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Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 07/2019, Volume 15, Issue 7, pp. P994 - P994
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 9, pp. 3510 - 3515
A 30-d course of oral administration of a semipurif ied extract of the root of Withania somnifera consisting predominantly of withanolides and withanosides... 
Oligomers | Anger | Pathology | Brain | Messenger RNA | Liver | Medical treatment | LDL lipoproteins | Amyloids | Alzheimers disease | Herbal extract | Neurodegenerative disease | Dementia | CLEARANCE | neurodegenerative disease | MEMORY | MULTIDISCIPLINARY SCIENCES | herbal extract | AMYLOID-BETA-PEPTIDE | dementia | BLOOD-BRAIN-BARRIER | SYNAPTIC PLASTICITY | STRATEGIES | Up-Regulation | Liver - pathology | Male | Low Density Lipoprotein Receptor-Related Protein-1 - physiology | Low Density Lipoprotein Receptor-Related Protein-1 - genetics | Neprilysin - biosynthesis | Amyloid beta-Peptides - blood | Alzheimer Disease - pathology | Brain - metabolism | Liver - drug effects | Microglia - pathology | Neprilysin - genetics | Phytotherapy | Drug Evaluation, Preclinical | Neprilysin - physiology | Disease Models, Animal | Oligonucleotides, Antisense - pharmacology | Microglia - drug effects | Plaque, Amyloid - pathology | Administration, Oral | Liver - metabolism | Alzheimer Disease - drug therapy | Presenilin-1 - genetics | Mice, Transgenic | Plant Extracts - isolation & purification | Low Density Lipoprotein Receptor-Related Protein-1 - biosynthesis | Maze Learning - drug effects | Organ Specificity | Brain - drug effects | Amyloid beta-Protein Precursor - genetics | Animals | Plant Roots - chemistry | Brain - pathology | Mice | Plant Extracts - therapeutic use | Alzheimer Disease - blood | Withania - chemistry | Prevention | Physiological aspects | Alzheimer's disease | Health aspects | Low density lipoproteins | Biological Sciences
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 08/2016, Volume 25, Issue 5, pp. 252 - 267
Aims: This study investigates the role of thiol homeostasis disruption in Parkinson's disease (PD) pathogenesis using a novel animal model. A single unilateral... 
Original Research Communications | OXIDIZING AGENT | MITOCHONDRIAL COMPLEX-I | TYROSINE-HYDROXYLASE | GLUTATHIONE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | NEURONS | ALPHA-SYNUCLEIN | STRESS | SUBSTANTIA-NIGRA | TRANSGENIC MICE | CELL-DEATH | Substantia Nigra - pathology | Dopaminergic Neurons - pathology | Glutathione - metabolism | Diamide - pharmacology | Male | Substantia Nigra - metabolism | Parkinsonian Disorders - etiology | Parkinsonian Disorders - metabolism | Sulfhydryl Compounds - metabolism | Dopaminergic Neurons - metabolism | Dopaminergic Neurons - drug effects | Parkinson Disease - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | MAP Kinase Kinase Kinase 5 - metabolism | Dopamine - metabolism | Disease Models, Animal | Locomotion - drug effects | Diamide - administration & dosage | Cell Line | Parkinson Disease - pathology | Substantia Nigra - drug effects | Animals | MAP Kinase Signaling System - drug effects | Parkinsonian Disorders - pathology | Mice | alpha-Synuclein - metabolism | Parkinson Disease - etiology | Usage | Parkinson's disease | Thiols | Research | Analysis | Basal ganglia | Animal models | Mesencephalon | Pathogenesis | Substantia nigra | Parkinsons disease | Innovations | Homeostasis | Kinases | Synuclein | Fibers | Proteins | Signal transduction | Neurodegeneration | Cascades | Neostriatum | Oxidation | Degeneration | Grip strength | Movement disorders | Glutathione | Dopamine receptors | Phenotypes | Dopamine | Neurodegenerative diseases | Neurons | Central nervous system diseases | MAP kinase | Locomotion | Signaling | Protein kinase | Cell death | Parathyroid hormone
Journal Article
Journal Article
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 07/2019, Volume 15, Issue 7, pp. P1324 - P1324
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 10/2015, Volume 87, pp. 312 - 325
Activation of apoptosis signal-regulating kinase 1 (ASK1)–p38 MAPK death signaling cascade is implicated in the death of dopaminergic neurons in substantia... 
Oxidative stress | Graph theory | Thiols | Cell death | Neurodegeneration | Oxidativestress | SUBSTANTIA-NIGRA LEADS | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOPAMINERGIC-NEURONS | NUCLEAR TRANSLOCATION | S-TRANSFERASE-MU | HEMIPARKINSONIAN RATS | MITOCHONDRIAL COMPLEX-I | ENDOCRINOLOGY & METABOLISM | REGULATING KINASE-1 | TREATED MICE | TRANSGENIC MICE | Tumor Necrosis Factor-alpha - metabolism | Antibodies, Neutralizing - administration & dosage | Substantia Nigra - pathology | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - administration & dosage | Dopaminergic Neurons - pathology | Mesencephalon - metabolism | Humans | Parkinson Disease - drug therapy | Substantia Nigra - metabolism | Corpus Striatum - metabolism | Dopaminergic Neurons - metabolism | Tumor Necrosis Factor-alpha - immunology | Dopaminergic Neurons - drug effects | Mesencephalon - drug effects | Thioredoxins - metabolism | Parkinson Disease - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | MAP Kinase Kinase Kinase 5 - metabolism | Corpus Striatum - pathology | Disease Models, Animal | Mesencephalon - pathology | Parkinson Disease - pathology | Substantia Nigra - drug effects | Animals | MAP Kinase Signaling System - drug effects | Corpus Striatum - drug effects | Mice | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Neurosciences | Parkinson's disease | Tumor necrosis factor | Glutathione transferase | Analysis | Oxidation-reduction reaction | Thioredoxin | Cytokines | Antibodies | Viral antibodies | GABA | Mitogens | Protein kinases | Integrins | Protein binding
Journal Article
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 07/2018, Volume 14, Issue 7, pp. P750 - P750
Journal Article
FASEB Journal, ISSN 0892-6638, 07/2007, Volume 21, Issue 9, pp. 2226 - 2236
Parkinson's disease (PD), a neurodegenerative disorder, causes severe motor impairment due to loss of dopaminergic neurons in substantia nigra pars compacta... 
Oxidative stress | DJ-1 | MPTP | Cell death | MAPK signaling | cell death | VIVO | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEURODEGENERATION | S-THIOLATION | CELL-DEATH | CELL BIOLOGY | BRAIN MITOCHONDRIA | MITOCHONDRIAL COMPLEX-I | AMINO-ACIDS | THIOREDOXIN | BIOLOGY | oxidative stress | Oncogene Proteins - genetics | Male | Intracellular Signaling Peptides and Proteins - metabolism | Protein Transport - drug effects | Antiparkinson Agents - therapeutic use | Cell Nucleus - metabolism | Neuroprotective Agents - pharmacology | Glutathione - analysis | Parkinsonian Disorders - drug therapy | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacokinetics | Neurons - chemistry | Thioctic Acid - pharmacology | Mesencephalon - chemistry | Electron Transport Complex I - drug effects | Peroxiredoxins | Protein Deglycase DJ-1 | Glycine - pharmacology | MPTP Poisoning - metabolism | Cytosol - metabolism | Mice | Neuroprotective Agents - therapeutic use | Glycine - analogs & derivatives | Neurons - pathology | Phosphorylation | Antiparkinson Agents - pharmacology | JNK Mitogen-Activated Protein Kinases - metabolism | Substantia Nigra - metabolism | Parkinsonian Disorders - metabolism | MAP Kinase Kinase 4 - metabolism | Protein Processing, Post-Translational - drug effects | Biotransformation | Oncogene Proteins - biosynthesis | Alkynes - pharmacology | MAP Kinase Kinase Kinase 5 - metabolism | Drug Evaluation, Preclinical | Dopamine - analysis | Mice, Inbred C57BL | Nuclear Proteins - metabolism | Antioxidants - pharmacology | Enzyme Activation - drug effects | MPTP Poisoning - drug therapy | Cystathionine gamma-Lyase - antagonists & inhibitors | Nerve Tissue Proteins - metabolism | Antioxidants - therapeutic use | Substantia Nigra - drug effects | Animals | Carrier Proteins - metabolism | MAP Kinase Signaling System - drug effects | Acetylcysteine - pharmacology | Thioctic Acid - therapeutic use
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 07/2017, Volume 13, Issue 7
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 07/2017, Volume 13, Issue 7, pp. P1004 - P1005
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 01/2018, Volume 38, Issue 5, pp. 1085 - 1099
Dendritic spine loss is recognized as an early feature of Alzheimer's disease (AD), but the underlying mechanisms are poorly understood. Dendritic spine... 
neurodegenerative disease | cognition | cytoskeleton | AMYLOID-PRECURSOR-PROTEIN | OPTICAL RECONSTRUCTION MICROSCOPY | SYNAPTIC PLASTICITY | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | STAIN-FREE TECHNOLOGY | OLDER PERSONS | LOCALIZATION MICROSCOPY | MOUSE MODEL | DYNAMICS | dementia | LOADING CONTROL
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 07/2019, Volume 15, Issue 7, pp. P1011 - P1011
Journal Article
Alzheimer's & Dementia, ISSN 1552-5260, 07/2019, Volume 15, Issue 7, p. P302
Journal Article
Journal Article