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1. Full Text Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression
by Tsankov, AM and Wadsworth, MH and Akopian, V and Charlton, J and Allon, SJ and Arczewska, A and Mead, BE and Drake, RS and Smith, ZD and Mikkelsen, TS and Shalek, AK and Meissner, A
DEVELOPMENT, ISSN 0950-1991, 10/2019, Volume 146, Issue 19, p. dev174722
Maintenance of pluripotency and specification towards a new cell fate are both dependent on precise interactions between extrinsic signals and transcriptional... 
STEM-CELLS | METHYLATION | DNMT3A | DEVELOPMENTAL BIOLOGY | DNA methyltransferases | FATE | IDENTIFICATION | GENE | RNA-SEQ | DNA methylation | Single-cell RNA-sequencing | DIFFERENTIATION | EXPRESSION | Pluripotency | CYCLE
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2. Full Text Polymer sequestrants for biological and environmental applications
by Archer, William R and Hall, Brady A and Thompson, Tiffany N and Wadsworth, Ophelia J and Schulz, Michael D
Polymer International, ISSN 0959-8103, 07/2019, Volume 68, Issue 7, pp. 1220 - 1237
Toxic contaminates have profound consequences on both health and the environment. Consequently, effective approaches for addressing the effects of these... 
heavy metal | radionuclides | toxin | sequestration | chelation | micropollutants | HEAVY-METAL IONS | CLOSTRIDIUM-DIFFICILE INFECTION | MOLECULARLY IMPRINTED POLYMER | POLYMER SCIENCE | POLYCYCLIC AROMATIC-HYDROCARBONS | ORGANOPHOSPHORUS PESTICIDES | ENHANCED ULTRAFILTRATION | AQUEOUS-SOLUTION | SELECTIVE EXTRACTION | PHARMACEUTICAL APPLICATIONS | SOLID-PHASE EXTRACTION | Polycyclic aromatic hydrocarbons | Forensic sciences | Environmental aspects | Mineral industry | Combustion | Poisoning | Polymer industry | Polymers | Mining industry | Heavy metals | Agricultural chemicals | Pollution sources | Pesticides | Agricultural economics | Contamination | Organic chemistry | Toxicants | Contaminants | Chelation | Toxins
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3. SEMI-PERMEABLE ARRAYS FOR ANALYZING BIOLOGICAL SYSTEMS AND METHODS OF USING SAME
by Wadsworth II, Marc H and Shalek, Alexander K and Love, J. Christopher and Carroll, Shaina and Hughes, Travis K and Gierahn, Todd M
05/2019
The present application provides a method of assembling a container for one or multiple parallel steps of biochemical analysis on one or more cells comprising... 
WINE | MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS | TRANSPORTING | ENZYMOLOGY | CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY | COMPOSITIONS OR TEST PAPERS THEREFOR | MICROBIOLOGY | PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | THEIR RELEVANT APPARATUS | METALLURGY | PROCESSES OF PREPARING SUCH COMPOSITIONS | BIOCHEMISTRY | CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES | CHEMISTRY | VINEGAR | PERFORMING OPERATIONS
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4. CALLING GENETIC VARIATION FROM SINGLE-CELL TRANSCRIPTOMES
by SHALEK, Alexander K and VAN GALEN, Peter and LOVE, J. Christopher and GIERAHN, Todd M and BERNSTEIN, Bradley and HOVESTADT, Volker and HUGHES, Travis and WADSWORTH II, Marc H and TU, Ang A
05/2019
The present invention relates to methods of deriving genetic information from RNA-seq libraries, that can enable an overlay of genetic information (such as... 
WINE | MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS | HYGIENE | ENZYMOLOGY | COMPOSITIONS OR TEST PAPERS THEREFOR | INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES | MEDICAL OR VETERINARY SCIENCE | MICROBIOLOGY | MEASURING | HUMAN NECESSITIES | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | TESTING | METALLURGY | PROCESSES OF PREPARING SUCH COMPOSITIONS | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | BIOCHEMISTRY | CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES | CHEMISTRY | VINEGAR | PHYSICS
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5. FUNCTIONALIZED SOLID SUPPORT
by SHALEK, Alexander K and HUGHES, Travis K and NAVIA, Andrew and CARROLL, Shaina and VAN HUMBECK, Jeffrey F and WADSWORTH II, Marc H
05/2019
The present invention relates to functionalized solid supports and methods of making functionalized solid supports. Methods for preparing a population of high... 
WINE | MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS | ENZYMOLOGY | MICROORGANISMS OR ENZYMES | COMPOSITIONS OR TEST PAPERS THEREFOR | MICROBIOLOGY | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | COMPOSITIONS THEREOF | PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS | METALLURGY | PROCESSES OF PREPARING SUCH COMPOSITIONS | BIOCHEMISTRY | CULTURE MEDIA | CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES | CHEMISTRY | VINEGAR
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6. Full Text Acute cervical spinal cord injury and extubation failure: A systematic review and meta-analysis
by Wilson, Miles and Nickels, Marc and Wadsworth, Brooke and Kruger, Peter and Semciw, Adam
Australian critical care : official journal of the Confederation of Australian Critical Care Nurses, ISSN 1036-7314, 03/2019
Respiratory complications are the most significant cause of morbidity and mortality in acute cervical spinal cord injury (CSCI). The prevalence of extubation... 
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7. Full Text Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity
by van Galen, Peter and Hovestadt, Volker and Wadsworth II, Marc H and Hughes, Travis K and Griffin, Gabriel K and Battaglia, Sofia and Verga, Julia A and Stephansky, Jason and Pastika, Timothy J and Lombardi Story, Jennifer and Pinkus, Geraldine S and Pozdnyakova, Olga and Galinsky, Ilene and Stone, Richard M and Graubert, Timothy A and Shalek, Alex K and Aster, Jon C and Lane, Andrew A and Bernstein, Bradley E
Cell, ISSN 0092-8674, 03/2019, Volume 176, Issue 6, pp. 1265 - 1281.e24
Acute myeloid leukemia (AML) is a heterogeneous disease that resides within a complex microenvironment, complicating efforts to understand how different cell... 
single-cell RNA-sequencing | cancer genetics | leukemia stem cells | immunity | acute myeloid leukemia | genotyping | STEM-CELLS | PROGENITOR | GENOMICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUPPRESSOR-CELLS | LEUKEMIA | FUTURE | CANCER | CELL BIOLOGY | RNA sequencing | RNA | Leukemia | Immunotherapy | Genes | Machine learning | Stem cells | Development and progression | Genetic transcription | T cells
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8. Full Text Seq-Well: A Sample-Efficient, Portable Picowell Platform for Massively Parallel Single-Cell RNA Sequencing
by Aicher, Toby P and Carroll, Shaina and Raddi, Gianmarco and Gierahn, Todd and Wadsworth, 2nd, Marc H and Hughes, Travis K and Love, Chris and Shalek, Alex K
Methods in molecular biology (Clifton, N.J.), 2019, Volume 1979, p. 111
Seq-Well is a low-cost picowell platform that can be used to simultaneously profile the transcriptomes of thousands of cells from diverse, low input clinical... 
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9. Full Text Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types
by Mead, Benjamin E and Ordovas-Montanes, Jose and Braun, Alexandra P and Levy, Lauren E and Bhargava, Prerna and Szucs, Matthew J and Ammendolia, Dustin A and MacMullan, Melanie A and Yin, Xiaolei and Hughes, Travis K and Wadsworth, Marc H and Ahmad, Rushdy and Rakoff-Nahoum, Seth and Carr, Steven A and Langer, Robert and Collins, James J and Shalek, Alex K and Karp, Jeffrey M
BMC Biology, ISSN 1741-7007, 06/2018, Volume 16, Issue 1, pp. 62 - 24
Background: Single-cell genomic methods now provide unprecedented resolution for characterizing the component cell types and states of tissues such as the... 
Chemical biology | Paneth cell | Single-cell RNA-seq | Systems biology | Intestinal organoid | Intestinal stem cell | Differentiation | Stem cell-derived models | HOMEOSTASIS | CROHNS-DISEASE | INTESTINAL STEM-CELLS | ALPHA-DEFENSINS | LARGE GENE LISTS | INFLAMMATORY-BOWEL-DISEASE | EPITHELIAL-CELLS | BIOLOGY | PANETH CELLS | WIDE | WNT | RNA sequencing | Usage | Epithelial cells | Analysis | Stem cells | Physiological aspects | Models | Research | Fidelity | Antimicrobial activity | Genes | Homeostasis | Workflow | Exploration | Antimicrobial agents | Gastrointestinal tract | Genomes | Gene expression | Ribonucleic acid--RNA | Small intestine | Molecular chains | Inflammatory bowel disease | Studies | Organoids | Proteomics | Physiology | Bioinformatics
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10. SEMI-PERMEABLE ARRAYS FOR ANALYZING BIOLOGICAL SYSTEMS AND METHODS OF USING SAME
by HUGHES, Travis, K and GIERAHN, Todd M and LOVE, J. Christopher and WADSWORTH, Marc, H and SHALEK, Alexander, K and CARROLL, Shaina
11/2018
The present application provides a method of assembling a container for one or multiple parallel steps of biochemical analysis on one or more cells comprising... 
WINE | MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS | ENZYMOLOGY | COMPOSITIONS OR TEST PAPERS THEREFOR | INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES | MICROBIOLOGY | MEASURING | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | TESTING | METALLURGY | PROCESSES OF PREPARING SUCH COMPOSITIONS | BIOCHEMISTRY | CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES | CHEMISTRY | VINEGAR | PHYSICS
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11. Full Text Allergic inflammatory memory in human respiratory epithelial progenitor cells
by Ordovas-Montanes, Jose and Dwyer, Daniel F and Nyquist, Sarah K and Buchheit, Kathleen M and Vukovic, Marko and Deb, Chaarushena and Wadsworth, Marc H and Hughes, Travis K and Kazer, Samuel W and Yoshimoto, Eri and Cahill, Katherine N and Bhattacharyya, Neil and Katz, Howard R and Berger, Bonnie and Laidlaw, Tanya M and Boyce, Joshua A and Barrett, Nora A and Shalek, Alex K
Nature, ISSN 0028-0836, 08/2018, Volume 560, Issue 7720, pp. 649 - 654
Barrier tissue dysfunction is a fundamental feature of chronic human inflammatory diseases(1). Specialized subsets of epithelial cells-including secretory and... 
STEM-CELLS | MULTIDISCIPLINARY SCIENCES | DUPILUMAB | DISEASE | INNATE LYMPHOID-CELLS | IMMUNOLOGY | CHRONIC RHINOSINUSITIS | BASAL-CELLS | Stem Cells - immunology | Epithelial Cells - metabolism | Epigenesis, Genetic | Humans | Middle Aged | Transcriptome | Hypersensitivity - immunology | Interleukin-13 - immunology | Case-Control Studies | Respiratory Mucosa - pathology | Young Adult | Sinusitis - immunology | Respiratory Mucosa - immunology | Sinusitis - pathology | Adult | Transcription, Genetic | Single-Cell Analysis | Hyperplasia - metabolism | Nasal Polyps - immunology | Rhinitis - immunology | Nasal Polyps - pathology | Cells, Cultured | Epithelial Cells - pathology | Interleukin-4 Receptor alpha Subunit - antagonists & inhibitors | Interleukin-4 Receptor alpha Subunit - immunology | Hyperplasia - pathology | Interleukin-4 - immunology | Sequence Analysis, RNA | Hypersensitivity - pathology | Epithelial Cells - immunology | Adolescent | Stem Cells - pathology | Aged | Rhinitis - pathology | Allergy | Medical research | Immunologic memory | Respiratory organs | Epithelial cells | Physiological aspects | Medicine, Experimental | Cardiopulmonary system | Allergic reaction | Repositories | Disease | Rhinitis | Ecosystems | Rhinosinusitis | Genomics | Hyperplasia | Genomes | Inflammatory diseases | Respiratory tract | Interleukin 4 | Surgery | Bioinformatics | Cytokines | Hypersensitivity | Basal cells | Interleukin 13 | Gene expression | Ribonucleic acid--RNA | Progenitor cells | Stem cells | Cells (biology) | In vivo methods and tests | Polyps | Chemokines
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12. Full Text 2022 - Single-Cell Analysis of AML Reveals Determinants of Disease Progression and Immune Evasion
by van Galen, Peter and Hovestadt, Volker and Griffin, Gabriel and Verga, Julia and Wadsworth, Marc and Hughes, Travis and Stephansky, Jason and Pastika, TImothy and Story, Jennifer Lombardi and Pinkus, Geraldine and Pozdnyakova, Olga and Graubert, Timothy and Shalek, Alex and Aster, Jon and Lane, Andrew and Bernstein, Bradley
Experimental Hematology, ISSN 0301-472X, 08/2018, Volume 64, pp. S47 - S47
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13. TUMOR AND MICROENVIRONMENT GENE EXPRESSION, COMPOSITIONS OF MATTER AND METHODS OF USE THEREOF
by IZAR, Benjamin and ROZENBLATT-ROSEN, Orit and REGEV, Aviv and PARIKH, Anuraag and GARRAWAY, Levi, A and WADSWORTH, Marc H, II and PRAKADAN, Sanjay and PURAM, Sidharth and TIROSH, Itay and BERNSTEIN, Bradley and SUVA, Mario and VENTEICHER, Andrew and SHALEK, Alexander, K
05/2018
This invention relates generally to compositions and methods for identifying genes and gene networks that respond to, modulate, control or otherwise influence... 
WINE | MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS | ENZYMOLOGY | COMPOSITIONS OR TEST PAPERS THEREFOR | MICROBIOLOGY | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | METALLURGY | PROCESSES OF PREPARING SUCH COMPOSITIONS | BIOCHEMISTRY | CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES | CHEMISTRY | VINEGAR
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14. TUMOR AND MICROENVIRONMENT GENE EXPRESSION, COMPOSITIONS OF MATTER AND METHODS OF USE THEREOF
by Venteicher Andrew and Regev Aviv and Garraway Levi A and Parikh Anuraag and Shalek Alexander K and Rozenblatt-Rosen Orit and Wadsworth II Marc H and Izar Benjamin and Bernstein Bradley and Puram Sidharth and Suva Mario and Prakadan Sanjay and Tirosh Itay
04/2018
This invention relates generally to compositions and methods for identifying genes and gene networks that respond to, modulate, control or otherwise influence... 
WINE | MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS | ENZYMOLOGY | COMPOSITIONS OR TEST PAPERS THEREFOR | MICROBIOLOGY | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | METALLURGY | PROCESSES OF PREPARING SUCH COMPOSITIONS | BIOCHEMISTRY | CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES | CHEMISTRY | VINEGAR
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15. Full Text Durvalumab as third-line or later treatment for advanced non-small-cell lung cancer (ATLANTIC): an open-label, single-arm, phase 2 study
by Garassino, Marina Chiara and Cho, Byoung-Chul and Kim, Dong-Wan and Kim, Joo-Hang and Kim, Sang-We and Kim, Young-Chul and Mazières, Julien and Vansteenkiste, Johan and Lena, Hervé and Corral Jaime, Jesus and Gray, Jhanelle E and Powderly, John and Chouaid, Christos and Bidoli, Paolo and Wheatley-Price, Paul and Park, Keunchil and Soo, Ross A and Huang, Yifan and Wadsworth, Catherine and Dennis, Phillip A and Rizvi, Naiyer A and Paz-Ares Rodriguez, Luis and Novello, Silvia and Hiret, Sandrine and Schmid, Peter and Laack, Eckart and Califano, Raffaele and Maemondo, Makoto and Chaft, Jamie and Vicente Baz, David and Berghmans, Thierry and Surmont, Veerle and Reck, Martin and Han, Ji-Youn and Holgado Martin, Esther and Belda Iniesta, Cristobal and Oe, Yuichiro and Chella, Antonio and Chopra, Akhil and Robinet, Gilles and Soto Parra, Hector and Thomas, Michael and Cheema, Parneet and Katakami, Nobuyuki and Su, Wu-Chou and Wolf, Juergen and Lee, Jong-Seok and Saka, Hideo and Milella, Michele and Ramos Garcia, Inmaculada and Sibille, Anne and Yokoi, Takashi and Kang, Eun Joo and Atagi, Shinji and Spaeth-Schwalbe, Ernst and Nishio, Makoto and Imamura, Fumio and Gabrail, Nashat and Veillon, Remi and Derijcke, Sofie and Maeda, Tadashi and Zylla, Dylan and Kubiak, Kendra and Santoro, Armando and Uy, Ma. Noemi and Lucien Geater, Sarayut and Italiano, Antoine and Kowalski, Dariusz and Barlesi, Fabrice and Chen, Yuh-Min and Spigel, David and Chewaskulyong, Busyamas and Garcia Gomez, Ramon and Alvarez Alvarez, Rosa and Yang, Chih-Hsin and Hsia, Te-Chun and Denis, Fabrice and Sakai, Hiroshi and Vincent, Mark and Goto, Koichi and Bosch-Barrera, Joaquim and Weiss, Glen and Canon, Jean-Luc and Scholz, Christian and Aglietta, Massimo and Kemmotsu, Hirotsugu and Azuma, Koichi and Bradbury, Penelope and Feld, Ronald and Chachoua, Abraham and Jassem, Jacek and Juergens, Rosalyn and Palmero Sanchez, Ramon and Malcolm, Albert and Vrindavanam, Nandagopal and Kubota, Kaoru and Waller, Cornelius and Waterhouse, David and Coudert, Bruno and Mark, Zsuzsanna and ... and ATLANTIC Investigators
The Lancet Oncology, ISSN 1470-2045, 04/2018, Volume 19, Issue 4, pp. 521 - 536
Immune checkpoint inhibitors are a new standard of care for patients with advanced non-small-cell lung cancer (NSCLC) without tyrosine kinase or anaplastic... 
MULTICENTER | METAANALYSIS | NSCLC | ONCOLOGY | RANDOMIZED CONTROLLED-TRIAL | ATEZOLIZUMAB | IMMUNE CHECKPOINT | NIVOLUMAB | MEDI4736 | CLINICAL ACTIVITY | DOCETAXEL | Lung cancer, Non-small cell | Care and treatment
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16. SEMI-PERMEABLE ARRAYS FOR ANALYZING BIOLOGICAL SYSTEMS AND METHODS OF USING SAME
by HUGHES, Travis, K and WADSWORTH II, Marc, H and GIERAHN, Todd M and LOVE, J. Christopher and SHALEK, Alexander, K and CARROLL, Shaina
08/2017
The present application provides a method of assembling a container for one or multiple parallel steps of biochemical analysis on one or more cells comprising... 
WINE | MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS | ENZYMOLOGY | COMPOSITIONS OR TEST PAPERS THEREFOR | INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES | MICROBIOLOGY | MEASURING | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | TESTING | METALLURGY | PROCESSES OF PREPARING SUCH COMPOSITIONS | BIOCHEMISTRY | CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES | CHEMISTRY | VINEGAR | PHYSICS
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17. SEMI-PERMEABLE ARRAYS FOR ANALYZING BIOLOGICAL SYSTEMS AND METHODS OF USING SAME
by HUGHES, Travis, K and GIERAHN, Todd M and WADSWORTH, Marc, H and SHALEK, Alexander, K and CARROLL, Shaina and LOVE, Christopher J
07/2017
The present application provides a method of assembling a container for one or multiple parallel steps of biochemical analysis on one or more cells comprising... 
WINE | MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS | ENZYMOLOGY | COMPOSITIONS OR TEST PAPERS THEREFOR | MICROBIOLOGY | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | METALLURGY | PROCESSES OF PREPARING SUCH COMPOSITIONS | BIOCHEMISTRY | CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES | CHEMISTRY | VINEGAR
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18. Full Text Abstract 3027: Dissecting mechanisms of anti-PD-1 therapy with massively parallel single-cell RNA-sequencing
by Miller, Brian C and Wadsworth, Marc H and Bi, Kevin and Hughes, Travis K and Manguso, Robert and Sharpe, Arlene H and Shalek, Alex K and Haining, Nicholas
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 3027 - 3027
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19. Full Text Erratum: Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput
by Gierahn, Todd M and Wadsworth, Marc H and Hughes, Travis K and Bryson, Bryan D and Butler, Andrew and Satija, Rahul and Fortune, Sarah and Love, J Christopher and Shalek, Alex K
Nature Methods, ISSN 1548-7091, 07/2017, Volume 14, Issue 7, pp. 752 - 752
Ribonucleic acid--RNA | Portability | Gene sequencing
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20. Magneto-inductive magnetic resonance imaging duodenoscope
by Syms, Richard R. A and Kardoulaki, Evdokia and Rea, Marc and Choonee, Kaushal and Taylor-Robinson, Simon and Wadsworth, Christopher and Young, Ian R
Progress in Electromagnetics Research, ISSN 1070-4698, 2017, Volume 159, pp. 125 - 138
A magnetic resonance imaging (MRI) duodenoscope is demonstrated, by combining nonmagnetic endoscope components with a thin-film receiver based on a... 
WIRES | PHYSICS, APPLIED | CATHETERS | MRI | RECEIVER COIL | TELECOMMUNICATIONS | GUIDE | ENGINEERING, ELECTRICAL & ELECTRONIC
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