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Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 376 - 12
Seeded polymerisation of proteins forming amyloid fibres and their spread in tissues has been implicated in the pathogenesis of multiple neurodegenerative... 
STRAINS | PROTEIN | IMAGE | CONFORMATIONAL PROPERTIES | MULTIDISCIPLINARY SCIENCES | P102L | STRAUSSLER-SCHEINKER-DISEASE | PHENOTYPIC HETEROGENEITY | Atomic force microscopy | Neurodegenerative diseases | Fibrils | Polymerization | Rods | Electron microscopy | Fibers | Adhesives | Microscopy | Neurodegeneration | Protein folding | Prions | Amyloid | Prion protein | Double-stranded
Journal Article
FRONTIERS IN MOLECULAR NEUROSCIENCE, ISSN 1662-5099, 07/2019, Volume 12, pp. 169 - 169
Prions are lethal pathogens, which cause fatal neurodegenerative diseases in mammals. They are unique infectious agents and are composed of self-propagating... 
STRAINS | prion disease | PROTEIN | tau | NEURONAL INCLUSIONS | alpha-synuclein | FRONTOTEMPORAL LOBAR DEGENERATION | NEUROSCIENCES | amyloid beta | BETA-AMYLOID FIBRILS | prion structure | HETEROGENEITY | prion-like | TDP-43 | DISEASE | prion | Alzheimer's disease | BRAIN | Nervous system diseases | Research | Mammals | Health aspects | Prions | Alzheimer’s disease
Journal Article
JAMA Neurology, ISSN 2168-6149, 04/2016, Volume 73, Issue 4, p. 447
  A major challenge for drug development in neurodegenerative diseases is that adequately powered efficacy studies with meaningful end points typically require... 
Genotype & phenotype | Simulation | Clinical trials | Neurological disorders | Dementia
Journal Article
Nature, ISSN 0028-0836, 09/2015, Volume 525, Issue 7568, pp. 247 - 250
Journal Article
PLoS Pathogens, ISSN 1553-7366, 07/2015, Volume 11, Issue 7
  Inherited prion disease (IPD) is caused by autosomal-dominant pathogenic mutations in the human prion protein (PrP) gene (PRNP). A proline to leucine... 
Proteins | Immunoglobulins | Hypotheses | Biomedical research | Brain research | Funding | Transgenic animals | Prions | Rodents | Creutzfeldt-Jakob disease | Mutation
Journal Article
Journal Article
PLoS Pathogens, ISSN 1553-7366, 09/2013, Volume 9, Issue 9
  Prions are infectious agents causing fatal neurodegenerative diseases of humans and animals. In humans, these have sporadic, acquired and inherited... 
Proteins | Immunization | Disease transmission | Biomedical research | Brain research | Neurodegeneration | Pathogenesis | Prions | Rodents | Creutzfeldt-Jakob disease | Mutation | Laboratory animals
Journal Article
Nature, ISSN 0028-0836, 06/2015, Volume 522, Issue 7557, pp. 478 - 481
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2017, Volume 376, Issue 3, pp. 292 - 294
In this case study, variant Creutzfeldt–Jakob disease (CJD) is shown to occur in a young man with heterozygosity, rather than homozygosity, at codon 129 of the... 
MEDICINE, GENERAL & INTERNAL | Magnetic Resonance Imaging | Brain - diagnostic imaging | Humans | Fatal Outcome | Brain - pathology | Adult | Heterozygote | Male | Creutzfeldt-Jakob Syndrome - genetics | Prion Proteins - genetics | Genotype & phenotype | Brain research | Disease | BSE | Creutzfeldt-Jakob disease | Prion protein | Heterozygosity
Journal Article
Science, ISSN 0036-8075, 12/2004, Volume 306, Issue 5702, pp. 1793 - 1796
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 11/2013, Volume 369, Issue 20, pp. 1904 - 1914
Journal Article