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Oncogene, ISSN 0950-9232, 03/2019, Volume 38, Issue 13, pp. 2241 - 2262
The poor outcomes in infant acute lymphoblastic leukemia (ALL) necessitate new treatments. Here we discover that EIF4E protein is elevated in most cases of... 
PROGNOSTIC-FACTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMPROVED SURVIVAL | INITIATION-FACTOR EIF4E | ACUTE MYELOID-LEUKEMIA | DRUG-RESISTANCE | ANTIVIRAL DRUG | CELL BIOLOGY | ONCOLOGY | GENETICS & HEREDITY | GENE-EXPRESSION | FACTOR 4E | RNA REGULON | CELL-CYCLE | Humans | Ribavirin - therapeutic use | Eukaryotic Initiation Factor-4E - physiology | Child, Preschool | Gene Expression Regulation, Leukemic - drug effects | Infant | Gene Expression Profiling | Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Drug Resistance, Neoplasm - genetics | Signal Transduction - drug effects | Microarray Analysis | Cell Line, Tumor | Protein Biosynthesis - drug effects | Multigene Family - drug effects | Pyrroles - therapeutic use | Eukaryotic Initiation Factor-4E - genetics | Molecular Targeted Therapy - methods | Drug Resistance, Neoplasm - drug effects | Cell proliferation | Phosphorylation | AKT1 protein | Acute lymphatic leukemia | Cell survival | Therapeutic applications | Leukemia | L-asparaginase | Myc protein | Lymphatic leukemia | Kinases | Ribavirin | Mcl-1 protein | Proteins | Chemotherapy | Stromal cells | Cell cycle | Xenografts | Bone marrow | Initiation factor eIF-4E | Asparaginase | Cytoplasm | Infant, KMT2A | Obatoclax | Acute lymphoblastic leukemia | EIF4E
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2008, Volume 118, Issue 6, pp. 2301 - 2315
Journal Article
Blood, ISSN 0006-4971, 01/2016, Volume 127, Issue 1, pp. 17 - 28
Journal Article
Blood, ISSN 0006-4971, 03/2015, Volume 125, Issue 11, pp. 1759 - 1767
Journal Article
Blood, ISSN 0006-4971, 10/2012, Volume 120, Issue 17, pp. 3510 - 3518
CRLF2 rearrangements, JAK1/2 point mutations, and JAK2 fusion genes have been identified in Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia... 
MAMMALIAN TARGET | RAPAMYCIN | IN-VITRO | ABERRANT STAT5 | RECEPTOR | OF-FUNCTION MUTATIONS | HEMATOLOGY | B-PROGENITOR | GENETIC ALTERATIONS | STAT5 ACTIVATION | CRLF2 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Immunoglobulins - genetics | Molecular Targeted Therapy | Immunoglobulins - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Janus Kinase 1 - metabolism | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | TOR Serine-Threonine Kinases - genetics | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Janus Kinase 1 - genetics | Janus Kinase 2 - metabolism | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Receptors, Cytokine - metabolism | Drug Evaluation, Preclinical | Child | Philadelphia Chromosome | Receptors, Cytokine - genetics | Janus Kinase 2 - antagonists & inhibitors | Disease Models, Animal | Pyrazoles - pharmacology | Acute Disease | Janus Kinase 2 - genetics | Survival Rate | Signal Transduction - genetics | Janus Kinase 1 - antagonists & inhibitors | Sirolimus - pharmacology | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Lymphoid Neoplasia
Journal Article
Blood, ISSN 0006-4971, 03/2018, Volume 131, Issue 9, pp. 995 - 999
As a consequence of acquired or intrinsic disease resistance, the prognosis for patients with relapsed or refractory T-cell acute lymphoblastic leukemia... 
INHIBITION | MARROW RELAPSE | LENALIDOMIDE | MALIGNANCIES | ANTIBODIES TARGETING CD38 | HEMATOLOGY | MURINE XENOGRAFT MODELS | MULTIPLE-MYELOMA CELLS | CHILDREN | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia | 100 | Brief Report
Journal Article
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 2642 - 2642
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2008, Volume 105, Issue 46, pp. 17931 - 17936
Journal Article
Blood, ISSN 0006-4971, 11/2013, Volume 122, Issue 21, pp. 330 - 330
Abstract Unlike children with single lineage autoimmune cytopenias, children with autoimmune destruction of multiple cell lineages often have chronic... 
Journal Article
Haematologica, ISSN 0390-6078, 04/2018, Volume 103, Issue 5, pp. 830 - 839
Survival of children with relapsed acute lymphoblastic leukemia is poor, and understanding mechanisms underlying resistance is essential to developing new... 
MUTS-ALPHA | MISMATCH REPAIR-DEFICIENCY | MICROSATELLITE INSTABILITY | DNA | CELL LINES | TEMOZOLOMIDE TREATMENT | DRUG-RESISTANCE | HEMATOLOGY | CHILDHOOD | MAINTENANCE THERAPY | MOLECULAR-MECHANISMS
Journal Article
Blood, ISSN 0006-4971, 11/2013, Volume 122, Issue 21, pp. 2672 - 2672
Abstract The Philadelphia chromosome (Ph)-like subtype of B-precursor acute lymphoblastic leukemia (ALL) comprises approximately 15% of high-risk ALL, has a... 
Journal Article