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Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 8, pp. 937 - 948
Summary Background Tumour mutational status is an important determinant of the response of metastatic colorectal cancer to targeted treatments. However, the... 
Hematology, Oncology and Palliative Medicine | KRAS MUTATIONS | 1ST-LINE TREATMENT | LEUCOVORIN | PLUS IRINOTECAN | ONCOLOGY | RANDOMIZED PHASE-III | INHIBITS GROWTH | ACQUIRED-RESISTANCE | FLUOROURACIL | PLACEBO PLUS | TUMOR-GROWTH | Predictive Value of Tests | Proto-Oncogene Proteins p21(ras) | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | Clinical Trials, Phase III as Topic | Time Factors | DNA Mutational Analysis | Colorectal Neoplasms - drug therapy | Real-Time Polymerase Chain Reaction | Precision Medicine | Receptor, TIE-1 - blood | Phosphatidylinositol 3-Kinases - blood | Genetic Predisposition to Disease | Adenocarcinoma - blood | ras Proteins - blood | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Disease Progression | Phenotype | Class I Phosphatidylinositol 3-Kinases | Biomarkers, Tumor - genetics | ras Proteins - genetics | Patient Selection | DNA, Neoplasm - blood | Female | Adenocarcinoma - genetics | Retrospective Studies | Pyridines - therapeutic use | Colorectal Neoplasms - mortality | Colorectal Neoplasms - blood | Kaplan-Meier Estimate | Proportional Hazards Models | Phenylurea Compounds - therapeutic use | Proto-Oncogene Proteins B-raf - blood | Proto-Oncogene Proteins - genetics | Treatment Outcome | Randomized Controlled Trials as Topic | Biomarkers, Tumor - blood | Phosphatidylinositol 3-Kinases - genetics | Disease-Free Survival | Proto-Oncogene Proteins B-raf - genetics | Aged | DNA, Neoplasm - genetics | Colorectal Neoplasms - pathology | Proto-Oncogene Proteins - blood | Adenocarcinoma - mortality | Medical colleges | Medical research | Cancer patients | Prognosis | Liver | DNA | Colorectal cancer | Genetic research | Medicine, Experimental | Metastasis
Journal Article
by Lozano, Rafael, Prof and Naghavi, Mohsen, PhD and Foreman, Kyle, MPH and Lim, Stephen, PhD and Shibuya, Kenji, Prof and Aboyans, Victor, Prof and Abraham, Jerry, MPH and Adair, Timothy, PhD and Aggarwal, Rakesh, Prof and Ahn, Stephanie Y, MPH and AlMazroa, Mohammad A, MD and Alvarado, Miriam, BA and Anderson, H Ross, Prof and Anderson, Laurie M, PhD and Andrews, Kathryn G, MPH and Atkinson, Charles, BS and Baddour, Larry M, Prof and Barker-Collo, Suzanne, PhD and Bartels, David H, BA and Bell, Michelle L, Prof and Benjamin, Emelia J, Prof and Bennett, Derrick, PhD and Bhalla, Kavi, PhD and Bikbov, Boris, MD and Abdulhak, Aref Bin, MD and Birbeck, Gretchen, Prof and Blyth, Fiona, PhD and Bolliger, Ian, AB and Boufous, Soufiane, PhD and Bucello, Chiara, BPsych and Burch, Michael, MD and Burney, Peter, Prof and Carapetis, Jonathan, Prof and Chen, Honglei, PhD and Chou, David, BA and Chugh, Sumeet S, Prof and Coffeng, Luc E, MD and Colan, Steven D, Prof and Colquhoun, Samantha, MPH and Colson, K Ellicott, BA and Condon, John, PhD and Connor, Myles D, PhD and Cooper, Leslie T, Prof and Corriere, Matthew, MD and Cortinovis, Monica, BiotechD and de Vaccaro, Karen Courville, MD and Couser, William, Prof and Cowie, Benjamin C, MBBS and Criqui, Michael H, Prof and Cross, Marita, PhD and Dabhadkar, Kaustubh C, MBBS and Dahodwala, Nabila, MD and De Leo, Diego, Prof and Degenhardt, Louisa, Prof and Delossantos, Allyne, BS and Denenberg, Julie, MA and Des Jarlais, Don C, PhD and Dharmaratne, Samath D, Prof and Dorsey, E Ray, MD and Driscoll, Tim, PhD and Duber, Herbert, MD and Ebel, Beth, MD and Erwin, Patricia J, MLS and Espindola, Patricia, MD and Ezzati, Majid, Prof and Feigin, Valery, Prof and Flaxman, Abraham D, PhD and Forouzanfar, Mohammad H, MD and Fowkes, Francis Gerry R, Prof and Franklin, Richard, PhD and Fransen, Marlene, PhD and Freeman, Michael K, BA and Gabriel, Sherine E, Prof and Gakidou, Emmanuela, PhD and Gaspari, Flavio, ChemD and Gillum, Richard F, Prof and Gonzalez-Medina, Diego, BA and Halasa, Yara A, DDS and Haring, Diana, BS and Harrison, James E, Prof and Havmoeller, Rasmus, MD and Hay, Roderick J, Prof and Hoen, Bruno, Prof and Hotez, Peter J, Prof and Hoy, Damian, PhD and Jacobsen, Kathryn H, PhD and James, Spencer L, MPH and Jasrasaria, Rashmi, BA and Jayaraman, Sudha, MD and Johns, Nicole, BA and Karthikeyan, Ganesan, MD and Kassebaum, Nicholas, MD and Keren, Andre, Prof and Khoo, Jon-Paul, MBBS and Knowlton, Lisa Marie, MD and Kobusingye, Olive, MMed and Koranteng, Adofo, MSc and Krishnamurthi, Rita, PhD and Lipnick, Michael, MD and Lipshultz, Steven E, Prof and ...
Lancet, The, ISSN 0140-6736, 2012, Volume 380, Issue 9859, pp. 2095 - 2128
Journal Article
by Murray, Christopher J L, Prof and Vos, Theo, Prof and Lozano, Rafael, Prof and Naghavi, Mohsen, PhD and Flaxman, Abraham D, PhD and Michaud, Catherine, MD and Ezzati, Majid, Prof and Shibuya, Kenji, Prof and Salomon, Joshua A, Prof and Abdalla, Safa, MBBS and Aboyans, Victor, Prof and Abraham, Jerry, MPH and Ackerman, Ilana, PhD and Aggarwal, Rakesh, Prof and Ahn, Stephanie Y, MPH and Ali, Mohammed K, MBChB and AlMazroa, Mohammad A, MD and Alvarado, Miriam, BA and Anderson, H Ross, Prof and Anderson, Laurie M, PhD and Andrews, Kathryn G, MPH and Atkinson, Charles, BS and Baddour, Larry M, Prof and Bahalim, Adil N, MEng and Barker-Collo, Suzanne, PhD and Barrero, Lope H, ScD and Bartels, David H, BA and Basáñez, Maria-Gloria, Prof and Baxter, Amanda, MPH and Bell, Michelle L, Prof and Benjamin, Emelia J, Prof and Bennett, Derrick, PhD and Bernabé, Eduardo, PhD and Bhalla, Kavi, PhD and Bhandari, Bishal, MSc and Bikbov, Boris, MD and Abdulhak, Aref Bin, MD and Birbeck, Gretchen, Prof and Black, James A, MPhil and Blencowe, Hannah, MBChB and Blore, Jed D, PhD and Blyth, Fiona, PhD and Bolliger, Ian, AB and Bonaventure, Audrey, MD and Boufous, Soufiane, PhD and Bourne, Rupert, Prof and Boussinesq, Michel, MD and Braithwaite, Tasanee, BMBCh and Brayne, Carol, Prof and Bridgett, Lisa, PhD and Brooker, Simon, Prof and Brooks, Peter, Prof and Brugha, Traolach S, Prof and Bryan-Hancock, Claire, BPsych and Bucello, Chiara, BPsyc and Buchbinder, Rachelle, Prof and Buckle, Geoffrey, MPH and Budke, Christine M, PhD and Burch, Michael, MD and Burney, Peter, Prof and Burstein, Roy, BA and Calabria, Bianca, BPsych and Campbell, Benjamin, BA and Canter, Charles E, Prof and Carabin, Hélène, Prof and Carapetis, Jonathan, Prof and Carmona, Loreto, MD and Cella, Claudia, PharmChemD and Charlson, Fiona, MPH and Chen, Honglei, PhD and Cheng, Andrew Tai-Ann, Prof and Chou, David, BA and Chugh, Sumeet S, Prof and Coffeng, Luc E, MD and Colan, Steven D, Prof and Colquhoun, Samantha, MPH and Colson, K Ellicott, BA and Condon, John, PhD and Connor, Myles D, PhD and Cooper, Leslie T, Prof and Corriere, Matthew, MD and Cortinovis, Monica, BiotechD and de Vaccaro, Karen Courville, MD and Couser, William, Prof and Cowie, Benjamin C, MBBS and Criqui, Michael H, Prof and Cross, Marita, PhD and Dabhadkar, Kaustubh C, MBBS and Dahiya, Manu, BDS and Dahodwala, Nabila, MD and Damsere-Derry, James, MPH and Danaei, Goodarz, MD and Davis, Adrian, Prof and Leo, Diego De, Prof and Degenhardt, Louisa, Prof and Dellavalle, Robert, MD and Delossantos, Allyne, BS and Denenberg, Julie, MA and Derrett, Sarah, PhD and Des Jarlais, Don C, PhD and ...
Lancet, The, ISSN 0140-6736, 12/2012, Volume 380, Issue 9859, pp. 2197 - 2223
Journal Article