephen W.G and Ricci, Jean-Ehrland
Cell Reports, ISSN 2211-1247, 09/2017, Volume 20, Issue 12, pp. 2846 - 2859
Mitophagy is an evolutionarily conserved process that selectively targets impaired mitochondria for degradation. Defects in mitophagy are often associated with... 
lung cancer | mitophagy | RBR-ligase | chemoresistance | PINK1 | E3 ligase | cell death | mtKeima | Parkin-independent | ARIH1 | RECESSIVE JUVENILE PARKINSONISM | ACTIVATE PARKIN | GENE | UBIQUITIN | DAMAGED MITOCHONDRIA | UBIQUITYLATION | AUTOPHAGY | PROTEINS | HUMAN HOMOLOG | LIGASE | CELL BIOLOGY | Neoplasms - metabolism | Protein Kinases - metabolism | Humans | Ubiquitin-Protein Ligases - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Autophagy - drug effects | Carrier Proteins - metabolism | Mitochondrial Degradation - drug effects | Protein Stability - drug effects | Cytoprotection - drug effects | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Death - drug effects | HeLa Cells | Neoplasms - pathology | Index Medicus
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15. Full Text A kindred with mutant IKAROS and autoimmunity
by Van Nieuwenhove, Erika and Garcia-Perez, Josselyn E and Helsen, Christine and Rodriguez, Princess D and van Schouwenburg, Pauline A and Dooley, James and Schlenner, Susan and van der Burg, Mirjam and Verhoeyen, Els and Gijsbers, Rik and Frietze, Seth and Schjerven, Hilde and Meyts, Isabelle and Claessens, Frank and Humblet-Baron, Stephanie and Wouters, Carine and Liston, Adrian
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 08/2018, Volume 142, Issue 2, pp. 699 - 702.e12
IKAROS function is conserved across species, with Kuehn et al3 identifying novel heterozygous IKZF1 mutations as the cause of an autosomal-dominant form of... 
B-CELLS | MUTATIONS | IMMUNOLOGY | ALLERGY | EXPRESSION | Lupus | Anticoagulants | Immunoglobulins | Ikaros protein | Gene expression | Hepatitis | Immunology | Lymphocytes | Transgenic animals | Genetic testing | Mutation | Deoxyribonucleic acid--DNA | Age | Life Sciences | Microbiology and Parasitology | Bacteriology | Virology | systemic lupus erythematosus | IKZF1 | B cells | autoimmunity | IKAROS | CD22
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16. Full Text Measles Virus Glycoprotein-Pseudotyped Lentiviral Vector-Mediated Gene Transfer into Quiescent Lymphocytes Requires Binding to both SLAM and CD46 Entry Receptors
by Cecilia Frecha and Camille Lévy and Caroline Costa and Didier Nègre and Fouzia Amirache and Robin Buckland and Steven J. Russell and François-Loïc Cosset and Els Verhoeyen
Journal of Virology, ISSN 0022-538X, 06/2011, Volume 85, Issue 12, pp. 5975 - 5985
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
WILD-TYPE | B-LYMPHOCYTES | PROTEIN | VIROLOGY | HEMAGGLUTININ | RHESUS-MONKEYS | MOLECULE SLAM | CD150 SLAM | T-CELL-ACTIVATION | MACROPINOCYTOSIS | TRANSDUCTION | Humans | Pinocytosis | Antigens, CD - genetics | Measles virus - chemistry | T-Lymphocytes - virology | Antigens, CD - metabolism | Lentivirus - metabolism | Measles virus - genetics | Signaling Lymphocytic Activation Molecule Family Member 1 | T-Lymphocytes - metabolism | Viral Envelope Proteins - metabolism | B-Lymphocytes - virology | Adult | Lentivirus - genetics | Membrane Cofactor Protein - metabolism | B-Lymphocytes - metabolism | Glycoproteins - genetics | Gene Transfer Techniques | Viral Envelope Proteins - genetics | Transduction, Genetic | Lymphocyte Activation | Receptors, Cell Surface - metabolism | Genetic Vectors - genetics | B-Lymphocytes - immunology | Membrane Cofactor Protein - genetics | T-Lymphocytes - immunology | Receptors, Cell Surface - genetics | Index Medicus | Virus-Cell Interactions
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