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Personalized Medicine, ISSN 1741-0541, 08/2015, Volume 12, Issue 4, pp. 403 - 415
The recognition that individuals respond differently to the same medication is not new and dates almost to the founding of western medicine. In the last... 
hemophilia | protein therapeutics | coagulation factors | personalized dosing | immunogenicity | pharmacogenetics | ANTIBODIES | RECOMBINANT FACTOR-VIII | PLASMA | PHARMACOKINETICS | FACTOR-IX | MILD HEMOPHILIA | PHARMACOLOGY & PHARMACY | INHIBITORS | FVIII | Proteins | Antigens | Genealogy | Peptides | Precision medicine | Genes | Population | Patients
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2013, Volume 110, Issue 33, pp. 13481 - 13486
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2013, Volume 110, Issue 33, p. 13481
  Synonymous mutations, which do not alter the protein sequence, have been shown to affect protein function [Sauna ZE, Kimchi-Sarfaty C (2011) Nat Rev Genet... 
Proteins | RNA-protein interactions | Genomics | Melanoma | Mutation | Apoptosis | Cancer
Journal Article
Molecular Therapy - Methods & Clinical Development, ISSN 2329-0501, 09/2018, Volume 10, pp. 105 - 112
The repurposing of the CRISPR/Cas microbial adaptive immune system for gene editing has resulted in an exponential rise in new technologies and promising... 
drug development | anti-drug antibodies | CRISPR/Cas9 | pre-existing antibodies | gene editing | immunogenicity | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNOGENICITY | IMPACT | STAPHYLOCOCCUS-AUREUS | IN-VIVO | DELIVERY | Proteins | CRISPR | Immunoglobulins | Immune response | Antibodies | Population | Genomes | Nuclease | Enzyme-linked immunosorbent assay
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, p. e0132433
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 21, pp. 3349 - 3349
Abstract Abstract 3349 Introduction: The protease ADAMTS13 (A Disintegrin and Metalloprotease with Thrombo Spondin type 1 repeat) cleaves multimers of von... 
Journal Article
Journal Article
Blood, ISSN 0006-4971, 11/2010, Volume 116, Issue 21, pp. 2197 - 2197
Abstract Abstract 2197 Hemophilia B is characterized by structural and functional defects in coagulation factor IX (FIX) caused by mutations in the F9 gene.... 
Journal Article
PLoS ONE, 07/2015, Volume 10, Issue 7
Hemophilia A (HA) is a bleeding disorder caused by deficiency of functional plasma clotting factor VIII (FVIII). Genetic mutations in the gene encoding FVIII... 
Journal Article
Journal Article
Blood, ISSN 0006-4971, 11/2006, Volume 108, Issue 11, pp. 2518 - 2518
Abstract CD30 is a transmembrane receptor which is selectively overexpressed on Hodgkin lymphoma and large cell anaplastic lymphoma and therefore an... 
Journal Article