Nature, ISSN 0028-0836, 2015, Volume 518, Issue 7538, pp. 197 - 206
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and...
INDIVIDUALS | PROVIDES INSIGHTS | METAANALYSIS | VARIANTS | MULTIDISCIPLINARY SCIENCES | HIPPOCAMPAL | GLYCEMIC TRAITS | ARCHITECTURE | TOPIRAMATE | LOCI | GENOME-WIDE ASSOCIATION | Body Mass Index | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Age Factors | Humans | Male | Continental Population Groups - genetics | Adiposity - genetics | Obesity - genetics | Europe - ethnology | Obesity - metabolism | Insulin - metabolism | Synapses - metabolism | Polymorphism, Single Nucleotide - genetics | Female | Glutamic Acid - metabolism | Energy Metabolism - genetics | Adipogenesis - genetics | Insulin Secretion | Quantitative Trait Loci - genetics | Body mass index | Obesity | Genetic research | Genetic aspects | Research | Diabetes | Gene expression | Health aspects | Studies | Genomics | Genetics | Biology | Genomes | Metabolic disorders | Meta-analysis | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
INDIVIDUALS | PROVIDES INSIGHTS | METAANALYSIS | VARIANTS | MULTIDISCIPLINARY SCIENCES | HIPPOCAMPAL | GLYCEMIC TRAITS | ARCHITECTURE | TOPIRAMATE | LOCI | GENOME-WIDE ASSOCIATION | Body Mass Index | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Age Factors | Humans | Male | Continental Population Groups - genetics | Adiposity - genetics | Obesity - genetics | Europe - ethnology | Obesity - metabolism | Insulin - metabolism | Synapses - metabolism | Polymorphism, Single Nucleotide - genetics | Female | Glutamic Acid - metabolism | Energy Metabolism - genetics | Adipogenesis - genetics | Insulin Secretion | Quantitative Trait Loci - genetics | Body mass index | Obesity | Genetic research | Genetic aspects | Research | Diabetes | Gene expression | Health aspects | Studies | Genomics | Genetics | Biology | Genomes | Metabolic disorders | Meta-analysis | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
Journal Article
The Journal of Nuclear Medicine, ISSN 0161-5505, 06/2008, Volume 49, Issue 6, pp. 892 - 898
Tumor delineation using noninvasive medical imaging modalities is important to determine the target volume in radiation treatment planning and to evaluate...
FDG | Dynamic pet | NSCLC | SUV | Glucose metabolic rate | Fluorodeoxyglucose F18 - pharmacokinetics | Reproducibility of Results | Radiopharmaceuticals - pharmacokinetics | Humans | Image Interpretation, Computer-Assisted - methods | Lung Neoplasms - metabolism | Middle Aged | Carcinoma, Non-Small-Cell Lung - metabolism | Imaging, Three-Dimensional - methods | Male | Metabolic Clearance Rate | Positron-Emission Tomography - methods | Sensitivity and Specificity | Glucose - metabolism | Female | Lung Neoplasms - diagnostic imaging | Aged | Carcinoma, Non-Small-Cell Lung - diagnostic imaging
FDG | Dynamic pet | NSCLC | SUV | Glucose metabolic rate | Fluorodeoxyglucose F18 - pharmacokinetics | Reproducibility of Results | Radiopharmaceuticals - pharmacokinetics | Humans | Image Interpretation, Computer-Assisted - methods | Lung Neoplasms - metabolism | Middle Aged | Carcinoma, Non-Small-Cell Lung - metabolism | Imaging, Three-Dimensional - methods | Male | Metabolic Clearance Rate | Positron-Emission Tomography - methods | Sensitivity and Specificity | Glucose - metabolism | Female | Lung Neoplasms - diagnostic imaging | Aged | Carcinoma, Non-Small-Cell Lung - diagnostic imaging
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2007, Volume 67, Issue 3, pp. 799 - 811
Purpose: The aim of this study was to investigate prospectively the rectal wall (Rwall) spatial dose distribution, toxicity, and mucosal changes after prostate...
Radiology | Hematology, Oncology and Palliative Medicine | Late rectal toxicity | Prostate radiotherapy | Endorectal Balloon | Endoscopic scoring | Telangiectasia | telangiectasia | TOLERANCE | endorectal balloon | TOXICITY | prostate radiotherapy | GLAND LOCALIZATION | CANCER | IMMOBILIZATION | RADIATION-THERAPY IMRT | DOSE-VOLUME HISTOGRAMS | INTRARECTAL BALLOON | MORBIDITY | ONCOLOGY | late rectal toxicity | endoscopic scoring | CARCINOMA | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Intestinal Mucosa - radiation effects | Radiotherapy Dosage | Prostatic Neoplasms - radiotherapy | Prospective Studies | Sigmoidoscopy | Rectum - pathology | Humans | Male | Rectum - radiation effects | Radiation Injuries - complications | Proctoscopy - methods | Rectum - blood supply | Radiation Injuries - prevention & control | Telangiectasis - etiology | Gastrointestinal Hemorrhage - etiology | Radiotherapy, Conformal - instrumentation | Radiation Injuries - pathology | Radiotherapy, Conformal - adverse effects | Telangiectasis - pathology | Radiotherapy, Conformal - methods | Radiotherapy | PROSTATE | PATIENTS | BALLOONS | NECROSIS | SPATIAL DOSE DISTRIBUTIONS | RECTUM | CARCINOMAS | RADIOLOGY AND NUCLEAR MEDICINE | RADIATION DOSES | RADIOTHERAPY
Radiology | Hematology, Oncology and Palliative Medicine | Late rectal toxicity | Prostate radiotherapy | Endorectal Balloon | Endoscopic scoring | Telangiectasia | telangiectasia | TOLERANCE | endorectal balloon | TOXICITY | prostate radiotherapy | GLAND LOCALIZATION | CANCER | IMMOBILIZATION | RADIATION-THERAPY IMRT | DOSE-VOLUME HISTOGRAMS | INTRARECTAL BALLOON | MORBIDITY | ONCOLOGY | late rectal toxicity | endoscopic scoring | CARCINOMA | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Intestinal Mucosa - radiation effects | Radiotherapy Dosage | Prostatic Neoplasms - radiotherapy | Prospective Studies | Sigmoidoscopy | Rectum - pathology | Humans | Male | Rectum - radiation effects | Radiation Injuries - complications | Proctoscopy - methods | Rectum - blood supply | Radiation Injuries - prevention & control | Telangiectasis - etiology | Gastrointestinal Hemorrhage - etiology | Radiotherapy, Conformal - instrumentation | Radiation Injuries - pathology | Radiotherapy, Conformal - adverse effects | Telangiectasis - pathology | Radiotherapy, Conformal - methods | Radiotherapy | PROSTATE | PATIENTS | BALLOONS | NECROSIS | SPATIAL DOSE DISTRIBUTIONS | RECTUM | CARCINOMAS | RADIOLOGY AND NUCLEAR MEDICINE | RADIATION DOSES | RADIOTHERAPY
Journal Article
The Journal of Nuclear Medicine (1978), ISSN 0161-5505, 2019, Volume 60, pp. 745 - 751
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2007, Volume 69, Issue 1, pp. 204 - 213
Purpose To investigate dose–volume effects in rat spinal cord irradiated with nonuniform dose distributions and to assess regional differences in...
Radiology | Hematology, Oncology and Palliative Medicine | Nonuniform dose distribution | Spinal cord | Normal tissue complication probability | White matter necrosis | Dose–volume effects | Dose-volume effects | RADIATION RESPONSE | NTCP MODELS | TOLERANCE | normal tissue complication probability | COMPLICATION PROBABILITY | FIELD SIZE | IRRADIATION | ONCOLOGY | dose-volume effects | nonuniform dose distribution | MYELOPATHY | spinal cord | white matter necrosis | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Rats, Wistar | Radiation Tolerance | Rats | Spinal Cord - radiation effects | Male | Reflex - radiation effects | Radiation Injuries, Experimental - pathology | Iridium Radioisotopes | Animals | Muscle Strength - radiation effects | Thoracic Vertebrae | Spinal Cord - pathology | Spinal Cord - physiopathology | Lumbar Vertebrae | Paresis - etiology | Dose-Response Relationship, Radiation | Paralysis - etiology | Radiation | SPINAL CORD | RADIATION DOSE DISTRIBUTIONS | NECROSIS | GAMMA RADIATION | IRIDIUM 192 | RATS | RADIOLOGY AND NUCLEAR MEDICINE | RADIATION DOSES | RADIOSENSITIVITY | HISTOLOGY | DOSE RATES | NONUNIFORM IRRADIATION
Radiology | Hematology, Oncology and Palliative Medicine | Nonuniform dose distribution | Spinal cord | Normal tissue complication probability | White matter necrosis | Dose–volume effects | Dose-volume effects | RADIATION RESPONSE | NTCP MODELS | TOLERANCE | normal tissue complication probability | COMPLICATION PROBABILITY | FIELD SIZE | IRRADIATION | ONCOLOGY | dose-volume effects | nonuniform dose distribution | MYELOPATHY | spinal cord | white matter necrosis | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Rats, Wistar | Radiation Tolerance | Rats | Spinal Cord - radiation effects | Male | Reflex - radiation effects | Radiation Injuries, Experimental - pathology | Iridium Radioisotopes | Animals | Muscle Strength - radiation effects | Thoracic Vertebrae | Spinal Cord - pathology | Spinal Cord - physiopathology | Lumbar Vertebrae | Paresis - etiology | Dose-Response Relationship, Radiation | Paralysis - etiology | Radiation | SPINAL CORD | RADIATION DOSE DISTRIBUTIONS | NECROSIS | GAMMA RADIATION | IRIDIUM 192 | RATS | RADIOLOGY AND NUCLEAR MEDICINE | RADIATION DOSES | RADIOSENSITIVITY | HISTOLOGY | DOSE RATES | NONUNIFORM IRRADIATION
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 04/2017, Volume 376, Issue 16, pp. 1527 - 1539
In two randomized trials comparing the PCSK9 inhibitor bococizumab with placebo, bococizumab had no benefit with respect to major adverse cardiovascular events...
MEDICINE, GENERAL & INTERNAL | EVENTS | REDUCTION | STATIN THERAPY | REDUCING LIPIDS | PCSK9 | GENETIC-VARIANTS | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Double-Blind Method | Follow-Up Studies | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Risk Factors | Male | Injections, Subcutaneous - adverse effects | Proprotein Convertase 9 - immunology | Hypercholesterolemia - drug therapy | Anticholesteremic Agents - adverse effects | Anticholesteremic Agents - immunology | Anticholesteremic Agents - therapeutic use | Proprotein Convertase 9 - antagonists & inhibitors | Lipids - blood | Treatment Failure | Antibodies - blood | Cholesterol, LDL - blood | Female | Antibodies, Monoclonal, Humanized - immunology | Myocardial infarction | Cerebral infarction | Lipoproteins (low density) | Immunoglobulins | Stroke | Risk groups | Clinical trials | Cardiovascular disease | Lipids | Subtilisin | Angina | Low density lipoprotein | Manuscripts | Cholesterol | Disease prevention | Kexin | Monoclonal antibodies | Cardiovascular diseases | Life Sciences | Human health and pathology
MEDICINE, GENERAL & INTERNAL | EVENTS | REDUCTION | STATIN THERAPY | REDUCING LIPIDS | PCSK9 | GENETIC-VARIANTS | Antibodies, Monoclonal, Humanized - adverse effects | Antibodies, Monoclonal, Humanized - therapeutic use | Double-Blind Method | Follow-Up Studies | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Risk Factors | Male | Injections, Subcutaneous - adverse effects | Proprotein Convertase 9 - immunology | Hypercholesterolemia - drug therapy | Anticholesteremic Agents - adverse effects | Anticholesteremic Agents - immunology | Anticholesteremic Agents - therapeutic use | Proprotein Convertase 9 - antagonists & inhibitors | Lipids - blood | Treatment Failure | Antibodies - blood | Cholesterol, LDL - blood | Female | Antibodies, Monoclonal, Humanized - immunology | Myocardial infarction | Cerebral infarction | Lipoproteins (low density) | Immunoglobulins | Stroke | Risk groups | Clinical trials | Cardiovascular disease | Lipids | Subtilisin | Angina | Low density lipoprotein | Manuscripts | Cholesterol | Disease prevention | Kexin | Monoclonal antibodies | Cardiovascular diseases | Life Sciences | Human health and pathology
Journal Article