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1. Full Text Caspase Inhibition Improves Ischemia-Reperfusion Injury After Lung Transplantation
by Syed M. Quadri and Lorne Segall and Marc de Perrot and Bing Han and Vernon Edwards and Nicola Jones and Thomas K. Waddell and Mingyao Liu and Shaf Keshavjee
American Journal of Transplantation, ISSN 1600-6135, 02/2005, Volume 5, Issue 2, pp. 292 - 299
Ischemia-reperfusion injury is associated with cell death in many organ systems. The role of programmed cell death (PCD) pathways and the ultimate clinical... 
ischemia-reperfusion injury | TUNEL | programmed cell death | lung transplant | caspase inhibition | Apoptosis | ischemia‐reperfusion injury | PROGRAMMED CELL-DEATH | SURGERY | NECROSIS | FORM | apoptosis | TRANSPLANTATION | In Situ Nick-End Labeling | Lung - pathology | Lung Transplantation | Animals | Apoptosis - drug effects | Reperfusion Injury - drug therapy | Lung - ultrastructure | Pentanoic Acids - pharmacology | Rats | Microscopy, Electron | Caspase Inhibitors | Lung - enzymology
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2. Full Text Whole genomes redefine the mutational landscape of pancreatic cancer
by Waddell, Nicola and Pajic, Marina and Patch, Ann-Marie and Chang, David K and Kassahn, Karin S and Bailey, Peter and Johns, Amber L and Miller, David and Nones, Katia and Quek, Kelly and Quinn, Michael C. J and Robertson, Alan J and Fadlullah, Muhammad Z. H and Bruxner, Tim J. C and Christ, Angelika N and Harliwong, Ivon and Idrisoglu, Senel and Manning, Suzanne and Nourse, Craig and Nourbakhsh, Ehsan and Wani, Shivangi and Wilson, Peter J and Markham, Emma and Cloonan, Nicole and Anderson, Matthew J and Fink, J. Lynn and Holmes, Oliver and Kazakoff, Stephen H and Leonard, Conrad and Newell, Felicity and Poudel, Barsha and Song, Sarah and Taylor, Darrin and Waddell, Nick and Wood, Scott and Xu, Qinying and Wu, Jianmin and Pinese, Mark and Cowley, Mark J and Lee, Hong C and Jones, Marc D and Nagrial, Adnan M and Humphris, Jeremy and Chantrill, Lorraine A and Chin, Venessa and Steinmann, Angela M and Mawson, Amanda and Humphrey, Emily S and Colvin, Emily K and Chou, Angela and Scarlett, Christopher J and Pinho, Andreia V and Giry-Laterriere, Marc and Rooman, Ilse and Samra, Jaswinder S and Kench, James G and Pettitt, Jessica A and Merrett, Neil D and Toon, Christopher and Epari, Krishna and Nguyen, Nam Q and Barbour, Andrew and Zeps, Nikolajs and Jamieson, Nigel B and Graham, Janet S and Niclou, Simone P and Bjerkvig, Rolf and Grützmann, Robert and Aust, Daniela and Hruban, Ralph H and Maitra, Anirban and Iacobuzio-Donahue, Christine A and Wolfgang, Christopher L and Morgan, Richard A and Lawlor, Rita T and Corbo, Vincenzo and Bassi, Claudio and Falconi, Massimo and Zamboni, Giuseppe and Tortora, Giampaolo and Tempero, Margaret A and Gill, Anthony J and Eshleman, James R and Pilarsky, Christian and Scarpa, Aldo and Musgrove, Elizabeth A and Pearson, John V and Biankin, Andrew V and Grimmond, Sean M and Australian Pancreatic Canc Genome and Australian Pancreatic Cancer Genome Initiative
Nature, ISSN 0028-0836, 02/2015, Volume 518, Issue 7540, pp. 495 - 501
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole-genome sequencing and copy number variation... 
REARRANGEMENT | INSTABILITY | METAANALYSIS | RANDOMIZED-TRIALS | ADENOCARCINOMA | MULTIDISCIPLINARY SCIENCES | GENES | PATTERNS | CHROMOTHRIPSIS | GEMCITABINE | CHEMOTHERAPY | Genomics | Humans | DNA Repair - genetics | Carcinoma, Pancreatic Ductal - genetics | Pancreatic Neoplasms - drug therapy | Point Mutation - genetics | DNA Mutational Analysis | Genes, BRCA2 | Pancreatic Neoplasms - classification | Female | Adenocarcinoma - genetics | Genes, BRCA1 | Platinum - pharmacology | Genomic Instability - genetics | Genotype | Pancreatic Neoplasms - genetics | Mutation - genetics | Adenocarcinoma - drug therapy | Poly(ADP-ribose) Polymerase Inhibitors | Genome, Human - genetics | Xenograft Model Antitumor Assays | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Genetic Markers - genetics | Mice | Copy number variations | Pancreatic cancer | Physiological aspects | Development and progression | Genetic aspects | Research | Tumor proteins | Risk factors | Genes | DNA damage | Clinical trials | Genomes | Cancer therapies | Patients | Biomarkers | Mutation | Chromosomes | Deoxyribonucleic acid--DNA | Tumors
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3. Full Text Apoptosis in Rat Placenta Is Zone-Dependent and Stimulated by Glucocorticoids
by Brendan J. Waddell and Susan Hisheh and A.M. Dharmarajan and Peter J. Burton
Biology of Reproduction, ISSN 0006-3363, 12/2000, Volume 63, Issue 6, pp. 1913 - 1917
Apoptosis, or physiological cell death, is elevated in the placenta of human pregnancies complicated by fetal growth retardation, suggesting that placental... 
Pregnancy | Conceptus | Placenta | Corticosterone | Apoptosis | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 | FETAL GROWTH | RIBONUCLEIC-ACID EXPRESSION | pregnancy | TISSUE | apoptosis | MODEL | DECIDUA | REPRODUCTIVE BIOLOGY | NITRIC-OXIDE | placenta | conceptus | corticosterone | EXPOSURE | BASAL | In Situ Nick-End Labeling | Rats, Wistar | Anti-Inflammatory Agents - pharmacology | Apoptosis - drug effects | Humans | Placenta - physiology | Enzyme Inhibitors - pharmacology | Rats | 11-beta-Hydroxysteroid Dehydrogenases | Gestational Age | Placenta - drug effects | Carbenoxolone - pharmacology | Organ Size - drug effects | Animals | Dexamethasone - pharmacology | Placenta - cytology | DNA Fragmentation | Glucocorticoids - pharmacology | Female | Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Apoptosis - physiology | Fetal Weight - drug effects
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4. Full Text Prostaglandin E1 protects lung transplants from ischemia-reperfusion injury: A shift from pro- to anti-inflammatory cytokines
by De Perrot, Marc and Fischer, Stefan and Liu, Mingyao and Jin, Rongyu and Bai, Xiao-Hui and Waddell, Thomas K and Keshavjee, Shaf
Transplantation, ISSN 0041-1337, 11/2001, Volume 72, Issue 9, pp. 1505 - 1512
Introduction. Prostaglandin E-1 (PGE(1)) has been demonstrated to reduce ischemia-reperfusion (IR) injury following lung transplantation. However, the... 
SURGERY | NECROSIS-FACTOR-ALPHA | INTERLEUKIN-10 | IMMUNOLOGY | MURINE PERITONEAL-MACROPHAGES | CELL-DEATH | TRANSPLANTATION | LIVER-INJURY | GENE-EXPRESSION | ESCHERICHIA-COLI INFECTION | UP-REGULATION | T-LYMPHOCYTES | B-MEDIATED TRANSCRIPTION | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Rats, Inbred Lew | Interleukin-10 - blood | Male | Interferon-gamma - metabolism | Interleukin-4 - biosynthesis | Alprostadil - therapeutic use | Lung Transplantation - pathology | Models, Animal | Cytokines - blood | In Situ Nick-End Labeling | Rats | Interleukin-4 - blood | Animals | Reperfusion Injury - prevention & control | Oxygen Consumption - drug effects | Lung Transplantation - physiology | Interleukin-10 - biosynthesis | Inflammation - prevention & control | Interleukin-2 - biosynthesis | Cytokines - biosynthesis | Interferon-gamma - blood | Apoptosis | Inflammation - physiopathology | Interleukin-2 - blood
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5. Full Text Genomic analyses identify molecular subtypes of pancreatic cancer
by Bailey, Peter and Chang, David K and Nones, Katia and Johns, Amber L and Patch, Ann-Marie and Gingras, Marie-Claude and Miller, David K and Christ, Angelika N and Bruxner, Tim J. C and Quinn, Michael C and Nourse, Craig and Murtaugh, L. Charles and Harliwong, Ivon and Idrisoglu, Senel and Manning, Suzanne and Nourbakhsh, Ehsan and Wani, Shivangi and Fink, Lynn and Holmes, Oliver and Chin, Venessa and Anderson, Matthew J and Kazakoff, Stephen and Leonard, Conrad and Newell, Felicity and Waddell, Nick and Wood, Scott and Xu, Qinying and Wilson, Peter J and Cloonan, Nicole and Kassahn, Karin S and Taylor, Darrin and Quek, Kelly and Robertson, Alan and Pantano, Lorena and Mincarelli, Laura and Sanchez, Luis N and Evers, Lisa and Wu, Jianmin and Pinese, Mark and Cowley, Mark J and Jones, Marc D and Colvin, Emily K and Nagrial, Adnan M and Humphrey, Emily S and Chantrill, Lorraine A and Mawson, Amanda and Humphris, Jeremy and Chou, Angela and Pajic, Marina and Scarlett, Christopher J and Pinho, Andreia V and Giry-Laterriere, Marc and Rooman, Ilse and Samra, Jaswinder S and Kench, James G and Lovell, Jessica A and Merrett, Neil D and Toon, Christopher W and Epari, Krishna and Nguyen, Nam Q and Barbour, Andrew and Zeps, Nikolajs and Moran-Jones, Kim and Jamieson, Nigel B and Graham, Janet S and Duthie, Fraser and Oien, Karin and Hair, Jane and Grützmann, Robert and Maitra, Anirban and Iacobuzio-Donahue, Christine A and Wolfgang, Christopher L and Morgan, Richard A and Lawlor, Rita T and Corbo, Vincenzo and Bassi, Claudio and Rusev, Borislav and Capelli, Paola and Salvia, Roberto and Tortora, Giampaolo and Mukhopadhyay, Debabrata and Petersen, Gloria M and Munzy, Donna M and Fisher, William E and Karim, Saadia A and Eshleman, James R and Hruban, Ralph H and Pilarsky, Christian and Morton, Jennifer P and Sansom, Owen J and Scarpa, Aldo and Musgrove, Elizabeth A and Bailey, Ulla-Maja Hagbo and Hofmann, Oliver and Sutherland, Robert L and Wheeler, David A and Gill, Anthony J and Gibbs, Richard A and Pearson, John V and Waddell, Nicola and ... and Australian Pancreatic Canc Genome and Australian Pancreatic Cancer Genome Initiative
Nature, ISSN 0028-0836, 03/2016, Volume 531, Issue 7592, pp. 47 - 52
Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-beta,... 
PATHWAYS | METASTASIS | DUCTAL ADENOCARCINOMA | PACKAGE | MULTIDISCIPLINARY SCIENCES | TUMOR | MUTATIONS | DIFFERENTIATION | Pancreatic Neoplasms - metabolism | Prognosis | Hepatocyte Nuclear Factor 3-beta - genetics | Genomics | Humans | Carcinoma, Pancreatic Ductal - metabolism | Gene Expression Regulation, Neoplastic | Transcriptome | Hepatocyte Nuclear Factor 3-gamma - genetics | Gene Regulatory Networks | Histone Demethylases - genetics | Tumor Suppressor Protein p53 - genetics | Carcinoma, Pancreatic Ductal - genetics | DNA Methylation | Tumor Suppressor Proteins - genetics | Carcinoma, Pancreatic Ductal - classification | Trans-Activators - genetics | Pancreatic Neoplasms - classification | Transcription, Genetic | Nuclear Proteins - genetics | Carcinoma, Pancreatic Ductal - immunology | Genes, Neoplasm - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Carcinoma, Pancreatic Ductal - pathology | Genome, Human - genetics | Homeodomain Proteins - genetics | Animals | Pancreatic Neoplasms - immunology | Survival Analysis | Cell Line, Tumor | Mice | Physiological aspects | Pancreatic cancer | Methods | Genes | Genomes | Mutation | Gene expression | Tumors
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6. Full Text Whole-genome landscapes of major melanoma subtypes
by Hayward, Nicholas K and Wilmott, James S and Waddell, Nicola and Johansson, Peter A and Field, Matthew A and Nones, Katia and Patch, Ann-Marie and Kakavand, Hojabr and Alexandrov, Ludmil B and Burke, Hazel and Jakrot, Valerie and Kazakoff, Stephen and Holmes, Oliver and Leonard, Conrad and Sabarinathan, Radhakrishnan and Mularoni, Loris and Wood, Scott and Xu, Qinying and Waddell, Nick and Tembe, Varsha and Pupo, Gulietta M and De Paoli-Iseppi, Ricardo and Vilain, Ricardo E and Shang, Ping and Lau, Loretta M. S and Dagg, Rebecca A and Schramm, Sarah-Jane and Pritchard, Antonia and Dutton-Regester, Ken and Newell, Felicity and Fitzgerald, Anna and Shang, Catherine A and Grimmond, Sean M and Pickett, Hilda A and Yang, Jean Y and Stretch, Jonathan R and Behren, Andreas and Kefford, Richard F and Hersey, Peter and Long, Georgina V and Cebon, Jonathan and Shackleton, Mark and Spillane, Andrew J and Saw, Robyn P. M and López-Bigas, Núria and Pearson, John V and Thompson, John F and Scolyer, Richard A and Mann, Graham J and Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7653, pp. 175 - 180
Melanoma of the skin is a common cancer only in Europeans, whereas it arises in internal body surfaces (mucosal sites) and on the hands and feet (acral sites)... 
TERT PROMOTER MUTATIONS | UVEAL MELANOMA | SEQUENCE DATA | MULTIDISCIPLINARY SCIENCES | RECURRENT MUTATIONS | FREQUENT SOMATIC MUTATIONS | MALIGNANT-MELANOMA | GENERAL FRAMEWORK | CANCER GENOMES | ACTIVATING MUTATIONS | DRIVER MUTATIONS | Membrane Proteins - genetics | Humans | X-linked Nuclear Protein | Phosphoproteins - genetics | RNA Splicing Factors - genetics | Mutation - genetics | Genes, p16 | Genome, Human - genetics | Tumor Suppressor Protein p53 - genetics | Ultraviolet Rays - adverse effects | Telomerase - genetics | Signal Transduction - drug effects | GTP Phosphohydrolases - genetics | Melanoma - genetics | Proto-Oncogene Proteins B-raf - genetics | Mitogen-Activated Protein Kinases - genetics | Neurofibromatosis 1 - genetics | Melanoma - classification | Nuclear Proteins - genetics | DNA Helicases - genetics | Telomere - genetics | Genetic research | Genetic aspects | Genomes | Research | Melanoma | Pathogenesis | Copy number | Mucosa | p53 Protein | Radiation | Security | Epidemiology | Metastases | Scholarships & fellowships | Reproduction (copying) | Coding | Mismatch repair | Clusters | Eye (anatomy) | Deoxyribonucleic acid--DNA | Medical research | Breakpoints | Radiation effects | MAP kinase | Exposure | Sun | Amplification | Bridges | Pathology | Ultraviolet radiation | Mutagenesis | Computation | Skin | Mutation | Internet | Aberration | Biotechnology | Genes | DNA damage | Carcinogens | Infrastructure | Signatures | Health | U.V. radiation | Inversions | Foldback | Data processing | Energy policy | Readers | Deamination | Protein kinase | Cell lines | Gene mapping | Tumors | Cancer | Index Medicus | Biological Science | 60 APPLIED LIFE SCIENCES
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7. Full Text Whole-genome characterization of chemoresistant ovarian cancer
by Patch, Ann-Marie and Christie, Elizabeth L and Etemadmoghadam, Dariush and Garsed, Dale W and George, Joshy and Fereday, Sian and Nones, Katia and Cowin, Prue and Alsop, Kathryn and Bailey, Peter J and Kassahn, Karin S and Newell, Felicity and Quinn, Michael C.J and Kazakoff, Stephen and Quek, Kelly and Wilhelm-Benartzi, Charlotte and Curry, Ed and Leong, Huei San and Hamilton, Anne and Mileshkin, Linda and Au-Yeung, George and Kennedy, Catherine and Hung, Jillian and Chiew, Yoke-Eng and Harnett, Paul and Friedlander, Michael and Quinn, Michael and Pyman, Jan and Cordner, Stephen and O'Brien, Patricia and Leditschke, Jodie and Young, Greg and Strachan, Kate and Waring, Paul and Azar, Walid and Mitchell, Chris and Traficante, Nadia and Hendley, Joy and Thorne, Heather and Shackleton, Mark and Miller, David K and Arnau, Gisela Mir and Tothill, Richard W and Holloway, Timothy P and Semple, Timothy and Harliwong, Ivon and Nourse, Craig and Nourbakhsh, Ehsan and Manning, Suzanne and Idrisoglu, Senel and Bruxner, Timothy J. C and Christ, Angelika N and Poudel, Barsha and Holmes, Oliver and Anderson, Matthew and Leonard, Conrad and Lonie, Andrew and Hall, Nathan and Wood, Scott and Taylor, Darrin F and Xu, Qinying and Lynn Fink, J and Waddell, Nick and Drapkin, Ronny and Stronach, Euan and Gabra, Hani and Brown, Robert and Jewell, Andrea and Nagaraj, Shivashankar H and Markham, Emma and Wilson, Peter J and Ellul, Jason and McNally, Orla and Doyle, Maria A and Vedururu, Ravikiran and Stewart, Collin and Lengyel, Ernst and Pearson, John V and Waddell, Nicola and Defazio, Anna and Grimmond, Sean M and Bowtell, David D. L and Australian Ovarian Canc Study Grp and Australian Ovarian Cancer Study Group and The Australian Ovarian Cancer Study Group
Nature, ISSN 0028-0836, 05/2015, Volume 521, Issue 7553, pp. 489 - 494
Patients with high-grade serous ovarian cancer (HGSC) have experienced little improvement in overall survival, and standard treatment has not advanced beyond... 
INTERNAL SHOCKS | M87 JET | MUTATIONAL PROCESSES | EVOLUTION | SIGNATURES | MULTIDISCIPLINARY SCIENCES | CLINICAL-TRIALS | BRCA1 | COPY-NUMBER ALTERATION | DISCOVERY | CHEMOTHERAPY RESISTANCE | Oncogene Proteins - genetics | PTEN Phosphohydrolase - genetics | Humans | Mutagenesis - genetics | Cystadenocarcinoma, Serous - genetics | DNA-Binding Proteins - genetics | Genes, Neurofibromatosis 1 | Germ-Line Mutation - genetics | Cyclin E - genetics | Cystadenocarcinoma, Serous - drug therapy | Promoter Regions, Genetic - genetics | Genome, Human - genetics | Ovarian Neoplasms - genetics | DNA Methylation | Drug Resistance, Neoplasm - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | DNA Mutational Analysis | Retinoblastoma Protein - genetics | Genes, BRCA2 | Female | Genes, BRCA1 | Ovarian Neoplasms - drug therapy | Cohort Studies | Drug Resistance, Neoplasm - drug effects | Care and treatment | Analysis | Genetic aspects | Nucleotide sequencing | Methylation | Ovarian cancer | DNA sequencing | Gene amplification | Genomes | Mutation | Metastasis | Gene expression | Chromosomes | Patients | Tumors
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8. Full Text Whole-genome landscape of pancreatic neuroendocrine tumours
by Scarpa, Aldo and Chang, David K and Nones, Katia and Corbo, Vincenzo and Patch, Ann-Marie and Bailey, Peter and Lawlor, Rita T and Johns, Amber L and Miller, David K and Mafficini, Andrea and Rusev, Borislav and Scardoni, Maria and Antonello, Davide and Barbi, Stefano and Sikora, Katarzyna O and Cingarlini, Sara and Vicentini, Caterina and McKay, Skye and Quinn, Michael C.J and Bruxner, Timothy J.C and Christ, Angelika N and Harliwong, Ivon and Idrisoglu, Senel and McLean, Suzanne and Nourse, Craig and Nourbakhsh, Ehsan and Wilson, Peter J and Anderson, Matthew J and Fink, J. Lynn and Newell, Felicity and Waddell, Nick and Holmes, Oliver and Kazakoff, Stephen H and Leonard, Conrad and Wood, Scott and Xu, Qinying and Nagaraj, Shivashankar Hiriyur and Amato, Eliana and Dalai, Irene and Bersani, Samantha and Cataldo, Ivana and Dei Tos, Angelo P and Capelli, Paola and Davì, Maria Vittoria and Landoni, Luca and Malpaga, Anna and Miotto, Marco and Whitehall, Vicki L.J and Leggett, Barbara A and Harris, Janelle L and Harris, Jonathan and Jones, Marc D and Humphris, Jeremy and Chantrill, Lorraine A and Chin, Venessa and Nagrial, Adnan M and Pajic, Marina and Scarlett, Christopher J and Pinho, Andreia and Rooman, Ilse and Toon, Christopher and Wu, Jianmin and Pinese, Mark and Cowley, Mark and Barbour, Andrew and Mawson, Amanda and Humphrey, Emily S and Colvin, Emily K and Chou, Angela and Lovell, Jessica A and Jamieson, Nigel B and Duthie, Fraser and Gingras, Marie-Claude and Fisher, William E and Dagg, Rebecca A and Lau, Loretta M.S and Lee, Michael and Pickett, Hilda A and Reddel, Roger R and Samra, Jaswinder S and Kench, James G and Merrett, Neil D and Epari, Krishna and Nguyen, Nam Q and Zeps, Nikolajs and Falconi, Massimo and Simbolo, Michele and Butturini, Giovanni and Van Buren, George and Partelli, Stefano and Fassan, Matteo and Khanna, Kum Kum and Gill, Anthony J and Wheeler, David A and Gibbs, Richard A and Musgrove, Elizabeth A and Bassi, Claudio and Tortora, Giampaolo and Pederzoli, Paolo and Pearson, John V and ... and Australian Pancreatic Canc Genome and Australian Pancreatic Cancer Genome Initiative
Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7643, pp. 65 - 71
The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to more sensitive detection methods, and this increase is creating challenges... 
MOLECULAR SUBTYPES | MUTATIONAL PROCESSES | TRANSLOCATION | SUPPRESSOR | PROTEIN | PATHWAY GENES | MULTIDISCIPLINARY SCIENCES | MTOR PATHWAY | TP53 MUTATIONS | CANCER | EWING SARCOMA | Calmodulin-Binding Proteins - genetics | RNA-Binding Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Genomics | Humans | DNA Glycosylases - genetics | Carcinoma, Neuroendocrine - genetics | Chromatin Assembly and Disassembly - genetics | Male | Pancreatic Neoplasms - genetics | DNA Copy Number Variations - genetics | DNA Repair - genetics | Germ-Line Mutation - genetics | Genome, Human - genetics | DNA Mutational Analysis | Base Sequence | Chromosome Aberrations | Female | Telomere - metabolism | RNA-Binding Protein EWS | Telomere - genetics | Genetic aspects | Nucleotide sequencing | Pancreatic cancer | Methods | DNA sequencing | Genes | Biomarkers | Genomes | Mutation | Signatures | Patients | Tumors | Index Medicus
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