X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (24) 24
humans (20) 20
cystic fibrosis (19) 19
cell biology (18) 18
inflammation (18) 18
cftr (16) 16
animals (15) 15
autophagy (15) 15
tissue transglutaminase (14) 14
mice (13) 13
cystic fibrosis transmembrane conductance regulator - genetics (9) 9
cystic fibrosis transmembrane conductance regulator - metabolism (9) 9
female (9) 9
immunology (8) 8
oxidative stress (8) 8
activation (7) 7
adolescent (7) 7
biochemistry & molecular biology (7) 7
celiac disease (7) 7
cystic-fibrosis (7) 7
digestive system diseases (7) 7
male (7) 7
pediatrics (7) 7
transglutaminase 2 (7) 7
adult (6) 6
disease models, animal (6) 6
mutation (6) 6
protein (6) 6
respiratory system (6) 6
t-cells (6) 6
transmembrane conductance regulator (6) 6
young adult (6) 6
cell line (5) 5
child (5) 5
congenital, hereditary, and neonatal diseases and abnormalities (5) 5
cystic fibrosis - drug therapy (5) 5
cystic fibrosis - genetics (5) 5
life sciences (5) 5
medicine, research & experimental (5) 5
proteins (5) 5
reactive oxygen species - metabolism (5) 5
transglutaminases - metabolism (5) 5
autophagy - drug effects (4) 4
beclin-1 (4) 4
biology (4) 4
cystamine - pharmacology (4) 4
cystic fibrosis - immunology (4) 4
cystic fibrosis - metabolism (4) 4
cystic fibrosis - pathology (4) 4
cystic fibrosis transmembrane conductance regulator - antagonists & inhibitors (4) 4
disease (4) 4
epithelial cells - pathology (4) 4
epithelial stress (4) 4
gliadin (4) 4
gluten (4) 4
immune response (4) 4
inhibition (4) 4
intestinal epithelial-cells (4) 4
intestine (4) 4
lung inflammation (4) 4
membrane proteins - metabolism (4) 4
mice, inbred cftr (4) 4
patients (4) 4
peptides (4) 4
proteostasis (4) 4
respiratory tract diseases (4) 4
sequestosome-1 protein (4) 4
abridged index medicus (3) 3
adaptor proteins, signal transducing - metabolism (3) 3
aggresomes (3) 3
apoptosis regulatory proteins - metabolism (3) 3
article (3) 3
autoimmunity (3) 3
beclin 1 (3) 3
binding (3) 3
celiac-disease (3) 3
cftr potentiator (3) 3
conductance (3) 3
cystamine - therapeutic use (3) 3
cysteamine (3) 3
drug repositioning (3) 3
endoplasmic-reticulum (3) 3
epithelial cells (3) 3
epithelial cells - drug effects (3) 3
epithelial cells - immunology (3) 3
epithelial cells - metabolism (3) 3
gtp-binding proteins (3) 3
in-vitro (3) 3
lung - pathology (3) 3
mice, inbred c57bl (3) 3
mice, knockout (3) 3
mice, transgenic (3) 3
models, biological (3) 3
mucosa (3) 3
neurodegenerative diseases (3) 3
permeability (3) 3
phagocytosis (3) 3
pharmacology & pharmacy (3) 3
physics (3) 3
plasma-membrane (3) 3
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature Cell Biology, ISSN 1465-7392, 09/2010, Volume 12, Issue 9, pp. 863 - 875
Accumulation of unwanted/misfolded proteins in aggregates has been observed in airways of patients with cystic fibrosis (CF), a life-threatening genetic... 
APOPTOSIS | UNFOLDED PROTEIN RESPONSE | BECLIN 1 | DOWN-REGULATION | ENDOPLASMIC-RETICULUM | MICE | GENE-TRANSFER | TISSUE TRANSGLUTAMINASE | NEURODEGENERATIVE DISEASES | CELL-DEATH | CELL BIOLOGY | Reactive Oxygen Species - metabolism | Respiratory Mucosa - drug effects | Sequestosome-1 Protein | Humans | Transglutaminases - genetics | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy - drug effects | Young Adult | Cystamine - therapeutic use | Inflammation - metabolism | Autophagy - genetics | Nasal Polyps - metabolism | Mice, Inbred CFTR | Respiratory Mucosa - cytology | Cystic Fibrosis - metabolism | Membrane Proteins - genetics | Mice, Transgenic | Protein Transport - genetics | Apoptosis Regulatory Proteins - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Models, Biological | Cystic Fibrosis - genetics | Transglutaminases - metabolism | Adolescent | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Mice | GTP-Binding Proteins | Cystic Fibrosis - drug therapy | Protein Binding - physiology | Microtubule-Associated Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Salicylates - pharmacology | Epithelial Sodium Channels - genetics | Apoptosis Regulatory Proteins - genetics | Adult | Cystamine - pharmacology | Membrane Proteins - metabolism | Acetylcysteine - therapeutic use | Beclin-1 | Cystic Fibrosis Transmembrane Conductance Regulator - antagonists & inhibitors | Cell Line | Small Ubiquitin-Related Modifier Proteins - metabolism | Heat-Shock Proteins - metabolism | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Antioxidants - pharmacology | Mice, Inbred Strains | Nasal Polyps - drug therapy | Antioxidants - therapeutic use | Animals | Acetylcysteine - pharmacology | Adaptor Proteins, Signal Transducing - genetics | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Organometallic Compounds - pharmacology | Complications and side effects | Active oxygen | Gene mutations | Lung diseases | Physiological aspects | Cystic fibrosis | Genetic aspects | Research | Health aspects | Risk factors
Journal Article
Autophagy, ISSN 1554-8627, 11/2014, Volume 10, Issue 11, pp. 2053 - 2074
Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as... 
PM, plasma membrane | autophagy | epigallocatechin gallate | TNF, tumor necrosis factor | CHX, cycloheximide | CXCL2, chemokine (C-X-C motif) ligand 2 | TGM2, transglutaminase 2 | CF, cystic fibrosis | CSNK2, casein kinase 2 | CFTR, cystic fibrosis transmembrane conductance regulator | EGCG, epigallocatechin gallate | SQSTM1, sequestosome 1 | CXCL8, chemokine (C-X-C motif) ligand 8 | cystic fibrosis | cysteamine | sweat chloride | FEV, forced expiratory volume | RPD, rectal potential difference | CFTR | BECN1/Beclin 1, autophagy-related | Sweat chloride | Cysteamine | Cystic fibrosis | Epigallocatechin gallate | Autophagy | GREEN TEA POLYPHENOLS | CELL BIOLOGY | TRANSMEMBRANE CONDUCTANCE REGULATOR | IN-VITRO | GENE | DISEASE | AIRWAY EPITHELIUM | KINASE CK2 | TISSUE TRANSGLUTAMINASE | CHLORIDE | Tumor Necrosis Factor-alpha - metabolism | Sequestosome-1 Protein | Humans | Male | Chlorides - chemistry | Young Adult | Adult | Cystamine - pharmacology | Female | Cell Membrane - metabolism | Membrane Proteins - metabolism | Interleukin-8 - metabolism | Catechin - pharmacology | Child | Cysteamine - administration & dosage | Beclin-1 | Mice, Inbred CFTR | Administration, Oral | Cystic Fibrosis - metabolism | Mice, Transgenic | Apoptosis Regulatory Proteins - metabolism | Homozygote | Phenotype | Pilot Projects | Animals | Adolescent | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Catechin - analogs & derivatives | Mice | Mutation | Adaptor Proteins, Signal Transducing - metabolism
Journal Article
Cell Death and Disease, ISSN 2041-4889, 01/2017, Volume 8, Issue 1, pp. e2544 - e2544
Journal Article
The EMBO Journal, ISSN 0261-4189, 01/2019, Volume 38, Issue 2, p. n/a
Intestinal handling of dietary proteins usually prevents local inflammatory and immune responses and promotes oral tolerance. However, in ~ 1% of the world... 
celiac disease | mucosal immunology | CFTR | gliadin | P31–43 peptide | OXIDATIVE STRESS | PROTEIN | CFTR FUNCTION | DIETARY ANTIGENS | BIOCHEMISTRY & MOLECULAR BIOLOGY | P31-43 peptide | INTESTINAL EPITHELIAL-CELLS | CELL BIOLOGY | CYTOKINE PRODUCTION | GLIADIN PEPTIDES | INFLAMMATION | TISSUE TRANSGLUTAMINASE | T-CELLS | Humans | Male | Peptide Fragments - pharmacology | Quinolones - pharmacology | Aminophenols - pharmacology | Young Adult | Protein Binding - drug effects | Protein Domains | Female | Child | Disease Models, Animal | Caco-2 Cells | Cell Line | Celiac Disease - genetics | Down-Regulation | Celiac Disease - drug therapy | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Cystic Fibrosis Transmembrane Conductance Regulator - chemistry | Quinolones - administration & dosage | Animals | Adolescent | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Protein Conformation | Mice | Gliadin - pharmacology | Aminophenols - administration & dosage | Celiac Disease - metabolism | Cereals | Peptides | Epithelial cells | Mucosa | Lymphocytes T | Activation | Antibody response | Proteins | Anions | Intestine | Gliadin | Ion channels | Inhibition | Gating | Gluten | Immune system | Binding | Translocation | Immune response | Channel gating | Therapeutic applications | World population | Cystic fibrosis | Inflammation | Immunological tolerance | Transglutaminase 2 | Nuclear transport | Environmental stress | Resistance | Celiac disease | Intolerance | Diet | Fibrosis | Cytoskeleton | Conductance | Histocompatibility antigen HLA | Autoimmune diseases | Wheat | Dismantling | Adenosine triphosphatase | Immunology | Membrane & Intracellular Transport | Molecular Biology of Disease
Journal Article
Cell Death and Disease, ISSN 2041-4889, 02/2019, Volume 10, Issue 2, pp. 114 - 7
Cystic fibrosis (CF) is a disease caused by loss-of-function mutations affecting the CF transmembrane conductance regulator (CFTR), a chloride channel. Recent... 
OXIDATIVE STRESS | GLIADIN | AUTOIMMUNITY | INFLAMMATION | EPITHELIAL STRESS | CYSTIC-FIBROSIS | AUTOPHAGY | TISSUE TRANSGLUTAMINASE | T-CELLS | CELL-DEATH | CELL BIOLOGY | Immune response | Peptides | Therapeutic applications | Homeostasis | Cystic fibrosis | Lymphocytes T | Inflammation | Adjuvanticity | Autophagy | Transglutaminase 2 | Celiac disease | Chloride conductance | Enterocytes | Immunogenicity | Antigenicity | Gliadin | Gluten | Phagocytosis
Journal Article
Gut, ISSN 0017-5749, 03/2010, Volume 59, Issue 3, pp. 311 - 319
BackgroundAn unresolved question in coeliac disease is to understand how some toxic gliadin peptides, in particular p31–43, can initiate an innate response and... 
ACTIVATION | ACID | PERMEABILITY | INFLAMMATION | DISEASE | CROSS-LINKING | ROSIGLITAZONE | GASTROENTEROLOGY & HEPATOLOGY | ASSOCIATION | T-CELLS | MODULATION
Journal Article
Journal Article
Autophagy, ISSN 1554-8627, 11/2012, Volume 8, Issue 11, pp. 1657 - 1672
Channel activators (potentiators) of cystic fibrosis (CF) transmembrane conductance regulator (CFTR), can be used for the treatment of the small subset of CF... 
cystamine | CFTR potentiators | autophagy | cystic fibrosis | therapy | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Therapy | Cystic fibrosis | Autophagy | Cystamine | GAMMA DOWN-REGULATION | OXIDATIVE STRESS | F508DEL-CFTR | PLASMA-MEMBRANE | INTESTINAL EPITHELIAL-CELLS | CELL BIOLOGY | PROTEIN-QUALITY CONTROL | MUTATION | TISSUE TRANSGLUTAMINASE | LUNG INFLAMMATION | CFTR | Inflammation - pathology | Epithelial Cells - metabolism | Sequestosome-1 Protein | Epithelial Cells - drug effects | Humans | Cystic Fibrosis - pathology | Male | Nasal Mucosa - pathology | Molecular Targeted Therapy | Autophagy - drug effects | Salicylates - pharmacology | Cystamine - therapeutic use | Organometallic Compounds - therapeutic use | Cystamine - pharmacology | Female | Cell Membrane - metabolism | Membrane Proteins - metabolism | Child | Cell Membrane - drug effects | Nasal Mucosa - drug effects | Beclin-1 | Epithelium - drug effects | Epithelium - pathology | Lung - pathology | Nasal Polyps - pathology | Epithelium - metabolism | Heat-Shock Proteins - metabolism | Epithelial Cells - pathology | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Antioxidants - pharmacology | Salicylates - therapeutic use | Apoptosis Regulatory Proteins - metabolism | Animals | Lung - drug effects | Adolescent | Genistein - pharmacology | Lipopolysaccharides - pharmacology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Cystic Fibrosis - drug therapy | Organometallic Compounds - pharmacology | Translational Research Paper
Journal Article
Journal of Immunology, ISSN 0022-1767, 05/2013, Volume 190, Issue 10, pp. 5196 - 5206
Journal Article
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 08/2013, Volume 20, Issue 8, pp. 1101 - 1115
Journal Article