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animals (19) 19
mice (18) 18
male (17) 17
mice, inbred c57bl (13) 13
humans (12) 12
gene expression (10) 10
articular-cartilage (9) 9
cartilage (9) 9
cartilage, articular - metabolism (9) 9
osteoarthritis (8) 8
rheumatology (8) 8
tgf-beta (8) 8
cell biology (7) 7
cells, cultured (7) 7
growth-factor-beta (7) 7
index medicus (7) 7
stem cells (7) 7
transforming growth factor beta - metabolism (7) 7
cartilage, articular - drug effects (5) 5
chondrocytes (5) 5
expression (5) 5
immunohistochemistry (5) 5
murine knee-joint (5) 5
osteoarthritis - pathology (5) 5
repair (5) 5
transforming growth factor beta - genetics (5) 5
biotechnology & applied microbiology (4) 4
blotting, western (4) 4
cartilage, articular - pathology (4) 4
cell & tissue engineering (4) 4
cell differentiation (4) 4
cell differentiation - drug effects (4) 4
collagen (4) 4
differentiation (4) 4
down-regulation (4) 4
glycosaminoglycans - biosynthesis (4) 4
immunology (4) 4
original articles (4) 4
osteophyte formation (4) 4
phosphorylation (4) 4
physiological aspects (4) 4
proteins (4) 4
proteoglycans - biosynthesis (4) 4
proteoglycans - metabolism (4) 4
receptors, transforming growth factor beta - metabolism (4) 4
rheumatoid-arthritis (4) 4
signal transduction (4) 4
transforming growth factors (4) 4
activation (3) 3
aged (3) 3
analysis (3) 3
arthritis (3) 3
articular cartilage (3) 3
bone morphogenetic protein 2 (3) 3
bone morphogenetic proteins (3) 3
chondrogenesis - drug effects (3) 3
electrophoresis, polyacrylamide gel (3) 3
female (3) 3
gene-expression (3) 3
glycosaminoglycans - analysis (3) 3
in-vitro chondrogenesis (3) 3
inflammation (3) 3
matrix metalloproteinase 13 - metabolism (3) 3
middle aged (3) 3
mouse (3) 3
orthopedics (3) 3
osteoarthritis - genetics (3) 3
osteoarthritis - metabolism (3) 3
osteoarthritis, knee - pathology (3) 3
patella - metabolism (3) 3
protein-serine-threonine kinases (3) 3
proteoglycans (3) 3
receptors, transforming growth factor beta - biosynthesis (3) 3
receptors, transforming growth factor beta - genetics (3) 3
recombinant proteins - biosynthesis (3) 3
research article (3) 3
rna, messenger - metabolism (3) 3
synovium (3) 3
tissue engineering (3) 3
transcription (3) 3
abridged index medicus (2) 2
adult (2) 2
affinity (2) 2
aggrecan (2) 2
aggrecans (2) 2
arthritis - metabolism (2) 2
arthritis, experimental - metabolism (2) 2
arthritis, experimental - pathology (2) 2
biglycan (2) 2
binding (2) 2
biochemical research methods (2) 2
bone marrow (2) 2
bone morphogenetic proteins - genetics (2) 2
cartilage - metabolism (2) 2
cartilage - pathology (2) 2
cartilage cells (2) 2
cartilage, articular - chemistry (2) 2
chondrocytes - drug effects (2) 2
culture techniques (2) 2
cytokines (2) 2
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21. Full Text Expression of TGF-β Signaling Regulator RBPMS (RNA-Binding Protein With Multiple Splicing) Is Regulated by IL-1β and TGF-β Superfamily Members, and Decreased in Aged and Osteoarthritic Cartilage
by Shanmugaapriya, S and van Caam, A and de Kroon, L and Vitters, Elly L and Walgreen, B and van Beuningen, H and Davidson, E. Blaney and van der Kraan, Peter M
Cartilage, ISSN 1947-6035, 10/2016, Volume 7, Issue 4, pp. 333 - 345
Objective RNA-binding protein with multiple splicing (RBPMS) has been shown to physically interact with Smads and enhance transforming growth factor-β... 
TGF-β | Smad 1/5/8 | Smad2/3 | RBPMS | osteoarthritis | Smad 1 | Smad2 | Basic Research Papers
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22. Full Text Catabolic factors and osteoarthritis-conditioned medium inhibit chondrogenesis of human mesenchymal stem cells
by Blaney Davidson, Esmeralda and heldens, genoveva and Vitters, Elly L and Schreurs, Wim and Piek, Ester and van den Berg, Wim B and van der Kraan, Peter M
Tissue Engineering Part A, ISSN 1937-3341, 07/2011, p. 110720044903004
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23. Full Text Inhibition of Endogenous TGF-{beta} During Experimental Osteoarthritis Prevents Osteophyte Formation and Impairs Cartilage Repair
by Scharstuhl, Alwin and Glansbeek, Harrie L and van Beuningen, Henk M and Vitters, Elly L and van der Kraan, Peter M and van den Berg, Wim B
The Journal of Immunology, ISSN 0022-1767, 07/2002, Volume 169, Issue 1, p. 507
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24. Stimulation of articular cartilage repair in established arthritis by local administration of transforming growth factor-β into murine knee joints
by Glansbeek, Harrie L and Van Beuningen, Henk M and Vitters, Elly L and Van Der Kraan, Peter M and Van Den Berg, Wim B
Laboratory Investigation, ISSN 0023-6837, 02/1998, Volume 78, Issue 2, pp. 133 - 142
A severe consequence of rheumatoid arthritis is depletion of proteoglycans (PGs) from articular cartilage leading to functional impairment of this tissue. We... 
RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | PROTEOGLYCAN SYNTHESIS | TGF-BETA | INTRAARTICULAR INJECTION | DOWN-REGULATION | RECEPTOR EXPRESSION | ZYMOSAN-INDUCED ARTHRITIS | PATHOLOGY | FACTOR-ALPHA | SYNOVIAL INFLAMMATION | TUMOR-NECROSIS-FACTOR | MEDICAL LABORATORY TECHNOLOGY | Arthritis - physiopathology | Decorin | Knee Joint - physiopathology | Male | RNA, Messenger - metabolism | Cartilage, Articular - physiopathology | Transforming Growth Factor beta - therapeutic use | Cartilage, Articular - metabolism | Extracellular Matrix Proteins | Aggrecans | Wound Healing - drug effects | Bone Morphogenetic Protein 2 | Knee Joint - drug effects | Lectins, C-Type | Mice, Inbred C57BL | Prostaglandins - biosynthesis | Biglycan | Animals | Injections, Intra-Articular | Transforming Growth Factor beta - administration & dosage | Bone Morphogenetic Proteins - therapeutic use | Mice | Cartilage, Articular - drug effects | Administration, Topical | Proteoglycans - genetics
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25. Full Text Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis
by Scharstuhl, A and Vitters, E.L and Kraan, P.M. van der and Berg, W.B. van den
Arthritis and Rheumatism, ISSN 0004-3591, 2003, Volume 48, Issue 12, pp. 3442 - 3451
OBJECTIVE: Osteoarthritis (OA) is a joint disease characterized by osteophyte development, fibrosis, and articular cartilage damage. Effects of exogenous... 
IN-VITRO | TGF-BETA | MURINE KNEE-JOINT | ARTICULAR-CARTILAGE | NEGATIVE REGULATION | RECEPTOR | DIFFERENTIATION | RHEUMATOLOGY | EXPRESSION | PERIOSTEAL CHONDROGENESIS | SMAD7 | Bone Morphogenetic Proteins - antagonists & inhibitors | Transgenes - physiology | Synovial Membrane - pathology | Male | Osteoarthritis, Knee - chemically induced | Adenoviridae - genetics | Bone Morphogenetic Proteins - genetics | Mink | Peptide Fragments - genetics | Bone Morphogenetic Protein 6 | Gene Transfer Techniques | Gene Expression | Peptide Fragments - metabolism | Transforming Growth Factor beta1 | Bone Morphogenetic Protein 4 | Protein Precursors - genetics | Respiratory Mucosa - cytology | Bone Morphogenetic Protein 2 | Mice, Inbred C57BL | Cells, Cultured | Proteoglycans - metabolism | Papain | Synovial Membrane - metabolism | Protein Precursors - metabolism | Animals | Transforming Growth Factor beta - genetics | Osteoarthritis, Knee - pathology | Mice | Osteoarthritis, Knee - physiopathology | Transforming Growth Factor beta - metabolism
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26. Full Text Large scale protein production of the extracellular domain of the transforming growth factor-β type II receptor using the Pichia pastoris expression system
by Scharstuhl, Alwin and Glansbeek, Harrie and Vitters, Elly L and van der Kraan, Peter M and van den Berg, Wim B
Journal of Chromatography B, ISSN 1570-0232, 2003, Volume 786, Issue 1, pp. 271 - 277
To study the (patho)physiological role of transforming growth factor-beta (TGF-beta), potent and selective inhibitors are necessary. Since TGF-beta signaling... 
Transforming growth factor β | Expression system | Pichia pastoris | Protein production | CHEMISTRY, ANALYTICAL | ACTIVATION | expression system | transforming growth factor beta | MURINE KNEE-JOINT | ARTICULAR-CARTILAGE | AFFINITY | BIOCHEMICAL RESEARCH METHODS | OSTEOPHYTE FORMATION | protein production | Enzyme-Linked Immunosorbent Assay | Signal Transduction | Electrophoresis, Polyacrylamide Gel | Isoelectric Focusing | Protein-Serine-Threonine Kinases | Glycosylation | Recombinant Proteins - biosynthesis | Blotting, Western | Receptors, Transforming Growth Factor beta - biosynthesis | Receptors, Transforming Growth Factor beta - metabolism | Pichia - genetics | Transforming Growth Factor beta - metabolism | Transforming Growth Factor beta2
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27. Full Text Expression of Recombinant Human Soluble Type II Transforming Growth Factor-[beta] Receptor inPichia pastorisandEscherichia coli:Two Powerful Systems to Express a Potent Inhibitor of Transforming Growth Factor-[beta]
by Glansbeek, Harrie L and Van Beuningen, Henk M and Vitters, Elly L and Van der Kraan, Peter M and Van den Berg, Wim B
Protein Expression and Purification, ISSN 1046-5928, 03/1998, Volume 12, Issue 2, p. 201
Physiological aspects | Bone morphogenetic proteins | Transforming growth factors | Recombinant proteins
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28. Early elevation of transforming growth factor-β, decorin, and biglycan mRNA levels during cartilage matrix restoration after mild proteoglycan depletion
by Van Der Kraan, Peter M and Glansbeek, Harrie L and Vitters, Elly L and Van Den Berg, Wim B
Journal of Rheumatology, ISSN 0315-162X, 03/1997, Volume 24, Issue 3, pp. 543 - 549
Objective, To elucidate the role of transforming growth factor-beta (TGF-beta) and the small proteoglycans biglycan and decorin in the repair of articular... 
aggrecan | repair | biglycan | decorin | transforming growth factor-β | cartilage | RHEUMATOID-ARTHRITIS | TGF-BETA | PROTEIN | TISSUE-REPAIR | RHEUMATOLOGY | IDENTIFICATION | transforming growth factor-beta | HUMAN ARTICULAR-CARTILAGE | DESTRUCTION | INVIVO | K WH RHEUMATOLOGY | GENE-EXPRESSION | BINDING | Decorin | Proteoglycans - antagonists & inhibitors | Chondroitin Sulfate Proteoglycans - genetics | Lectins, C-Type | Mice, Inbred C57BL | Transforming Growth Factor beta - physiology | Proteoglycans - biosynthesis | RNA, Messenger - analysis | Male | Biglycan | Knee Joint - chemistry | Cartilage, Articular - physiology | Up-Regulation - drug effects | Regeneration | Animals | Transforming Growth Factor beta - genetics | Extracellular Matrix Proteins | Aggrecans | Papain - pharmacology | Mice | Proteoglycans - genetics | Cartilage, Articular - chemistry
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29. Full Text Collagen type I antisense and collagen type IIA messenger RNA is expressed in adult murine articular cartilage
by van der Kraan, Peter M and Vitters, Elly L and Meijers, Tineke H.M and Poole, A.Robin and van den Berg, Wim B
Osteoarthritis and Cartilage, ISSN 1063-4584, 11/1998, Volume 6, Issue 6, pp. 417 - 426
Objective: Articular cartilage has only limited capacities for repair and it is not known what is the exact mechanism of matrix restoration. It was... 
Chondrocytes, Repair, Collagen I, Collagen II, Collagen X | Collagen I | Collagen II | Repair | Collagen X | Chondrocytes | collagen X | AMINO-PROPEPTIDE | repair | LOCALIZATION | chondrocytes | EARLY MOUSE DEVELOPMENT | X COLLAGEN | ALKALINE-PHOSPHATASE | RHEUMATOLOGY | collagen II | OSTEOARTHRITIC CARTILAGE | collagen I | TISSUES | ORTHOPEDICS | PROCOLLAGEN | KNEE-JOINT | Immunohistochemistry | Gene Expression | Proteoglycans - metabolism | RNA, Messenger - analysis | Male | Papain | Mice, Inbred Strains | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | RNA, Antisense - analysis | Animals | Knee Joint | Cartilage, Articular - metabolism | RNA, Antisense - metabolism | Collagen - genetics | Mice | Collagen - analysis | Cartilage, Articular - drug effects
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30. Full Text Expression of Recombinant Human Soluble Type II Transforming Growth Factor-beta Receptor in Pichia pastoris and Escherichia coli: Two Powerful Systems to Express a Potent Inhibitor of Transforming Growth Factor-beta
by Glansbeek H.L and van Beuningen H.M and Vitters E.L and van der Kraan P.M and van den Berg W.B
Protein Expression and Purification, ISSN 1046-5928, 03/1998, Volume 12, Issue 2, pp. 201 - 207
Transforming growth factor-beta (TGF-beta) is a potent regulator of cell metabolism, proliferation, and differentiation. To study the role of endogenous... 
DOMAIN | TGF-BETA | METHYLOTROPHIC YEAST | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | AFFINITY | CLONING | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | LIGAND | GROWTH-FACTOR-BETA-1 | BINDING | FACTOR-BETA-1 | Receptors, Transforming Growth Factor beta - genetics | Receptors, Transforming Growth Factor beta - chemistry | Humans | Protein-Serine-Threonine Kinases | DNA, Complementary - genetics | Gene Expression Regulation, Developmental - genetics | Thymidine - analysis | Tritium | Recombinant Proteins - biosynthesis | DNA Primers - chemistry | Osmolar Concentration | Base Sequence | Transforming Growth Factor beta - antagonists & inhibitors | Biological Assay | Thymidine - metabolism | Electrophoresis, Polyacrylamide Gel | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Protein Folding | Receptors, Transforming Growth Factor beta - biosynthesis | Receptors, Transforming Growth Factor beta - metabolism | Escherichia coli - genetics | Pichia - genetics | DNA, Complementary - chemistry | Transforming Growth Factor beta - metabolism
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31. Full Text Local changes in proteoglycan synthesis during culture are different for normal and osteoarthritic cartilage
by Lafeber, FP and van der Kraan, PM and van Roy, HL and Vitters, EL and Huber-Bruning, O and van den Berg, WB and Bijlsma, JW
American Journal of Pathology, ISSN 0002-9440, 06/1992, Volume 140, Issue 6, pp. 1421 - 1429
Proteoglycan synthesis of mild-to-moderate osteoarthritic human knee cartilage was compared with that of normal cartilage of the same donor. Immediately after... 
CHONDROCYTES | ARTICULAR-CARTILAGE | PATHOLOGY | Sulfates - metabolism | Culture Techniques | Humans | Middle Aged | Osteoarthritis - metabolism | Proteoglycans - biosynthesis | Male | Reference Values | Tissue Distribution | Autoradiography | Cartilage, Articular - pathology | Cartilage, Articular - metabolism | Female | Aged | Osteoarthritis - pathology | Thymidine - metabolism
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32. Full Text Expression of Recombinant Human Soluble Type II Transforming Growth Factor-β Receptor inPichia pastorisandEscherichia coli:Two Powerful Systems to Express a Potent Inhibitor of Transforming Growth Factor-β
by Glansbeek, Harrie L and van Beuningen, Henk M and Vitters, Elly L and van der Kraan, Peter M and van den Berg, Wim B
Protein Expression and Purification, ISSN 1046-5928, 03/1998, Volume 12, Issue 2, pp. 201 - 207
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33. Full Text Induction of osteoarthritis by intra-articular injection of collagenase in mice. Strain and sex related differences
by van Osch, Gerjo J.V.M and van der Kraan, Peter M and Vitters, Elly L and Blankevoort, Leendert and van den Berg, Wim B
Osteoarthritis and Cartilage, ISSN 1063-4584, 1993, Volume 1, Issue 3, pp. 171 - 177
To study the effects of strain and sex on the development of injury-induced osteoarthritis (OA) in murine knee joints, two doses of highly purified bacterial... 
Mouse strains | Cartilage | Knee joint | Osteoarthritis | Arthritis, Experimental - genetics | Genetic Predisposition to Disease | Species Specificity | Mice, Inbred C57BL | Risk Factors | Male | Osteoarthritis - genetics | Arthritis, Experimental - pathology | Joints - injuries | Animals | Arthritis, Experimental - etiology | Injections, Intra-Articular | Sex Factors | Female | Mice | Osteoarthritis - pathology | Osteoarthritis - etiology | Microbial Collagenase
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34. Full Text Inhibition of proteoglycan synthesis by transforming growth factor beta in anatomically intact articular cartilage of murine patellae
by van der Kraan, P M and Vitters, E L and van den Berg, W B
Annals of the Rheumatic Diseases, ISSN 0003-4967, 05/1992, Volume 51, Issue 5, pp. 643 - 647
The effect of transforming growth factor beta (TGF beta) on proteoglycan synthesis and degradation in anatomically intact articular cartilage of murine... 
PLATE CHONDROCYTES | SERUM | RHEUMATOLOGY | CULTURE | MOUSE | Proteoglycans - antagonists & inhibitors | Animals | Patella - metabolism | Cartilage, Articular - metabolism | Proteoglycans - biosynthesis | Proteoglycans - metabolism | Mice | Antibodies, Monoclonal - metabolism | Transforming Growth Factor beta - metabolism | Insulin-Like Growth Factor I - metabolism | Physiological aspects | Proteoglycans | Articular cartilage | Transforming growth factors
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35. Full Text Maintenance of the synthesis of large proteoglycans in anatomically intact murine articular cartilage by steroids and insulin-like growth factor I
by van der Kraan, P M and Vitters, E L and Postma, N S and Verbunt, J and van den Berg, W B
Annals of the Rheumatic Diseases, ISSN 0003-4967, 10/1993, Volume 52, Issue 10, pp. 734 - 741
OBJECTIVES--The exact regulation of the synthesis of cartilage specific molecules, such as collagen type II and aggrecan, by articular chondrocytes is unknown,... 
TRIAMCINOLONE HEXACETONIDE | EXPERIMENTAL ARTHRITIS | STIMULATION | INHIBITION | METABOLISM | RABBIT COSTAL CHONDROCYTES | INVITRO | PROLIFERATION | RHEUMATOLOGY | GLYCOSAMINOGLYCAN SYNTHESIS | HYDROCORTISONE | Hindlimb | Insulin-Like Growth Factor I - pharmacology | Mice, Inbred C57BL | Proteoglycans - biosynthesis | Male | Triamcinolone Acetonide - pharmacology | Prednisolone - pharmacology | Stimulation, Chemical | Animals | Patella - metabolism | Cartilage, Articular - metabolism | Papain - pharmacology | Mice | In Vitro Techniques | Joints - metabolism | Physiological aspects | Proteoglycans | Articular cartilage | Cartilage cells | Steroids (Drugs) | Insulin-like growth factor 1
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36. Full Text Analysis of changes in proteoglycan content in murine articular cartilage using image analysis
by van der Kraan, Peter M and de Lange, Jos and Vitters, Elly L and van Beuningen, Henk M and van Osch, Gerjo J.V.M and van Lent, Peter L.E.M and van den Berg, Wim B
Osteoarthritis and Cartilage, ISSN 1063-4584, 1994, Volume 2, Issue 3, pp. 207 - 214
The extracellular matrix of articular cartilage consists mainly of type II collagen and large aggregating proteoglycan (aggrecan). During arthritis and other... 
Cartilage | Image analysis | Proteoglycans | Murine | Glycosaminoglycans - analysis | Coloring Agents | Mice, Inbred C57BL | Proteoglycans - metabolism | Spectrophotometry - methods | Microscopy, Electron | Spectrophotometry - standards | Animals | Cartilage, Articular - metabolism | Osteoarthritis, Knee - pathology | Patella | Sensitivity and Specificity | Mice | Osteoarthritis, Knee - metabolism
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37. Full Text High susceptibility of human articular cartilage glycosaminoglycan synthesis to changes in inorganic sulfate availability
by van der Kraan, Peter M and Vitters, Elly L and de Vries, Bernard J and van den Berg, Wim B
Journal of Orthopaedic Research, ISSN 0736-0266, 07/1990, Volume 8, Issue 4, pp. 565 - 571
The effect of sulfate concentration in the medium on glycosaminoglycan synthesis in articular cartilage of five different species was examined in relation to... 
Articular cartilage | Glycosaminoglycans | Sulfate | ORTHOPEDICS | Cricetinae | Arthritis - metabolism | Arthritis - pathology | Cartilage, Articular - cytology | Humans | Middle Aged | Cells, Cultured | Rats | Male | Sulfates - pharmacology | Rats, Inbred Strains | Dose-Response Relationship, Drug | Cartilage, Articular - pathology | Animals | Cartilage, Articular - metabolism | Mesocricetus | Aged | Mice | Glycosaminoglycans - biosynthesis
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38. Full Text Inhibition of glycosaminoglycan synthesis in anatomically intact rat patellar cartilage by paracetamol-induced serum sulfate depletion
by Van Der Kraan, Peter M and De Vries, Bernard J and Vitters, Elly L and Van Den Berg, Wim B and Van De Putte, Levinus B.A
Biochemical Pharmacology, ISSN 0006-2952, 1988, Volume 37, Issue 19, pp. 3683 - 3690
We have studied the effect of low sulfate concentrations on the glycosaminoglycan synthesis in rat patellar cartilage in vivo as well as in vitro. The oral... 
Salicylates - pharmacology | Animals | Salicylic Acid | Acetaminophen - pharmacology | Sulfates - blood | Rats | Male | Cartilage - metabolism | In Vitro Techniques | Rats, Inbred Strains | Glycosaminoglycans - biosynthesis
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39. Full Text Bone morphogenetic protein 2 stimulates articular cartilage proteoglycan synthesis in vivo but does not counteract interleukin‐1α effects on proteoglycan synthesis and content
by Glansbeek, Harrie L and van Beuningen, Henk M and Vitters, Elly L and van der Kraan, Peter M and van den Berg, Wim B and Morris, Elisabeth A
Arthritis & Rheumatism, ISSN 0004-3591, 06/1997, Volume 40, Issue 6, pp. 1020 - 1028
Objective. To study the effect of bone morphogenetic protein 2 (BMP‐2) on articular cartilage proteoglycan (PG) synthesis in vivo and to investigate whether... 
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40. Full Text Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor ?/bone morphogenetic protein inhibitors during experimental osteoarthritis
by Scharstuhl, Alwin and Vitters, Elly L and van der Kraan, Peter M and van den Berg, Wim B
Arthritis & Rheumatism, ISSN 0004-3591, 12/2003, Volume 48, Issue 12, pp. 3442 - 3451
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