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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2014, Volume 111, Issue 8, pp. 3128 - 3133
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 12/2018, Volume 293, Issue 52, pp. 20137 - 20156
Myocilin ( ) was discovered more than 20 years ago and is the gene whose mutations are most commonly observed in individuals with glaucoma. Despite extensive... 
Journal Article
Molecular Cell, ISSN 1097-2765, 05/2019, Volume 74, Issue 3, pp. 542 - 554.e5
Developing and adult tissues use different -regulatory elements. Although DNA at some decommissioned embryonic enhancers is hypomethylated in adult cells, it... 
decommissioned developmental genes | epigenetic memory | DNA hypomethylation | STEM-CELLS | METHYLATION | SIGNATURES | EPIGENETIC MEMORY | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | TISSUE | MECHANISMS | REGULATORS | DIFFERENTIATION | EXPRESSION | CELL BIOLOGY | Epigenetic inheritance | Embryonic development | Anopheles | Developmental biology | DNA | Memory | Genes
Journal Article
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 444 - 444
Journal Article
Cancer Research, ISSN 0008-5472, 07/2013, Volume 73, Issue 13 Supplement, pp. A20 - A20
Journal Article
Protein Expression and Purification, ISSN 1046-5928, 07/2018, Volume 147, pp. 38 - 48
Myocilin (MYOC) is a secreted protein found in human aqueous humor (AH) and mutations in the gene are the most common mutation observed in glaucoma patients.... 
Human aqueous humor | Modeled structure | Myocilin | Dimer | Protein isolation | Protein purification | NON-SECRETION | TRABECULAR MESHWORK CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TIGR | BIOCHEMICAL RESEARCH METHODS | PREVALENCE | IDENTIFICATION | CLEAVAGE | OPEN-ANGLE GLAUCOMA | GENE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MUTATIONS | OLFACTOMEDIN-HOMOLOGY DOMAIN
Journal Article
PLoS Biology, ISSN 1544-9173, 12/2009, Volume 7, Issue 12, pp. e1000256 - e1000256
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2011, Volume 108, Issue 30, pp. 12243 - 12248
The HDL receptor, scavenger receptor, class B, type I (SR-BI), is a homooligomeric cell surface glycoprotein that controls HDL structure and metabolism by... 
COS cells | Receptors | Lipoproteins | Thiols | HDL lipoproteins | Thiosemicarbazones | Disulfides | Scavenger receptors | Lipids | Mice | Chemical biology | Lipoprotein | Cholesterol | Disulfide | lipoprotein | disulfide | MULTIDISCIPLINARY SCIENCES | IDENTIFICATION | MASS-SPECTROMETRY | HIGH-DENSITY-LIPOPROTEIN | HEART-DISEASE | SCAVENGER RECEPTOR | CHOLESTERYL ESTER | chemical biology | METABOLISM | MEDIATED ENDOCYTOSIS | cholesterol | A-I | BINDING | Humans | Lipoproteins, HDL - metabolism | Cercopithecus aethiops | Scavenger Receptors, Class B - chemistry | Biological Transport, Active | Mass Spectrometry | Thiosemicarbazones - pharmacology | Binding Sites | Mutant Proteins - antagonists & inhibitors | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Mutagenesis, Site-Directed | Mutant Proteins - genetics | Models, Molecular | Recombinant Proteins - chemistry | Lipid Metabolism | Mutant Proteins - metabolism | Scavenger Receptors, Class B - genetics | Recombinant Proteins - genetics | Cyclopentanes - pharmacology | Cysteine - chemistry | Animals | Scavenger Receptors, Class B - antagonists & inhibitors | Mutant Proteins - chemistry | Scavenger Receptors, Class B - metabolism | In Vitro Techniques | COS Cells | Amino Acid Substitution | Physiological aspects | Cysteine | Glycoproteins | Genetic aspects | Metabolism | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2014, Volume 111, Issue 8, p. 3128
  Defects in epigenetic regulation play a fundamental role in the development of cancer, and epigenetic regulators have recently emerged as promising... 
Cell growth | Chromatin | Epigenetics | Mutation | Cells | Tumors | Cancer
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 02/2014, Volume 111, Issue 8, pp. 3128 - 3128
Defects in epigenetic regulation play a fundamental role in the development of cancer, and epigenetic regulators have recently emerged as promising therapeutic... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2011, Volume 108, Issue 30, p. 12243
The HDL receptor, scavenger receptor, class B, type I (SR-BI), is a homooligomeric cell surface glycoprotein that controls HDL structure and metabolism by... 
Molecules | Lipids | Glycoproteins | Metabolism | Mass spectrometry
Journal Article
PLoS Biology, ISSN 1544-9173, 12/2009, Volume 7, Issue 12
  A single nucleotide substitution in intron 3 of IGF2 in pigs abrogates a binding site for a repressor and leads to a 3-fold up-regulation of IGF2 in skeletal... 
Proteins | Genes | Genomics | Genetics | Mutation
Journal Article
Plos Biology, ISSN 1544-9173, 2009, Volume 7, Issue 12
A single nucleotide substitution in intron 3 of IGF2 in pigs abrogates a binding site for a repressor and leads to a 3-fold up-regulation of IGF2 in skeletal... 
Veterinärmedicin | Veterinary Science
Journal Article
55th ASMS Conference Proceedings, 01/2007
Candidate-based biomarker discovery relies upon specific, quantitative assays optimized for the selective detection of target proteins, and represents a... 
Journal Article
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