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by der Zee, Julie and Gijselinck, Ilse and Mossevelde, Sara and Perrone, Federica and Dillen, Lubina and Heeman, Bavo and Bäumer, Veerle and Engelborghs, Sebastiaan and Bleecker, Jan and Baets, Jonathan and Gelpi, Ellen and Rojas‐García, Ricardo and Clarimón, Jordi and Lleó, Alberto and Diehl‐Schmid, Janine and Alexopoulos, Panagiotis and Perneczky, Robert and Synofzik, Matthis and Just, Jennifer and Schöls, Ludger and Graff, Caroline and Thonberg, Håkan and Borroni, Barbara and Padovani, Alessandro and Jordanova, Albena and Sarafov, Stayko and Tournev, Ivailo and Mendonça, Alexandre and Miltenberger‐Miltényi, Gabriel and Simões do Couto, Frederico and Ramirez, Alfredo and Jessen, Frank and Heneka, Michael T and Gómez‐Tortosa, Estrella and Danek, Adrian and Cras, Patrick and Vandenberghe, Rik and Jonghe, Peter and Deyn, Peter P and Sleegers, Kristel and Cruts, Marc and Broeckhoven, Christine and Goeman, Johan and Nuytten, Dirk and Smets, Katrien and Robberecht, Wim and Damme, Philip Van and Bleecker, Jan De and Santens, Patrick and Dermaut, Bart and Versijpt, Jan and Michotte, Alex and Ivanoiu, Adrian and Deryck, Olivier and Bergmans, Bruno and Delbeck, Jean and Bruyland, Marc and Willems, Christiana and Salmon, Eric and Pastor, Pau and Ortega‐Cubero, Sara and Benussi, Luisa and Ghidoni, Roberta and Binetti, Giuliano and Hernández, Isabel and Boada, Mercè and Ruiz, Agustín and Sorbi, Sandro and Nacmias, Benedetta and Bagnoli, Silvia and Sorbi, Sandro and Sanchez‐Valle, Raquel and Llado, Albert and Santana, Isabel and Rosário Almeida, Maria and Frisoni, Giovanni B and Maetzler, Walter and Matej, Radoslav and Fraidakis, Matthew J and Kovacs, Gabor G and Fabrizi, Gian Maria and Testi, Silvia and Belgian Neurology Consortium and European Early-Onset Dementia Cons
Human Mutation, ISSN 1059-7794, 03/2017, Volume 38, Issue 3, pp. 297 - 309
We investigated the mutation spectrum of the TANK‐Binding Kinase 1 ( TBK1 ) gene and its associated phenotypic spectrum by exonic resequencing of TBK1 in a... 
TANK‐Binding Kinase 1 | TBK1 | mutations | FTD | ALS | frontotemporal dementia | amyotrophic lateral sclerosis | NFκB luciferase reporter assay | TANK-Binding Kinase 1 | REPEAT EXPANSION | LOBAR DEGENERATION | C9ORF72 | FAMILIAL ALS | BELGIAN COHORT | NFkB luciferase reporter assay | TDP-43 | DISEASE | GENETICS & HEREDITY | ARGYROPHILIC GRAINS | DIAGNOSTIC-CRITERIA | HEXANUCLEOTIDE REPEAT | Sequence Deletion | Humans | Middle Aged | Amyotrophic Lateral Sclerosis - diagnosis | Male | NF-kappa B - metabolism | Case-Control Studies | Female | Protein-Serine-Threonine Kinases - metabolism | Frontotemporal Dementia - genetics | European Continental Ancestry Group - genetics | Genetic Association Studies | Amyotrophic Lateral Sclerosis - genetics | Protein-Serine-Threonine Kinases - genetics | Frontotemporal Dementia - diagnosis | Phenotype | Alleles | Heterozygote | Aged | Enzyme Activation | Mutation | Frontotemporal Dementia - epidemiology | Amino Acid Substitution | Amyotrophic Lateral Sclerosis - epidemiology | Cohort Studies | RNA | Analysis | Luciferase | Amino acids | Amyotrophic lateral sclerosis | Genetic aspects | Dementia | Proteins | Transcription | Risk groups | mRNA turnover | Nonsense-mediated mRNA decay | Sclerosis | Pathogenicity | Missense mutation | Dementia disorders | Frontotemporal dementia | Age | Index Medicus
Journal Article
Journal of Pain and Palliative Care Pharmacotherapy, ISSN 1536-0288, 2014, Volume 28, Issue 3, pp. 312 - 313
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 6/2019, Volume 137, Issue 6, pp. 901 - 918
Journal Article
Acta Neurologica Belgica, ISSN 0300-9009, 6/2012, Volume 112, Issue 2, pp. 141 - 145
Until more effective and especially disease-modifying treatments for Alzheimer’s disease (AD) are available, the therapeutic arsenal consists of cholinesterase... 
Neurology | Neurosciences | Biomedicine | Alzheimer’s disease | Galantamine | Rivastigmine | Donepezil | Pharmacoeconomics | Medicine/Public Health, general | Cholinesterase inhibitors | Neuroradiology
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 2017, Volume 60, Issue 4, pp. 1237 - 1239
In a recent review, Mukadam, Sommerlad, and Livingston (2017) argue that bilingualism offers no protection against cognitive decline. The authors examined the... 
Cognitive decline | prospective cohort studies | retrospective studies | dementia | multilingualism | DIAGNOSIS | ALZHEIMERS-DISEASE | DELAYS | RISK | NEUROSCIENCES | RESERVE | COMMUNITY | ONSET | AGE | Dementia disorders | Bilingualism | Cognitive ability | Dementia | Index Medicus
Journal Article
Bilingualism, ISSN 1366-7289, 07/2015, Volume 18, Issue 3, pp. 568 - 574
Journal Article
Brain, ISSN 0006-8950, 02/2016, Volume 139, Issue 2, pp. 452 - 467
Journal Article
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 11/2016, Volume 43, Issue 12, pp. 2219 - 2227
The cannabinoid type 2 receptor (CB2R) is expressed by immune cells such as monocytes and macrophages. In the brain, CB2R is primarily found on microglia. CB2R... 
Medicine & Public Health | PET imaging | Alzheimer’s disease | CB 2 R | Orthopedics | Cannabinoid type 2 receptor | Oncology | Neuroinflammation | Nuclear Medicine | Imaging / Radiology | Cardiology
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 02/2018, Volume 62, pp. 245.e1 - 245.e7
TANK-binding kinase 1 (TBK1) loss-of-function (LoF) mutations are known to cause frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), often... 
RNA sequencing | Loss-of-function | Early onset Alzheimer's disease | TBK1 | Frontotemporal dementia | BELGIAN COHORT | IMMUNITY | AMYOTROPHIC-LATERAL-SCLEROSIS | BINDING KINASE 1 | MUTATIONS | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | Alzheimer's disease | Index Medicus
Journal Article
Journal Article
Acta neurologica Belgica, 06/2012, Volume 112, Issue 2, p. 141
Until more effective and especially disease-modifying treatments for Alzheimer's disease (AD) are available, the therapeutic arsenal consists of cholinesterase... 
Cholinesterase Inhibitors - economics | Economics, Pharmaceutical | Cost-Benefit Analysis | Humans | Alzheimer Disease - drug therapy | Female | Male | Cholinesterase Inhibitors - therapeutic use | Alzheimer Disease - economics
Journal Article
Journal of Headache and Pain, ISSN 1129-2369, 02/2019, Volume 20, Issue 1, pp. 16 - 16
BackgroundIn patients with frequent migraine, prophylactic treatments are used. Patients often request non-pharmacological alternatives. One treatment option... 
Headache | Exercise | Treatment | Headache characteristics | Migraine | Physical therapy | MANAGEMENT | EFFICACY | ADULTS | MECHANISMS | NEUROSCIENCES | CLINICAL NEUROLOGY | PROPHYLAXIS | THERAPY | Care and treatment | Usage | Aerobic exercises | Therapeutics, Physiological | Research | Health aspects | Index Medicus
Journal Article