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Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2372 - 13
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e91921
Polarization of hepatocytes is manifested by bile canalicular network formation and activation of LKB1 and AMPK, which control cellular energy metabolism. The... 
CANALICULAR MEMBRANE | BILE-ACID TRANSPORT | ACTIVATED PROTEIN-KINASE | SALT EXPORT PUMP | MULTIDISCIPLINARY SCIENCES | LIVER | AMPK | EXTRACELLULAR-MATRIX | BINDING CASSETTE TRANSPORTERS | LKB1 | EXPRESSION | Cell Polarity | Protein-Serine-Threonine Kinases - deficiency | AMP-Activated Protein Kinases - metabolism | Taurocholic Acid - metabolism | Golgi Apparatus - drug effects | rab GTP-Binding Proteins - genetics | Hepatocytes - metabolism | Endosomes - metabolism | Hepatocytes - cytology | Cyclic AMP-Dependent Protein Kinases - genetics | ATP-Binding Cassette Transporters - genetics | Endosomes - drug effects | ATP-Binding Cassette Transporters - metabolism | Cell Membrane - metabolism | Cyclic AMP - metabolism | Cell Membrane - drug effects | Hepatocytes - drug effects | Cyclic AMP-Dependent Protein Kinases - metabolism | Taurocholic Acid - pharmacology | rab GTP-Binding Proteins - metabolism | Myosin Type V - metabolism | Signal Transduction | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Bile Acids and Salts - metabolism | Mice, Knockout | Protein Transport | Cyclic AMP - pharmacology | Animals | Myosin Type V - genetics | ATP Binding Cassette Subfamily B Member 11 | Golgi Apparatus - metabolism | Mice | Primary Cell Culture | AMP-Activated Protein Kinases - genetics | Fluorescence | Cyclic adenylic acid | Muscle proteins | Collagen | Myosin | Deoxycholic acid | Protein kinase A | Polarization | Energy metabolism | Network formation | Liver | Cyclic AMP | Cultures | Metabolism | Kinases | Particle tracking | Golgi apparatus | LKB1 protein | Acids | Fluorescence recovery after photobleaching | Hepatocytes | Rodents | Membrane trafficking | Transporter | Photobleaching | Bile
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 5884 - 5884
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 09/2014, Volume 106, Issue 9
Journal Article
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 1260 - 1260
Journal Article
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. LB-243 - LB-243
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 04/2019, Volume 79, Issue 7, pp. 1438 - 1450
Aberrant activation of the PI3K-mTOR signaling pathway occurs in >80% of head and neck squamous cell carcinomas (HNSCC), and overreliance on this signaling... 
MAMMALIAN TARGET | RAPAMYCIN | MOLECULAR TARGET | MECHANISM | ONCOLOGY | PHOSPHORYLATION | LANDSCAPE | TRANSLATION INITIATION | REPRESSOR | EXPRESSION | MICE LACKING
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 02/2019, Volume 25, Issue 4, pp. 1156 - 1164
Purpose: We studied the impact of mTOR signaling inhibition with rapamycin in head and neck squamous cell carcinoma(HNSCC) in the neoadjuvant setting. The... 
MAMMALIAN TARGET | PHASE-II TRIAL | MOLECULAR TARGET | EVEROLIMUS | ONCOLOGY | RECURRENT | STATISTICS | SQUAMOUS-CELL CARCINOMA | GENOMIC CHARACTERIZATION | METASTATIC HEAD | PROGRESSION
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 09/2014, Volume 106, Issue 9, p. 1
  Cetuximab, a monoclonal blocking antibody against the epidermal growth factor receptor EGFR, has been approved for the treatment of squamous cell carcinomas... 
Epidermal growth factor | Medical treatment | Head & neck cancer | Mutation | Cells | Tumors
Journal Article
Cancer Prevention Research, ISSN 1940-6207, 03/2015, Volume 8, Issue 3, pp. 197 - 207
Most squamous cell carcinomas of the head and neck (HNSCC) exhibit a persistent activation of the PI3K-mTOR signaling pathway. We have recently shown that... 
HEAD | IN-VITRO | MOLECULAR TARGET | HIV | ONCOLOGY | PROTEIN-KINASE | ACTIVE ANTIRETROVIRAL THERAPY | HUMAN-PAPILLOMAVIRUS | CELL CARCINOMA | LIPODYSTROPHY SYNDROME | NECK-CANCER | Cell Proliferation | TOR Serine-Threonine Kinases - metabolism | Tissue Array Analysis | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Mouth Neoplasms - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Case-Control Studies | Head and Neck Neoplasms - metabolism | Immunoenzyme Techniques | Papillomavirus Infections - pathology | Female | Papillomavirus Infections - etiology | Tumor Cells, Cultured | Papillomaviridae - physiology | Mouth Neoplasms - prevention & control | Oncogene Proteins, Viral - metabolism | Head and Neck Neoplasms - prevention & control | Metformin - pharmacology | Mouth Neoplasms - etiology | Carcinoma, Squamous Cell - prevention & control | Blotting, Western | Head and Neck Neoplasms - pathology | Hypoglycemic Agents - pharmacology | Xenograft Model Antitumor Assays | Carcinoma, Squamous Cell - etiology | Animals | Class I Phosphatidylinositol 3-Kinases | Cell Cycle | Signal Transduction - drug effects | Head and Neck Neoplasms - etiology | Mice, Nude | Papillomavirus Infections - metabolism | Papillomavirus Infections - prevention & control | Octamer Transcription Factor-3 - metabolism | Mouth Neoplasms - pathology | Mice | Apoptosis | Index Medicus | mTOR | metformin | cancer prevention | HPV
Journal Article