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Journal of Clinical Oncology, ISSN 0732-183X, 08/2011, Volume 29, Issue 22, pp. 3085 - 3096
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2013, Volume 31, Issue 15, pp. 1825 - 1833
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 6, pp. 682 - 688
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 10/2014, Volume 371, Issue 15, pp. 1426 - 1433
After a prolonged response, an anaplastic thyroid cancer developed resistance to mammalian target of rapamycin (mTOR) inhibition by somatic mutation of mTOR at... 
MEDICINE, GENERAL & INTERNAL | ACTIVATION | MTOR MUTATIONS | PROTEIN | LYMPHANGIOLEIOMYOMATOSIS | INHIBITION | TUBEROUS SCLEROSIS COMPLEX | ANGIOMYOLIPOMA | GENE-PRODUCTS | SENSITIVITY | SIROLIMUS | Sirolimus - analogs & derivatives | Sirolimus - therapeutic use | Humans | Middle Aged | Thyroid Neoplasms - diagnostic imaging | Thyroid Carcinoma, Anaplastic | Antineoplastic Agents - therapeutic use | Combined Modality Therapy | Neoplasm Recurrence, Local - pathology | Radiography | Thyroid Neoplasms - therapy | Thyroid Neoplasms - genetics | Drug Resistance, Neoplasm - genetics | TOR Serine-Threonine Kinases - genetics | Neoplasm Recurrence, Local - diagnostic imaging | TOR Serine-Threonine Kinases - chemistry | Lymphatic Metastasis - pathology | Tumor Suppressor Proteins - genetics | Female | Protein Conformation | Mutation | Everolimus | Thyroid Neoplasms - pathology | Thyroid cancer | Research | Drug therapy | Patient outcomes | TOR protein | Tuberous sclerosis 2 protein | Nonsense mutation | Genomes | Metastasis | Drug resistance | Kinases | Cancer therapies | Metastases | Thyroid carcinoma | Proteins | Allosteric properties | Deoxyribonucleic acid--DNA | Crystal structure | Thyroid | Rapamycin | FDA approval | Radiation therapy | Patients | Studies | TSC2 protein | Chemotherapy | Womens health | Biopsy | Tumors
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7399, pp. 502 - 506
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 12/2014, Volume 111, Issue 51, pp. E5564 - E5573
Journal Article
Investigational New Drugs, ISSN 0167-6997, 2/2014, Volume 32, Issue 1, pp. 178 - 187
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1324 - 13
Journal Article
Cell Reports, ISSN 2211-1247, 03/2019, Volume 26, Issue 10, pp. 2667 - 2680.e7
CDK4/6 inhibition is now part of the standard armamentarium for patients with estrogen receptor-positive (ER ) breast cancer, so that defining mechanisms of... 
targeted therapy | SMAD4 | CDK6 | exosomes | breast cancer | microRNA | TGF-β | drug resistance | palbociclib | ribociclib | BREAST-CANCER | CELLS | DEPENDENT KINASE 4/6 | MOLECULAR PORTRAITS | THERAPY | AMPLIFICATION | CYCLIN D1 | ABEMACICLIB | EXPRESSION | CELL BIOLOGY
Journal Article