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by Thompson, Eric M, MD and Hielscher, Thomas, MSc and Bouffet, Eric, Prof and Remke, Marc, MD and Luu, Betty, BSc and Gururangan, Sridharan, Prof and McLendon, Roger E, Prof and Bigner, Darell D, Prof and Lipp, Eric S, MD and Perreault, Sebastien, MD and Cho, Yoon-Jae, MD and Grant, Gerald, MD and Kim, Seung-Ki, Prof and Lee, Ji Yeoun, MD and Rao, Amulya A Nageswara, MD and Giannini, Caterina, Prof and Li, Kay Ka Wai, MD and Ng, Ho-Keung, Prof and Yao, Yu, MD and Kumabe, Toshihiro, MD and Tominaga, Teiji, Prof and Grajkowska, Wieslawa A, Prof and Perek-Polnik, Marta, Prof and Low, David C Y, MBBCh and Seow, Wan Tew, MBBS and Chang, Kenneth T E, MBBCh and Mora, Jaume, Prof and Pollack, Ian F, Prof and Hamilton, Ronald L, MD and Leary, Sarah, MD and Moore, Andrew S, PhD and Ingram, Wendy J, PhD and Hallahan, Andrew R, MBBS and Jouvet, Anne, MD and Fèvre-Montange, Michelle, PhD and Vasiljevic, Alexandre, MD and Faure-Conter, Cecile, MD and Shofuda, Tomoko, PhD and Kagawa, Naoki, MD and Hashimoto, Naoya, MD and Jabado, Nada, MD and Weil, Alexander G, MD and Gayden, Tenzin, PhD and Wataya, Takafumi, MD and Shalaby, Tarek, MD and Grotzer, Michael, Prof and Zitterbart, Karel, PhD and Sterba, Jaroslav, Prof and Kren, Leos, MD and Hortobágyi, Tibor, Prof and Klekner, Almos, PhD and László, Bognár, Prof and Pócza, Tímea, MSc and Hauser, Peter, MD and Schüller, Ulrich, MD and Jung, Shin, Prof and Jang, Woo-Youl, MD and French, Pim J, Prof and Kros, Johan M, Prof and van Veelen, Marie-Lise C, MD and Massimi, Luca, MD and Leonard, Jeffrey R, Prof and Rubin, Joshua B, MD and Vibhakar, Rajeev, MD and Chambless, Lola B, MD and Cooper, Michael K, MD and Thompson, Reid C, Prof and Faria, Claudia C, MD and Carvalho, Alice, MD and Nunes, Sofia, MD and Pimentel, José, MD and Fan, Xing, MD and Muraszko, Karin M, Prof and López-Aguilar, Enrique, MD and Lyden, David, Prof and Garzia, Livia, PhD and Shih, David J H, PhD and Kijima, Noriyuki, MD and Schneider, Christian, MD and Adamski, Jennifer, PhD and Northcott, Paul A, PhD and Kool, Marcel, PhD and Jones, David T W, PhD and Chan, Jennifer A, MD and Nikolic, Ana, MD and Garre, Maria Luisa, MD and Van Meir, Erwin G, Prof and Osuka, Satoru, MD and Olson, Jeffrey J, Prof and Jahangiri, Arman, BSc and Castro, Brandyn A, BSc and Gupta, Nalin, MD and Weiss, William A, Prof and Moxon-Emre, Iska, MSc and Mabbott, Donald J, PhD and Lassaletta, Alvaro, MD and Hawkins, Cynthia E, Prof and Tabori, Uri, MD and Drake, James, Prof and Kulkarni, Abhaya, Prof and ...
Lancet Oncology, The, ISSN 1470-2045, 2016, Volume 17, Issue 4, pp. 484 - 495
Journal Article
BMC Cancer, ISSN 1471-2407, 03/2012, Volume 12, Issue 1, pp. 80 - 80
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 3/2013, Volume 125, Issue 3, pp. 373 - 384
Journal Article
International Journal of Cancer, ISSN 0020-7136, 10/2012, Volume 131, Issue 8, pp. 1800 - 1809
Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 that catalyzes the trimethylation of histone H3 on Lys 27, and... 
polycomb repressive complex 2 | histone lysine methylation | DZNEP | medulloblastoma | EZH2 | PROSTATE | METHYLATION | CANCER | TUMORS | THERAPY | GENE | ONCOLOGY | MYC | PHARMACOLOGICAL DISRUPTION | EXPRESSION | RNA, Small Interfering - genetics | Luciferases - metabolism | Apoptosis - drug effects | Humans | Case-Control Studies | DNA Copy Number Variations | DNA-Binding Proteins - metabolism | DNA Methylation | Flow Cytometry | Neoplastic Stem Cells - metabolism | Medulloblastoma - pathology | Neoplastic Stem Cells - pathology | Colony-Forming Units Assay | Cerebellar Neoplasms - pathology | Tumor Cells, Cultured | Medulloblastoma - genetics | Spheroids, Cellular | Child | Cerebellar Neoplasms - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Cerebellum - metabolism | Transcription Factors - antagonists & inhibitors | Medulloblastoma - metabolism | Adenosine - pharmacology | Cerebellar Neoplasms - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Blotting, Western | Enhancer of Zeste Homolog 2 Protein | Transcription Factors - metabolism | Polycomb Repressive Complex 2 | Cell Differentiation - drug effects | Adenosine - analogs & derivatives | Adolescent | Cell Proliferation - drug effects | Histones - metabolism | Cell Cycle - drug effects | Cell Transformation, Neoplastic - pathology | Oncology, Experimental | Children's hospitals | Genes | Brain tumors | Research | Genetic transcription | Stem cell research | Lysine | Medulloblastoma | Stem cells | Universities and colleges | Methylation | Cancer | Biomarkers | Cell growth | Cancer therapies | Tumors | Polycomb repressive complex 2
Journal Article
by Cavalli, Florence M.G and Remke, Marc and Rampasek, Ladislav and Peacock, John and Shih, David J.H and Luu, Betty and Garzia, Livia and Torchia, Jonathon and Nor, Carolina and Morrissy, A. Sorana and Agnihotri, Sameer and Thompson, Yuan Yao and Kuzan-Fischer, Claudia M and Farooq, Hamza and Isaev, Keren and Daniels, Craig and Cho, Byung-Kyu and Kim, Seung-Ki and Wang, Kyu-Chang and Lee, Ji Yeoun and Grajkowska, Wieslawa A and Perek-Polnik, Marta and Vasiljevic, Alexandre and Faure-Conter, Cecile and Jouvet, Anne and Giannini, Caterina and Nageswara Rao, Amulya A and Li, Kay Ka Wai and Ng, Ho-Keung and Eberhart, Charles G and Pollack, Ian F and Hamilton, Ronald L and Gillespie, G. Yancey and Olson, James M and Leary, Sarah and Weiss, William A and Lach, Boleslaw and Chambless, Lola B and Thompson, Reid C and Cooper, Michael K and Vibhakar, Rajeev and Hauser, Peter and van Veelen, Marie-Lise C and Kros, Johan M and French, Pim J and Ra, Young Shin and Kumabe, Toshihiro and López-Aguilar, Enrique and Zitterbart, Karel and Sterba, Jaroslav and Finocchiaro, Gaetano and Massimino, Maura and Van Meir, Erwin G and Osuka, Satoru and Shofuda, Tomoko and Klekner, Almos and Zollo, Massimo and Leonard, Jeffrey R and Rubin, Joshua B and Jabado, Nada and Albrecht, Steffen and Mora, Jaume and Van Meter, Timothy E and Jung, Shin and Moore, Andrew S and Hallahan, Andrew R and Chan, Jennifer A and Tirapelli, Daniela P.C and Carlotti, Carlos G and Fouladi, Maryam and Pimentel, José and Faria, Claudia C and Saad, Ali G and Massimi, Luca and Liau, Linda M and Wheeler, Helen and Nakamura, Hideo and Elbabaa, Samer K and Perezpeña-Diazconti, Mario and Chico Ponce de León, Fernando and Robinson, Shenandoah and Zapotocky, Michal and Lassaletta, Alvaro and Huang, Annie and Hawkins, Cynthia E and Tabori, Uri and Bouffet, Eric and Bartels, Ute and Dirks, Peter B and Rutka, James T and Bader, Gary D and Reimand, Jüri and Goldenberg, Anna and Ramaswamy, Vijay and Taylor, Michael D
Cancer Cell, ISSN 1535-6108, 06/2017, Volume 31, Issue 6, pp. 737 - 754.e6
Journal Article
by Remke, Marc and Ramaswamy, E.A and Peacock, Munro and Shih, David J and Koelsche, Christian and Northcott, Paul A and Hill, Nadia and Cavalli, Silvia and Kool, Marcel and Wang, Xin and Mack, Stephen and Barszczyk, Mark and Morrissy, A. Sorana and Wu, Xiaochong and Agnihotri, Sameer and Luu, Phan and Jones, David and Garzia, Livia and Dubuc, Aian and Zhukova, Nataliya and Vanner, Robert and Kros, Johan and French, Pim and Meir, Erwin and Vibhakar, Rajeev and Zitterbart, Karel and Chan, Jennifer and Bognár, László and Klekner, Almos and Lach, Boleslaw and Jung, Shin and Saad, Fred and Liau, Linda and Albrecht, Steffen and Zollo, Maurizio and Cooper, Michael and Thompson, Reid and Delattre, Olivier and Bourdeaut, Franck and Doz, François and Garami, Miklós and Hauser, Peter and Carlotti, Carlos and Van Meter, Timothy and Massimi, Luca and Fults, Daniel and Pomeroy, Laura and Kumabe, Toshiro and Ra, Young Shin and Leonard, Jeffrey and Elbabaa, Samer and Mora, Jaume and Rubin, Joshua and Cho, Yoon-Jae and McLendon, Roger and Bigner, Darell and Eberhart, Charles and Fouladi, Maryam and Wechsler-Reya, Robert and Faria, Rui and Croul, Sidney and Huang, Anding and Bouffet, Eric and Hawkins, Cynthia and Dirks, Maaike and Weiss, William and Schüller, Ulrich and Pollack, Aaron and Rutkowski, Piotr and Meyronet, David and Jouvet, Anne and Fèvre-Montange, Michelle and Jabado, Nada and Perek-Polnik, Marta and Grajkowska, Wieslawa and Kim, Seung-Ki and Rutka, James and Malkin, Elissa and Tabori, Uri and Pfister, Stefan and Korshunov, Aney and Deimling, Aneas and Taylor, Michael
Acta neuropathologica, ISSN 0001-6322, 10/2013, Volume 126, Issue 6, pp. 917 - 929
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 5829 - 17
..., Elias P. Rosen 6, Rajeev Vibhakar7,8, Jiao Zhang9,10, Olivier Saulnier 9,10, Maria Vladoiu9,10, Ibrahim El-Hamamy11,12, Lincoln D. Stein11,12, Michael D. Taylor... 
CELLS | HEDGEHOG PATHWAY | VISMODEGIB | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | GROWTH | CEREBELLUM | PROLIFERATION | MATH1 EXPRESSION | PRECURSORS | BRAIN | Anilides - therapeutic use | MyoD Protein - genetics | Neoplastic Stem Cells - drug effects | Humans | Male | Smoothened Receptor - genetics | Hedgehog Proteins - genetics | Medulloblastoma - pathology | Female | Cerebellar Neoplasms - pathology | Gain of Function Mutation | Medulloblastoma - genetics | Single-Cell Analysis | Molecular Targeted Therapy - methods | Pyridines - therapeutic use | Cell Proliferation - genetics | Cerebellar Neoplasms - drug therapy | Mice, Transgenic | Signal Transduction - genetics | Cerebellar Neoplasms - genetics | Hedgehog Proteins - antagonists & inhibitors | Cerebellum - pathology | Drug Resistance, Neoplasm - genetics | Animals | Signal Transduction - drug effects | Transcription Factor HES-1 - genetics | RNA-Seq | Anilides - pharmacology | Cerebellum - cytology | Cell Proliferation - drug effects | Mice | Pyridines - pharmacology | Medulloblastoma - drug therapy | Therapy | Brain tumors | Transgenic mice | Ribonucleic acid--RNA | Cell differentiation | Neuronal-glial interactions | Heterogeneity | Cell activation | Inhibitors | Pathways | Hedgehog protein | Medulloblastoma | Stromal cells | Stem cells | Mutation | Differentiation | Tumors
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2013, Volume 288, Issue 3, pp. 1918 - 1928
Journal Article
Journal Article
by Northcott, Paul A and Shih, David J. H and Peacock, John and Garzia, Livia and Sorana Morrissy, A and Zichner, Thomas and Stútz, Adrian M and Korshunov, Andrey and Reimand, Júri and Schumacher, Steven E and Beroukhim, Rameen and Ellison, David W and Marshall, Christian R and Lionel, Anath C and MacK, Stephen and Dubuc, Adrian and Yao, Yuan and Ramaswamy, Vijay and Luu, Betty and Rolider, Adi and Cavalli, Florence M. G and Wang, Xin and Remke, Marc and Wu, Xiaochong and Chiu, Readman Y. B and Chu, Andy and Chuah, Eric and Corbett, Richard D and Hoad, Gemma R and Jackman, Shaun D and Li, Yisu and Lo, Allan and Mungall, Karen L and Ming Nip, Ka and Qian, Jenny Q and Raymond, Anthony G. J and Thiessen, Nina and Varhol, Richard J and Birol, Inanc and Moore, Richard A and Mungall, Andrew J and Holt, Robert and Kawauchi, Daisuke and Roussel, Martine F and Kool, Marcel and Jones, David T. W and Witt, Hendrick and Fernandez-L, Africa and Kenney, Anna M and Wechsler-Reya, Robert J and Dirks, Peter and Aviv, Tzvi and Grajkowska, Wieslawa A and Perek-Polnik, Marta and Haberler, Christine C and Delattre, Olivier and Reynaud, Stéphanie S and Doz, François F and Pernet-Fattet, Sarah S and Cho, Byung-Kyu and Kim, Seung-Ki and Wang, Kyu-Chang and Scheurlen, Wolfram and Eberhart, Charles G and Fèvre-Montange, Michelle and Jouvet, Anne and Pollack, Ian F and Fan, Xing and Muraszko, Karin M and Yancey Gillespie, G and Di Rocco, Concezio and Massimi, Luca and Michiels, Erna M. C and Kloosterhof, Nanne K and French, Pim J and Kros, Johan M and Olson, James M and Ellenbogen, Richard G and Zitterbart, Karel and Kren, Leos and Thompson, Reid C and Cooper, Michael K and Lach, Boleslaw and McLendon, Roger E and Bigner, Darell D and Fontebasso, Adam and Albrecht, Steffen and Jabado, Nada and Lindsey, Janet C and Bailey, Simon and Gupta, Nalin and Weiss, William A and Bognár, László and Klekner, Almos and Van Meter, Timothy E and Kumabe, Toshihiro and Tominaga, Teiji and Elbabaa, Samer K and Leonard, Jeffrey R and Rubin, Joshua B and ...
Nature, ISSN 0028-0836, 08/2012, Volume 487, Issue 7409, pp. 49 - 56
Journal Article