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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2011, Volume 108, Issue 13, pp. 5449 - 5454
Journal Article
Journal Article
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7546, pp. 239 - 242
Non-small-cell lung cancer is the leading cause of cancer-related death worldwide(1). Chemotherapies such as the topoisomerase II (TopoII) inhibitor etoposide... 
SURVIVAL | ADENOCARCINOMA | MULTIDISCIPLINARY SCIENCES | COMPLEXES | SWI/SNF | GENE-EXPRESSION PROFILES | MUTATIONS | DRUG-COMBINATION | POLYCOMB | MICROARRAY DATA | CANCER CELL-LINES | Polycomb Repressive Complex 2 - antagonists & inhibitors | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Humans | Lung Neoplasms - pathology | Molecular Targeted Therapy | Antineoplastic Agents, Phytogenic - therapeutic use | Nuclear Proteins - genetics | DNA Helicases - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Lung Neoplasms - enzymology | Carcinoma, Non-Small-Cell Lung - genetics | Genes, erbB-1 - genetics | Etoposide - pharmacology | Etoposide - therapeutic use | Topoisomerase II Inhibitors - pharmacology | Transcription Factors - genetics | Anaphase - drug effects | Enhancer of Zeste Homolog 2 Protein | Topoisomerase II Inhibitors - therapeutic use | Xenograft Model Antitumor Assays | Animals | Cell Line, Tumor | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Antineoplastic Agents, Phytogenic - pharmacology | Cell Cycle - drug effects | Protein research | Care and treatment | Oncology, Experimental | Genetic aspects | Research | Lung cancer, Non-small cell | Drug therapy | Gene expression | Cancer | Proteins | Genes | Lung cancer | Genetic engineering | Mutation | Kinases | Cancer therapies | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Etoposide | Chemotherapy | EZH2 inhibition | BRG1 | EGFR
Journal Article
PLoS One, ISSN 1932-6203, 2011, Volume 6, Issue 1, pp. e16282 - e16282
Angiogenesis is a balanced process controlled by pro-and anti-angiogenic molecules of which the regulation is not fully understood. Besides classical gene... 
HISTONE METHYLTRANSFERASE ACTIVITY | OVEREXPRESSION | COMPLEX | ANGIOGENESIS | BIOLOGY | H3 LYSINE-27 METHYLATION | GROUP PROTEIN EZH2 | GENE-EXPRESSION | MICRORNAS | TUMOR-GROWTH | CANCER | Endothelial Cells - metabolism | Humans | Angiogenic Proteins - physiology | Cells, Cultured | Transcription Factors - biosynthesis | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Down-Regulation - genetics | Enhancer of Zeste Homolog 2 Protein | Polycomb Repressive Complex 2 | Animals | Mice | MicroRNAs - genetics | Histones - metabolism | Methylation | DNA-Binding Proteins - biosynthesis | Vascular Endothelial Growth Factor A - physiology | Endothelial Cells - physiology | Neovascularization, Physiologic | Epigenetic inheritance | Enzymes | MicroRNA | Gliomas | Genes | Neovascularization | Genetic transcription | Health aspects | Vascular endothelial growth factor | Endothelium | Post-transcription | Pediatrics | Regulations | Regulators | Neurosciences | Chromatin | Toxicity | Gene regulation | Glioblastoma | Methyltransferase | Multiple myeloma | Oncology | Neurosurgery | Blood | Medical schools | Vascularization | Proteins | Angiogenesis | Cell growth | Inhibition | Medical research | Hematology | Blood vessels | Cultures | siRNA | Breast cancer | Gene expression | Endothelial cells | Polycomb group proteins | Gene silencing | Neurology | Signaling | Brain research | Lysine | Stem cells | Aberration | Bayesian analysis | Histone H3 | Index Medicus | Medical Biotechnology | Medical and Health Sciences | Medicin och hälsovetenskap | Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) | Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) | Medicinsk bioteknologi
Journal Article
Scientific Reports, ISSN 2045-2322, 2013, Volume 3, Issue 1, pp. 1911 - 1911
Journal Article
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 04/2013, Volume 72, Issue 4, pp. 614 - 620
Objectives Epigenetic modifications such as DNA methylation and histone acetylation have been implicated in the pathogenesis of systemic sclerosis. However,... 
SCLERODERMA FIBROBLASTS | METHYLATION | EPIGENETICS | COLLAGEN EXPRESSION | DISEASE | EXTRACELLULAR-MATRIX | MECHANISMS | RHEUMATOLOGY | SYSTEMIC-SCLEROSIS | PREVENTS | T-CELLS | Scleroderma, Diffuse - metabolism | Fibroblasts - enzymology | Antibiotics, Antineoplastic - pharmacology | Humans | Middle Aged | Male | Fibrosis - metabolism | Epigenesis, Genetic - physiology | Young Adult | Scleroderma, Diffuse - pathology | Fos-Related Antigen-2 - metabolism | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Scleroderma, Diffuse - chemically induced | Adult | Mice, Inbred DBA | Epigenesis, Genetic - drug effects | DNA Methylation - physiology | Disease Models, Animal | Fibrosis - chemically induced | Cells, Cultured | Enzyme Inhibitors - pharmacology | Fibroblasts - pathology | Collagen - metabolism | Animals | Bleomycin - pharmacology | Dermis - pathology | Mice | Fibrosis - pathology | Histones - metabolism | DNA Methylation - drug effects | Jumonji Domain-Containing Histone Demethylases - metabolism | Care and treatment | Fibrosis | Histones | Influence | Genetic aspects | Research | Methylation | Chromatin | Immunoglobulins | Disease | Pathogenesis | Gene expression | Experiments | Proteins | Studies | Biopsy | Collagen | DNA methylation | Epigenetics | Fibroblasts | Extracellular matrix | Deoxyribonucleic acid--DNA | Cancer | Index Medicus
Journal Article
International Journal of Cancer, ISSN 0020-7136, 10/2012, Volume 131, Issue 8, pp. 1800 - 1809
Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 that catalyzes the trimethylation of histone H3 on Lys 27, and... 
polycomb repressive complex 2 | histone lysine methylation | DZNEP | medulloblastoma | EZH2 | PROSTATE | METHYLATION | CANCER | TUMORS | THERAPY | GENE | ONCOLOGY | MYC | PHARMACOLOGICAL DISRUPTION | EXPRESSION | RNA, Small Interfering - genetics | Luciferases - metabolism | Apoptosis - drug effects | Humans | Case-Control Studies | DNA Copy Number Variations | DNA-Binding Proteins - metabolism | DNA Methylation | Flow Cytometry | Neoplastic Stem Cells - metabolism | Medulloblastoma - pathology | Neoplastic Stem Cells - pathology | Colony-Forming Units Assay | Cerebellar Neoplasms - pathology | Tumor Cells, Cultured | Medulloblastoma - genetics | Spheroids, Cellular | Child | Cerebellar Neoplasms - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Cerebellum - metabolism | Transcription Factors - antagonists & inhibitors | Medulloblastoma - metabolism | Adenosine - pharmacology | Cerebellar Neoplasms - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Blotting, Western | Enhancer of Zeste Homolog 2 Protein | Transcription Factors - metabolism | Polycomb Repressive Complex 2 | Cell Differentiation - drug effects | Adenosine - analogs & derivatives | Adolescent | Cell Proliferation - drug effects | Histones - metabolism | Cell Cycle - drug effects | Cell Transformation, Neoplastic - pathology | Oncology, Experimental | Children's hospitals | Genes | Brain tumors | Research | Genetic transcription | Stem cell research | Lysine | Medulloblastoma | Stem cells | Universities and colleges | Methylation | Cancer | Biomarkers | Cell growth | Cancer therapies | Tumors | Index Medicus | Polycomb repressive complex 2
Journal Article