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Science, ISSN 0036-8075, 12/2017, Volume 358, Issue 6367, p. eaan4368
Kinase inhibitors are important cancer therapeutics. Polypharmacology is commonly observed, requiring thorough target deconvolution to understand drug... 
REFINEMENT | PROTEIN | CHEMICAL PROTEOMICS | INHIBITOR SELECTIVITY | DATA QUALITY | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | INTEGRATIVE GENOMICS VIEWER | SALT-INDUCIBLE KINASES | CANCER | COMPREHENSIVE ANALYSIS | fms-Like Tyrosine Kinase 3 - antagonists & inhibitors | Lung Neoplasms - drug therapy | Lung Neoplasms - enzymology | Cytokines - metabolism | Humans | Drug Discovery - methods | Antineoplastic Agents - chemistry | Molecular Targeted Therapy | Xenograft Model Antitumor Assays | Leukemia, Myeloid, Acute - enzymology | Protein Kinase Inhibitors - chemistry | Animals | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Line, Tumor | Leukemia, Myeloid, Acute - drug therapy | Antineoplastic Agents - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Proteomics - methods | Salts | Target recognition | Lung cancer | Selectivity | Drug development | Cancer therapies | Signal transduction | Biomolecules | Protein-tyrosine kinase | Tyrosine | Medical research | Imatinib | Decision making | Medical treatment | Mass spectroscopy | Tumor necrosis factor-α | Embryos | Bruton's tyrosine kinase | Mode of action | Side effects | Inhibitors | Interleukin 10 | Affinity | Drug discovery | Mass spectrometry | Acute myeloid leukemia | Drugs | Deregulation | Leukemia | Interleukin | Medical services | Clinical trials | Leucine | Kinases | Biological effects | Epidermal growth factor | Salt-inducible kinase | Xenografts | Cell survival | Epidermal growth factor receptors | Research & development--R&D | Therapeutic applications | Myeloid leukemia | Markers | Data processing | Lead compounds | Leucine zipper proteins | Signaling | Proteomics | Cancer | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2017, Volume 23, Issue 1, pp. 69 - 78
In acute myeloid leukemia (AML), therapy resistance frequently occurs, leading to high mortality among patients. However, the mechanisms that render leukemic... 
TRANSFORMATION | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | SOMATIC MUTATIONS | CELL BIOLOGY | THERAPY | GENE EZH2 | DIFFERENTIATION | INHIBITOR | EXPRESSION | Immunohistochemistry | CDC2 Protein Kinase | Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors | Neoplasm Transplantation | Cyclin-Dependent Kinases - metabolism | Cytarabine - pharmacology | Immunoprecipitation | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Bortezomib - pharmacology | Gene Knockdown Techniques | Young Adult | Flow Cytometry | Mass Spectrometry | Aged, 80 and over | Leukemia, Myeloid, Acute - drug therapy | Adult | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Enhancer of Zeste Homolog 2 Protein - genetics | Enhancer of Zeste Homolog 2 Protein - metabolism | Blotting, Western | Homeodomain Proteins - genetics | Drug Resistance, Neoplasm - genetics | Protein Kinase Inhibitors | Animals | Proteomics | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Aged | Mice | Protein Processing, Post-Translational | Histones - metabolism | Proteasome Endopeptidase Complex - metabolism | Pyridones - pharmacology | Leukemia, Myeloid, Acute - genetics | Genetic aspects | Methyltransferases | Drug resistance | Health aspects | Drugs | Therapy | Hsp90 protein | Phosphorylation | Leukemia | Chemoresistance | Cytotoxicity | Kinases | Degradation | Proteins | Cytarabine | Restoration | Histone methyltransferase | HOX gene | Protein-tyrosine kinase | Tyrosine | Bortezomib | Myeloid leukemia | Heat shock proteins | Gene expression | Patients | Sensitivity | Inhibitors | Derepression | Cell lines | Proteasomes | Blast resistance | Methylation | Acute myeloid leukemia | Heat shock | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, pp. e0120925 - e0120925
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5378 - 13
Journal Article
世界胃肠病学杂志:英文版, ISSN 1007-9327, 2009, Volume 15, Issue 47, pp. 5924 - 5935
AIM:To analyze the effect of chemotherapeutic drugs and specific kinase inhibitors,in combination with the death receptor ligand tumor necrosis factor-related... 
RNA干扰 | TRAIL | 细胞凋亡基因 | 流式细胞仪 | 受体激酶 | PD98059 | 酶抑制剂 | 肿瘤坏死因子相关凋亡诱导配体 | 5-fluorouracil | c-Jun N-terminal kinase | BCL-xL | MCL-1 | Sorafenib | Phosphoinositol-3-kinase | Hepatocellular carcinoma | Tumor necrosis factor-related apoptosis inducing ligand | Doxorubicin | (Mitogen-activated protein kinase)/(extracellular signal regulated kinase) kinase | Apoptosis | BCL-XL | 3-KINASE/AKT PATHWAY | MEDIATED APOPTOSIS | RAF/MEK/ERK PATHWAY | CANCER-THERAPY | PROTEIN-KINASE CASCADE | CLINICAL-TRIALS | INHIBITOR | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Doxorubicin - therapeutic use | Humans | Liver Neoplasms - drug therapy | bcl-X Protein - genetics | Antineoplastic Agents - therapeutic use | Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism | TNF-Related Apoptosis-Inducing Ligand - metabolism | Enzyme Inhibitors - therapeutic use | Fluorouracil - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Carcinoma, Hepatocellular - drug therapy | Myeloid Cell Leukemia Sequence 1 Protein | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Liver Neoplasms - pathology | Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics | Apoptosis - physiology | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | TNF-Related Apoptosis-Inducing Ligand - genetics | Carcinoma, Hepatocellular - metabolism | Index Medicus | Mitogen-activated protein kinase | (extracellular signal regulated kinase) kinase | Original
Journal Article
世界胃肠病学杂志:英文版, ISSN 1007-9327, 2008, Volume 14, Issue 24, pp. 3829 - 3840
AIM: TO explore the role of Bcl-XL and Myeloid cell leukaemia (Mcl)-I for the apoptosis resistance of colorectal carcinoma (CRC) cells towards current... 
细胞凋亡 | Bcl-XL | 结肠直肠癌 | 5-fluorouracil | Irinotecan | Myeloid cell leukaemia-1 | Oxaliplatin | Bcl-x | Colorectal carcinoma | Epidermal growth factor receptor 1 | Apoptosis | Bcl-xL | Colorectal Cancer
Journal Article
Leukemia, ISSN 0887-6924, 06/2019
Acute myeloid leukemia (AML) is an aggressive hematologic neoplasm resulting from the malignant transformation of myeloid progenitors. Despite intensive... 
Journal Article
HAEMATOLOGICA, ISSN 0390-6078, 03/2019, Volume 104, Issue 3, pp. 546 - 555
Combination chemotherapy has proven to be a favorable strategy to treat acute leukemia. However, the introduction of novel compounds remains challenging and is... 
NETWORK | INDUCED APOPTOSIS | PROTEIN DISULFIDE-ISOMERASE | RESISTANCE | REDOX | MECHANISMS | INHIBITOR | HEMATOLOGY | REVEALS
Journal Article
BLOOD, ISSN 0006-4971, 07/2019, Volume 134, Issue 3, pp. 263 - 276
FLT3, DNMT3A, and NPM1 are the most frequently mutated genes in cytogenetically normal acute myeloid leukemia (AML), but little is known about how these... 
GENE-MUTATIONS | IMPACT | QUIESCENCE | TANDEM DUPLICATION | HES1 | ACUTE MYELOID-LEUKEMIA | IDENTIFICATION | HEMATOLOGY | TRANSPLANTATION | P57(KIP2) | BLOOD
Journal Article