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by Dickinson, Mary E and Flenniken, Ann M and Ji, Xiao and Teboul, Lydia and Wong, Michael D and White, Jacqueline K and Meehan, Terrence F and Weninger, Wolfgang J and Westerberg, Henrik and Adissu, Hibret and Baker, Candice N and Bower, Lynette and Brown, James M and Caddle, L. Brianna and Chiani, Francesco and Clary, Dave and Cleak, James and Daly, Mark J and Denegre, James M and Doe, Brendan and Dolan, Mary E and Edie, Sarah M and Fuchs, Helmut and Gailus-Durner, Valerie and Galli, Antonella and Gambadoro, Alessia and Gallegos, Juan and Guo, Shiying and Horner, Neil R and Hsu, Chih-Wei and Johnson, Sara J and Kalaga, Sowmya and Keith, Lance C and Lanoue, Louise and Lawson, Thomas N and Lek, Monkol and Mark, Manuel and Marschall, Susan and Mason, Jeremy and McElwee, Melissa L and Newbigging, Susan and Nutter, Lauryl M. J and Peterson, Kevin A and Ramirez-Solis, Ramiro and Rowland, Douglas J and Ryder, Edward and Samocha, Kaitlin E and Seavitt, John R and Selloum, Mohammed and Szoke-Kovacs, Zsombor and Tamura, Masaru and Trainor, Amanda G and Tudose, Ilinca and Wakana, Shigeharu and Warren, Jonathan and Wendling, Olivia and West, David B and Wong, Leeyean and Yoshiki, Atsushi and Wurst, Wolfgang and MacArthur, Daniel G and Tocchini-Valentini, Glauco P and Gao, Xiang and Flicek, Paul and Bradley, Allan and Skarnes, William C and Justice, Monica J and Parkinson, Helen E and Moore, Mark and Wells, Sara and Braun, Robert E and Svenson, Karen L and de Angelis, Martin Hrabe and Herault, Yann and Mohun, Tim and Mallon, Ann-Marie and Henkelman, R. Mark and Brown, Steve D. M and Adams, David J and Lloyd, K. C. Kent and McKerlie, Colin and Beaudet, Arthur L and Bućan, Maja and Murray, Stephen A and The International Mouse Phenotyping Consortium and Int Mouse Phenotyping Consortium
Nature (London), ISSN 1476-4687, 2016, Volume 537, Issue 7621, pp. 508 - 514
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous... 
MICRO-CT | MULTIDISCIPLINARY SCIENCES | DISEASE | GENOME-WIDE | MAMMALIAN GENE-FUNCTION | SCREENS | GLYCOGENIN-1 DEFICIENCY | IDENTIFICATION | EXPRESSION | MOUSE EMBRYO | RESOURCE | Genetic research | Phenotype | Research | High-throughput screening (Biochemical assaying) | Methods | Genotype & phenotype | Disease | Developmental biology | Genes | Genomes | Mutation | Embryos | knockout | embryonic lethal | mouse | KOMP | IMPC | EUCOMM
Journal Article
Nihon eiseigaku zasshi. Japanese journal of hygiene, 2018, Volume 73, Issue 2, pp. 97 - 100
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 539, Issue 7629, pp. 378 - 383
... Hayashi [1, 11]; Qinghua Liu [1, 12]; Kazuhiko Kume [4]; Shigeharu Wakana [8]; Joseph S. Takahashi (corresponding author) [1, 6, 13]; Masashi Yanagisawa... 
CLOCK GENE | MUTANTS | AROUSAL | RHYTHMS | SALT-INDUCIBLE KINASE | MULTIDISCIPLINARY SCIENCES | CIRCADIAN PACEMAKER | NEURONAL EXCITABILITY | GABAERGIC NEURONS | REM-SLEEP | CIRCUIT | Sleep Deprivation | Phosphorylation | Sleep, REM - physiology | Caenorhabditis elegans Proteins - chemistry | Caenorhabditis elegans Proteins - metabolism | Ion Channels - genetics | Electroencephalography | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Nerve Tissue Proteins - chemistry | Time Factors | RNA Splicing - genetics | Conserved Sequence | Electromyography | Neurons - metabolism | Sleep - physiology | Ion Channels - chemistry | Protein-Serine-Threonine Kinases - metabolism | Amino Acid Sequence | Caenorhabditis elegans - genetics | Wakefulness - genetics | Protein-Serine-Threonine Kinases - genetics | Sleep - genetics | Drosophila Proteins - chemistry | Random Allocation | Sleep, REM - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Ion Channels - metabolism | Mutagenesis | Wakefulness - physiology | Mice | Protein-Serine-Threonine Kinases - chemistry | Drosophila Proteins - genetics | Mutation | Caenorhabditis elegans Proteins - genetics | Homeostasis - genetics | Usage | Sleep | Physiological research | Genetic aspects | Genetic screening | Methods | Proteins | Genotype & phenotype | Rodents | Genetics | Kinases | Index Medicus
Journal Article
PLoS Genetics, ISSN 1553-7390, 04/2017, Volume 13, Issue 4, p. e1006696
...Author(s): Haruhiko Fujihira 1, Yuki Masahara-Negishi 1, Masaru Tamura 2, Chengcheng Huang 1, Yoichiro Harada 1, Shigeharu Wakana 2, Daisuke Takakura 3, Nana... 
CAENORHABDITIS-ELEGANS | PATHWAY | PEPTIDE-N-GLYCANASE | GENETICS & HEREDITY | DOLICHOL-LINKED OLIGOSACCHARIDES | DISORDER | ER-ASSOCIATED DEGRADATION | NONLYSOSOMAL DEGRADATION | ENDOPLASMIC-RETICULUM | IDENTIFICATION | MAMMALIAN-CELLS | Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase - genetics | Cytoplasm - enzymology | Humans | Mice, Inbred C57BL | Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase - metabolism | Genetic Diseases, Inborn - genetics | Glycosylation | Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase - genetics | Genetic Diseases, Inborn - therapy | Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase - deficiency | Mice, Knockout | Animals | Models, Animal | Mice | Sequence Deletion - genetics | Physiological aspects | Care and treatment | Genetic aspects | Genetic disorders | Research | Transferases | Heart | Cell culture | Peptides | Pathogenesis | Biochemistry | Lethality | Veterinary medicine | Cytosol | Proteins | Degradation | Genotype & phenotype | Eukaryotes | Clusters | Life sciences | Inhibition | Enzymes | Antigens | Data acquisition | Abnormalities | Glycoprotein turnover | Mammals | Embryos | Studies | Mutagenesis | Quality control | Mutation | Endoplasmic reticulum | Residues | Planck, Max | N-Acetylglucosamine | Destruction | Mental disorders | Laboratories | Genes | Homeostasis | Schizophrenia | Lysosomes | mRNA | Biosynthesis | Gene deletion | Defects | Rodents | Compartments | Biodegradation | Hum | Deglycosylation | Dopamine | Data processing | Proteomics | Cancer | Acetone
Journal Article
Nature communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, p. 1DUMMY
.... Speak21, Karen P. Steel21,27, Karen L. Svenson7, The International Mouse Phenotyping Consortiumw, Shigeharu Wakana23, David West28, Sara Wells8, Henrik Westerberg8... 
CONSORTIUM | BIOMEDICAL-RESEARCH | BIAS | MULTIDISCIPLINARY SCIENCES | MICE | SCIENCE | EXPRESSION | GENE-FUNCTION | Phenotype | Animals | Body Weight | Quantitative Trait, Heritable | Mammals - physiology | Female | Genotype | Mice | Genes, Modifier | Sex Characteristics | Genotype & phenotype | Animal models | Biological effects | Sex | Dimorphism | Sexual dimorphism | Mammals | Mutants
Journal Article
PloS one, ISSN 1932-6203, 2019, Volume 14, Issue 7, p. e0220199
... University Graduate School of Medicine, Zaifu-cho, Hirosaki, Aomori, Japan Shigeharu Wakana Roles Investigation Affiliations Technology and Development Team for Mouse... 
MULTIDISCIPLINARY SCIENCES | B cells | Research | DNA binding proteins | Genetic transcription | Proteins | CRISPR | Transcription factors | Immunology | Lymphocytes B | Poultry | Mice | Biochemistry | Biology | Genomes | Pax5 protein | Deoxyribonucleic acid--DNA | Deoxyribonucleic acid | DNA
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2019, Volume 116, Issue 32, pp. 16062 - 16067
Journal Article
The FASEB journal, ISSN 1530-6860, 2017, Volume 31, Issue 6, pp. 2252 - 2266
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