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Journal of Clinical Investigation, ISSN 0021-9738, 06/2019, Volume 129, Issue 6, p. 2542
Preclinical studies demonstrate that rapid-acting antidepressants, including ketamine, require stimulation of mTORC1 signaling. This pathway is regulated by... 
Amino acids | Stress (Psychology) | Neurons | Antidepressants, Tricyclic
Journal Article
Science, ISSN 0036-8075, 3/2013, Volume 339, Issue 6124, pp. 1216 - 1219
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2012, Volume 7, Issue 12, pp. e51395 - e51395
Background: SRT2104 has been developed as a selective small molecule activator of SIRT1, a NAD(+)-dependent deacetylase involved in the regulation of energy... 
INSULIN | SKELETAL-MUSCLE | RESVERATROL | LONGEVITY | MAGNETIC-RESONANCE-SPECTROSCOPY | METABOLISM | VIVO | MULTIDISCIPLINARY SCIENCES | DEACETYLATES | P-31 | PREDICTION | Sirtuin 1 - metabolism | Glucose Tolerance Test | Double-Blind Method | Placebo Effect | Humans | Imidazoles - adverse effects | Middle Aged | Male | Imidazoles - pharmacology | Imidazoles - pharmacokinetics | Enzyme Activation - drug effects | Thiazoles - adverse effects | Thiazoles - pharmacokinetics | Pilot Projects | Time Factors | Lipids - blood | Endpoint Determination | Female | Aged | Exercise - physiology | Thiazoles - pharmacology | Safety | Type 2 diabetes | Glucose metabolism | Low density lipoproteins | Physiological aspects | Clinical trials | Nuclear magnetic resonance spectroscopy | Triglycerides | Glucose | Health aspects | Glucose tolerance tests | Dextrose | Adenosine triphosphatase | Elderly people | Disease | Oxidative metabolism | Liver | Family medical history | ADP | Magnetic resonance spectroscopy | Mitochondria | Exercise | Lipid metabolism | Drug dosages | Medical research | Adenosine diphosphate | Metabolism | Molecular chains | Studies | Energy balance | Aerobic capacity | Metabolic pathways | Geriatrics | Lipoproteins (low density) | Oxidative stress | Phosphorylation | Homeostasis | Lipids | Biological effects | Diabetes mellitus (non-insulin dependent) | Age | Adenosine | Diabetes mellitus | Muscles | Radioactive half-life | Pharmacology | Phosphocreatine | Cholesterol | Medicine | NAD | Glucose tolerance | Musculoskeletal system | Weight control | Oxidative phosphorylation | Magnetic resonance imaging | Insulin resistance | Resonance | Diabetes | Elderly | Pharmaceuticals | Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 2011, Volume 1, Issue 1, pp. 70 - 70
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7411, pp. 394 - 398
Cardiac hypertrophy is initiated as an adaptive response to sustained overload but progresses pathologically as heart failure ensues(1). Here we report that... 
PROTEIN | CONTRACTILITY | MYOCYTES | STRETCH | MULTIDISCIPLINARY SCIENCES | IN-VIVO | INVOLVEMENT | GENE-EXPRESSION | APELIN | ANGIOTENSIN-II | CARDIOMYOCYTES | Blood Pressure | Mechanotransduction, Cellular - drug effects | Receptors, G-Protein-Coupled - metabolism | Arrestins - genetics | Cardiomegaly - pathology | Male | Receptors, G-Protein-Coupled - agonists | Mechanotransduction, Cellular - physiology | Arrestins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Female | Intercellular Signaling Peptides and Proteins - deficiency | Mechanoreceptors - metabolism | Apelin | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Cardiomegaly - physiopathology | Adipokines | Mice, Knockout | Aorta - pathology | Myocytes, Cardiac - pathology | Animals | Cardiomegaly - prevention & control | Myocytes, Cardiac - drug effects | Receptors, G-Protein-Coupled - deficiency | Signal Transduction - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | beta-Arrestins | Apelin Receptors | Mice | Receptors, G-Protein-Coupled - genetics | Arrestins - deficiency | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Cardiomegaly - metabolism | Genetically modified mice | Physiological aspects | Development and progression | Research | Heart enlargement | Proteins | Heart failure | Cardiomyocytes | Kinases | Laboratory animals | Rodents | Index Medicus
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 4107 - 10
The mechanistic target of rapamycin complex 1 (mTORC1) has been linked to several important chronic medical conditions many of which are associated with... 
ENERGY-BALANCE | ASSAY | METABOLISM | MEMORY | FOOD-INTAKE | MULTIDISCIPLINARY SCIENCES | BARRIER | NEUROSCIENCE | GENES | SESTRINS | AGE | TOR protein | Exploration | Amino acids | Protein biosynthesis | Cognition | Rapamycin | Leucine | Protein turnover
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, pp. e46364 - e46364
Chronic inflammation is a major contributing factor in the pathogenesis of many age-associated diseases. One central protein that regulates inflammation is... 
LIFE-SPAN | ACETYLATION | PHOSPHORYLATION | NEGATIVE REGULATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DNA-DAMAGE | DEPENDENT GENE-EXPRESSION | CELL-SURVIVAL | CYTOKINE RELEASE | SMALL-MOLECULE ACTIVATORS | Inflammation - chemically induced | Sirtuin 1 - metabolism | Transcription Factor RelA - antagonists & inhibitors | Humans | Transcriptional Activation - drug effects | Male | Benzimidazoles - chemistry | Sirtuin 1 - genetics | Transcription Factor RelA - genetics | Inflammation - metabolism | Inflammation - drug therapy | Tumor Necrosis Factor-alpha - immunology | Acetylation | Interleukin-12 - biosynthesis | Cell Line | Anti-Inflammatory Agents - pharmacology | Inflammation - immunology | Animals | Anti-Inflammatory Agents - chemistry | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | Small Molecule Libraries | Interleukin-12 - immunology | Lipopolysaccharides - pharmacology | Benzimidazoles - pharmacology | Thiazoles - chemistry | Mice | Mice, Inbred BALB C | Protein Processing, Post-Translational | Thiazoles - pharmacology | Tumor Necrosis Factor-alpha - biosynthesis | Phosphorylation | Pathogenesis | Arthritis | Kinases | Lipopolysaccharides | Proteins | Reduction | Rodents | Transcription activation | Post-translation | Aging | Chronic obstructive pulmonary disease | Synaptotagmin | Age | Chronic illnesses | NF-κB protein | Antiinflammatory agents | Cytokines | Secretion | Interleukin 12 | Pharmacology | Inflammation | Tumor necrosis factor-α | Metabolism | Gene expression | Chemical compounds | SIRT1 protein | NAD | Signaling | Deacetylation | New classes | Kidney diseases | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2013, Volume 110, Issue 9, pp. 3333 - 3338
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 548 - 12
Journal Article