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ISSN 1463-9076, 6/2017, Volume 19, Issue 25, pp. 16387 - 16394
Soluble amyloid-beta (Aβ) oligomers are the prime causative agents of cognitive deficits during early stages of Alzheimer's disease (AD). The transient nature... 
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1814, pp. 63 - 74
Pair-wise interactions at the single-molecule level can be done with nanoprobing techniques, such as AFM force spectroscopy, optical tweezers, and magnetic... 
Nanoprobing | AFM | Click chemistry | Force spectroscopy | Protein-protein interactions | Amyloid oligomers
Journal Article
Biophysical Journal, ISSN 0006-3495, 02/2017, Volume 112, Issue 3, pp. 299a - 300a
Journal Article
Physical Chemistry Chemical Physics, ISSN 1463-9076, 2017, Volume 19, Issue 25, pp. 16387 - 16394
Soluble amyloid-beta (Aβ) oligomers are the prime causative agents of cognitive deficits during early stages of Alzheimer's disease (AD). The transient nature... 
Journal Article
Biophysical Journal, ISSN 0006-3495, 05/2015, Volume 108, Issue 9, p. 2333
  Immobilization is a key step involved in probing molecular interactions using single-molecule force spectroscopy methods, including atomic force microscopy... 
Peptides | Spectrum analysis | Polymers | Molecular biology | Deoxyribonucleic acid--DNA
Journal Article
Biophysical Journal, ISSN 0006-3495, 05/2015, Volume 108, Issue 9, pp. 2333 - 2339
Immobilization is a key step involved in probing molecular interactions using single-molecule force spectroscopy methods, including atomic force microscopy... 
DYNAMIC FORCE SPECTROSCOPY | STREPTAVIDIN | BIOPHYSICS | DNA | BONDS | BIOTIN | BINDING | AGGREGATION | Microscopy, Atomic Force | Immobilized Proteins - chemistry | Amyloid beta-Peptides - chemistry | Protein Array Analysis - methods | Atomic force microscopy | DNA synthesis | Biotin | Peptides | Analysis | Investigations | Proteins and Nucleic Acids
Journal Article
Journal of Clinical Microbiology, ISSN 0095-1137, 01/2017, Volume 55, Issue 1, pp. 183 - 198
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 01/2003, Volume 125, Issue 3, pp. 654 - 661
The ability of modified antisense oligonucleotides (AONs) containing acyclic interresidue units to support RNase H-promoted cleavage of complementary RNA is... 
NMR | GENE | ANALOGS | STABILITY | ESCHERICHIA-COLI | ARABINONUCLEIC ACIDS ANA | HYBRID DUPLEXES | EXPRESSION | CHEMISTRY, MULTIDISCIPLINARY | RIBONUCLEASE-H | OLIGONUCLEOTIDES
Journal Article
Nucleosides, Nucleotides and Nucleic Acids, ISSN 1525-7770, 10/2003, Volume 22, Issue 5-8, pp. 1335 - 1338
Oligonucleotide analogues comprised of 2′-deoxy-2′-fluoro- β -D-arabinose units joined via P3′-N5′ phosphoramidate linkages (2′F-ANA 5′N ) were prepared for... 
RNase H | Thermal stability | 5′-Amino-2′-deoxy-2′-fluoroarabinonucleosides | Amines | Arabinonucleosides | Fluorine | Base Sequence | Humans | Oligodeoxyribonucleotides - chemical synthesis | Oligodeoxyribonucleotides - chemistry | Thymine | Substrate Specificity | Kinetics | Uracil | Ribonuclease H - metabolism
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 10/2002, Volume 80, Issue 10, p. 951
  The design of new antisense oligomers with improved binding affinity for targeted RNA, while still activating RNase H, is a major research area in medicinal... 
Proteins | Oligonucleotides | Genetics | Research
Journal Article
Nucleosides, Nucleotides and Nucleic Acids, ISSN 1525-7770, 10/2003, Volume 22, Issue 5-8, pp. 1339 - 1342
Interesting and very promising antisense properties of 2′-deoxy-2′-fluoroarabinonucleic acids ((a) Wilds, C.J.; Damha, M.J.... 
Nucleoside synthesis | Guanine arabinonucleoside
Journal Article
Nucleosides, Nucleotides and Nucleic Acids, ISSN 1525-7770, 10/2003, Volume 22, Issue 5-8, pp. 1251 - 1254
We present procedures for nucleoside and oligonucleotide synthesis, binding affinity (T m ) and structural analysis (CD spectra) of 2′-deoxy-2′,2″-difluoro- α... 
α | β | Anomers | Oligonucleotide | 2′-Deoxy-2′-2″-difluorothymidine | Thermal stability | / | Circular dichroism
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 2002, Volume 80, Issue 10, pp. 951 - 961
Journal Article
Journal of nature and science, ISSN 2377-2700, 2016, Volume 2, Issue 4
Probing of biomolecular complexes by single-molecule force spectroscopy (SMFS) methods including AFM requires proper and suitable coupling methods for... 
Journal Article
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