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Trends in Pharmacological Sciences, ISSN 0165-6147, 2013, Volume 34, Issue 11, pp. 596 - 598
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 03/2019, Volume 26, Issue 4, pp. 597 - 604
Vishva M. Dixit, M.D., Vice President of Physiological Chemistry at Genentech, Inc. has made many contributions to biomedicine, and his early work on apoptosis... 
DOMAIN-CONTAINING RECEPTOR | DEATH DOMAIN | ACTIVATION | PROTEIN | CLEAVES | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMALIAN HOMOLOG | FAS | IDENTIFICATION | FAMILY | MEMBER | CELL BIOLOGY | Apoptosis | Q and A
Journal Article
Nature cell biology, ISSN 1465-7392, 12/2018, Volume 20, Issue 12, pp. 1330 - 1331
RIPK1 plays a key role in several inflammatory and cell death signalling pathways. Understanding its regulation is pivotal for identifying diseases that might... 
RIPK1 | PHOSPHORYLATION | INFLAMMATION | CELL BIOLOGY | Signal transduction | Inflammation | Cell death | Mortality | Apoptosis
Journal Article
Nature Reviews Immunology, ISSN 1474-1733, 07/2016, Volume 16, Issue 7, pp. 407 - 420
Inflammasomes are multiprotein signalling platforms that control the inflammatory response and coordinate antimicrobial host defences. They are assembled by... 
AIM2 INFLAMMASOME | DNA SENSOR | INNATE IMMUNE RECOGNITION | III SECRETION APPARATUS | NLRC4 INFLAMMASOME | CYTOPLASMIC LPS | HOST-DEFENSE | MELANOMA 2 | NLRP3 INFLAMMASOME | IMMUNOLOGY | CELL-DEATH | Inflammasomes - physiology | Signal Transduction - immunology | Animals | Humans | Cell death | Research
Journal Article
细胞研究:英文版, ISSN 1001-0602, 2016, Volume 26, Issue 4, pp. 484 - 498
Dynamic modulation of protein levels is tightly controlled in response to physiological cues. In mammalian cells, much of the protein degradation is carried... 
动态调制 | 药物靶点 | 药物开发 | 蛋白质水平 | 美国食品 | 蛋白质降解 | 泛素-蛋白酶体系统 | 哺乳动物细胞 | hydrophobic tag | SERD | ubiquitin-proteasome system | PROTAC | degrader | drug target | Ubiquitination - drug effects | Proteasome Endopeptidase Complex - metabolism | Proteasome Inhibitors | Drug Discovery | Ubiquitin - metabolism | Review
Journal Article
Science, ISSN 0036-8075, 11/2003, Volume 302, Issue 5650, pp. 1581 - 1584
Paracaspase (MALT1), a member of an evolutionary conserved superfamily of caspase-like proteins, has been shown to bind and colocalize with the protein Bcl10... 
T lymphocytes | Proteins | Spleen | Phosphorylation | Receptors | Phenotypes | B lymphocytes | Enzyme linked immunosorbent assay | Antibodies | Reports | T cell antigen receptors | CELLS | IMMUNE-RESPONSES | CARMA1 | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | BCL10 | MARGINAL-ZONE | PROTEINS | MALT LYMPHOMA
Journal Article
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 07/2011, Volume 12, Issue 7, pp. 439 - 452
Journal Article
Science, ISSN 0036-8075, 9/2013, Volume 341, Issue 6151, pp. 1246 - 1249
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 03/2011, Volume 208, Issue 3, pp. 417 - 420
High levels of reactive oxygen species (ROS) are observed in chronic human diseases such as neurodegeneration, Crohn's disease, and cancer. In addition to the... 
TNF RECEPTOR | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | IMMUNOLOGY | DISEASE | Inflammation - metabolism | Reactive Oxygen Species - metabolism | Signal Transduction | Humans | Mitochondria - metabolism | Mitochondria - physiology | Cytokines - biosynthesis | Cytokines - physiology | Inflammation - physiopathology | Minireview
Journal Article
Journal Article