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Nature, ISSN 0028-0836, 11/2009, Volume 462, Issue 7269, pp. 108 - 112
Journal Article
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2014, Volume 89, Issue 4, pp. 830 - 838
Purpose To evaluate the safety, efficacy and biomarkers of short-course proton beam radiation and capecitabine, followed by pancreaticoduodenectomy in a phase... 
Radiology | Hematology, Oncology and Palliative Medicine | RECTAL-CANCER | ONCOLOGY-GROUP | ONCOLOGY | RESECTION | LONG-TERM SURVIVAL | RANDOMIZED CONTROLLED-TRIAL | PERIAMPULLARY CARCINOMA | SHORT-COURSE RADIOTHERAPY | FAILURE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | CHEMOTHERAPY | RADIATION-THERAPY | Pancreatic Neoplasms - chemistry | Proto-Oncogene Proteins p21(ras) | Receptors, CXCR - analysis | Prognosis | Prospective Studies | Capecitabine | Carcinoembryonic Antigen - blood | Humans | Middle Aged | Male | Pancreaticoduodenectomy | Chemoradiotherapy, Adjuvant - mortality | Fluorouracil - therapeutic use | Deoxycytidine - therapeutic use | Proto-Oncogene Proteins - analysis | Aged, 80 and over | Carcinoma, Pancreatic Ductal - mortality | Female | Pancreatic Neoplasms - mortality | CA-19-9 Antigen - blood | Genes, ras - genetics | Pancreatic Neoplasms - blood | Fluorouracil - analogs & derivatives | Biomarkers, Tumor - analysis | Pancreatic Neoplasms - pathology | Carcinoma, Pancreatic Ductal - therapy | ras Proteins - analysis | Carcinoma, Pancreatic Ductal - pathology | Chemoradiotherapy, Adjuvant - methods | Carcinoma, Pancreatic Ductal - blood | Carcinoma, Pancreatic Ductal - chemistry | Antimetabolites, Antineoplastic - therapeutic use | Hepatocyte Growth Factor - blood | Aged | Proton Therapy - methods | Deoxycytidine - analogs & derivatives | Pancreatic Neoplasms - therapy | Adenocarcinoma | Sects | Nuclear radiation | Index Medicus | SURGERY | GLYCINE | PATIENTS | BIOPSY | GENE MUTATIONS | PANCREAS | PROTON BEAMS | RADIATION DOSES | TOXICITY | CHEST | PAIN | BIOLOGICAL MARKERS | ASPARTIC ACID | CARCINOMAS | RADIOLOGY AND NUCLEAR MEDICINE | RADIOTHERAPY | BLOOD
Journal Article
Journal Article
Cancer, ISSN 0008-543X, 05/2014, Volume 120, Issue 10, pp. 1482 - 1490
In this study, NRAS mutations were observed almost exclusively in rectal cancers compared with colon cancers. This result suggests that there may be a biologic... 
mutation | NRAS | BRAF | colorectal cancer | clinicopathologic | ASSOCIATIONS | CODON 12 | COLON-CANCER | RECTAL-CANCER | CIGARETTE-SMOKING | POLYMORPHISMS | ONCOLOGY | TUMOR SITE | CARCINOMAS | KRAS | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Rectal Neoplasms - chemistry | Gene Expression Profiling | Tumor Suppressor Protein p53 - genetics | Proto-Oncogene Proteins B-raf - analysis | Rectal Neoplasms - genetics | DNA Mutational Analysis | Aged, 80 and over | Adult | Colonic Neoplasms - chemistry | Female | Adenocarcinoma - genetics | Rectal Neoplasms - pathology | Retrospective Studies | Adenocarcinoma - chemistry | Adenomatous Polyposis Coli Protein - genetics | Colonic Neoplasms - mortality | Biomarkers, Tumor - analysis | Membrane Proteins - genetics | Risk Factors | Kaplan-Meier Estimate | Genotype | Proto-Oncogene Proteins - genetics | Adenocarcinoma - secondary | Rectal Neoplasms - mortality | Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases | GTP Phosphohydrolases - genetics | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Aged | Biomarkers, Tumor - genetics | Mutation | Neoplasm Staging | Adenocarcinoma - mortality | Care and treatment | Usage | Colorectal cancer | Genetic aspects | Metastasis | Risk factors
Journal Article
The Oncologist, ISSN 1083-7159, 01/2012, Volume 17, Issue 1, pp. 14 - e34
摘要 背景 西妥昔单抗和帕尼单抗是靶向作用于表皮生长因子受体(EGFR)的单克隆抗体,已获准用于治疗KRAS野生型转移性结直肠癌患者。尚无数据描述帕尼单抗在西妥昔单抗治疗中进展的患者中的活性。作者开展了一项单组II期试验,研究帕尼单抗用于既往西妥昔单抗治疗中进展的KRAS野生型转移性结直肠癌患者。 患者和方法。... 
1ST-LINE TREATMENT | MONOTHERAPY | EFFICACY | ONCOLOGY | BEVACIZUMAB | SAFETY | INFUSION REACTIONS | IRINOTECAN | OXALIPLATIN | CHEMOTHERAPY | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Colorectal Neoplasms - genetics | Humans | Middle Aged | Antibodies, Monoclonal - therapeutic use | Drug Resistance, Neoplasm | Male | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - therapeutic use | Antibodies, Monoclonal, Humanized | Colorectal Neoplasms - drug therapy | Female | Cetuximab | Index Medicus | Clinical Trial Reports
Journal Article
Investigational New Drugs, ISSN 0167-6997, 2/2015, Volume 33, Issue 1, pp. 128 - 137
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2012, Volume 83, Issue 3, pp. e337 - e343
Purpose Pancreatic neuroendocrine tumors (pNET) are rare neoplasms associated with poor outcomes without resection, and involved surgical margins are... 
Radiology | Hematology, Oncology and Palliative Medicine | Adjuvant radiotherapy | Margin positive | Local control | Survival | Pancreatic neuroendocrine tumor | SURGERY | NEOPLASMS | ONCOLOGY | ENDOCRINE TUMORS | EXPERIENCE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Capecitabine | Humans | Middle Aged | Male | Neoplasm Recurrence, Local - mortality | Neoplasm, Residual | Pancreatic Neoplasms - drug therapy | Fluorouracil - therapeutic use | Deoxycytidine - therapeutic use | Radiotherapy, Adjuvant - mortality | Aged, 80 and over | Adult | Dose Fractionation | Female | Pancreatic Neoplasms - mortality | Retrospective Studies | Liver Neoplasms - secondary | Neuroendocrine Tumors - pathology | Radiotherapy Dosage | Fluorouracil - analogs & derivatives | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - radiotherapy | Tumor Burden | Neuroendocrine Tumors - radiotherapy | Antimetabolites, Antineoplastic - therapeutic use | Neuroendocrine Tumors - secondary | Radiotherapy, Adjuvant - methods | Neuroendocrine Tumors - mortality | Sex Factors | Neuroendocrine Tumors - drug therapy | Aged | Deoxycytidine - analogs & derivatives | Prognosis | Radiotherapy | Nuclear radiation | Radiation | Tumors | DIAGNOSIS | PATIENTS | URACILS | METASTASES | PANCREAS | EVALUATION | FEMALES | RADIATION DOSES | CHEMOTHERAPY | MULTIVARIATE ANALYSIS | LIVER | RADIOLOGY AND NUCLEAR MEDICINE | RADIOTHERAPY | MALES | HAZARDS
Journal Article