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Science, ISSN 0036-8075, 12/2015, Volume 350, Issue 6267, pp. aac5464 - aac5464
Journal Article
Pain, ISSN 0304-3959, 2012, Volume 153, Issue 1, pp. 80 - 85
A novel small molecule inhibitor of Na 1.7 has been developed, and favorable efficacy using this therapeutic in erythromelalgia patients with Na 1.7... 
Pain genetics | Congenital indifference to pain | Clinical development | SCN9A | Erythromelalgia | Sodium channel blockers | Neuropathic pain
Journal Article
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2017, Volume 112, Issue 3, pp. 333a - 333a
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2018, Volume 115, Issue 4, p. E792
Many ion channels, including Nav1.7, Cav1.3, and Kv1.3, are linked to human pathologies and are important therapeutic targets. To develop efficacious and safe... 
Membranes | Veratridine | Research & development--R&D | Calcium channels (voltage-gated) | Assaying | Drug development | Design | Pathology | Sodium channels (voltage-gated) | Potassium channels (voltage-gated) | Ion channels | Membrane potential | Drug discovery | Binding sites
Journal Article
Medicinal Chemistry Research, ISSN 1054-2523, 04/2013, Volume 22, Issue 4, p. 1825
The structure--activity relationship of a new series of tetracyclic spirooxindoles led to the discovery of compound 25a, a potent hNa.sub.V1.7 blocker with... 
Journal Article
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