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Acta Neuropathologica, ISSN 0001-6322, 1/2015, Volume 129, Issue 1, pp. 133 - 146
Journal Article
Journal Article
by Sturm, Dominik and Witt, Hendrik and Hovestadt, Volker and Khuong-Quang, Dong-Anh and Jones, David T.W and Konermann, Carolin and Pfaff, Elke and Tönjes, Martje and Sill, Martin and Bender, Sebastian and Kool, Marcel and Zapatka, Marc and Becker, Natalia and Zucknick, Manuela and Hielscher, Thomas and Liu, Xiao-Yang and Fontebasso, Adam M and Ryzhova, Marina and Albrecht, Steffen and Jacob, Karine and Wolter, Marietta and Ebinger, Martin and Schuhmann, Martin U and van Meter, Timothy and Frühwald, Michael C and Hauch, Holger and Pekrun, Arnulf and Radlwimmer, Bernhard and Niehues, Tim and von Komorowski, Gregor and Dürken, Matthias and Kulozik, Andreas E and Madden, Jenny and Donson, Andrew and Foreman, Nicholas K and Drissi, Rachid and Fouladi, Maryam and Scheurlen, Wolfram and von Deimling, Andreas and Monoranu, Camelia and Roggendorf, Wolfgang and Herold-Mende, Christel and Unterberg, Andreas and Kramm, Christof M and Felsberg, Jörg and Hartmann, Christian and Wiestler, Benedikt and Wick, Wolfgang and Milde, Till and Witt, Olaf and Lindroth, Anders M and Schwartzentruber, Jeremy and Faury, Damien and Fleming, Adam and Zakrzewska, Magdalena and Liberski, Pawel P and Zakrzewski, Krzysztof and Hauser, Peter and Garami, Miklos and Klekner, Almos and Bognar, Laszlo and Morrissy, Sorana and Cavalli, Florence and Taylor, Michael D and van Sluis, Peter and Koster, Jan and Versteeg, Rogier and Volckmann, Richard and Mikkelsen, Tom and Aldape, Kenneth and Reifenberger, Guido and Collins, V. Peter and Majewski, Jacek and Korshunov, Andrey and Lichter, Peter and Plass, Christoph and Jabado, Nada and Pfister, Stefan M
Cancer cell, ISSN 1535-6108, 2012, Volume 22, Issue 4, pp. 425 - 437
Journal Article
The lancet oncology, ISSN 1470-2045, 2016, Volume 17, Issue 11, pp. 1521 - 1532
Journal Article
The lancet oncology, ISSN 1470-2045, 2017, Volume 18, Issue 5, pp. 682 - 694
Journal Article
Cancer cell, ISSN 1535-6108, 2015, Volume 27, Issue 5, pp. 728 - 743
Journal Article
by Kool, Marcel and Jones, David T.W and Jäger, Natalie and Northcott, Paul A and Pugh, Trevor J and Hovestadt, Volker and Piro, Rosario M and Esparza, L. Adriana and Markant, Shirley L and Remke, Marc and Milde, Till and Bourdeaut, Franck and Ryzhova, Marina and Sturm, Dominik and Pfaff, Elke and Stark, Sebastian and Hutter, Sonja and Şeker-Cin, Huriye and Johann, Pascal and Bender, Sebastian and Schmidt, Christin and Rausch, Tobias and Shih, David and Reimand, Jüri and Sieber, Laura and Wittmann, Andrea and Linke, Linda and Witt, Hendrik and Weber, Ursula D and Zapatka, Marc and König, Rainer and Beroukhim, Rameen and Bergthold, Guillaume and van Sluis, Peter and Volckmann, Richard and Koster, Jan and Versteeg, Rogier and Schmidt, Sabine and Wolf, Stephan and Lawerenz, Chris and Bartholomae, Cynthia C and von Kalle, Christof and Unterberg, Andreas and Herold-Mende, Christel and Hofer, Silvia and Kulozik, Andreas E and von Deimling, Andreas and Scheurlen, Wolfram and Felsberg, Jörg and Reifenberger, Guido and Hasselblatt, Martin and Crawford, John R and Grant, Gerald A and Jabado, Nada and Perry, Arie and Cowdrey, Cynthia and Croul, Sydney and Zadeh, Gelareh and Korbel, Jan O and Doz, Francois and Delattre, Olivier and Bader, Gary D and McCabe, Martin G and Collins, V. Peter and Kieran, Mark W and Cho, Yoon-Jae and Pomeroy, Scott L and Witt, Olaf and Brors, Benedikt and Taylor, Michael D and Schüller, Ulrich and Korshunov, Andrey and Eils, Roland and Wechsler-Reya, Robert J and Lichter, Peter and Pfister, Stefan M and on behalf of the ICGC PedBrain Tumor Project and ICGC PedBrain Tumor Project
Cancer cell, ISSN 1535-6108, 2014, Volume 25, Issue 3, pp. 393 - 405
Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB). Clinical response is highly variable. To... 
TERT PROMOTER MUTATIONS | ONCOLOGY | GROWTH | RESISTANCE | HEDGEHOG PATHWAY INHIBITOR | ITRACONAZOLE | SUBGROUPS | PEDIATRIC MEDULLOBLASTOMA | TUMORS | MOUSE MODELS | ADULT | CELL BIOLOGY | Neoplasm Transplantation | Oncogene Proteins - genetics | Humans | Zinc Finger Protein Gli2 | Child, Preschool | Molecular Sequence Data | Infant | Male | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - metabolism | Biphenyl Compounds - therapeutic use | Promoter Regions, Genetic - genetics | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Young Adult | Telomerase - genetics | Hedgehog Proteins - genetics | Base Sequence | Smoothened Receptor | Adult | Female | N-Myc Proto-Oncogene Protein | Patched Receptors | Medulloblastoma - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Child | Pyridines - therapeutic use | Cerebellar Neoplasms - drug therapy | Repressor Proteins - genetics | DNA Copy Number Variations - genetics | Signal Transduction - genetics | Cerebellar Neoplasms - genetics | Mice, SCID | Phosphatidylinositol 3-Kinases - genetics | DEAD-box RNA Helicases - genetics | Drug Resistance, Neoplasm - genetics | Animals | Adolescent | Receptors, G-Protein-Coupled - antagonists & inhibitors | Mice, Inbred NOD | High-Throughput Nucleotide Sequencing | Mice | Receptors, G-Protein-Coupled - genetics | Medulloblastoma - drug therapy | Kruppel-Like Transcription Factors - genetics | Patched-1 Receptor | Receptors, Cell Surface - genetics | Genetic aspects | Nucleotide sequencing | Analysis | Medulloblastoma | Genomics | DNA sequencing
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2012, Volume 148, Issue 1-2, pp. 59 - 71
Journal Article
by Northcott, Paul A and Lee, Catherine and Zichner, Thomas and Stütz, Adrian M and Erkek, Serap and Kawauchi, Daisuke and Shih, David J. H and Hovestadt, Volker and Zapatka, Marc and Sturm, Dominik and Jones, David T. W and Kool, Marcel and Remke, Marc and Cavalli, Florence M. G and Zuyderduyn, Scott and Bader, Gary D and VandenBerg, Scott and Esparza, Lourdes Adriana and Ryzhova, Marina and Wang, Wei and Wittmann, Andrea and Stark, Sebastian and Sieber, Laura and Seker-Cin, Huriye and Linke, Linda and Kratochwil, Fabian and Jäger, Natalie and Buchhalter, Ivo and Imbusch, Charles D and Zipprich, Gideon and Raeder, Benjamin and Schmidt, Sabine and Diessl, Nicolle and Wolf, Stephan and Wiemann, Stefan and Brors, Benedikt and Lawerenz, Chris and Eils, Jürgen and Warnatz, Hans-Jörg and Risch, Thomas and Yaspo, Marie-Laure and Weber, Ursula D and Bartholomae, Cynthia C and von Kalle, Christof and Turányi, Eszter and Hauser, Peter and Sanden, Emma and Darabi, Anna and Siesjö, Peter and Sterba, Jaroslav and Zitterbart, Karel and Sumerauer, David and van Sluis, Peter and Versteeg, Rogier and Volckmann, Richard and Koster, Jan and Schuhmann, Martin U and Ebinger, Martin and Grimes, H. Leighton and Robinson, Giles W and Gajjar, Amar and Mynarek, Martin and von Hoff, Katja and Rutkowski, Stefan and Pietsch, Torsten and Scheurlen, Wolfram and Felsberg, Jörg and Reifenberger, Guido and Kulozik, Andreas E and von Deimling, Andreas and Witt, Olaf and Eils, Roland and Gilbertson, Richard J and Korshunov, Andrey and Taylor, Michael D and Lichter, Peter and Korbel, Jan O and Wechsler-Reya, Robert J and Pfister, Stefan M
Nature (London), ISSN 1476-4687, 2014, Volume 511, Issue 7510, pp. 428 - 434
Journal Article